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All Journal International Journal of Public Health Science (IJPHS) Proceedings of KNASTIK Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Science and Technology Indonesia Communications in Science and Technology Jurnal Kebidanan JFL : Jurnal Farmasi Lampung KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sehat Indonesia (JUSINDO) Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan
Arif Budi Setianto
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Science and Technology Indonesia

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Nanotechnology-Based Nanopolymeric Polyherbal Formulation for Enhanced Antioxidant and Anti-Glycation Activity Astuti, Febriana; Mustofa; Arif Budi Setianto; Akrom
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.972-981

Abstract

Elevated oxidative stress and glycation give to the enhancement of degenerative condition such as diabetes and heart disease. Herbal extracts such as Apium graveolens, Centella asiatica, and Orthosiphon stamineus possess well-documented antioxidant and anti-glycation properties. However, their therapeutic effectiveness is measured by poor bioavailability, highlighting the need for innovative formulations. Nanotechnology presents a indicative of success approach by improving the solubility and distribution of active compounds. This study developed a nanopolymeric formulation by combining extracts of Apium graveolens, Centella asiatica, and Orthosiphon stamineus utilizing the ionic gelation method by chitosan, NaTPP, and Tween 80. The nanoparticles were characterized based on particle size, PDI, zeta capability, TEM, and FTIR. In vitro assays utilizing peripheral blood mononuclear cells (PBMCs) were conducted to analyze antioxidant activity through Nrf2 and GST expression, and anti-glycation capability by measuring AGEs. The nanopolyherbal particles had an average size of 186 ± 46.81 nm, by a PDI of 0.434 ± 0.04 and a zeta capability of -29.69 ± 1.54 mV. Both 1% and 3% nanopolyherbal treatments increased Nrf2 stages (66.77 ± 7.65 and 63.13 ± 2.75, respectively) and GST stages (87.97 ± 49.48 and 73.57 ± 4.61) compared to the control group (Nrf2: 54.1 ± 1.0; GST: 68.93 ± 2.28). The nanopolyherbal formulation also significantly decreased AGE itemion (1%: 1075.67 ± 107.51; 3%: 813.33 ± 117.05) compared to the control (1497.33 ± 161.58). These outcomes reveal that the nanopolyherbal formulation enhances antioxidant activity and inhibits glycation in PBMCs, suggesting its capability for managing oxidative stress-related condition.
Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Co-Authors Abdul Fadlil Akrom, Akrom Anwar, Muslih Ari Wahyudi Capritasari, Rafiastiana Faikah Dyah Utami Febriana Astuti Hasan, Nuradnin Hasna, Elly Rosita Husain, Dewi Putri Ichwan Ridwan Rais Iis Wahyuningsih Kintoko Lasanudin, Rindi Ibrahim Ma'ruf, Muhammad Mohamad Reski Manno Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nining Sugihartini Nugroho, Nazih Basuki Nuradnin Hasan Putri Purnamasari Putri, Meilisa Sapto Yuliani Sri Mulyaningsih Sri Mulyaningsih Sun, Suny Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Yunda Maymanah Rahmadewi