Claim Missing Document
Check
Articles

Found 30 Documents
Search

A PRELIMINARY STUDY OF INVESTIGATING OF COMPOUND GROUP CONTAINED IN ETHANOLIC EXTRACT OF MAHAGONY (Swietenia mahagoni L. Jacq.) SEEDS RELATED TO Α-GLUCOSIDASE INHIBITION Anjar Purba Asmara
Jurnal Natural Volume 18, Number 2, June 2018
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v18i2.9236

Abstract

A preliminary study to determine the group of compound contained in the ethanolic extract of mahagony (Swietenia mahagoni L. Jacq.) seeds and its inhibitory activity to a-glucosidase enzyme has been done. The information from this study will be used in the further investigation about the specific constituents related to the bioactivity. The seed was grounded and then extracted with ethanol by maceration technique. The crude extract was separated with liquid-liquid extraction by using n-hexane, ethyl acetate, and methanol as the solvents. The best eluent for isolation, chloroform:ethanol (1:1), was determined by thin layer chromatography while alumina as stationary phase. The isolation step with column chromatography gave two types of isolates, yellow and colorless isolate. In order to get information about the compound, the crude extract was subjected to phytochemical assignment and the isolate with the better activity was analyzed by infrared spectroscopy. The inhibitory activity for the yellow isolate with IC50 as 19.345 ppm was better than the colorless isolate. Therefore, the IR spectroscopy assay was subjected to the yellow isolate. Based on the comparison IR spectra with literatures, it has suggested that the yellow isolate contains tetranortriterpenoid or limonoid group.Keywords: Swietenia mahagoni L. Jacq., diabetes type 2, a-glucosidase, tetranortriterpenoidREFERENCE World Health Organization. Global report on diabetes. http://www.who.int. Accessed on 18 July 2017.Kementerian Kesehatan Republik Indonesia. 2014. Situasi dan analisis diabetes. Jakarta: Pusat Data dan Informasi Kemenkes RI.Dutta, M., Raychaudhuri, U., Chakroborty, R., and Maji, D. 2011. Role of diet and plants on diabetic patients - a critical appraisal. Science and Culture. 77 (3–4).Eid, A.M.M., Elmarzugi, N.A., and El-Enshasy, H.A. 2013. A Review on the phytopharmacological effect of Swietenia macrophylla, Int J Pharm Pharm Sci. 5 (3): 47-53.Bera, T.K., Chatterjee, K., Jana, K., Ali, K.M., De, D., Maiti, M., and Ghosh, D. 2012. Antihyperglycemic and antioxidative effect of hydro-methanolic (2:3) extract of the seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: an approach through pancreas. Genomic Medicine, Biomarkers, and Health Sciences. 4: 107-117.Li, D.D, Chen, J.H, Chen, Q, Li, G.W, Chen, J, and Yue, J.M. 2005. Swietenia mahagony extract shows agonistic activity to PPAR-γ and gives ameliorative effects on diabetic db/db mice. Acta Pharmacol Sinica. 26 (2): 220-222.Sathish, R., Natarajan, K., and Selvakumar, S. 2010. Antidiabetic activity of Swietenia mahagoni seed powder in alloxan induced diabetic mice. Research J. Pharmacology and Pharmacodynamics. 2(4): 296-299.Wresdiyati, T., Sa’diah, S., and Winarto, A., Febriyani, V. 2015. Alpha-glucosidase inhibition and hypoglycemic activities of Sweitenia mahagoni seed extract. HAYATI Journal of Biosciences. 22 (2): 73-78.Sukardiman, Riza, N.F., Rakhmawati,  Studiawan, H., Mulja, H.S., and Rahman, A. 2013. Hypoglycemic activity of 96% ethanolic extract of Andrographis paniculata Nees. and Swietenia mahagoni Jacq. combination, E-Journal Planta Husada,. 1.Masitha, M. 2011. Skrining aktivitas penghambatan enzim α-glukosidase dan penapisan fitokimia dari beberapa tanaman obat yang digunakan sebagai antidiabetes di indonesia. Skripsi. FMIPA UI.Aliyan, A.H. 2012. Uji penghambatan aktivitas alfa-glukosidase dan identifikasi golongan senyawa kimia dari fraksi aktif ekstrak biji mahoni (Swietenia macrophylla King). Skripsi. FMIPA UI.Ibrahim, M.A., Koorbanally, N.A., and Islam, M.S. 2014. Antioxidative activity and inhibition of key enzymes linked to type-2 diabetes (a-glucosidase and a-amylase) by Khaya senegalensis. Acta Pharm. 