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All Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer Indonesian Health Journal
Rakhma, Sastia
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Increase in Neopterin Serum Levels Based On Exposure Duration of Silica Dust in Marble Industry Workers Suryaman, Rachmat; Astuti, Tri Wahju; Rakhma, Sastia; Sari, Fitri Indah
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.684

Abstract

Background: Workers in the marble industry face the risk of exposure to dust containing silica crystals in their workplace, a substantial contributor to most occupational lung diseases. Neopterin, an early biomarker of the cellular immune response, is recognized for its association with silica dust exposure. According to a previous study, neopterin levels significantly increased in workers with silicosis compared to controls with no exposure to marble dust. This study aims to analyze changes in neopterin levels based on the duration of silica dust exposure among marble workers. Methods: The study design is an analytical cross-sectional study with a subject pool comprising 32 marble industry workers, categorized into 4 groups based on the duration of exposure: 1-5 years, 5-10 years, >10 years, and control. A comparative analysis was conducted with a control group. Neopterin levels were assessed through the utilization of the Human Neopterin ELISA kit. Analysis using T-tests, ANOVA, and Pearson correlation tests, providing a comprehensive evaluation of the impact of exposure duration. Results: Chest X-ray shows normal results in a routine procedure for most workers. When compared to the control groups, there was a significant increase in serum neopterin levels in all workers. A significant increase was also obtained in neopterin levels among workers with over 5 and over 10 years of exposure. Also, a significant positive correlation between neopterin levels and the duration of exposure. But, among smoker workers, neopterin levels and the Brinkman index level do not show a significant increase. Notably, workers who use nonstandard face masks demonstrate no significant difference in neopterin levels. Conclusion: As marble industry workers are exposed to silica dust for an extended period, there is a corresponding increase in their serum neopterin levels. The duration of silica dust exposure, specifically exceeding five years, significantly influences the elevation of serum neopterin levels.
53-year-old Woman with Sjögren's Syndrome and Anti-synthetase Syndrome Manifesting as Interstitial Lung Disease Krisdiyanto, Peter; Noor Chozin, Iin; Rakhma, Sastia; Rachma Erawati, Dini; Aditya Rahman, Perdana
Malang Respiratory Journal Vol. 8 No. 1 (2026): Volume 8 No 1, March 2026 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2026.008.01.01

Abstract

Background: Sjogren's Syndrome (SS) one of rare disease (approximately 1,0% population) that common manifest as Interstitial Lung Disease (ILD). This pathological condition has a poor prognosis, causes mortality, and is the most common complication. One of the systemic autoimmune diseases characterized by impaired function of the exocrine glands. Anti-synthetase syndrome (ASS) is an autoimmune condition, characterized by aminoacyl-transfer-RNA-synthetase antibodies accompanied by ILD, myositis, or arthritis. Case Report: A 53-year-old housewife was diagnosed with SS 3 years ago with osteoporosis and spinal compression. Complaints of dry skin, muscle weakness, back pain, joint pain, and shortness of breath after doing strenuous activities. History of treatment with Azathioprine 2 x 50 mg for 1 month and replaced with Mycophenolate mofetil (MMF) 2 x 360 mg after ILD was found on High-Resolution Computed Tomography (HRCT). Laboratory results showed anemia Hb 10.3, elevated CK-NAC levels (563 U/L), and positive anti-PL-7-Ab results. HRCT shows Usual Interstitial Pneumonia (UIP). Body-plethysmography results shows respiratory restriction (40%). Discussion: SS is identified by the presence of myositis-specific antibodies, accompanied by at least 2 conditions, ILD, inflammatory myopathy, or inflammatory polyarthritis. Anti-threonyl-tRNA-synthetase specific antibody (anti-PL-7) is one of the rarest. ILD presentation on HRCT helps identify SS or combination of ASS. The type of ILD that appears inpatients is a picture of UIP. Treatment of SS with Azathioprine is replaced with MMF after ILD is known and if progress is found, there is a place for giving anti-fibrotics. Conclusion: A 53-year-old woman with SS who found specific anti-PL-7 antibodies manifested ILD and inflammatory myopathy supports a combined diagnosis of ASS.
Co-Authors Aditya Rahman, Perdana Ana Rima Setijadi Arinto Yudi Ponco Wardoyo Astuti, Tri Wahyu Asyari, Claudia Herda Choizin, Iin Chozin, Iin Noor Djajalaksana, Susanthy Erawati, Dini Rachma Fahlevie, Fahlevie Fitri Indah Sari Herda Asyari, Claudia Krisdiyanto, Peter Mahendra, Reza Aditya Nanik Setijowati Noor Chozin, Iin Novita Silvana Thomas, Novita Silvana Permatasari, Adinda Pramitra Pratiwi, Suryanti Dwi Putra, Ngakan Putu Parsama Rachma Erawati, Dini Rakhma, Rakhma Sartono, Teguh Rahayu Setiadi, Satya Setyawan, Ungky Setyawan, Ungky Agus Sugiri, Yani Jane R. Suryaman, Rachmat Tri Wahju Astuti, Tri Wahju WIDIASTUTI - Yudhanto, Hendy Setyo