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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Melayu Jurnal Gizi Klinik Indonesia JURNAL FARMASIMED (JFM) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Respirasi (JR) Narra J Jurnal Kesehatan
Darmawi Darmawi
Fakultas Kedokteran Universitas Riau
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Vaksin Human Chorionic Gonadotropin (hCG) sebagai Kandidat Kontrasepsi Imunologi pada Wanita Darmawi Darmawi
Jurnal Kesehatan Melayu Vol 1, No 1 (2017): September 2017
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.08 KB) | DOI: 10.26891/jkm.v1i1.2017.29-34

Abstract

Tercatat pada tahun 2017 ada sekitar 7,5 miliar jumlah populasi manusia dengan angka pertumbuhan 1 miliar setiap 12 tahun. Peningkatan populasi ini terjadi 95% di negara berkembang. Setiap tahun ada sekitar 80 juta wanita di seluruh dunia setiap tahunnya mengalami kehamilan yang tidak diinginkan dan sebagian besar wanita pada kelompok ini menggunakan beberapa metode kontrasepsi yang telah tersedia. Oleh karena itu, diperlukan metode kontrasepsi baru dan lebih baik yang dapat diterima, efektif, dapat dijangkau dan tersedia diberbagai negara berkembang, yaitu dengan metode kontrasepsi imunologi. Salah satu metode kontrasepsi imunologi pada wanita adalah vaksin hCG. Vaksin hCG ini pertama kali dipublikasikan oleh Talwar, et al pada tahun 1976 dan menjadi satu-satunya metode kontrasepsi imunologi yang telah melewati uji klinis fase II. hCG merupakan target potensial dan terbaik dalam mencegah kehamilan tanpa adanya efek samping yang merugikan. Berbeda dari kontrasepsi steroid yang dapat menghambat ovulasi, metode vaksin hCG tidak menganggu ovulasi dan produksi hormon steorid seks serta tidak menganggu keteraturan siklus menstruasi. Baik protein ujung C (CTP) dari β-hCG maupun β-hCGnya sendiri telah digunakan sebagai kandidat imunogen untuk mengembangkan kontrasepsi imunologi. Metode ini diketahui aman, efektif menekan angka kehamilan dan bersifat reversibel.
Gambaran Histopatologi Pankreas Tikus Putih (Rattus norvegicus) Pasca Perlakuan Iskemia-Reperfusi Ginjal Elva Rosiana; Wiwit Ade Fidiawati; Darmawi Darmawi
Jurnal Ilmu Kedokteran Vol 13, No 1 (2019): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.415 KB) | DOI: 10.26891/JIK.v13i1.2019.58-66

Abstract

Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion (reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidative stress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the cell death. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion. This study was an experimental laboratory research with post-test-only control group design including 20 male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutes ischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) and treatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathological characteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.
Depresi, ansietas dan stres serta hubungannya dengan obesitas pada remaja Huriatul Masdar; Pragita Ayu Saputri; Dani Rosdiana; Fifia Chandra; Darmawi Darmawi
Jurnal Gizi Klinik Indonesia Vol 12, No 4 (2016): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.23021

