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All Journal Folia Medica Indonesiana Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Jurnal Ilmiah Universitas Batanghari Jambi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Widya Medika
Nur Rochmah
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas Airlangga-RSUD Dr. Soetomo, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Hubungan Fungsi Tiroid Dengan Pertumbuhan Pada Anak Sindrom Down Di Poli Endokrin Anak Rsud Dr. Soetomo Surabaya Hafidhatul Aisy; Nur Rochmah; Hermawan Susanto; Azwin Mengindra Putera Lubis
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.522 KB) | DOI: 10.36418/syntax-literate.v7i11.10034

Abstract

Anak-anak dengan Sindrom Down (SD) memiliki peningkatan risiko mengalami disfungsi tiroid. Hormon tiroid berperan penting dalam proses pertumbuhan sehingga gangguan fungsi tiroid dapat mempengaruhi pertumbuhannya. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi tiroid dengan pertumbuhan pada anak SD. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional menggunakan sumber data rekam medis pasien. Variabel bebas dalam penelitian ini adalah fungsi tiroid dan variabel terikatnya adalah pertumbuhan. Tinggi/ panjang badan merupakan parameter pertumbuhan yang dinilai menggunakan kurva standar untuk anak-anak dengan SD. Hasil dari penelitian ini adalah subjek penelitian terdiri dari 27 pasien SD (17 laki-laki, 20 perempuan) yang berusia 1 sampai 47 bulan dengan rerata usia 10.00±10.87 bulan. Distribusi fungsi tiroid terdiri dari 15 hipotiroid sentral (55.6%), 8 hipotiroid subklinis (29.6%), 3 hipotiroid primer (11.1%), dan 1 eutiroid (3.7%). Mayoritas subjek memiliki tinggi badan normal (22/27, rerata z-score -0,03±2,37). Nilai signifikansi korelasi antara fungsi tiroid (kadar TSH dan FT4) dan pertumbuhan (perubahan z-score) berturut-turut p=0,287 dan p=0,143 yang berarti p>0,05 sehingga tidak ada korelasi yang signifikan. Sehingga dapaty diterik kesimpulan bahwa tidak terdapat hubungan antara fungsi tiroid dengan pertumbuhan anak dengan SD. Namun disarankan untuk melakukan skrining fungsi tiroid, mendiagnosis, memonitor, dan memberikan terapi dini pada anak SD untuk mencegah perburukan kondisi perkembangan, pertumbuhan, dan metabolisme.
Antibodies to Glutamic Acid Decarboxylase-65 is Associated with Total Daily Dose of Insulin Requirement in Children with Type 1 Diabetes Faisal Faisal; Nur Rochmah; Muhammad Faizi; Novina Novina; Erni Nuraeni
The Indonesian Biomedical Journal Vol 15, No 4 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i4.2377

Abstract

BACKGROUND: Type 1 diabetes (T1D) mostly occurs due to the destruction of pancreatic beta cells due to autoimmune processes. Diagnosis of T1D can be established by examining the c-peptide levels and the markers of pancreatic autoantibodies, including glutamic acid decarboxylase 65 autoantibodies (GAD-65). However, the association between c-peptide and anti-GAD-65 toward patients’ clinical manifestations needs to be further explored. Hence, the aim of current study was to identify the association of anti-GAD65 with c-peptide and clinical characteristics in children with T1D.METHODS: Case-control study involving 47 T1D children (T1D group) and 41 healthy children (control group) younger than 18 years old was conducted. Secondary data regarding subjects’ demographic characteristics and medical history were collected from subjects, and serum blood was drawn from each subject for the anti-GAD65 and c-peptide measurement. Anti-GAD65 and c-peptide levels were measured using an Enzyme-Linked Immunosorbent Assay (ELISA) methods.RESULTS: Anti-GAD65 antibody was detected in 78.7% T1D group, while only 2.43% were detected in control group subject (p=0.0000). The c-peptide level of T1D group was 0.07±0.19 nmol/L and control group was 1.5±0.77 nmol/L (p=0.0000). The total daily dose of insulin in subjects with positive anti-GAD65 was greater than in the negative anti-GAD65 (p=0.012). The sensitivity and specificity of the anti-GAD65 were 85.4% was 66.7%, respectively.CONCLUSION: The results of this study show that anti-GAD65 was associated with total daily dose of insulin requirement in children with T1D.KEYWORDS: diabetes mellitus, type 1 diabetes, anti-GAD65, c-peptide
CORRELATION BETWEEN BREASTFEEDING AND 3 – 24 MONTHS OLD CHILDREN DEVELOPMENT IN KEPUTIH HEALTH CENTER SURABAYA Chatrine Evania Palangan Sangka; Sri Umijati; Nur Rochmah
JURNAL WIDYA MEDIKA Vol. 7 No. 1 (2021): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i1.2879

Abstract

Children's developmental disorders were increased in Indonesia. One of the factors affecting 3 – 24 months old children development is breastfeeding. However, in several studies, the correlation between the two was still uncertain. This study aimed to determine the correlation between breastfeeding and 3 – 24 months old children development with a cross-sectional study design. Randomly selected 78 mothers who had 3 – 24 months old children at the Keputih Health Center Surabaya. Researchers interviewed mothers about breastfeeding duration and breastfeeding method, as well as their children's development based on Prescreening Developmental Questionnaire (PDQ). Researchers also assessed children's development to answer PDQ. The correlation between breastfeeding and children’s development was then analyzed using the Chi-Square test. Exclusive breastfeeding was widely obtained in children with overall development (83.3%) and fine motor aspects (85.7%) at the appropriate age. Direct breastfeeding was widely obtained in children with speech and language development at the appropriate age (81.9%). Breastfeeding duration was related to overall children’s development (p=0.014) and fine motor aspect (p=0.025). The breastfeeding method was related to children's speech and language aspects (p=0.018). Breastfeeding duration was related to overall children’s development, particularly in the fine motor aspect. The breastfeeding method was related to children's speech and language aspects.
Co-Authors Ahmad Suryawan Azwin Mengindra Putera Bambang Hermanto Chatrine Evania Palangan Sangka Darto Saharso Erni Nuraeni Fadhil Abiyyu Yofi Faisal Faisal Faisal Faisal Fatimah Arief Fatimah Indarso Hafidhatul Aisy Herman Kosasih Hermawan Susanto Irwina Rahma Andriani Juniastuti Juniastuti Kevin Almas Maromi Leonardo Ferryanto Mak Samadhi Moersintowarti BN Muhammad Faizi Netty Harjantien Neurinda Permata Kusumastuti Novina Novina Nurul Ima Suciwiyati Soraya Salle Pasulu Sri Umijati Sukmawati Basuki Wika Yuli Deakandi