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All Journal Indonesian Journal of Chemistry JFIOnline Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology
Khalijah Awang
Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Journal : Malacca Pharmaceutics

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Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia Khairan, Khairan; Arini, Musfira; Idroes, Rinaldi; Awang, Khalijah; Jacob, Claus
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.29

Abstract

The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.
Antibacterial Potential of Geothermal Plant Extracts from Jaboi Crater, Indonesia: A Thin Layer Chromatography-Bioautography Approach Khairan, Khairan; Mubaraq, Farhil; Maulydia, Nur Balqis; Awang, Khalijah; Idroes, Rinaldi
Malacca Pharmaceutics Vol. 3 No. 2 (2025): September 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i2.312

Abstract

Antimicrobial resistance (AMR) poses an urgent global health concern, prompting the need for alternative therapeutic agents. This study evaluated the antimicrobial potential of ethyl acetate extracts from five medicinal plant species (Memecylon edule, Garcinia dioica, Syzygium sp., Memecylon caeruleum, and Aporosa octandra) collected from the geothermal Jaboi Crater in Aceh, Indonesia. Phytochemical profiling was performed using thin layer chromatography (TLC), and antimicrobial activity was assessed via TLC-bioautography against Escherichia coli, Staphylococcus aureus, and Candida albicans. The results revealed the presence of phenolic and terpenoid compounds, with antibacterial activity observed only against E. coli. No inhibition was detected against S. aureus or C. albicans. The study highlights the selective antimicrobial potential of geothermal plant extracts and underscores the relevance of bioautography as a rapid screening tool. While preliminary, these findings support further investigation into geothermal flora as a source of antibacterial compounds and call for advanced studies to isolate active constituents and explore their mechanisms of action.
Co-Authors A. Hamid A. Hadi Ace Tatang Hidayat Arini, Musfira Azmi, Mohamad Nurul Claus Jacob, Claus Darwati, Desi Harneti Putri Huspa Diah, Muhammad Fajar Fauzi Abdullah Farabi, Kindi Ghazi Mauer Idroes Gunawan, Latifah Hideo Hayashi Hiroshi Morita Hutagaol, Ricson Pemimpin Khairan Khairan Kindi Farabi Lala, Andi Marc Litaudon Mat Ropi Mukhtar Maulana, Aga Maulydia, Nur Balqis Mayshah Purnamasari Mubaraq, Farhil Mustofa, Hidayat Nurul Musvira, Intan Nafiah, Mohamad Azlan Naini, Al Arofatus Nurdin Saidi Nurlelasari Nurlelasari Primahana, Gian Rani Maharani Rinaldi Idroes Shiono, Yoshihito Sianturi, Julinton Sofa Fajriah Tjandrawati Mozef Tri Mayanti Unang Supratman