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All Journal Majalah Obat Tradisional Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Biodjati Proceeding ISETH (International Summit on Science, Technology, and Humanity) Molekul: Jurnal Ilmiah Kimia Dinamika Kerajinan dan Batik: Majalah Ilmiah
Cici Darsih
Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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EKSTRAK KAYU TEGERAN (Cudrania javanensis Trécul) SEBAGAI ANTI JAMUR Peniophora sp. Ilyas, Muhammad; Rosyida, Vita Taufika; Pratiwi, Diah; Indrianingsih, A. Wheni; Hernawan, .; Apriyana, Wuri; Darsih, Cici
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol 6, No 1 (2019): June 2019
Publisher : Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (665.684 KB) | DOI: 10.29122/jbbi.v6i1.3168

Abstract

Antifungal Activity of Tegeran Wood (Cudrania javanensis Trécul) Extracts against Fungus Peniophora sp.  ABSTRACTThe fungus Peniophora sp. can degrade natural dyes, causing discoloration on batik cloth. This study was aimed to evaluate the antifungal activity of tegeran wood (Cudrania javanensis) extracts against Peniophora sp. isolated from the aqueous extract of mahogany (Swietenia mahagoni) bark. Aqueous and methanol extraction procedures gave tegeran wood extracts whose concentrations were then varied into 100, 250 and 500 ppm. Phytochemical analysis of the extracts were carried out, and the results showed that the average values of the total polysaccharides and terpenoids of both aqueous and methanol extracts did not differ significantly (p<0.05), whereas those of polyphenols did (p<0.05). The total polyphenols of the methanol extract (484.723 mg GAE/g) was higher than that of the aqueous extract (389.903 mg GAE/g). Results showed that the methanol extract of tegeran wood showed higher antifungal activity against Peniophora sp. than the aqueous extract, and was also higher than ketoconazole control (100 ppm). The minimum inhibitory concentration of the methanol extract against Peniophora sp. growth was of 500 ppm with the antifungal activity value (AFA) of 76.30%.Keywords: antifungal activity, Cudrania javanensis, Peniophora sp., Swietenia mahagoni, wood extract ABSTRAKJamur Peniophora sp. dapat mendegradasi zat warna alam sehingga warna yang dihasilkan pada kain batik lebih pudar. Penelitian ini dilakukan untuk mempelajari aktivitas anti jamur dari ekstrak kayu tegeran (Cudrania javanensis) terhadap Peniophora sp. yang diisolasi dari ekstrak air kulit mahoni (Swietenia mahagoni). Ekstraksi menggunakan metanol dan air, menghasilkan ekstrak kayu tegeran, yang kemudian konsentrasinya divariasi menjadi 100, 250 dan 500 ppm. Analisis fitokimia ekstrak kayu tegeran dilakukan, dan hasilnya menunjukkan bahwa nilai rata-rata total polisakarida dan terpenoid ekstrak metanol dan air kayu tegeran tidak berbeda nyata (p<0,05). Sedangkan total polifenol kedua ekstrak berbeda nyata (p<0,05). Total polifenol ekstrak metanol kayu tegeran (484,723 mg GAE/g) lebih besar dibandingkan dengan ekstrak air (389,903 mg GAE/g). Hasil menunjukkan bahwa aktivitas anti jamur ekstrak metanol lebih baik dibandingkan dengan ekstrak air kayu tegeran, dan juga lebih tinggi dibandingkan dengan kontrol ketoconazole (100 ppm). Konsentrasi minimum ekstrak metanol kayu tegeran yang dapat menghambat pertumbuhan jamur Peniophora sp. adalah 500 ppm dengan nilai penghambatan (AFA) sebesar 76,30%.Kata Kunci: aktivitas anti jamur, Cudrania javanensis, ekstrak kayu, Peniophora sp., Swietenia mahagoni
EKSTRAK KAYU TEGERAN (Cudrania javanensis Trécul) SEBAGAI ANTI JAMUR Peniophora sp. Darsih, Cici; Ilyas, Muhammad; Rosyida, Vita Taufika; Pratiwi, Diah; Indrianingsih, A. Wheni; Hernawan, .; Apriyana, Wuri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 6 No. 1 (2019): June 2019
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (665.684 KB) | DOI: 10.29122/jbbi.v6i1.3168