64: 311–324.Harborne, J. B. 1984. Phytochemical methods: a guide to modern techniques of plant analysis. New York: Chapman and Hall.Kadota, S., Marpaung, L., Tohru, K., and Ekimoto, H. 1990. Constituents of the seeds of Switenia mahagoni JACQ. I. isolation, structures, and 1H- and 13C-nuclear magnetic resonance signal assignments of new tetranorterpenoids related to swietenine and swietenolide. Che. Pharm. Bull. 38(3): 639–651.Rahman, A. K. M. S., Chowdhury, A. K. A., Ali, H.A., Raihan, S.Z, Ali, M.S., Nahar, L., and Sarker, S.D. 2009. Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains. J Nat Med. 63: 41–45.Yadav, L.D.S. 2005. Organic spectroscopy. Allahabad: Kluwer Academic Publishers.Dewanjee, S., Maiti, A., Das, A.K., Mandal, S.C., and Dey, S.P. 2009. Swietenine: a potential oral hypoglycemic from swietenia macrophylla seed. Fitoterapia. 80: 249–251.Maiti, A., Dewanjee, S., and Sahu, R. 2009. Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla Seeds, Phytother. Res. 23: 1731–1733.Marliana, S.D., Suryanti, V., and Suyono. 2005. Skrining fitokimia dan analisis kromatografi lapis tipis komponen kimia buah labu siam (Sechium edule Jacq. Swartz.) dalam ekstrak etanol, Biofarmasi. 3 (1): 26-31.Nurhayati, Siadi, K., and Harjono. 2012. Pengaruh konsentrasi natrium benzoat dan lama penyimpanan pada kadar fenolat total pasta tomat, Indo. J. Chem. Sci. Vol. 1 (2): 158-163.Siadi, K. 2012. Ekstrak bungkil biji jarak pagar (Jatropha curcas) sebagai biopestisida yang efektif dengan penambahan larutan NaCl. Jurnal MIPA. 35 (1): 80-81.Klein, D.R. 2012. Organic chemistry. New Jersey: John Wiley Sons.Pavia, D.L., Lampman, G.M., and Kriz, G.S. 2001. Introduction to spectroscopy. London: Thomson Learning.Minaeva, V.A., Minaev, B.F., Baryshnikov, G.V., Romeyko, O.M., and Pittelkow, M. 2013. The FTIR spectra of substituted tetraoxa[8]circulenes and their assignments based on DFT calculations, Vibrational Spectroscopy. 65: 147–158.Mootoo, B.S., Ali, A, Motilal, R, Pingal, R, Ramlal, A, Khan, A, Reynolds, W.F, and McLean, S. 1999. Limonoids from Swietenia macrophylla and S. aubrevilleana. J. Nat. Prod. 62: 1514-1517.Lin, B.D., Yuan, T., Zhang, C.R., Dong, L., Zhang, B., Wu, Y., and Yue, J.M. 2009. Structurally diverse limonoids from the fruits of Swietenia mahagoni. J. Nat. Prod. 72: 2084–2090.Cheng, Y.B., Chien, Y.T., Lee, J.C., Tseng, C.K., Wang, H.C., Lo, W., Wu, Y.H., Wang, S.Y., Wu, Y.C., and Chang, F.R. 2014. Limonoids from the seeds of Swietenia macrophylla with inhibitory activity against dengue virus 2. J. Nat. Prod. dx.doi.org/10.1021/np5002829.Zhang, W.M., Liu, J.Q., Deng, Y.Y., Xia, J.J., Zhang, R.N., Li, Z.R., and Qiu, M.H. 2014. Diterpenoids and limonoids from the leaves and twigs of Swietenia mahagoni. Nat. Prod. Bioprospect. 4:53–57.Ma, Y.Q., Jiang, K., Deng, Y., Guo, L., Wan, Y.Q., and Tan, C.H. 2017. Mexicanolide-type limonoids from the seeds of Swietenia macrophylla, Journal of Asian Natural Products Research, DOI: 10.1080/1028-6020.2017.1335715.Zang, Y., amd Xu, H. 2017. Recent progress in the chemistry and biology of limonoids. RSC Adv. 7: 35191–35220.Tan, Q.G., and Luo, X.D. 2011. Meliaceous limonoids: chemistry and biological activities. Chem. Rev., 111, 7437–7522.Fang, X., Di, Y. T, and Hao, X. J. 2011. The advances in the limonoid chemistry of the Meliaceae family. Current Organic Chemistry. 15: 1363-1391.Taylor, D. A. H. The chemistry of the limonoids from meliaceae. https://link.spri-nger.com/book-series/126. Accessed on 21 July 2017.Zang, Y., amd Xu, H. 2017. Recent progress in the chemistry and biology of limonoids. RSC Adv. 7: 35191–35220.
THE EFFECTIVENESS OF COAGULANTS AND FLOCCULANTS IN IMPROVING CLARIFIER WATER QUALITY: A CASE STUDY AT PT PERTA ARUN GAS, LHOKSEUMAWE Rahmah, Maulidia; Mahrizal, Mahrizal; Asmara, Anjar Purba
Walisongo Journal of Chemistry Vol. 8 No. 1 (2025): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v8i1.23656

