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Journal : Asian Journal of Social and Humanities

Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats Mochtar, Fransiska; Pangkahila, Wimpie I.; Dewi, I Gusti Ayu Sri Mahendra; Saraswati, Made Ratna; Azizah, Norma Nur Azizah
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.204

Abstract

Obesity is a condition where excessive fat is accumulated, which poses a health risk. Several treatments for obesity have been carried out, ranging from lifestyle adjustments to medication to surgery. Corrosolic acid (CA) is a natural compound that has the potential to act as an obesity agent through many mechanisms, including through reactive oxygen species (ROS). This study aims to prove that CA can reduce MDA levels and HMG-CoA reductase levels and increase leptin levels and GLP-1 levels in male Wistar rats with obesity. Wistar obese rats were orally treated with CA compound induction at a dose of 10 mg/Kg BW. MDA, HMG-CoA reductase, leptin and GLP-1 levels were examined using serum and plasma from mice in both groups of mice before and after treatment, using the ELISA method. CA to the treatment group can reduce the body weight of rat MDA levels significantly at p<0.0001, HMG-CoA reductase levels significantly at p<0.0001 and increase leptin and GLP-1 levels significantly at p<0.0001. CA's mechanism for treating obesity is through the ROS mechanism because CA has antioxidant levels that can capture free radicals in the body.CA has been proven to be an alternative drug in treating obesity by reducing body weight, MDA, and HMG-CoA levels and increasing leptin and GLP-1 levels in obese Wistar rats.
Co-Authors Anak Agung Ayu Ngurah Susraini and I G. Alit-Artha annie minerva datui Astuti, Ida Ayu Jelantik Azizah, Norma Nur Azizah Budi Heryanto Desak Made Cittarasmi Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Dewi, Ida Ayu Krisna Cantika Dewi, Ni Putu Wulan Tantri Diah Widityasari, Diah E. Joewarini Efrisca M Br Damanik Ening Krisnuhoni Firman Parulian Sitanggang Gde Ngurah Idraguna Pinatih Handoko, Jovi Carina Henky, . Herman Saputra Herman Saputra Herman Saputra Herman Saputra Hutapea, Yuliance Nurhawati I Gusti Alit Artha I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Ngurah Bagus Rai Mulya Hartawan I Kadek Adi Purnama Sandhi I Ketut Suwiyoga I Made Gotra I Made Muliarta I Made Muliarta I MADE MULIARTA . I Made Naris Pujawan I Made Wirya Sastra I W. Sudarsa I Wayan Juli Sumadi I Wayan Juli Sumadi IB Caka Gunantara Ida Ayu Eugenia Natasha Blanco Oka Ida Ayu, Priandini Ivana Juliarty Sitanggang Kadek Agus Suhardinatha Putra Kadek Dwi Pradnyawati kadek pramesti dewi Katrin Rotua Simbolon Limantoro, Joshua Lisanthoni, Johnathan Luh Ayu Widayanti Luh putu Iin Indrayani Luh Putu Iin Indrayani Maker Made Dwi Hartayati MADE RATNA SARASWATI . Mochtar, Fransiska Moestikaningsih Moestikaningsih Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Ketut Ari Widhiasih, Ni Ketut Ari Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Winarti Nur Silfiah Nyoman Srie Laksminingsih Paramitha, Ni Made Laksmi Dewi Paskarani, Putu Erika Patriawan, Putu Popi Imelda Margareth Sitompul Putu Ayu Widya Pramesti Putu Ayu Winda Wirastuti Giri Putu Dony Astika Wiguna Putu Risky Yoga Pradnyana Shameni Subramaniam Silvia Nuhyil Indriani Sinaga, Naomi Juliana tanaka, Tanaka Tjandra Kristiana Volman Tampubolon Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wilananda, Ida Bagus Ardya Kurnia Wimpie I Pangkahila Winari, Ni Wayan