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All Journal Medicina INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Indonesian Journal of Cancer Jurnal Ilmiah Kedokteran Wijaya Kusuma JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Indonesian Journal of Cancer Journal of Global Pharma Technology Asian Journal of Social and Humanities
I Gusti Ayu Sri Mahendra Dewi
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

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HIGH INTERLEUKIN-6, LOW CD4+ AND CD8+ T-LYMPHOCYTES EXPRESSIONS AS RISK FACTORS OF CERVICAL CARSINOMA INFECTED BY HUMAN PAPILLOMA VIRUS TYPE-52 Mahendra-Dewi, I G. A. S,; Suwiyoga, I K.; Joewarini, E.; Alit-Artha, and I G.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

In Indonesia cervical carcinoma is the most common cancer in women and one of the leading cause of mortality. High risk human papillomavirus (HPV) is the major risk factor of cervical cancer. This study aims to know the role of IL-6, CD4+ and CD8+ T-lymphocyte for the risk of cervical carcinoma infected by HPV52. This study was a case control study, specimens of cervical carcinoma patients infected by HPV type-52 as the case group and HPV type-16 or 18 as the control group. HPV genotyping used SPF10 primer and type specific E7 primer by LiPA. Immunohistochemistry method was used to know expression of IL-6, CD4+ and CD8+ T lymphocyte. Pearson’s c2 test was applied with statistical significance was set at the 2-sided 0.05 level. The odds ratios (OR) were calculated for the risk, with 95% confidence intervals on SPSS 16.0 for windows. PCR examination was performed in 185 paraffin-embedded tissue. The risk of high IL-6 expression in cervical carcinoma infected by HPV type-52 was statistically significant 6-fold higher compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05) and HPV type 18 (OR = 6.00 ; CI 95% = 1.13-31.99; p = 0.03; p < 0.05). The risk of low CD4+ T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 6-fold higher and 7.43-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 6.00 ; CI 95% = 1.003-35.91; p = 0.04; p < 0.05) and HPV type 18 (OR = 7.43 ; CI 95% = 1.23-45.01; p = 0.02; p < 0.05). The risk of low CD8+ T lymphocyte expression in cervical carcinoma infected by HPV type 52 was statistically significant 13.5-fold higher and 11-fold higher respectively compare with cervical carcinoma infected by HPV type 16 (OR = 13.50 ; CI 95% = 1.42-128.26; p = 0.01; p < 0.05) and HPV type 18 (OR = 11.00 ; CI 95% = 1.16-103.94; p = 0.02; p < 0.05). No significance different between cases and controls group in mean-age, parity and sexual activity (p > 0.05). In conclusion, this study found that high IL-6 expression, low CD4+ and CD8+ T lymphocyte expression were the risk factors of cervical carcinoma infected by HPV type 52.
Obstetric and Gynecologic Departments, Faculty of Medicine Udayana University, Bali-Indonesia Mahendra-Dewi, I G. A. S.; Suwiyoga, and I K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 1 (2013): IJBS Vol.7 No.1 January-June 2013
Publisher : Udayana University

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Abstract

The high risk of human papillomavirus (HPV) have already known widely and accepted as a causative agent for cervical cancer. Epidemiologically, predominant high-risk is HPV-16 and squamous cell carcinomas (SCC) is the most common histological type. HPV genotype probably correlates to histologic type. This study aims to determine how many fold is the risk of SCC on HPV-16 infection. This is a case control with SCC HPV-16 positive as the cases and SCC HPV-16 negative as the controls. Tissues diagnosed as SCC and non SCC was paraffin-embedded. SPF-10 and specific E7-primer types by LiPA were employed for genotyping of HPV-16. c2 was applied to analyze the correlation. A number of 65 SCC consisted of 33 cases and 32 controls were observed in this study. The risk of SCC on HPV-16 infection was 3.40-fold (95% CI = 1.44-8.03; p = 0.004) compare with HPV-16 negative. Controls in this study consist of 18 (27.69%) of HPV-18, 9 (13.85%) of HPV-52, and 5 (7.69%) of other HPV types. The mean-age of case group and control group infected by HPV were 52.28 ± 12.43 and 47.70 ± 8.02 year, respectively (p = 0.02). HPV-16 infection caused SCC is 3.5 more than other high risk group.
Co-Authors Anak Agung Ayu Ngurah Susraini and I G. Alit-Artha annie minerva datui Astuti, Ida Ayu Jelantik Azizah, Norma Nur Azizah Budi Heryanto Desak Made Cittarasmi Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Desak Putu Gayatri Saraswati Seputra Dewi, Ida Ayu Krisna Cantika Dewi, Ni Putu Wulan Tantri Diah Widityasari, Diah E. Joewarini Efrisca M Br Damanik Ening Krisnuhoni Firman Parulian Sitanggang Gde Ngurah Idraguna Pinatih Handoko, Jovi Carina Henky, . Herman Saputra Herman Saputra Herman Saputra Herman Saputra Hutapea, Yuliance Nurhawati I Gusti Alit Artha I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Ngurah Bagus Rai Mulya Hartawan I Kadek Adi Purnama Sandhi I Ketut Suwiyoga I Made Gotra I Made Muliarta I Made Muliarta I MADE MULIARTA . I Made Naris Pujawan I Made Wirya Sastra I W. Sudarsa I Wayan Juli Sumadi I Wayan Juli Sumadi IB Caka Gunantara Ida Ayu Eugenia Natasha Blanco Oka Ida Ayu, Priandini Ivana Juliarty Sitanggang Kadek Agus Suhardinatha Putra Kadek Dwi Pradnyawati kadek pramesti dewi Katrin Rotua Simbolon Limantoro, Joshua Lisanthoni, Johnathan Luh Ayu Widayanti Luh putu Iin Indrayani Luh Putu Iin Indrayani Maker Made Dwi Hartayati MADE RATNA SARASWATI . Mochtar, Fransiska Moestikaningsih Moestikaningsih Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Ketut Ari Widhiasih, Ni Ketut Ari Ni Made Mahastuti Ni Putu Ekawati Ni Putu Sriwidyani Ni Wayan Winarti Nur Silfiah Nyoman Srie Laksminingsih Paramitha, Ni Made Laksmi Dewi Paskarani, Putu Erika Patriawan, Putu Popi Imelda Margareth Sitompul Putu Ayu Widya Pramesti Putu Ayu Winda Wirastuti Giri Putu Dony Astika Wiguna Putu Risky Yoga Pradnyana Shameni Subramaniam Silvia Nuhyil Indriani Sinaga, Naomi Juliana tanaka, Tanaka Tjandra Kristiana Volman Tampubolon Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wilananda, Ida Bagus Ardya Kurnia Wimpie I Pangkahila Winari, Ni Wayan