Abstract

This study evaluated the effectiveness of coagulants and flocculants in improving clarifier water quality, with a focus on pH, iron (Fe) concentration, and turbidity levels. In accordance with Indonesia’s Ministry of Health Regulation No. 32/2017 on environmental health standards for water, clarifier water samples were analyzed before and after treatment. The results show that the treated water complied with the specified standards, with pH levels ranging from 6.5 to 8.5, Fe concentrations below 1 mg/L, and turbidity under 25 NTU. The application of aluminum sulfate as a coagulant and polymer as a flocculant effectively reduced Fe concentrations and turbidity while adjusting the pH to acceptable levels. These findings confirm the critical role of coagulation and flocculation in industrial water treatment processes and demonstrate their potential for enhancing water quality in clarifier systems.
OPTIMISATION OF SULFURIC ACID CONCENTRATION FOR ENHANCED FE2+ ION REMOVAL USING ACTIVATED CHARCOAL FROM BOILED PEANUT SHELLS: CHARACTERISATION AND PERFORMANCE EVALUATION Asmara, Anjar; Kamila , Nisaul; Kamila, Nisaul
Lingkar: Journal of Environmental Engineering Vol. 5 No. 1 (2024): LINGKAR : Journal of Environmental Engineering
Publisher : Department of Environmental Engineering (Prodi Teknik Lingkungan), Fakultas Sains dan Teknologi, UIN Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Groundwater containing iron(II) (Fe2+) ions causes yellowish-brown discolouration and sediment formation. Since bioadsorbents can remove Fe2+ ions, this study investigated the effect of varying H2SO4 activator concentrations (5%, 7%, 9%, 11%, and 13%) on adsorption efficiency and identifies the optimal concentration for activated charcoal derived from boiled peanut shells (Arachis hypogaea L.) to remove the metal ions from well groundwater in Punge Jurong Village in Aceh Province of Indonesia. The process included carbonising the peanut shell waste, activating the charcoal, and testing the adsorbent on well groundwater. The results were analysed using SSA, SEM, and FTIR instruments, along with statistical analysis via SPSS 15 for one-way of analysis of variance (ANOVA). The adsorption efficiencies were 60.43%, 55.53%, 59.01%, 61.81%, 61.94%, and 59.10% corresponding to the activated carbons by H2SO4 (5%, 7%, 9%, 11%, and 13%) and commercial activated carbon, respectively. The IR-assisted characterisation on the boiled peanut shell waste bioadsorbent suggested that wave number shifting on O–H, C=C and C–O typical regions might be due to protonation affect by the acid activator. Conclusively, the study indicates that 13% H2SO4 is the most effective activator concentration for Fe2+ ion removal using activated carbon derived from boiled peanut shells.
STUDI PERSPEKTIF SENSORIK DAN KADAR KAFEIN KOPI KHOP BANDA ACEH Nurhayati; Asmara, Anjar Purba; Sabarni
AMINA Vol. 3 No. 3 (2021): December 2021
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kajian kandungan kafein yang berkaitan dengan cita rasa kopi unik dari Aceh, kopi Khop, masih terbatas. Studi ini bertujuan untuk menentukan hubungan antara kadar kafein dalam bubuk kopi Khop dan karakteristik sensorik dengan analisis regresi linear. Bubuk kopi Khop dipisahkan berdasarkan empat kategori: halus (fine, F), sedang (medium, M), kasar (coarse, C), dan original (O). Keempat jenis bubuk kopi tersebut diseduh dengan air panas (90 oC) lalu diuji karakteristik sensoriknya menggunakan uji organoleptik meliputi rasa asam dan pahit, aroma, warna, dan residu ampas. Sampel kopi tersebut juga diukur kadar kafeinnya menggunakan spektrometer UV-vis dan harga pH-nya. Analisis dengan regresi linear sederhana menunjukkan hubungan linear negatif antara kadar kafein bubuk F, M, dan C dengan skor deskriptor sensorik kopi Khop. Berdasarkan hasil uji tersebut, kadar kafein bukan merupakan faktor tunggal yang menentukan hasil penilaian karakter sensorik bubuk kopi Khop yang ditunjukkan dengan linearitas negatif antara kadar kafein dan skor aroma kopi.
KAJIAN POTENSI RUMPUT LAUT COKLAT Sargassum SEBAGAI BAHAN BAKU PUPUK ORGANIK CAIR Asmara, Anjar Purba
AMINA Vol. 4 No. 3 (2022): December 2022
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/amina.v4i3.5532

