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All Journal ACTA VETERINARIA INDONESIANA Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Fitofarmaka Indonesia Justek : Jurnal Sains Dan Teknologi Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Majalah Farmasetika Jurnal Farmagazine Jurnal Farmasi JCDD Pharmaceutical And Biomedical Sciences Journal (PBSJ) Prosiding Seri Seminar Nasional Jurnal Karya Abdi Masyarakat Prosiding Simposium Nasional Multidisiplin (SinaMu) Jurnal Medika Farmaka Prosiding Seminar Nasional Unimus Journal of Tropical Pharmacy and Chemistry Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Erni Rustiani
Universitas Pakuan
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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

 1 
PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30 Nurhikmah, Wilda; Erni Rustiani; Dania Triska Puspita
Jurnal Ilmiah Manuntung Vol 9 No 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.661

Abstract

Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Methods of making tablets by wet granulation. Tablet quality testing includes organoleptic, weight uniformity, thickness, diameter, hardness, friability, and disintegration time. The flavonoid quercetin was used as a marker for tablet analysis. The results showed that the tablets were round in shape, white-gray in color, had a slightly bitter taste and had a characteristic aromatic odor. The average value of tablet weight uniformity is 290.06 – 306.45 mg (KV <5%), tablet diameter is 0.91 -0.92 cm, thickness is 0.41 – 0.48 cm, hardness is 4.06 – 7.95 kp, friability 0.17 – 0.21% and tablet disintegration time < 15 minutes. The results of the statistical analysis showed that the differences in the concentration of PVP K-30 did not affect the hardness and friability of the tablets (p> 0.05). The level of the flavonoid quercetin in the tablet is 0.17 – 0.21%. The conclusion that Kebar grass extract tablets can be made using PVP K-30 at a concentration of 2-4% as a binder and the quality of the tablets is not significantly different.
MIKROGRANUL MUKOADHESIF EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight.)) DENGAN PERBEDAAN POLIMER HPMC DAN KITOSAN Rustiani, Erni; Bina Lohita Sari; Dea Safira Nur Izmah
Jurnal Ilmiah Manuntung Vol 8 No 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.481

Abstract

Daun salam (Syzygium polyanthum (Wight.)) mengandung senyawa polifenol yang bermanfaat dalam pengobatan hiperkolesterolemia dengan menurunkan kadar low density lipoprotein (LDL). Bentuk sediaan mikrogranul mukoadhesif mampu memperpanjang waktu kontak zat aktif dengan mukosa sehingga efek terapi lebih baik. Penelitian ini bertujuan membuat mikrogranul mukoadhesif ekstrak daun salam dengan perbedaan polimer Hidroksi Propil Metil Selulosa (HPMC) dan kitosan. Sediaan dibuat sebanyak 4 formula yaitu formula I (HPMC 25%), formula II (HPMC 30%), formula III (Kitosan 25%) dan formula IV (Kitosan 30%). Mikrogranul dibuat dengan metode granulasi basah. Parameter pengujian mikrogranul meliputi kadar air, laju alir, sudut diam, ukuran partikel, kadar polifenol total, uji wash off dan uji morfologi. Hasil penelitian mikrogranul mukoadhesif ekstrak daun salam menunjukkan seluruh formula memiliki kadar air < 5%, laju alir dan sudut diam termasuk mudah mengalir. Ukuran mikrogranul berada pada range 48,7 – 637 µm dengan kadar polifenol total 4,15 – 4,27%. Hasil uji wash off menunjukkan kadar polifenol total mikrogranul di lambung 1,33 - 3,23 % (31,97 - 75,63%) dan di usus 1,26 – 3,76% (27,95 - 88,03%). Mikrogranul mukoadhesif ekstrak daun salam terbaik menggunakan polimer HPMC 30%.
Co-Authors Alciee Santika Susanti Almasyhur Almasyhur Almasyhur, Almasyhur Almasyuhuri Almasyuhuri Ameliya, Helvi Asri Wulandari Asri Wulandari Aulia Fitriani Bina Lohita Sari Cantika Zaddana Cyntia Wulandari Dania Triska Puspita Daniel Sinaga Dea Safira Nur Izmah Devi Fiebrilia Fiebrilia Dwi Indriati Dwi Indriati E. Mulyati Effendi Ella Noorlaela Fiebrilia, Devi Fiebrilia Fitri Dwiputri Fitria Dewi Sulistiyono Ike Yulia W Ike Yulia W. Ike Yulia Wiendarlina Indriani, Lusi Indriati, Dwi Kyky Widayanti Lathifah, Umi Lia Suliawati Lia Suryani LIANA ARSYANTI Linda Actia Lulu Nurzillah Lusi Agus Setiani Lusi Indriani Mareda Apriani Melliavita Putri Min Rachminiwati Mindiya Fatmi Mira Miranti Mira Miranti MOERFIAH . Muhamad Nur Ambiya Mulyati Effendi Musnawati Musnawati Mutiara, Tia Nhestricia, Nhadira Nisa Najwa Nisa Najwa Rokhmah Nurhikmah, Wilda Opi Damahyanti Peny Ningtyas, Sekar Pipih Agustina Pungky Umi Sa’diyah Rahminiwati, Min Rega Anitania Retnosari Andrajati Rina Agustina Rini Ambarwati Sara Nurmala SATA YOSHIDA SRIE RAHAYU Sekar Peny Ningtyas Septia Andini Sofihidayati, Trirakhma Sri Wardatun Suci Sintya Tia Mutiara Trirakhma Sofihidayati Trirakhma Sofihidayati Trirakhma Sofihidayati Ulfa Nur Awinda Ulfa Nur Awinda Yuliana Kusumawati Zulkarnaen, Dea Muthia Zahara