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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Kesehatan Andalas MNJ (Malang Neurology Journal) Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Pengabdian Dharma Wacana Respiratory Science
Tri Wahju Astuti, Tri Wahju
Lab/SMF Paru FKUB/RSSA
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Ekspresi IFN-γ dan IL-4 CD4+T Limfosit pada Tuberkulosis Kontak terhadap Antigen 38 Kda Mycobacterium tuberculosis Nugrahani, Iin Trilistiyanti; Kusuma, HMS Chandra; Raras, Tri Yudani Mardining; Arthamin, Maimun Zulhaidah; Astuti, Tri Wahju; Tanoerahardjo, Francisca
Jurnal Kedokteran Brawijaya Vol 28, No 4 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2015.028.04.8

Abstract

Mengendalikan epidemi tuberkulosis pada anak adalah prioritas kesehatan global. Efikasi vaksin Bacillus of Calmette and Guerin (BCG) sangat bervariasi sehingga memerlukan pengembangan vaksin baru. Antigen rekombinan 38 Kda Mycobacterium tuberculosis sebagai kandidat vaksin harus melalui uji imunogenitas. Tujuan studi ini untuk mengidentfikasi apakah antigen  38 Kda dapat menstimuli ekspresi IFN-γ dan IL-4 limfosit TCD4+ pada kultur PBMC anak dengan kontak TB. Studi ini dilakukan pada kultur PBMC dari 8 kontak TB dan 8 anak sehat yang diinduksi oleh antigen 38 Kda (kelompok 1), PPD (kelompok 2) dan tanpa perlakuan (kelompok 3). Ekspresi IFN-γ dan IL-4 limfosit TCD4+ diukur dengan flowcytometry. Rerata kadar IFN-γ untuk kontak TB tertinggi pada kelompok 3 (p=0,76), sedangkan rerata IL-4 tertinggi pada kelompok 2(p=0,68).RerataIFN-γ untukkelompok sehattertinggi pada kelompok3(p=0,78) sedangkanrerata IL-4 tertinggi pada kelompok 2 (p=0,32). Rerata ekspresi IFN-γ dan IL-4 yang diinduksi oleh antigen 38 Kda, masing-masing lebih tinggi pada kontakTB daripada subjek sehat (p=0,62 dan 0,39). Pengaruh respon imun yang protektif ditunjukkan oleh rasio ekspresi IFN-γ dan IL-4 yang lebih dari 1, baik pada kontak TB dan sehat (1,22 dan 1,28). Tidak ada perbedaan signifikan antara perlakuan pemberian antigen38 kDa, PPD dan tanpa perlakuan. Dapat disimpulkan bahwa antigen 38 Kda dapat menstimuli  ekspresi IFN-γ dan IL-4 limfosit TCD4+pada kultur PBMC kontak TB. Kata Kunci: Antigen rekombinan 38 Kda, Mycobacterium tuberculosis, IFN-γ, IL-4, limfositTCD4+
NEUROLOGICAL MANIFESTATION ON HOSPITALIZED PATIENT WITH PROBABLE COVID-19 IN SAIFUL ANWAR HOSPITAL INDONESIA (SERIAL CASES) Munir, Badrul; Rianawati, Sri Budhi; Kurniawan, Shahdevi Nandar; Santoso, Widodo Mardi; Arisetijono, Eko; Candradikusuma, Didi; Heri, Sutanto; Chozin, Iin Noor; Dwi, Pratiwi Suryanti; Astuti, Tri Wahju; Asmiragani, Syaifullah
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Coronavirus disease 2019 (Covid-19) caused by SARS-Cov-2 had been spreading worldwide including Indonesia, but In Indonesia, it was difficult to diagnose confirmation Covid-19 by Polymerase Change Reaction (PCR). and in clinical practice to treat covid-19,  Indonesia Health Ministry use term probable covid-19 for patients under observation Covid-19, but study for neurological manifestation on  probable Covid-19 is very lacking.Objective: Knowing the neurological manifestation of patient probable Covid-19.Methods: Observational study from Covid-19 medical record and neuro-Covid-19 medical record of all probable Covid-19 hospitalized in the isolation ward of Saiful Anwar Hospital (RSSA) Malang since March-May, 2020 (3 months). Probable Covid-19 criteria were given by Covid-19 task force team based on Health Minister Indonesia criteria. This criterion was based on clinical manifestation (severe upper respiratory symptoms, or mild-severe pneumonia), radiologic examination (lung infiltrate and or chest CT scan), and laboratory examination. Neurological manifestation is based on clinical symptom appeared while patient hospitalized, supported with radiologic and laboratory data which was supervised by neurologist or neurologist resident. All data was inputted to neuro-Covid-19 e-registry on the smartphone application, sent periodically to the data center in Neurology Department RSSA Malang.Results: A hundred and fourteen probable Covid-19 was registered with mean age 34,5 year old and mostly at the young age of 20-50 years (38%). The neurological manifestation was observed in 4 patients (3,4% from all possible Covid-19 patients) with thrombotic stroke as the most common manifestation (50%), followed by myelum tumor (25%) and hypoxia encephalopathy (25%). Stroke patients in probable Covid-19 had old age (72 and 82 years) accompanied by several comorbid such as hypertension, DM and CVA history and Covid symptoms of cough, shortness of breath and fever. Hemiparesis was found improved with aspirin and neurotropic therapy. Patient with myelum tumor had a covid symptom of shortness of breath, cough, and fever with UMN tetraparesis. Previous MRI examination results suspected meningioma. The patient died while hospitalized. Patients with hypoxia encephalopathy admitted with decreased consciousness due to shortness of breath with acidosis respiratory symptoms (pH 7,22 ). This condition improved after oxygenation without focal neurologic deficit.Conclusion: Neurological manifestation in probable Covid-19 was 3,4% of all patients. The most common diagnosis was a thrombotic stroke, followed by myelum tumor, hypoxia encephalopathy, and mortality rate is 25%.
Correlation Between Coinfection of Severe and Critically Ill COVID-19 Patients In Intensive Care Unit with Leucocyte, Neutrophil, CRP, Procalcitonin and Length of Stay Prayitno, Harman; Sugiri, Yani Jane; Astuti, Tri Wahju; Fatoni, Arie Zainul; Hastuti, Nurima Diyah Puji
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.167