Abstract

Antifungal Activity of Tegeran Wood (Cudrania javanensis Trécul) Extracts against Fungus Peniophora sp.  ABSTRACTThe fungus Peniophora sp. can degrade natural dyes, causing discoloration on batik cloth. This study was aimed to evaluate the antifungal activity of tegeran wood (Cudrania javanensis) extracts against Peniophora sp. isolated from the aqueous extract of mahogany (Swietenia mahagoni) bark. Aqueous and methanol extraction procedures gave tegeran wood extracts whose concentrations were then varied into 100, 250 and 500 ppm. Phytochemical analysis of the extracts were carried out, and the results showed that the average values of the total polysaccharides and terpenoids of both aqueous and methanol extracts did not differ significantly (p&lt;0.05), whereas those of polyphenols did (p&lt;0.05). The total polyphenols of the methanol extract (484.723 mg GAE/g) was higher than that of the aqueous extract (389.903 mg GAE/g). Results showed that the methanol extract of tegeran wood showed higher antifungal activity against Peniophora sp. than the aqueous extract, and was also higher than ketoconazole control (100 ppm). The minimum inhibitory concentration of the methanol extract against Peniophora sp. growth was of 500 ppm with the antifungal activity value (AFA) of 76.30%.Keywords: antifungal activity, Cudrania javanensis, Peniophora sp., Swietenia mahagoni, wood extract ABSTRAKJamur Peniophora sp. dapat mendegradasi zat warna alam sehingga warna yang dihasilkan pada kain batik lebih pudar. Penelitian ini dilakukan untuk mempelajari aktivitas anti jamur dari ekstrak kayu tegeran (Cudrania javanensis) terhadap Peniophora sp. yang diisolasi dari ekstrak air kulit mahoni (Swietenia mahagoni). Ekstraksi menggunakan metanol dan air, menghasilkan ekstrak kayu tegeran, yang kemudian konsentrasinya divariasi menjadi 100, 250 dan 500 ppm. Analisis fitokimia ekstrak kayu tegeran dilakukan, dan hasilnya menunjukkan bahwa nilai rata-rata total polisakarida dan terpenoid ekstrak metanol dan air kayu tegeran tidak berbeda nyata (p&lt;0,05). Sedangkan total polifenol kedua ekstrak berbeda nyata (p&lt;0,05). Total polifenol ekstrak metanol kayu tegeran (484,723 mg GAE/g) lebih besar dibandingkan dengan ekstrak air (389,903 mg GAE/g). Hasil menunjukkan bahwa aktivitas anti jamur ekstrak metanol lebih baik dibandingkan dengan ekstrak air kayu tegeran, dan juga lebih tinggi dibandingkan dengan kontrol ketoconazole (100 ppm). Konsentrasi minimum ekstrak metanol kayu tegeran yang dapat menghambat pertumbuhan jamur Peniophora sp. adalah 500 ppm dengan nilai penghambatan (AFA) sebesar 76,30%.Kata Kunci: aktivitas anti jamur, Cudrania javanensis, ekstrak kayu, Peniophora sp., Swietenia mahagoni
The Development of Antioxidant Nutraceuticals containing Chrysanthemum indicum L. Gummy Candy Rahmasari, Firdaus Salvia; Sahid, Muhammad Novrizal Abdi; Siswanti, Dwi Umi; Darsih, Cici; Utami, Indrawati Dian; Alam, Lucky Prabowo Miftachul; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87112

Abstract

Chrysanthemum flowers (Chrysanthemum indicum L.) have been shown to contain flavonoid compounds and exert antioxidant activity. This brings Chrysanthemum indicum potential to be developed as a nutraceutical product. This study aims to evaluate the antioxidant activity of Chrysanthemum flowers before and after the formulation of Chrysanthemum indicum flower extract as a gummy candy. Gummy candy formulas were developed using variations of gelatin and pectin as gelling agents. In this study, Chrysanthemum flower extract was formulated into gummy candy. The physical characteristics evaluated include organoleptic tests, weight uniformity, elasticity, and moisture content. Optimization was performed using the simplex lattice design (SLD) method with the aid of the Design Expert software Ver. 13. The antioxidant activity of the chrysanthemum flower extract and gummy candy extract was evaluated using the DPPH radical scavenging method. Ascorbic acid was used as a positive control. The optimum formula for preparing the gummy candy was 11.51% of gelatin and 1.24% of pectin. The evaluation of weight uniformity, elasticity, and moisture content suggested that there is no significant difference between the optimum formula and the predicted value. Both the chrysanthemum flower extract and chrysanthemum flower gummy candy had strong antioxidant activity. The IC50 value of the extract was 67.80 ± 2.37 mg/mL while the gummy candy IC50 value was 82.93 ± 2.55 mg/mL. The antioxidant activity of Chrysanthemum indicum was slightly decreased after being formulated into gummy candy. These studies suggested that scientists are expected to anticipate the decrease of Chrysanthemum antioxidant activity in the gummy manufacturing process.
Formulation and Antioxidant Activity of Gotu Kola Jelly Candy with Plant-based Polymers as a Gelling Agent Devi, Dwitya Devi Nurlistyo; Darsih, Cici; Yuniarti, Nunung; Ardiningtyas, Bondan; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89699

