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HUBUNGAN ASUPAN BESI HEME DAN NON-HEME KADAR FERRITIN PADA CALON PENGANTIN PEREMPUAN DI KOTA PADANG
Ulya Uti - Fasrini;
Wiyola Audina;
Defrin Defrin;
Desmawati Desmawati;
Hudila Rifa Karmia;
Abdiana Abdiana
Jurnal Sehat Mandiri Vol 16 No 1 (2021): Jurnal Sehat Mandiri, Volume 16, No.1 Juni 2021
Publisher : Poltekkes Kemenkes Padang
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DOI: 10.33761/jsm.v16i1.363
Women of childbearing age are prone to anemia, especially iron-deficiency anemia. The outcome might be seen in the high maternal mortality rate in the Padang city (16 cases. Serum ferritin can be used as an initial indicator to determine iron deficiency. A decrease in serum ferritin levels can be influenced by iron intake. This study aimed to determine the relationship between heme and non-heme iron intake with ferritin serum concentration in women’s bride candidates in Padang City. This analytical study with a cross-sectional design involved 30 bride candidates, 20-30 years old. Iron intake were collected using the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), and serum ferritin levels were measured using the Enhanced ChemiLuminescence Immuno Assay (ECLIA) method. Data were analyzed using the Pearson correlation coefficient test. The results showed the mean of heme and non-heme iron intake was 2.76 ± 0.90 mg/day and 3.83 ± 0.97 mg/day, respectively, and the mean of serum ferritin levels was 46.27 ± 27.61 ng/ml. The test showed no significant correlation between heme (r=0.094, p=0.622) and non-heme iron (r=-0.179, p=0.345) intake with serum ferritin levels. This study concludes that there is no relationship between heme and non-heme iron intake with serum ferritin levels on bride candidates in Padang City. Therefore, to prevent the incidence of anemia during pregnancy, it is highly recommended for the brides to increase their iron intake from both animal and vegetable sources.
Correlation of Brain Derived Neurotrophic Factors (BDNF) With Maternal and Perinatal Outcome in Preeclampsia
Mayuliani Mayuliani;
Yusrawati Yusrawati;
Defrin Defrin
Andalas Obstetrics And Gynecology Journal Vol 5, No 2 (2021)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.5.2.148-160.2021
Objective: To analyze the correlation between BDNF and maternal and perinatal outcomes in preeclampsia.Methods: This was an observational analytic study with a cross-sectional design on 73 pregnant women with preeclampsia. The study began in January 2020 to June 2020 in the Obstetrics and Gynecology Department of Dr M. Djamil Hospital Padang.Results: The mean BDNF levels of pregnant women with preeclampsia were 519.9 ± 325.4 pg/ml. The correlation between BDNF and systolic blood pressure, diastolic blood pressure, and Mean Arterial Pressure was negatively correlated (r = -0.145, -0.1, and -0.218), with a weak correlation. There was no statistically significant relationship between BDNF and systolic blood pressure, diastolic blood pressure, and mean arterial pressure (p> 0.05). BDNF correlation with infant birth weight and the birth length was positively correlated (0.196 and 0.205) with a weak correlation. The correlation between BDNF level and Apgar score was negatively correlated (-0.039 and -0.054) with a weak correlation. There was no statistically significant correlation between BDNF with birth weight, birth length, and Apgar score (p> 0.05).Conclusion: The mean BDNF level in preeclampsia was lower than normal pregnancy, there was a negative correlation between BDNF levels and maternal outcomes in preeclampsia with a weak correlation. There was a positive correlation between BDNF levels and perinatal outcomes (birth weight and birth length) in preeclampsia and there was a negative correlation between BDNF levels and Apgar score in preeclampsia with a weak correlation.Keywords: Brain Derived Neurotrophic Factors, Preeclampsia, Maternal Outcome, Perinatal Outcome
PERBANDINGAN ANTARA KADAR VITAMIN C PLASMA DARAH HAMIL ATERM PADA KETUBAN PECAH DINI DENGAN HAMIL ATERM TANPA KETUBAN PECAH DINI