Abstract

Background: Obesity can occur in all ages, including adolescents. Multiple factors were known related to obesity including psychological factor. Eating excessively could be response toward loneliness, grief or depression. Anxiety can contribute to determining the food intake and nutrient substance, and stress can cause behavioral disorders such as abnormal (excessive) eating behavior that leads to obesity. Objective: The aimed of this research was to know depression, anxiety, and stress and their relationship with obesity in adolescents in Pekanbaru. Method: A cross-sectional research was performed, involving 132 subjects taken from 7 of 14 State Senior High Schools in Pekanbaru, 66 subjects were overweight/obese and 66 subjects were normal. Body mass index per age was used to determine their nutritional status according to Indonesian Ministry of Health Standard 2010 for nutritional status of 5-18 years old children. Depression, anxiety, and stress were measured by using DASS 42 Scale, and categorized only into normal or having depression/anxiety/stress. Data were statistically analyzed by using Chi-Square test with significance level 95%.Results: The results showed 17.4% subjects were categorized depression, 65.2% were anxiety and 34.8% were stress. Statistically analyzed using Fisher test showed that there was significant association between depression with obesity (p=0.003, OR=0,219) and stress with obesity (p=0.044, OR=0,028).Conclusion: Psychological aspects such as depression and stress were related to obesity in State Senior High Schools Students in Pekanbaru
Repurposing drugs in endometrial cancer using genomic variants database Darmawi Darmawi; Donel S; Wiwin Suhandri; Winarto Winarto; Wirawan Adikusuma; Lalu Muhammad Irham; Wiwit Ade Fidiawati; Renardy Reza Razali; Auren Nathania; Leina Putri Zahra
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Promising candidate drug target genes for repurposing in cervical cancer: A bioinformatics-based approach Pratiwi, Nurfi; Ulfah, Aida J.; Rachmadina, Rachmadina; Irham, Lalu M.; Afief, Arief R.; Adikusuma, Wirawan; Darmawi, Darmawi; Kemal, Rahmat A.; Rangkuti, Ina F.; Savira, Maya
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.938

Abstract

Cervical cancer is the fourth most common cancer among women globally, and studies have shown that genetic variants play a significant role in its development. A variety of germline and somatic mutations are associated with cervical cancer. However, genomic data derived from these mutations have not been extensively utilized for the development of repurposed drugs for cervical cancer. The objective of this study was to identify novel potential drugs that could be repurposed for cervical cancer treatment through a bioinformatics approach. A comprehensive genomic and bioinformatics database integration strategy was employed to identify potential drug target genes for cervical cancer. Using the GWAS and PheWAS databases, a total of 232 genes associated with cervical cancer were identified. These pharmacological target genes were further refined by applying a biological threshold of six functional annotations. The drug target genes were then cross-referenced with cancer treatment candidates using the DrugBank database. Among the identified genes, LTA, TNFRSF1A, PRKCZ, PDE4B, and PARP were highlighted as promising targets for repurposed drugs. Notably, these five target genes overlapped with 12 drugs that could potentially be repurposed for cervical cancer treatment. Among these, talazoparib, a potent PARP inhibitor, emerged as a particularly promising candidate. Talazoparib is currently being investigated for safety and tolerability in other cancers but has not yet been studied in the context of cervical cancer. Further clinical trials are necessary to validate this finding and explore its potential as a repurposed drug for cervical cancer.
Unveiling the impacts of metformin on hepatocellular carcinoma: A bioinformatic exploration in cell lines Soraya, Soraya; Arfianti, Arfianti; Adikusuma, Wirawan; Irham, Lalu M.; Hamidy, Muhammad Y.; Winarto, Winarto; Rangkuti, Ina F.; Darmawi, Darmawi
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.968

Abstract

The most common type of liver cancer is hepatocellular carcinoma (HCC), accounting for 75–85% of cases. Despite its associated side effects, sorafenib remains the standard treatment for HCC. Given the critical need to improve therapeutic efficacy while minimizing adverse effects, alternative drugs must be thoroughly investigated. Numerous studies indicate that combining sorafenib with metformin results in a more favorable treatment profile. The aim of this study was to employ bioinformatics methodologies to elucidate the molecular pathways and genetic underpinnings of metformin's efficacy in HCC treatment. Genes associated with metformin and its action against HCC (Huh-7 and HepG2 cells) were acquired from the NCBI-GEO data collection by utilizing pre-determined keywords. Subsequently, pathways implicated in metformin-mediated HCC treatment were analyzed through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Our analysis revealed the involvement of multiple pathways, with metabolic pathways implicated in 80% of the total cases. Neurodegenerative pathways were involved in only around 60% of the total cases. These findings align with the multifaceted mechanisms of metformin’s action, encompassing adenosine monophosphate-activated protein kinase activation, apoptosis induction, insulin regulation, anti-inflammatory responses, and modulation of cell proliferation. This comprehensive investigation sheds light on the intricate molecular landscape underpinning metformin's therapeutic efficacy in HCC, thereby informing potential avenues for optimizing treatment strategies.
LITERATURE REVIEW: MOLECULAR MECHANISMS OF ACUPUNCTURE IN MALE INFERTILITY TREATMENT Dwiputri, Rinesia; Darmawi, Darmawi; Afdal, Afdal
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2781