Abstract

Centella asiatica or gotu kola has a long history as a brain supplement. Gotu kola supplements are sold as liquid and dried extract which is less attractive for a younger generation. Jelly candy is an alternative dosage form with better acceptability across ages. However, the use of animal-derived polymers such as pork gelatine in the candy restricts those who practice vegetarian and halal lifestyles from consuming the products. This study aims to explore plant-based polymers glucomannan and kappa-carrageenan as gelling agents in the preparation of gotu kola jelly candy. Preparation of the jelly candy formula was designed based on Simplex Lattice Design. Evaluation of physical characteristics of jelly candy includes organoleptic, weight uniformity, moisture content, pH, and elasticity. The antioxidant activity of gotu kola before and after the manufacturing process was evaluated. The results showed that a combination of kappa-carrageenan 1.33% and glucomannan 0.67% is the optimum formula. Adding more proportion of kappa-carrageenan reduced jelly elasticity and moisture content. While adding glucomannan improved its elasticity responses but increased moisture content. Evaluation of the antioxidant activity of gotu kola in jelly candy suggested that gotu kola experienced a significant reduction in antioxidant activity following the production process. The IC50 of the crude extract initially was129.23 ppm while post jelly candy manufacturing, the IC50 increased to 197.49 ppm. This study suggested that improvement in extraction and production processes is necessary to maintain gotu kola antioxidant activity.
In Vitro Antioxidant and Anti-Obesity Activities of Ethanolic Extract from Microalgae Strain MRB-2 Ni’maturrohmah, Dwi; Darsih, Cici; Susanti, Hani; Hidhayati, Noor; Indrianingsih, Anastasia Wheni; Handayani, Sri; Hasby, Rizal Maulana; Laksitorini, Marlyn Dian
Jurnal Biodjati Vol 9 No 1 (2024): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i1.30385

Abstract

Obesity has a 15-fold higher risk of coronary heart disease, stroke, and diabetes mellitus. Microalga isone of the natural resources that potentially treat obesity. The purpose of this study was to evaluate the total phenolic contents (TPC), antioxidant, and anti-obesity properties of ethanolic extract of microalgae strain MRB-2. The TPC was determined using the Follin-Ciocalteu method. The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the anti-obesity was analyzed using an anti-lipase pancreatic assay. The morphology of microalga cells was also determined using Scanning Electron Microscopy (SEM). The results revealed that the TPC of ethanolic extract from the ultrasound extraction method was higher than the maceration method with the value of 2.75±0.26 mg GAE/g. While the scavenging activity toward DPPH radicals of ethanolic extract from the maceration method was higher than ultrasound, with a value of 38.92±1.94% at 0.8 mg/mL. The lipase inhibitory activity of extract from the maceration method was higher than ultrasound with a value of 20.81±2.24% at 0.38 mg/mL. Our results indicate that ethanolic extract of MRB-2 was potentially developed for anti-obesity foods and health-functional foods derived from new peatland microalgae.
White Rot Fungus (Marasmius sp.) Delignification on Sugarcane Bagasse for Bioethanol Production Darsih, Cici; Wahono, Satriyo Krido; Rosyida, Vita Taufika; Kismurtono, M.
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2015: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.2355

Abstract

Sugarcane bagasse is one of the potential lignocellulose materials for alternative energy especially on the development of bioethanol, the second generation technology. This paper investigates the delignification of sugarcane bagasse by the white rot fungus (Marasmius sp.). Sugarcane bagasse was delignified by fungus; then hydrolyzed by xylane enzyme and fermented by Saccharomyces cerevisiae through simultaneous processes of saccharification and fermentation (SSF). Pretreatment of the sugarcane bagasse was conducted by fungus with various time periods of incubations for 15, 30, and 45 days. SSF of pretreated sugarcane bagasse was conducted for 3, 6, 9, 12, and 15 days. Lignin, cellulose, and hemicellulose were determined by Chesson method. Bagasse structure before and after delignification were determined by Fourier Transform Infrared (FTIR) Spectroscopy. The results showed that the best result of bagasse delignification, containing 16.04% of cellulose, 26.61% of hemicellulose, and 51.89% of cellulose, was on 15 days of incubation. The bioethanol was obtained in 3 days of incubation with bioethanol concentration of 0.85% or 0.4 g/L.
DYEING OF COTTON FABRIC WITH NATURAL DYE FROM CUDRANIA JAVANENSIS USING SOKA LEAVES EXTRACT AS BIOMORDANT Darsih, Cici; Lestari, Dwi Wiji; Pratiwi, Diah; Indrianingsih, A Wheni; Rosyida, Vita Taufika; Apriana, Wuri; Nisa, Khoirun; Hayati, Septi Nur; Handayani, Sri; Wulanjati, Martha Purnami
Dinamika Kerajinan dan Batik: Majalah Ilmiah Vol. 36 No. 2 (2019): Dinamika Kerajinan dan Batik : Majalah Ilmiah
Publisher : Balai Besar Standardisasi dan Pelayanan Jasa Industri Kerajinan dan Batik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22322/dkb.v36i2.5446

