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Saiful Anam
MA. Qurratul Uyun Pamekasan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Social Sciences Transportation Other

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Journal : Journal Of World Science

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Pachydermoperiostosis Mimicking Acromegaly: a Rare Case Report in Sardjito General Hospital Yogyakarta Indonesia Anam, Saiful; Sinorita, Hemi
Journal of World Science Vol. 3 No. 4 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i4.593

Abstract

Pachydermoperiostosis is a genetic disorder characterized by pachydermia and periostosis. The clinical and radiological features of pachydermoperiostosis are similar to acromegaly. The Prevalence of pachydermoperiostosis is estimated 0.16%. The ratio of male-to-female incidence is 7 to 1. We report a man 26 years old with complaints of pain and swelling in the wrist joints, fingers, knee joints and ankle joints bilaterally; seborrheic dermatitis, eyelid ptosis, and thickening of facial skin, which has been progressive since he was 17 years old. Manus, genu and pedis x-ray results showed a features of mixed connective tissue disease. Magnetic resonance imaging result of the pituitary gland with contrast  was normal. Laboratory results for growth hormone (GH) and insulin growth factor-1 (IGF-1) were normal. Histopathology results of the facial skin biopsy showed grade 1 pachydermia in pachydermoperiostosis. In conclusion, the appearance of pachydermia on skin biopsy, with normal  growth hormone and insulin growth factor-1 results can differentiate pachydermoperiostosis from acromegaly.
Co-Authors Abdul Halik Achmad Rijanto Ade Setia Pratama Agung Wijaya, Agung Ahmad Zulfikar Ali Ani Purwati, Ani Aris Yulia, Aris Chrisvianti, Nita Fitriani, Azizah Fitriani, Herni Hemi Sinorita Heru Tjaraka Heru Tjaraka Hidayatullah Hidayatullah Indrianto, Dian Istiqomah, Inuk Wahyuni Ivanda, Muhammad Nur Miftakhul Liza Marina Malindo, Tito Miftakhul Ivanda, Muhammad Nur Moraza, Gitra Muhammad Abdul Aziz Mujibno, Mujibno Nur Lailiyatul Inayah Nurhadi, Muizzu Nurrohman Harimulyono pramesthi, gita winandha Prameswari, Regita Widya Pratama, Ade Setia Pratama, Shakti Abdillah Priyo Amboro, Yudhi Rifa’i, Muhamad Nanang Rina Shahriyani Shahrullah Rony Wardhana Roy Budiharjo Safri Haliding Salimin Salimin, Salimin Sapuguh, Iman Selvia, Dila sembada, Yoga septian alea Sifaunajah, Agus Syahruddin, Erwin Teodora Winda Mulia Wahyu Nugroho Zulfika, Dicki Nizar