Abstract

Infertilitas adalah suatu kondisi ketidakmampuan pasangan untuk hamil setelah melakukan hubungan seksual selama satu tahun atau lebih tanpa menggunakan kontrasepsi. Pada infertilitas, faktor pria berperan sekitar 30-50%.  Banyak faktor yang mempengaruhi infertilitas pada pria, salah satunya adalah parameter pria yang tidak normal. Terapi untuk mengatasi infertilitas pria dapat berupa farmakologi dan non farmakologi, salah satu terapi non farmakologi adalah akupunktur. Tujuan dari tinjauan pustaka ini adalah untuk mengetahui mekanisme molekuler akupunktur dalam pengobatan infertilitas pria. Jenis penelitian ini adalah tinjauan literatur dengan analisis sistematis. Sumber data penelitian ini berasal dari Google Scholar dengan menggunakan kata pencarian di internet, yaitu molekuler, infertilitas dan akupunktur. Diperoleh 7 artikel yang diterbitkan antara tahun 2005 sampai 2023 dan yang kemudian dianalisis tujuan, kesesuaian topik, dan variabel yang digunakan.  Kriteria inklusi yang digunakan adalah jurnal yang bertemakan infertilitas pria dan akupunktur serta jurnal berbahasa Inggris. Sedangkan kriteria eksklusi adalah jurnal yang tidak ada pembahasan mengenai mekanisme molekuler dan jurnal yang tidak lengkap. Pada infertilitas pria, akupunktur dapat memperbaiki disfungsi seksual pria, analisis air mani yang abnormal, infertilitas imunologi, peradangan genital, varikokel, dan infertilitas pria idiopatik. Mekanisme akupunktur adalah meningkatkan sirkulasi darah pada testis dan epididimis, mengurangi kadar ROS air mani, mengurangi peradangan, memodulasi sistem kekebalan tubuh, dan meningkatkan motilitas sperma dan parameter air mani.
Identification Target Genes for Potential Biomarkers in Endometriosis from Transcriptomics Database Zahlina, Dian; Iskandar, Benni; Adikusuma, Wirawan; Yusuf, Muhammad; Tiara Fani, Rifia; Ocktariyana, Ocktariyana; Darmawi, Darmawi
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 1 (2026): Jurnal Kesehatan Volume 17 Nomor 1 Tahun 2026 (on progress)
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i1.1281

Abstract

Endometriosis is a common benign gynecological disease characterized by the ectopic growth of endometrial tissue. Its pathogenesis is influenced by complex genetic and epigenetic factors, making diagnosis and treatment challenging. This study aimed to identify molecular pathways and candidate genes associated with endometriosis using transcriptomic data. Three datasets (GSE7307, GSE23339, and GSE25628) were retrieved from the Gene Expression Omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). A total of 339 intersecting DEGs were obtained and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The results indicated enrichment in biological processes related to epithelial cell proliferation and angiogenesis, cellular components associated with the lysosomal lumen and extracellular matrix, and molecular functions involving Wnt-activated receptor activity and low-density lipoprotein particle binding. Ten genes (TAGLN, C7, TCF21, GATA6, GPC3, FZD7, TCEAL2, KLF2, FMO1, and HOXC6) were identified as potential candidate biomarkers. These findings provide preliminary molecular insights into endometriosis and may support future experimental and clinical studies for biomarker development.
Gastrointestinal Adverse Effects of Elobixibat in Chronic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Citra Safitri Wirman; Kurniawan, Rudi Erwin; Darmawi; Benni Iskandar
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rncke15