Abstract

Tegeran wood (Cudrania javanensis) has been used for dyeing process of batik in Indonesian textile small medium scale enterprise. This wood gave soga color when it was mixed with others natural dye. This study was aim to evaluate the caharacteristic, fastness properties, and strength color of dyed cotton fabrics using C. javanensis with bio-mordant soka leaves extract. Extraction of C. javanensis was carried out using water. The post mordant process was carried out by applying alum (KAl(SO4)2•12H2O) solution and soka leaves extract on cotton fabrics with the concentration of 0.5 and 1% b/v. Characteristic of dyed cotton fabrics then was evaluated using Fourier-Transform Infrared (F-TIR) Spectroscopy. The results exhibited that, binding between tegeran wood on cotton using mordant alum and soka leaves extract was similar.The fastness properties both dyed cottons toward light and  washing at 40ºC exhibited poor and very poor values with values of 1-2 and 1. The dry and wet rubbing of dyed cotton using soka leaves extract mordant better than using alum. The soka leaves extract gave yellow and brightness color on cotton.The results suggested that soka leaves extract can be used as mordant substitute the alum mordant and apllied with others natural dyes.
In Vitro Antioxidant and α-Glucosidase Inhibitor Metabolites of Chrysanthemum indicum Flower Represented by Molecular Networking Darsih, Cici; Azzizah, Rikka Nur; Siswanti, Dwi Umi; Laksitorini, Marlyn Dian
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.12831

Abstract

ABSTRACT. Chrysanthemum indicum flower is known as a Chinese medicinal plant and is consumed as a tea or food supplement. Several research reported the profiling metabolites of this flower using High-Performance Liquid Chromatography (HPLC) or Liquid Chromatography Mass Spectroscopy (LC-MS). However, there is a limitation of those methods, which are the yields several formula obtained by searching in database based on parent masses so give less effectiveness identify of compound. This study aimed to identify the metabolites in the ethanolic extract of C. indicum using a de-replication strategy by coupling Liquid Chromatography Orbitrap HRMS with a molecular network approach. This study also evaluated the total phenolic contents (TPC) using Folin-Ciocalteu method, Fourier Transfer Infrared (FTIR) Spectroscopy, while the scavenging activity against DPPH radical method was used to determine the antioxidant activity and the inhibition of α-glucosidase was conducted using α-glucosidase assay. The studies showed that there were diverse families of metabolites were putatively identified in C. indicum such as flavonoids and derivates, amino acids, fatty acids and derivates, phenol and derivates, terpenoids, and glucose. The detailed metabolites in extract were approached using application of molecular networking. In agreement with the molecular networking, the extract exerted strong antioxidant activity with % inhibition value of 76.20±1.35 at 100 µg/mL. Whereas, the α-glucosidase inhibitory activity showed good activity with % inhibition value of 83.04±0.52 at 50 µg/mL. The results of this study provide a new metabolite library for C. indicum ethanol extract as well as the confirmation of some of its biological activities. Keywords: Chrysanthemum, profiling metabolites, LC-HRMS
Co-Authors Alam, Lucky Prabowo Miftachul Apriana, Wuri Ardiningtyas, Bondan Azzizah, Rikka Nur Devi, Dwitya Devi Nurlistyo Diah Pratiwi Dwi Umi Siswanti Dwi Wiji Lestari, Dwi Wiji Handayani, Sri Hani Susanti, Hani Hayati, Septi Nur Hernawan, . Hernawan, . Hidhayati, Noor Indrianingsih, A Wheni Indrianingsih, A. Wheni Indrianingsih, A. Wheni Indrianingsih, Anastasia Wheni Khoirun Nisa Kismurtono, M. Marlyn Dian Laksitorini, Marlyn Dian Martha Purnami Wulanjati, Martha Purnami Muhammad Ilyas Ni’maturrohmah, Dwi Nunung Yuniarti Rahmasari, Firdaus Salvia Rizal Maulana Hasby, Rizal Maulana Rosyida, Vita Taufika Rosyida, Vita Taufika Sahid, Muhammad Novrizal Abdi Utami, Indrawati Dian Wahono, Satriyo Krido Wuri Apriyana, Wuri