Defrin Defrin;
Rosfita Rasyid
Andalas Obstetrics And Gynecology Journal Vol 2, No 2 (2018)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.2.2.101-108.2018
Premature rupture of membranes is the most common complication of pregnancy. The incidence of premature rupture of membranes in pregnancy ranged from 6% to 10%, and 20% of these cases occur before 37 weeks gestation. The incidence of premature rupture of membranes in Indonesia ranges from 4.5% to 7.6% of all pregnancies. This research was conducted to determine the cross-sectional differences in the blood plasma levels of vitamin C in term pregnancy premature rupture of membranes with blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes in M. Jam- il Padang hospital, Achmad Muchtar Bukittinggi hospital, and Pariaman Hospital. There are significant differences in vitamin C blood plasma levels in term pregnancy with premature rupture of membranes and term pregnancy without premature rupture of membranes ( P < 0.05). Mean levels of vitamin C in blood plasma at term pregnancy with premature rupture of membranes lower than in the blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes.Keywords: Premature rupture of membrane in aterm, blood plasma levels of vitamin C
Perbandingan Nilai Risk Malignancy Index Kanker Ovarium Tipe Serosum dan Musinosum RSUP Dr. M. Djamil Padang pada Tahun 2017
Frita Dwi Luhuria;
Defrin Defrin;
Andi Friadi
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.4.1.87-94.2020
The Risk Malignancy Index (RMI) is one of the simplest assessments that can assist in diagnosing and determining the prognosis of benign and malignant adnexa masses. Epithelial carcinoma is the most common type of about 90% of ovarian cancers. As many as 35-40% of the epithelial type are serous and 6-10% are musinosum.This study aims to compare the picture of RMI value on the incidence of ovarian cancer serosum and musinosum type. This study was cross sectinal comparative study from medical records of ovarian cancer patients at obstetrics and gynecology section in DR M Djamil Hospital Padang from January 1st, 2017 until December 31st, 2017. The population was found one hundred and forty of patients with ovarian cancer and only one hundred and twenty nine of patients met the inclusion criteria and there were no exclusion criteria. Next RMI value is calculated based on RMI 1 formula, result is described in tabular form and data processing with SPSS program. Conclucion of this study is there were no differences in age distribution, ascites occurrence and age of menopause in serous and musinosum ovarian cancer. There is a difference in Ca, 125 levels in serous with musinosum ovarian cancer which also contribute to the high value of RMI. The mean value of patients‘s RMI in serous type ovarian cancer is higher than the mean value of RMI in patients with type Musinosum ovarian cancer. Keywords: index of risk malignancy, menopause, ultrasonography, anatomic pathology, serous ovarian carcinoma
Differences of Increased Bishop Scores Between Neutrophil Swab Vaginal ≤ 5 and > 5 in 41 Weeks of Pregnancy Induced With Misoprostol
Boby Hartanto;
Joserizal Serudji;
Defrin Defrin
Andalas Obstetrics And Gynecology Journal Vol 5, No 2 (2021)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.5.2.178-185.2021
The incidence of labor induction with various indications was to increase. The key to successful labor induction is a ripe cervix. Research shows that the degree of cervical rippening as assessed by the Bishop score is influenced by the level of neutrophils contained in the cervical stroma which can be detected by performing a vaginal swab. Neutrophils will produce collagenase in the form of matrix metalloproteinase - 8 (MMPs - 8) which will degrade cervical collagen fibers, so that the cervix becomes soft and ripe. Misoprostol is the drug most widely used in labor induction today. Purpose: This study was to determine the difference in Bishop score increase between vaginal swab neutrophils ≤ 5 and > 5 in pregnancy ≥ 41 weeks induced by misoprostol.Keywords: Bishop score, neutrophil, vaginal swab, misoprostol
