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All Journal ACTA VETERINARIA INDONESIANA Media Veteriner Jurnal Sain Veteriner Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Journal of Tropical Biodiversity and Biotechnology Livestock and Animal Research Aceh International Journal of Science and Technology
Teguh Budipitojo
Bagian Anatomi, Fakultas Kedokteran Hewan, Universitas Gadjah Mada, Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Immunology & microbiology Veterinary

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Small intestine histologic neuronal features of type-2 diabetes mellitus rats treated with ethanolic extract red betel leaf (Piper crocatum) nanoparticle (EERbLNp) Pangestiningsih, Tri Wahyu; Primatika, Roza Azizah; Budipitojo, Teguh; Wendo, Woro Danur
Livestock and Animal Research Vol 21, No 1 (2023): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v21i1.67929

Abstract

Objective: This study marked histological features of small intestine neurons in the type-2 diabetes mellitus (T2DM) rat model treated with ethanolic extract red betel leaf nanoparticle (EERbLNp)Methods: Thirty male Wistar rats were allotted into five groups (six rats each). Group I is nondiabetic control; group II is streptozotocin-nicotinamide (STZ-NA)-induced T2DM; group III-V are the STZ-NA-induced T2DM treated daily per oral with EERbL-Np at the doses 30, 60, and 90 mg/kg, respectively, within 28days. The duodenum, jejunum, and ileum were collected for routine histological staining and cresyl violet special staining to evaluate the feature of neurons in the Meissner (submucosa) and Auerbach (muscular) plexus. Descriptive statistical analysis ANOVA and Tukey HSD were used to compare neuron indexes among groups.Results: The necrotic neuron index in the duodenal and ileal Auerbach plexus, including the degenerative neuron index in the jejunal Auerbach plexus, were significantly decreased with the EERbL-Np treatment at the dosages 60 and 90mg/kg.Conclusions: The 60 mg/kg EERbL-Np administration in the T2DM model may provide a neuroprotectant candidate in duodenal and ileal neuropathy. Dosage of 90mg/kg EERbL-Np is also promising in jejunal neuropathy treatment.
Co-Authors . Ariana Adi Winarto Agustin Indrawati Anni Nurliani Anni Nurliani Aqiilah, Khairunnisa Ariana -, Ariana Ariana Ariana Budiariati, Vista Dewi K. Musana, Dewi K. Dwi Liiek Kusindarta Dwi Liliek Kusindarta Guntari Titik Mulyani Hery Wijayanto Hevi Wihadmadyatami Kustiati, Ulayatul Roza Azizah Primatika, Roza Azizah Saragih, Golda Rani Soehartini Jatman Tri Wahyu Pangestiningsih Woro Danur Wendo Yosephine Nicolory Paula Yosephine Nicolory Paula Yuda Heru Fibrianto Yuda Heru Fibrianto