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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Medical Journal of Indonesia Indonesian Journal of Biotechnology Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Sistem Kesehatan Universa Medicina Paediatrica Indonesiana GIZI INDONESIA Chimica et Natura Acta Indonesian Journal of Chemistry Journal of Epidemiology and Public Health The Indonesian Journal of Infectious Diseases FLUIDA Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Tunas Medika Jurnal Kedokteran & Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Bachti Alisjahbana
Infectious Diseases And Tropical Diseases Division, Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Chimica et Natura Acta

 1 
In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes for The Early Detection of Nasopharyngeal Carcinoma Depamede, Brian Umbu Rezi; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Hafidhoh, Sanny; Nururrohmah, Siti; Tryawan, Ilham Ngongu; Yusuf, Muhammad
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.51749

Abstract

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, and hydrophilicity, then characteristic was analyzed and evaluated. The epitope candidates were compared with other saliva protein biomarkers to find if there were cross-reactions. CYFRA 21-1 consists of 57 amino acids, where two immunogenic epitopes (C3 and D2) were chosen. The Ramachandran Plot of both epitopes shows that 100% of the amino acids were in the favoured area. Epitopes C3 and D2 have no cross-reaction with other protein biomarkers. The predicted immunogenic epitopes have the potential as antigen to produce antibodies for developing saliva-based immunodiagnostics to early diagnose NPC patients.
Co-Authors Afandi, Ressa Novita Agnes Rengga Indrati Ahmad Sulaeman Amaylia Oehadian Andre van der Venn Angèle JGMGerver-Jansen Angky Tririni Anita Yuwita Anna Alisjahbana Annisa Ikhsanawati, Annisa Ardini S. Raksanagara Ardini S. Raksanagara, Ardini S. Baskoro, Toni Basti Andriyoko Bestari, Muhamad Begawan Bevi Lidya Bevi Lidya Budi Santoso Budiman , Budiman Clara M Kusharto Depamede, Brian Umbu Rezi Dewi Kartika Turbawaty Dhiya Salsabila Dick van Soolingen Dida Ahmad Gurnida Dwi Agustian Dwihardiani, Bintari Edhyana Sahiratmadja Endang Sutedja Eva Mardiana Hidayat Evan Susandi Fauzian Giansyah Febriani, Ulfah Dwi Felisia . Finny Fitry Yani Gumilang, Manik Intan Guntur Darmawan Hadyana Sukandar Hafidhoh, Sanny Hendra Subroto, Hendra Henriette A Delemarre–van de Waal Henry Chandra Herry Garna Hesti Lina Wiraswati Hidayat, Eva Mardiana Hikmat Permana Hikmat Permana Hinta Meijerink Hofiyah Djauhari Ida Parwati Ida Parwati Iman Rahayu Irvan Afriandi Irvan Afriandi Jeffery Malachi Candra Jose RL Batubara Juhariah Juhariah Julia Hartati Koesoemadinata, Raspati Cundarani Korry Novitriani Krishna Yana Krisnian, Tharani Kumia Wahyudi Kusumawardhani, R.N. Yasmin Lelly Yuniarti Leonardus Wiydatmoko Loe, Luse marni banowati Menik Herdwiyanti Muhamad Zulchoir Rasyid Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Nanan Sekarwana Nanny Natalia Mulyani Soetedjo Nanny Natalia Mulyani Soetedjo Ni Sayu Dewi B. Nina Dwi Putri Nisa Fauziah Novi Jayanti Nuni Sulastri Nurizzatun Nafsi Nurul Hidayah Chairunnisa Nururrohmah, Siti Nury Fitria Dewi obin sarwita Panji Fortuna Hadisoemarto Parse, Rocci Jack Prayudi Santoso Putri Vidyaniati Raspati Cundarani Koesoemadinata Ratna Yulistya Ningrum Reinout van Crevel Reinout van Crevel Ressa Novita Afandi Resvi Livia Rina Triasih Rocci Jack Parse Rovina Ruslami Rovina Ruslami, Rovina Santoso, Ida Parwati Sari Syahruni Setyaningrum, Sinta Siti Soidah Sofia Imaculata Stephen M. Graham, Stephen M. Sulaiman Ngongu Depamede Suparman Hardinsyah, Suparman Susan Margaret McAllister Susandi, Evan Susantina Prodjosoewojo Syndi Nurmawati Teow Sheng Hao Tharani Krisnian Tjahjani M. Sudiro Tony Sadjimin Toto Subroto Toto Subroto Toto Subroto Trinugroho Heri Fadjari, Trinugroho Heri Trisasi Lestari, Trisasi Tryawan, Ilham Ngongu Tya Listiaty Ulfah Dwi Febriani Umi Baroroh Uun Sumardi, Uun Willem J Gerver Wirawan, Chevie Woro Indri Padmosiwi Yana, Krishna Yani Triyani Yani Triyani Yanti Mulyana Yeva Rosana Yovita Hartantri Yulniar Tasli