The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia
David Perdana;
Defrin Defrin;
Firdawati Firdawati
Andalas Obstetrics And Gynecology Journal Vol 5, No 1 (2021)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.5.1.82-89.2021
The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of HIF-1α
Prevalence of pregnant women with reactive HBsAg in Padang City in 2019
Try Genta Utama;
Defrin Defrin
Andalas Obstetrics And Gynecology Journal Vol 6, No 1 (2022)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.6.1.21-26.2022
Introduction: Hepatitis B is an infectious disease that occurs in the liver caused by the hepatitis B virus (HBV). Transmission vertically 95% occurs in the perinatal period (during delivery) and 5% intra uterine. Hepatitis B infection can be acute to chronic. Chronic infection was defined as hepatitis B surface antigen (HBsAg) persistently in blood or serum for more than 6 months with or without active viral replication and evidence of hepatocellular injury or inflammation. Indonesia as a country with high endemicity of Hepatitis B is currently focusing on preventing mother to child transmission (PPIA) because 95% of hepatitis B transmission is vertical, namely from hepatitis B positive mothers to their babies. The number of pregnant women who have been tested for Hepatitis B using the HBsAg Rapid Diagnostic Test (RDT) in 2018 in Indonesia is still relatively small, which is only 39.95% of the target pregnant women who should be examined. In West Sumatra itself occupies the 30th position out of 34 provinces with the percentage of HBsAg reactive pregnant women as much as 0.97%.Objective: This study aims to determine the incidence of pregnant women with reactive HBsAg in the city of Padang.Methods: This research is a descriptive study. The data was taken from the recap of the number of pregnant women who were screened for hepatitis B in all public health centers in the city of Padang during 2019.Result : There are 13,174 (72%) pregnant women who have been tested for HBsAg. Found 131 (0.95%) people with reactive HBsAg. The highest cases were found in the Lubuk Kilangan Public Health Center with 14 cases and the lowest in the opposite health center and Ulak Karang health center with 0 cases. The highest case finding occurred in June with 17 cases and the lowest in November with 7 cases.Conclusion: The prevalence of pregnant women with reactive HBsAg was 0.95% in Padang City in 2019.Keywords: Hepatitis B, HBsAg, Pregnant Women
Amniotic Fluid Embolism in Post Caesarean Section
Defrin Defrin;
Heri Farnas
Andalas Obstetrics And Gynecology Journal Vol 4, No 2 (2020)
Publisher : Universitas Andalas
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DOI: 10.25077/aoj.4.2.161-166.2020
Background: According to WHO, around 73% of maternal deaths globally are caused by direct obstetric causes. The amniotic fluid embolism is a life-threatening obstetric emergency characterized by sudden cardiopulmonary system failure and can be accompanied by Disseminated Intravascular Coagulation (DIC). The amniotic fluid embolism event usually occurs during labor and birth, but can also occur immediately in the post partum period or after pregnancy termination. About 56% of women will not survive for first 2 hours after the acute event. Amniotic fluid embolism is an unpredictable event, so that no prophylactic intervention can be carried out effectively and the handling and enforcement of a diagnosis that still debatable.Objective: To report maternal deaths due to amniotic fluid embolism post cesarean sectionMethod: Case ReportCase: Reported case of a 30 years old woman with an initial diagnosis in emergency departement with decreased consciousness due to Severe hypoxia due to Pulmonary emboli due to Amniotic fluid emboli on P2A0L2 post Cesarean Section first day of puerperium. The patient experienced a sudden loss of consciousness accompanied by severe shortness of breath after 6 hours after cesarean section surgery in a private hospital. After initial examination and