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All Journal HAYATI Journal of Biosciences Jurnal Pengolahan Hasil Perikanan Indonesia Jurnal Ilmu Tanah dan Lingkungan (Journal of Soil Science and Environment) VALENSI Jurnal Bios Logos CHEMISTRY PROGRESS JURNAL KIMIA SAINS DAN APLIKASI JURNAL TEKNOLOGI LINGKUNGAN IPTEK Journal of Proceedings Series Jurnal Riset Kimia SEMIRATA 2015 Jurnal Kimia Mulawarman IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Science and Technology Indonesia Jurnal Penelitian Sains Chimica et Natura Acta Indonesian Journal of Pure and Applied Chemistry Sains Natural: Journal of Biology and Chemistry Jurnal Tanah dan Iklim
Charlena
Departemen Kimia,Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor Kampus IPB Dramaga Jl.Agatis Wing 2 Level 4, Bogor 16144, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Science and Technology Indonesia

 1 
Hydroxyapatite-ZnO Biomimetic Toothpaste Formulation from Rice Snail Shell Waste Wisaeni Intannia; Charlena Charlena; Irma Herawati Suparto
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.486-493

Abstract

Toothpaste is a preparation for dental treatment to clean, beautify, and replace minerals that decay from the surface of the teeth. Prevention of damage to the mineral layer of the teeth, the addition of remineralizing agents to toothpaste preparations in the form of hydroxyapatite-ZnO composites is carried out. This study aims to synthesize and characterize hydroxyapatite-ZnO, as well as to formulate hydroxyapatite-ZnO toothpaste from rice field conch shell waste. Hydroxyapatite-ZnO composites have been successfully synthesized using the sol-gel method and characterized using X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). The XRD result obtained a crystal size of 59.90 nm with a crystallinity percentage of 68.85%. The absorption band at a wave number of 452 cm−1 is an indication that the ZnO compound has been successfully combined with hydroxyapatite. SEM-EDX analysis showed that the morphology of the compound was granular with a rough surface, uneven size, and shape. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria. The results of the hydroxyapatite-ZnO toothpaste formulation in the 45% formula had good physical stability compared to other formulas. The antibacterial properties of hydroxyapatite-ZnO toothpaste preparations showed a very strong inhibitory effect on Streptococcus mutans bacteria.
Synthesis and Characterization of ZnO/Cellulose Acetate Composite and its Activity as Antibacterial Agent Khefanny, Yemima Chellyne; Charlena; Sugiarti, Sri
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.215-223

Abstract

Cellulose is an abundant natural polymer that can be applied in various fields. Cellulose has many types and derivatives, one of which is cellulose acetate. Cellulose can be obtained from various natural sources such as kepok banana peel. The a-cellulose content in kepok banana peel is high enough at 94% so that it can be utilized as a cellulose acetate raw material. Modification of cellulose acetate using antibacterial agents is needed, considering that cellulose does not have antibacterial properties. Metal oxide materials such as ZnO nanoparticles are used as antibacterial agents. This study added ZnO nanoparticles to cellulose acetate and tested its antibacterial activity. The characteristics of ZnO were analyzed by UV-Vis, PSA, and FTIR. The characteristics of cellulose acetate and composites were analyzed by FTIR and XRD. Antibacterial activity tests were performed on all samples. The results showed the band gap value of ZnO was 3.37 eV. The average size of ZnO nanoparticle distribution using PSA was 96.23 nm with an average PI value of 0.151. An indicator that the ZnO compound and cellulose acetate have been sucessfully mixed is the absorption band at wave number 488 cm−1. A composite crystal size of 24.14 nm and a crystallinity percentage of 34.05% were found using XRD data. S. aureus bacteria are more inhibited by all evaluated substances antibacterial properties than E. coli germs. ZnO/Cellulose Acetate composite is categorized as strong inhibition, while ZnO nanoparticles are categorized as medium inhibition.
Phytoestrogens Therapy for Osteoporosis Treatment Using Indonesian Medicinal Plants: A Brief Review Sianipar, Rut Novalia Rahmawati; Iswantini, Dyah; Charlena, Charlena; Wahyudi, Setyanto Tri; Prasetyo, Joni
Science and Technology Indonesia Vol. 9 No. 4 (2024): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.4.949-964

Abstract

A problematic bone remodeling cycle is known to produce more osteoclasts than osteoblasts, making bones more fragile and this condition shows osteoporosis. In this context, estrogen deficiency in the human body is associated with the regulation of osteoporosis. Therefore, this study aimed to investigate the knowledge about basic concepts of bone, osteoporosis, phytoestrogens, and Indonesian medicinal plants for osteoporosis treatment. Data were obtained from literature on various databases including Science Direct, Wiley Online Library, Scopus, Pubmed, and Google Scholar. Adequate therapy is needed to increase estrogen content and an effective approach is to consume medicinal plants that contain phytoestrogens, which have identical structure and activity to human estrogen (17β-estradiol). The results showed that there were observations comprising in vitro, in vivo, and in silico studies on 18 Indonesian medicinal plants as antiosteoporosis treatments. The Leguminosae or Fabaceae family, which has a significant amount of isoflavones (the primary group of phytoestrogens) was found to dominate as an antiosteoporosis agent. Therefore, the development of phytoestrogens therapy from Indonesian medicinal plants must be implemented for the future treatment of osteoporosis.
Synthesis and Characterization of Hydroxyapatite Composites Based on Tutut (Belamya Javanica) and Magnetite by Coprecipitation as Adsorbents of Pb Metals Ion Charlena; Nazriati; Marita Soebrata, Betty; Dicky Iswara, Muhammad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.111-122

