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Pemanfataan Media Powtoon Dalam Pembelajaran Fisika Untuk Meningkatkan Hasil Belajar Dan Keaktifan Siswa Asmaul Khusna
Student Research Journal Vol. 2 No. 2 (2024): April : Student Research Journal
Publisher : Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/srjyappi.v2i2.1151

Abstract

This research aims to improve the learning outcomes and activity of class XA MAN 4 Madiun students in Physics and Energy lessons through the use of Powtoon media. This research is classroom action research consisting of 2 cycles. The subjects of this research were all students in class XA MAN 4 Madiun, totaling 31 students. The data analyzed in this research are observation sheets, questionnaires and written test results. The data analysis technique was carried out using quantitative description techniques. The indicator of success for this research is that 75% of students have completed the KKM. In the pre-cycle, 48% (15) students completed the KKM. In the first cycle, 71% (22) students completed the KKM. Then, in cycle II there were 90% (28) students who completed the KKM. Research success was obtained in cycle II. The use of Powtoon learning media has also succeeded in increasing students' active learning as proven by the success indicator of this research being more than 75% of the number of students in the A and B grade classifications. The success of the research to increase students' active learning in class was obtained in cycle II, namely 83.9%. (26) students.
Generalized Pustular Psoriasis pada Pasien Diabetes Melitus Tipe 2: (Case Report) Asmaul Khusna; Heffi Anindya Putri
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8464

Abstract

Generalized pustular psoriasis (GPP) is a severe inflammatory form of psoriasis characterized by widespread sterile pustular eruptions. Pro-inflammatory mediators released during chronic inflammation may contribute to comorbidities, including type 2 diabetes mellitus (T2DM). A 65-year-old woman presented with pustular eruptions over almost the entire body for seven days, accompanied by burning sensation and pruritus. Some pustules coalesced forming “lakes of pus,” while others appeared as erythematous plaques with coarse white scales. The patient had a history of T2DM. Based on clinical findings, the patient was diagnosed with GPP. She was hospitalized for seven days and followed up weekly until week 10. Inflammatory mediators such as Th-1, TNF-α, IL-6, IL-7, IL-8, IL-17, and IL-23 in psoriasis may inhibit insulin receptor signaling and glucose uptake, leading to insulin resistance and increased blood glucose levels. The duration of treatment until remission in psoriasis patients with T2DM tends to be longer than in non-diabetic patients. In patients with comorbidities, low-dose methotrexate (5–7.5 mg/week) was administered. The coexistence of GPP and T2DM may lead to more severe exacerbations, prolonged treatment duration, and reduced quality of life, posing challenges in management.
Permethrin Resistance and Alternative Therapies in Scabies : A Systematic Review Asmaul Khusna; Dinna Devi; Heffi Anindya Putri
The International Journal of Medical Science and Health Research Vol. 34 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/vv4xxh23

Abstract

Introduction: Scabies, caused by Sarcoptes scabiei var. hominis, affects over 200 million people globally, with permethrin 5% cream serving as first-line treatment for decades. However, emerging evidence suggests increasing permethrin treatment failures, raising concerns about resistance. This systematic review aims to synthesize evidence on permethrin resistance in scabies and evaluate the effectiveness and safety of alternative therapeutic options. Methods: A systematic review was conducted following PRISMA guidelines. We searched multiple databases for studies investigating permethrin resistance or alternative scabies treatments. Included studies comprised randomized controlled trials, cohort studies, case-control studies, case series (≥5 patients), systematic reviews, and meta-analyses reporting clinical outcomes in human patients with confirmed or clinically diagnosed scabies. A total of 144 studies met inclusion criteria and underwent data extraction for resistance evidence, alternative therapy details, comparative effectiveness, safety profiles, and clinical context. Results: Documented permethrin resistance demonstrated significant geographic heterogeneity, with European studies reporting cure rates as low as 27-31% compared to 73-96% in South Asian settings. Global treatment failure prevalence increased by 0.58% annually (95% CI not reported). Resistance mechanisms included voltage-gated sodium channel mutations and enhanced glutathione S-transferase activity. Alternative therapies showed variable effectiveness: two-dose oral ivermectin (200 μg/kg one week apart) achieved 78-100% cure versus 58% for single-dose (P=0.021); topical ivermectin 1% achieved 96-100% cure by four weeks; benzyl benzoate 25% showed 87% cure in some studies but caused burning in 24% of patients; sulfur preparations achieved 94.4-100% cure by four weeks with mild adverse effects. Combination permethrin-ivermectin therapy demonstrated superior efficacy (84.6% vs 67.5-70.7% for monotherapies, P<0.01). Mass drug administration with ivermectin reduced scabies prevalence by 79% (95% CI not reported). Discussion: The geographic disparity in permethrin efficacy likely reflects true biological resistance evolution in regions with prolonged permethrin use, rather than methodological artifacts. Alternative therapies, particularly two-dose oral ivermectin and topical ivermectin, demonstrate excellent effectiveness in permethrin-resistant cases. Treatment selection should consider resistance patterns, patient age, pregnancy status, and resource availability. Combination approaches may offer advantages in refractory cases. Conclusion: Permethrin resistance represents an emerging global challenge requiring revised treatment algorithms. Two-dose oral ivermectin (200 μg/kg one week apart) should be considered first-line in regions with documented resistance, while topical ivermectin offers advantages in young children. Future research should focus on standardized resistance surveillance, novel agents including moxidectin and spinosad, and implementation strategies for resistant populations.