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Journal : Journal of Global Pharma Technology

The Validity Assessment of E-Cadherin Expression to Differentiate Ductal and Lobular Type Invasive Breast Carcinoma I Gusti Ayu Sri Mahendra Dewi
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Currently, breast cancer is one of the leading causes of cancer related death in women worldwide. The diagnosis of breast cancer still depends on biopsy to determine the histopathological subtype and the nature of the cancer. However, the subtypes alone could not differentiate between lobular and ductal carcinoma. Therefore, this study aimed to evaluate the validity of E-cadherin expression as biomarker to differentiate ductal and lobular invasive breast carcinomas. Methods: An analytic observational cross sectional study was conducted using 47 biopsy samples of ductal and lobular type invasive breast carcinoma examined at Anatomical Pathology Laboratory Faculty of Medicine, Udayana University/ RSUP Sanglah Denpasar in 2017. The samples were evaluated using H & E staining while E-cadherin expression was examined by using Immunohistochemistry technique (IHC). Pearson chi-square was performed to analyze the data with p-value less than 0.05 was considered significant or valid. Result: Descriptive statistics showed that the samples were homogeneous in term of age between ductal and lobular types (p=0.668). Breast cancer was found to be more prevalent on the left breast compared to the right one in both in ductal and lobular types. IHC staining showed that E-cadherin expression was significantly lower in lobular types (9.1% positive) compared to ductal (60.0% positivity) and, thus, can be used to differentiate them (p=0.000). Conclusion: E-cadherin expression was a valid biomarker to differentiate ductal and lobular type invasive breast carcinoma. More comprehensive study with larger number of samples is required to assess the generality of this findingKeywords: E-cadherin, Breast carcinoma, Ductal type, Lobular type.
Co-Authors Anak Agung Ayu Ngurah Susraini and I G. Alit-Artha annie minerva datui Astuti, Ida Ayu Jelantik Azizah, Norma Nur Azizah Budi Heryanto Desak Made Cittarasmi Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Dewi, Ida Ayu Krisna Cantika Dewi, Ni Putu Wulan Tantri Diah Widityasari, Diah E. Joewarini Efrisca M Br Damanik Ening Krisnuhoni Firman Parulian Sitanggang Gde Ngurah Idraguna Pinatih Handoko, Jovi Carina Henky, . Herman Saputra Herman Saputra Herman Saputra Herman Saputra Hutapea, Yuliance Nurhawati I Gusti Alit Artha I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Ngurah Bagus Rai Mulya Hartawan I Kadek Adi Purnama Sandhi I Ketut Suwiyoga I Made Gotra I Made Muliarta I Made Muliarta I MADE MULIARTA . I Made Naris Pujawan I Made Wirya Sastra I W. Sudarsa I Wayan Juli Sumadi I Wayan Juli Sumadi IB Caka Gunantara Ida Ayu Eugenia Natasha Blanco Oka Ida Ayu, Priandini Ivana Juliarty Sitanggang Kadek Agus Suhardinatha Putra Kadek Dwi Pradnyawati kadek pramesti dewi Katrin Rotua Simbolon Limantoro, Joshua Lisanthoni, Johnathan Luh Ayu Widayanti Luh putu Iin Indrayani Luh Putu Iin Indrayani Maker Made Dwi Hartayati MADE RATNA SARASWATI . Mochtar, Fransiska Moestikaningsih Moestikaningsih Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Ketut Ari Widhiasih, Ni Ketut Ari Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Winarti Nur Silfiah Nyoman Srie Laksminingsih Paramitha, Ni Made Laksmi Dewi Paskarani, Putu Erika Patriawan, Putu Popi Imelda Margareth Sitompul Putu Ayu Widya Pramesti Putu Ayu Winda Wirastuti Giri Putu Dony Astika Wiguna Putu Risky Yoga Pradnyana Shameni Subramaniam Silvia Nuhyil Indriani Sinaga, Naomi Juliana tanaka, Tanaka Tjandra Kristiana Volman Tampubolon Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wilananda, Ida Bagus Ardya Kurnia Wimpie I Pangkahila Winari, Ni Wayan