Abstract

Increased industrial activity can result in the emission of pollutants into the environment, such as heavy metals, which are a significant source of concern. A practical approach to reduce this problem is to utilize Pb metal adsorption. This study aims to synthesize HAp from Bellamya javanica clam shells and characterize the HAp-Fe3O4 composite as a Pb metal ion adsorbent. FTIR and XRD analysis results showed the successful fabrication of the composite, resulting in a crystal dimension of 7.63 nm and a crystallinity level of 84.80%. SEM characterization showed a porous structure with a particle size of 10.98 um. Adsorption studies of Pb(II) ions showed that the HAp-Fe3O4 composite efficiently adsorbed Pb(II) ions, with the adsorption efficiency increasing from 95.80% to 98.40%. The adsorption isothermal model of the HAp-Fe3O4 composite follows the Freundlich model with a 1/n value of 0.31 and a KF value of 25.35 L/g. The adsorption kinetics study of the HAp-Fe3O4 composite follows the pseudo second-order model with an R2 value of 1, and the thermodynamic study shows the Gibbs free energy is negative, which indicates that the adsorption process is thermodynamically optimal and spontaneous. In addition, the enthalpy value is positive, indicating that the interaction between the adsorbent and lead ions is endothermic, and the entropy is negative, indicating the reduction of random collisions of lead ions in the solid (adsorbent) and aqueous solution during adsorption.
Synthesis and Antibacterial Properties of Fluorapatite and FAp-ZnO-Chitosan Composite as Dental Implant Materials Charlena; Khofiyatuzziyadah, Alif Aryan; Akhiruddin; Purwantiningsih
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.562-573

Abstract

Regenerative biomaterials research has continued to grow in recent decades, one of which is dental implants. The material that can be used is fluorapatite (FAp), as it is a significant element of human bones and teeth. FAp has better chemical and thermal stability than other apatite materials. However, FAp has low antibacterial properties, so it needs to be composited with other antibacterial materials, such as zinc oxide (ZnO) and chitosan. In addition, chitosan was also added to stabilize FAp and ZnO an effort to increase antibacterial and in vitro bioactivity in apatite formation. Therefore, this research intends to synthesize and assess the antibacterial properties and in vitro bioactivity of FAp-ZnO chitosan to increase its potential as a dental implant manufacturing material. FAp and ZnO were synthesized and then composited with chitosan into FAp-ZnO-chitosan by a simple mixing method. The FAp-ZnO-chitosan composite was successfully synthesized by looking at X-ray diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Scanning Electron Microscope-Energy Dispersive X-ray (SEM EDX) characterization results. The in vitro bioactivity of the composite showed new surface growth during immersion with simulated body fluid (SBF) solution, indicating potential attachment of the implant material to the tissue. The antibacterial properties of FAp-ZnO-chitosan also showed an increased zone of inhibition compared to the single material. This indicates that the FAp-ZnO-chitosan composite material has the potential to be used as a dental implant material.
Co-Authors Aditya, Muhammad Hafizh Agung Dhamar Syakti Ahmad Syahreza Akhiruddin Akhiruddin Maddu Aldes Lebani Ananda Novita Hi Pattu Armi Wulanawati Aslihati Aslihati Chonny Damayanti Daniel Putra Oktavianus Laia Dede Heri Yuli Yanto Dicky Iswara, Muhammad Dila Ardiansyah Dyah Iswantini Hanies Ambarsari Henny Purwaningsih Ida Ayu Putu Sri Widnyani Irma Herawati Suparto Irma Herawati Suparto Irma Herawati Suparto Iswandi Anas Iswandi Anas Iswara, Muhammad Dicky J. SRI ADININGSIH Joni Prasetyo, Joni Khefanny, Yemima Chellyne Khofiyatuzziyadah, Alif Aryan Komar Sutriah L.I NURHAYATI LADY R. WIDOWATI Manasye Erlangga Marita Soebrata, Betty Mas?ud, Zainal Alim Maulida Oktaviani Moch. Irgham Zuhfria Moh. Yani Nazriati Nazriati dkk. Niken Dyah Wanodyanti Nurmawan, Cucu Putri Nurul Afiati Aflakhah Purwaningsih, Henny Purwantiningsih Ravena Ravena Rosdiana, Tina S. SRI DWININGSIH Setyanto Tri Wahyudi Sianipar, Rut Novalia Rahmawati Sulistioso Giat Sukaryo Susi Sulistia, Susi Tatang Hidayat Tetty Kemala Tina Rosdiana Wisaeni Intannia Wulan Islamia Yadi Setiadi Yadi Setiadi Yessie Widya Sari Zainal Alim Mas'ud Zainal Alim Mas’ud