Abstract

Rumput laut coklat Sargassum memiliki banyak senyawa kimia yang dapat dimanfaatkan bagi industri kesehatan, obat-batan, makanan, dan juga pertanian. Beberapa senyawa kimia penting dari Sargassum diantaranya adalah alginat, florotanin, fukoidan, dan metabolit primer seperti karbohidrat, protein, serta asam lemak. Kandungan mineral yang beragam, seperti Ca, Cu, Fe, Mg, Mn, Na, S, Zn, juga dimiliki oleh spesies ini. Zat-zat tersebut dapat dimanfaatkan untuk menjaga dan meningkatkan kesuburan tanah yang ramah lingkungan. Tulisan ini bertujuan untuk merangkum kandungan senyawa apa saja di dalam Sargassum dan sejauh mana riset tentang potensi spesies ini sebagai bahan baku pupuk organik cair (POC) telah dilakukan.
Penentuan Metode Komputasi Untuk Analisis Hubungan Kuantitatif Struktur dan Aktivitas Senyawa Turunan Triazolopiperazin Amida Anjar Purba Asmara; Mudasir Mudasir; Dwi Siswanta
Elkawnie Vol. 1 No. 1 (2015)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v1i1.515

Abstract

Penentun metode komputasi untuk analisis hubungan kuantitatif struktur dan aktivitas (HKSA) telah dilakukan pada senyawa turunan triazolopiperazin amida sebagai inhibitor enzim DPP IV yang merupakan penyebab diabetes melitus tipe 2 (DM2). Metode komputasi yang digunakan untuk analisis ini adalah metode semiempirik. Analisis dilakukan dengan pemodelan struktur senyawa turunan triazolopiperazin amida dan perhitungan deskriptor HKSA dilakukan menggunakan program Hyperchem. Parameter yang digunakan adalah pergeseran kimia 13C NMR, panjang ikatan antaratom, sudut ikatan antaratom, dan muatan atom bersih. Hasil perhitungan parameter tersebut dibandingkan dengan data empiris dan hasil perhitungan metode ab initio. Hasil penelitiannya menunjukkan bahwa metode semiempirik yang sesuai untuk analisis HKSA senyawa turunan triazolopiperazin amida adalah AM1 dan PM3.
Analisis Hubungan Kuantitatif Struktur Dan Aktivitas Senyawa Turunan Triazolopiperazin Amida Menggunakan Metode Semiempirik AM1 Anjar Purba Asmara; Mudasir Mudasir; Dwi Siswanta
Elkawnie Vol. 1 No. 2 (2015)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v1i2.525

Abstract

QSAR studies had done on derivatives of triazolopiperazine amide as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies had began by modeling the structures of the derivatives of triazolopiperazine amide and calcutating the descriptors of QSAR by semiempirical AM1 method which available on HyperchemÒprogram. QSAR analysis had done by multilinear regression method analysis which is available on SPSSÒprogram using electronic and molecular parameters. The best QSAR equation model for method of semiempirical AM1:-log IC50 =  152.252 + (18,.295*qC1) + (2.343*qC5) + (2263.448*qC9) +  (1662.252*qC10) – (350.806*qC15) + (639.687*qO25)+ (6.515*EH)n = 18; r2 = 0.712; adjusted r2 = 0.510; Fhit/Ftab = 1.124; PRESS = 0.006 The main side of the compound can be determined through the equation. It can be used to study in preventing the disease of DM2 by inhibiting of enzyme DPP IV.
Analysis of Vitamin C Level Contained in Mango Gadung (Mangifera indica L) With Varied Retention Time Anjar Purba Asmara
Elkawnie Vol. 2 No. 1 (2016)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v2i1.658

