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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Biopropal Industri Jurnal Kimia Riset Jurnal Biologi Tropis ANNALES BOGORIENSES Narra J Makara Journal of Science Jurnal Sains Materi Indonesia Annales Bogorienses
Marissa Angelina
Pusat Penelitian Kimia-LIPI, Kawasan PUSPIPTEK Serpong 15314, Tangerang 15314
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : HAYATI Journal of Biosciences

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Evaluation of Curcumin-derived Carbon-dots' Inhibitory Activity as SARS-CoV-2 Antiviral Candidate Using Chemical Crosslinking Taharuddin, Audrey Angelina Putri; Yamahoki, Nicholas; Stephanie, Rebecca; Agustiyanti, Dian Fitria; Wisnuwardhani, Popi Hadi; Angelina, Marissa; Rubiyana, Yana; Ningrum, Ratih Asmana; Wardiana, Andri; Desriani, Desriani; Hariyatun, Hariyatun; Iskandar, Ferry; Permatasari, Fitri Aulia; Giri-Rachman, Ernawati Arifin; Fibriani, Azzania
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.232-239

Abstract

In our previous work, we demonstrated that curcumin-derived carbon dots (Cur-CDs) have potential as antivirals for COVID-19. However, the precise mechanism of action remains unclear. This study investigated the potential of Cur-CDs against SARS-CoV-2 by targeting the dimerization of the C-terminal domain of nucleocapsid protein (N-CTD) using chemical crosslinking. Recombinant SARS-CoV-2 N-CTD was expressed, purified, and subjected to chemical crosslinking. The dimerization inhibition ability of Cur-CDs was assessed with ligand concentrations ranging from 0 to 2,000 μg/mL. Successful inhibition —defined as a noticeable reduction in SARS-CoV-2 N-CTD dimer band intensity on SDS-PAGE—was observed when Cur-CDs were present at 8 to 16 times the protein concentration. We hypothesize that Cur-CDs bind to the dimerization residues, preventing non-covalent interactions between monomers and limiting dimer formation. Our findings suggest that Cur-CDs could be a promising antiviral strategy for SARS-CoV-2, especially targeting the dimerization of the nucleocapsid protein. Additionally, this study also highlights the use of chemical crosslinking as a valuable tool for interaction-based drug screening.
Co-Authors . Megawati A.A. Ketut Agung Cahyawan W Agustiyanti, Dian F. Agustiyanti, Dian Fitria Anak Agung Istri Sri Wiadnyani Andri Wardiana, Andri Antonius Herry Cahyana Aoki, Chie Beti Ernawati Dewi Desriani Desriani Desti, Hidayati Dewijanti, Indah Dwiatmi Dewijanti, Indah Dwiatmi Dwi Hilda Putri ERNAWATI ARIFIN GIRI-RACHMAN Ferry Iskandar Fibriani, Azzania HAK HOTTA Hariyatun, Hariyatun Indah D Dewijanti, Indah D Indah Dewiyanti, Indah Irdawati Irdawati Kamarisima, Kamarisima Kasiyati Kasiati Khoerunisah, Marya Salfia Lia Meilawati Megawati - Meitha, Karlia Meliana, Yenny Mirawati Sudiro Muchammad Irsyad, Muchammad Ningrum, Ratih A. Nugroho, Herjuno A. Nurfauziyah Permatasari, Fitri Aulia Popi Hadi Wisnuwardhani, Popi Hadi Priharto, Neil Putria, Devi Kasih RAHMANI, SILMI RATIH ASMANA NINGRUM S, Banjarnahor S D Santi, Mei Ria Saputra, Ziyan Saputri, Ariyanti Septiani, Popi Septiyanti, Melati Soedarmono, Pratiwi Sofa Fajriah Sofna D.S. Banjarnahor Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Sri Hartati Stephanie, Rebecca Taharuddin, Audrey Angelina Putri Tan, Marselina I. Tri Yuliani, Tri Triana Dewi, Rizna Wisnuwardhani, Popi H. Yamahoki, Nicholas Yana Rubiyana, Yana Zakri, Dwika Febriana