Abstract

Chronic constipation is a common gastrointestinal disorder that negatively affects quality of life and increases healthcare burden worldwide. Elobixibat, an ileal bile acid transporter inhibitor, has been introduced as a novel therapy to enhance intestinal fluid secretion and improve colonic motility in patients with chronic constipation. However, concerns remain regarding gastrointestinal adverse effects, particularly their potential relationship with dosage. Therefore, this study aimed to evaluate gastrointestinal adverse effects associated with elobixibat and to assess whether these events demonstrate a dose-dependent pattern. This systematic review and meta-analysis followed the PRISMA 2020 guidelines and was registered in PROSPERO (CRD420251155537). A literature search was conducted in PubMed and ScienceDirect to identify randomized controlled trials investigating elobixibat in chronic constipation patients published up to December 2025. Study eligibility was determined using the PICOS framework. Data on adverse effects, dosage, and treatment duration were extracted and analyzed using proportional meta-analysis with a random-effects model in R Studio, and risk of bias was assessed using the RoB2 tool. Five randomized controlled trials involving 922 participants are included in the analysis. The pooled proportion of diarrhea is 21%, abdominal distension is 26%, and abdominal pain is 16%, while unspecified gastrointestinal disorders represent the most frequently reported adverse events at 49%. Overall, gastrointestinal adverse events show a dose-dependent pattern, with higher doses associated with increased event rates. These findings indicate that elobixibat is associated with dose-dependent gastrointestinal adverse effects, highlighting the importance of individualized dosing and gradual titration to improve treatment tolerability.
Ki-67 Expression and Histopathological Type, Metastatic Status, and Risk Factors in Lung Cancer Muhammad Khairani; Sri Melati Munir; Darmawi Darmawi; Indra Yovi; Indi Esha; Zarfiardy Aksa Fauzi; Zahtamal Zahtamal
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.35-43

Abstract

Introduction: Lung cancer remains a leading cause of cancer-related morbidity and mortality worldwide. In Indonesia, the incidence and death rates associated with this disease remain alarmingly high. Ki-67 is a potential biomarker for assessing cellular proliferation and metastatic potential. However, its clinical application in lung cancer remains inconsistent. This study aimed to analyze the association between Ki-67 expression and histopathological subtype, metastatic status, and clinical risk factors in patients with lung cancer. Methods: This study enrolled 42 patients diagnosed with lung cancer at Arifin Achmad General Hospital, Pekanbaru, Indonesia. Statistical analysis used the Chi-square or Fisher’s exact test (non-parametric tests) for categorical data and the Kolmogorov-Smirnov test, depending on the data characteristics. Participants were selected based on predefined inclusion criteria, complete medical documentation, and available Ki-67 immunohistochemistry results. Results: Among the 42 patients analyzed, 34 (80.9%) exhibited metastasis. The findings revealed a significant correlation between Ki-67 expression and metastasis (p=0.0038), whereas no significant associations were observed with age, sex, smoking status, or histopathological classification. Most patients (approximately 69%) had low Ki-67 expression. Conclusion: Ki-67 expression was associated with metastatic status in patients with lung cancer and might serve as a prognostic biomarker. Further studies with larger sample sizes are needed to validate these findings.
Co-Authors Afdal Afdal, Afdal Afief, Arief R. Arfianti Arfianti Auren Nathania BENNI ISKANDAR Citra Safitri Wirman Dani Rosdiana Donel S Dwiputri, Rinesia Elva Rosiana Fifia Chandra Hamidy, Muhammad Y. Huriatul Masdar Indi Esha Indra Yovi Irham, Lalu M. Kemal, Rahmat A. Kurniawan, Rudi Erwin Lalu Muhammad Irham Leina Putri Zahra Maya Savira Muhammad Khairani Muhammad Yusuf Nurfi Pratiwi, Nurfi Ocktariyana, Ocktariyana Pragita Ayu Saputri Rachmadina, Rachmadina Rangkuti, Ina F. Renardy Reza Razali Soraya Soraya Sri Melati Munir Tiara Fani, Rifia Ulfah, Aida J. Winarto Winarto Winarto Winarto Wirawan Adikusuma Wiwin Suhandri Wiwit Ade Fidiawati Zahlina, Dian Zahtamal Zahtamal Zarfiardy Aksa Fauzi