Abstract

Background: Severe or critical COVID-19 infections are linked to admissions in the intensive care unit (ICU), which increases the risk of coinfection and results in a worsened prognosis. This research seeks to evaluate the relationship between bacterial and fungal coinfection in COVID-19 and leukocyte, neutrophil, C-Reactive Protein (CRP), procalcitonin levels, length of stay, and outcome (whether the patient was discharged from ICU to the ward or died). Method: This research constitutes a retrospective cohort analysis. Data was collected from the medical records of patients admitted to the ICU of Saiful Anwar General Hospital in Malang from August 2020 to August 2021, who tested positive for COVID-19. A total of 352 individuals qualified according to the inclusion criteria. Results: Coinfection occurred in 22.2% of COVID-19 patients, with bacterial 84.61%, fungal 11.53%, and both bacterial and fungal 3.84%. The average stay for patients without coinfection was 6 days, while it was 13 days for those with coinfection. We also observed a rise in mortality rate for coinfection at 71.8% compared to 31% for non-coinfection. Coinfection with bacterial, fungal, or both types in COVID-19 shows a positive correlation with Leucocyte (P=0.001; r=0.356), Neutrophil (P=0.001; r=0.438), CRP (P=0.003; r=0.164) and Procalcitonin (P=0.001; r=0.192) as well as a positive correlation with the length of stay (P=0.001) and a negative correlation with the outcome (P=0.001). Conclusion: Coinfection occurred in just about one-fifth of COVID-19 patients. We suggest prescribing antimicrobials only when there is a compelling reason. Timely detection of bacterial and fungal coinfection was essential to identify high-risk patients and determine appropriate interventions to prevent longer hospital stays and reduce mortality.
Gambaran Infeksi Nontuberculous Mycobacteria (NTM) pada Penderita Suspek TB Paru Menggunakan Multiplex PCR (MPCR)-Universal Lateral Flow Assay (ULFA) Kit Akbar, Putri Wulan; Iskandar, Agustin; Astuti, Tri Wahju; Indriana, Kristin
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1394