Abstract

This research is aimed to determine the level of vitamin C in the mango Gadung which stored as long as 0 days; 1 day; 2 days; and 3 days. It is used iodimetric titration. Standard iodine solution used as titrant while starch as the indicator. Determination of raw normality iodine standardization carried out by titration of iodine with sodium thiosulphate solution primer. Normality primary sodium thiosulphate solution (0.0125 N) are determined through standardized sodium thiosulphate with potassium dichromate. Levels of vitamin C in the fruit is determined by linear regression analysis were made based on the graph of the vitamin C levels versus volume of iodine standard solution which used in the titration. The curve gives the equation as following: y = 413.8 x – 1.238. Levels of vitamin C of mango Gadung which has varied retention time as follows: 0.26% (0 days); 0.22% (1 day); 0.20% (2 days); and 0.16% (3 days).
The Effect of Minimum Quantity Lubrication (MQL) and Depth of Cut on Surface Roughness in Turning of AISI 1020 Steel Rahul, Rahul; Rismanto, Muhammad; Iqbal, Muhammad; Sirajuddin, Awal Syahrani; Asmara, Anjar; Hair, Jumadil
Jurnal Rekayasa Mesin Vol. 17 No. 1 (2026)
Publisher : Jurusan Teknik Mesin, Fakultas Teknik, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jrm.v17i1.2127

Abstract

This study aims to investigate the effect of the Minimum Quantity Lubrication (MQL) method using wasted cooking oil and depth of cut on surface roughness in the turning process of AISI 1020 steel. The tests were conducted on a manual lathe machine with a spindle speed of 800 rpm, a cutting length of 100 mm, and depth of cut values of 0.2 mm, 0.4 mm, and 0.6 mm. The independent variables used were MQL with wasted cooking oil and depth of cut, while the dependent variable observed was surface roughness. The test results show that the lowest surface roughness (Ra) value of 1.423 µm was obtained at a depth of cut of 0.2 mm with MQL. Conversely, the highest surface roughness value of 3.515 µm was recorded at a depth of cut of 0.6 mm without MQL. Increasing the depth of cut resulted in an increase in surface roughness. However, the application of the MQL method with wasted cooking oil can reduce surface roughness compared to the turning process without MQL. Therefore, the combination of wasted cooking oil as an MQL lubricant and optimal depth of cut can improve surface quality and support the principles of green manufacturing by utilizing wasted cooking oil, which helps reduce the environmental impact of industrial waste.
In Silico Analysis of Antibacterial Activity of Fatty Acids in Swietenia humilis Zucc. Seed Extract Against Staphylococcus aureus sortase A enzyme Asmara, Anjar Purba; Hernawan, Hernawan; Nuzlia, Cut
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.87473

Abstract

This study utilised molecular docking to predict the binding affinity of various fatty acids (FAs) found in Swietenia humilis to the sortase A (SrtA) protein target from Staphylococcus aureus. Binding energies, measured in kcal/mol, indicated the strength and stability of ligand-protein interactions, with lower values signifying stronger binding. The binding affinities of eight FAs as the active constituents in n-hexane extract of S. humilis and the positive control, gentamicin, were compared to assess their theoretical antibacterial activity. Palmitoleic acid exhibited the strongest binding affinity (-5.6 kcal/mol) among the FAs, suggesting the highest potential antibacterial activity, followed by linoleic, palmitic, linolenic, arachidic, tricosanoic, stearic, and oleic acids in decreasing order of affinity. Despite having weaker binding energies than gentamicin, a common gram-positive inhibitor from aminoglycoside derivative, FAs showed multiple hydrogen bonds and van der Waals interactions with key residues like ARG197, VAL168, VAL166, and ILE182, contributing to their binding stability. Palmitoleic acid formed multiple hydrogen bonds (ARG197 and GLY119) and significant van der Waals interactions, highlighting its strong theoretical binding. Stearic and oleic acids, although having higher binding energies, also formed critical hydrogen bonds, suggesting moderate potential activity. Gentamicin's single hydrogen bond suggests a highly specific binding site, which may result in high antibacterial activity despite fewer interaction points. The study indicated that FAs like palmitoleic and oleic acid show substantial potential as supplementary antibacterial agents, especially in the context of combating antibiotic resistance. This finding can pave a path for drug design and development to address the S. aureus's resistance.