treatment by administering oxygen through the Nonrebreathing Mask, there was no improvement in the O2 saturation value and then the patient was intubated by the anesthetist. After intubation, the O2 saturation value still does not increase, then the patient suddenly experiences cardiac arrest and followed with cardiac resuscitation for 2 cycles accompanied by resuscitation drugs then the patient returns to spontaneous circulation. From the cardiology department, inotropic therapy was given and echocardiographic investigations were carried out. On echocardiographic examination, they found McConnel's sign which showed suspicios of pulmonary embolism. At the time the patient will be moved to the intensive care unit, the patient experiences a cardiac arrest for the second time, then resuscitation is performed again for 2 cycles, but it does not work and the patient is declared dead.Conclusion: Amniotic fluid embolism is an obstetric emergency condition that cannot be predicted and has a high mortality rate. Treatment is supportive to support the cardiopulmonary system and management of coagulopathy that may occur.Keywords: maternal mortality, amniotic fluid embolism
ARDS+TB Paru Kasus Baru dalam Pengobatan OAT Kat 1 Fase Intensif pada G6P5A0H5 Gravid 27-28 Minggu
Anggun Pratissa;
Defrin Defrin
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 4
Publisher : Fakultas Kedokteran, Universitas Andalas
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DOI: 10.25077/jka.v7i0.929
Tuberkulosis (TB) masih menjadi masalah kesehatan di dunia demikian juga tuberkulosis pada kehamilan. Berdasarkan laporan WHO, Indonesia menempati urutan ketiga terbesar angka kejadian TB di dunia setelah Cina dan India. Tuberkulosis pada kehamilan mempunyai gejala klinis yang serupa dengan tuberkulosis pada wanita tidak hamil. Diagnosis mungkin ditegakkan terlambat karena gejala awal yang tidak khas.. Penanganan yang tidak benar pada penderita TB akan menimbulkan berbagai macam komplikasi, salah satunya adalah sindrom gagal nafas dewasa (Adult Respiratory Distress Sindrome/ARDS). ARDS dapat menyebabkan 70% angka kematian pada penderita TB. Berikut ini dilaporkan kasus seorang pasien wanita dengan usia 38 tahun dengan diagnosis : ARDS + TB Paru kasus baru dalam pengobatan OAT Kat 1 fase intensif pada G6P5A0H5 gravid 27-28 minggu. Tujuan penelitian ini adalah agar diagnosis TB dalam kehamilan dapat ditegakkan secara akurat, sehingga dapat diterapi secara tepat dan tidak menyebabkan resiko yang cukup besar bagi ibu dan janin.
Pengaruh Pemberian Madu Murni Kaliandra Terhadap Perubahan Derajat Dismenorhea pada Remaja Putri di Poltekes Kemenkes Padang Tahun 2019
Titin Dewi Sartika Silaban;
Arni Amir;
Defrin Defrin
Jurnal Kesehatan Andalas Vol 8, No 4 (2019): Online December 2019
Publisher : Fakultas Kedokteran, Universitas Andalas
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DOI: 10.25077/jka.v8i4.1141
Abstrak Menstruasi sering menimbulkan masalah salah seperti dismenorhea yang dapat mengakibatkan penurunan produktivitas pada wanita usia subur. Madu merupakan minuman herbal yang memiliki banyak kandungan seperti glukosa, fruktosa, flavanoid dan lain sebagainya yang baik bagi kesehatan tubuh. Tujuan: Menentukan pengaruh pemberian madu murni kaliandra terhadap perubahan derajat dismenorhea pada remaja putri. Metode: Penelitian ini menggunakan desain one-group pretest-postest di Poltekses Kemenkes Padang dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas pada bulan akhir Januari 2018 sampai April 2019. Sampel dipilih secara simple random sampling dengan memenuhi kriteria inklusi dan eksklus,i sehingga didapatkan sampel berjumlah 36 remaja putri yang mengalami dismenorhea. Uji statistik menggunakan Wilcoxon signed rank test dengan nilai p < 0,05 dianggap bermakna secara statistik. Hasil: Terdapat pengaruh pemberian madu murni kaliandra terhadap perubahan derajat dismenorhea dengan nilai p=0,000. Simpulan: Terdapat penurunan derajat dismenorhea setelah pemberian madu murni kaliandra pada remaja putri yang mengalami dismenorhea saat menstruasi.