Abstract

Infeksi paru akibat Nontuberculous Mycobacteria (NTM) dan Mycobacterium tuberculosis (MTB) dapat memberikan gambaran klinis yang serupa sehingga berpotensi menyebabkan kesalahan diagnosis dan terapi. Pemeriksaan Multiplex PCR (MPCR)-Universal Lateral Flow Assay (ULFA) merupakan pemeriksaan berbasis molekuler untuk mendeteksi gen rpoB, IS1660 dan mtp40 yang dapat digunakan untuk membedakan infeksi NTM dari infeksi TB. Tujuan:  Mendapatkan gambaran infeksi NTM menggunakan MPCR-ULFA pada penderita terduga TB paru. Metode: Penelitian ini merupakan studi deskriptif dengan pendekatan potong lintang yang dilaksanakan sejak April sampai Juli 2019. Sebanyak 39 sampel sputum dari pasien terduga TB paru dari RSUD Kanjuruhan Kepanjen, Kabupaten Malang diperiksakan apusan BTA, GeneXpert dan MPCR-ULFA. Hasil: Sebanyak 5 sampel (12,8%) sputum dari pasien terduga TB paru terdeteksi sebagai NTM positif menggunakan pemeriksaan MPCR-ULFA. Empat dari lima sampel (80%) tersebut memiliki kesesuaian dengan hasil GeneXpert dan apusan BTA, yakni MTB negatif.  Pemeriksaan molekuler baik GeneXpert maupun MPCR-ULFA keduanya mendeteksi keberadaan gen rpoB dari Mycobacterium. Metode MPCR-ULFA mengamplifikasi 3 gen target sekaligus (IS1660, mtp40 dan rpoB) sehingga dapat mendeteksi infeksi NTM atau MTB. Simpulan: Prevalensi NTM pada pasien terduga TB paru di RSUD Kanjuruhan Kepanjen menggunakan MPCR-ULFA mencapai 12,8%. Sebanyak 80% dari NTM positif memiliki hasil pemeriksaan GeneXpert dan apusan BTA negatif.Kata kunci: GeneXpert, MPCR-ULFA, NTM, suspek TB paru
The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer Tjahyadi, Rizal Muldani; Setyawan, Ungky Agus; Astuti, Tri Wahju; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp171-180

Abstract

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.
The Effect of Anemia on Prognostic in Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy Kartikasari, Ulfah; Pratiwi, Suryanti Dwi; Astuti, Tri Wahju; Setijowati, Nanik
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.120-129

Abstract

Introduction: Lung cancer has the highest incidence and mortality rate, which contributes to approximately 2.2 million cancer cases (11.4%) of total cancers worldwide. More than 70% of lung cancer cases present in the late, non-operable stage. Anemia is one of the conditions that could precipitate cancers and affect the patient's clinical presentation, including tissue oxygenation, organ function, and quality of life. It could also increase the risk of bleeding, post-operative mortality, and iron absorption rate in the case of ineffective erythropoiesis. All of these could affect the prognostic factor of the cancer. This study aimed to evaluate the effect of the severity of anemia on overall survival (OS) and progression-free survival (PFS) in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. Methods: This was a retrospective cohort study involving 80 subjects of NSCLC patients treated with platinum-based chemotherapy from January 2018 to December 2020. Subjects were divided into two groups (39 patients in the normal group and 41 patients in the anemia group). Results: The mean pre-treatment hemoglobin (Hb) was 10.55 ± 1.25 g/dL in NSCLC patients with anemia. The bone metastasis, OS, and PFS values of the normal and anemia groups were significant (p = 0.008; p = 0.002; p = 0.27). Anemia was significantly related to OS (r = 0.146, p = 0.000) and PFS (r = 0.264, p = 0.000) in NSCLC patients treated with platinum-based chemotherapy. Conclusion: Higher severity of anemia can reduce OS and PFS in NSCLC patients treated with platinum-based chemotherapy.
Edukasi Faktor Resiko Penyakit Paru, Perilaku Hidup Bersih dan Sehat pada Pekerja Sampah Astuti, Tri Wahju; Sari, Fitri Indah; Dini, Zata; Anggraeni, Rizki Diah
Jurnal Pengabdian Dharma Wacana Vol 4, No 3 (2023): Jurnal Pengabdian Dharma Wacana
Publisher : Yayasan Pendidikan dan Kebudayaan Dharma Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37295/jpdw.v4i3.449

Abstract

Saat ini di Kota Malang tercatat terdapat 59 tempat pembuangan sampah akhir yang tersebar di 5 wilayah kecamatan. Dari pengamatan, didapatkan rendahnya pemahaman akan pola hidup sehat, resiko penyakit paru dan pernapasan yang dapat terjadi akibat pajanan di tempat kerja, serta kurangnya kesadaran menggunakan alat pelindung diri yang tepat. Selain itu pada para pekerja masih terdapat kebiasaan merokok. Berdasarkan identifikasi masalah tersebut penting untuk dilakukan kegiatan pengabdian kepada masyarakat pada kelompok pekerja ini. Pengabdian kepada masyarakat ini bertujuan untuk memberikan proses pembelajaran dan memotivasi masyarakat khususnya para pekerja, dan pemangku kepentingan mengenai lingkungan kerja yang bersih dan sehat, serta meningkatkan kesadaran untuk menggunakan alat pelindung diri yang tepat. Pada kegiatan ini juga dilakukan skrining kesehatan pekerja. Kegiatan pengabdian masyarakat dengan metode ARRIF yang terdiri dari Analisis, Rumusan, Rencana Intervensi, Forum Komunikasi. Edukasi dan evaluasi meliputi pengetahuan tentang alat pelindung diri, pola hidup bersih dan sehat, penyakit paru akibat kerja, dan bahaya merokok yang tercakup dalam 12 pertanyaan. Dari total 68 pekerja  didapatkan 35 pekerja  (52%) berpengetahuan baik, 18 pekerja  (26%) berpengetahuan sedang, dan 15 pekerja  (22%) berpengetahuan kurang. Penggunaan APD lengkap pada pegawai lebih tinggi dibandingkan pada pemulung. Yakni 33% dibandingkan 10% dari total pegawai dan pemulung yang berpartisipasi.
Increase in Neopterin Serum Levels Based On Exposure Duration of Silica Dust in Marble Industry Workers Suryaman, Rachmat; Astuti, Tri Wahju; Rakhma, Sastia; Sari, Fitri Indah
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.684

Abstract

Background: Workers in the marble industry face the risk of exposure to dust containing silica crystals in their workplace, a substantial contributor to most occupational lung diseases. Neopterin, an early biomarker of the cellular immune response, is recognized for its association with silica dust exposure. According to a previous study, neopterin levels significantly increased in workers with silicosis compared to controls with no exposure to marble dust. This study aims to analyze changes in neopterin levels based on the duration of silica dust exposure among marble workers. Methods: The study design is an analytical cross-sectional study with a subject pool comprising 32 marble industry workers, categorized into 4 groups based on the duration of exposure: 1-5 years, 5-10 years, >10 years, and control. A comparative analysis was conducted with a control group. Neopterin levels were assessed through the utilization of the Human Neopterin ELISA kit. Analysis using T-tests, ANOVA, and Pearson correlation tests, providing a comprehensive evaluation of the impact of exposure duration. Results: Chest X-ray shows normal results in a routine procedure for most workers. When compared to the control groups, there was a significant increase in serum neopterin levels in all workers. A significant increase was also obtained in neopterin levels among workers with over 5 and over 10 years of exposure. Also, a significant positive correlation between neopterin levels and the duration of exposure. But, among smoker workers, neopterin levels and the Brinkman index level do not show a significant increase. Notably, workers who use nonstandard face masks demonstrate no significant difference in neopterin levels. Conclusion: As marble industry workers are exposed to silica dust for an extended period, there is a corresponding increase in their serum neopterin levels. The duration of silica dust exposure, specifically exceeding five years, significantly influences the elevation of serum neopterin levels.
Co-Authors Agustin Iskandar Anggraeni, Rizki Diah Arie Zainul Fatoni Arinto Yudi Ponco Wardoyo Asmiragani, Syaifullah Badrul Munir, Badrul Chozin, Iin Noor Didi Candradikusuma Dini, Zata Djajalaksana, Susanthy Dwi, Pratiwi Suryanti Eko Arisetijono Fitri Indah Sari Francisca Tanoerahardjo, Francisca Hastuti, Nurima Diyah Puji Heri, Sutanto HMS Chandra Kusuma Iin Trilistiyanti Nugrahani, Iin Trilistiyanti Indriana, Kristin Kartikasari, Ulfah Maimun Zulhaidah Arthamin, Maimun Zulhaidah Nanik Setijowati Pratiwi, Suryanti Dwi Prayitno, Harman Putri Wulan Akbar Rakhma, Sastia Setyawan, Ungky Agus Shahdevi Nandar Kurniawan, Shahdevi Nandar Sri Budhi Rianawati, Sri Budhi Sugiri, Yani Jane Suryaman, Rachmat Tjahyadi, Rizal Muldani Tri Yudani Mardining Raras Widodo Mardi Santoso, Widodo Mardi