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Weight Gain in Type 2 Diabetes Mellitus Patients Receiving Sulfonylurea Medications at a Tertiary Hospital in Surabaya, Indonesia Respati, Ghagat Dresta Putra; Prajitno, Jongky Hendro; Setiawati, Rosy; Wironegoro, Rio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.52126

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. The prevalence of diabetes in Indonesia is 1.5%, although East Java recorded a 2.1% rate in 2013. T2DM medications, such as sulfonylureas, may lead to hypoglycemia and weight gain. This study aimed to investigate the weight gain effects of sulfonylureas in T2DM patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: This retrospective cross-sectional study used retrograde anamnesis on 41 T2DM patients receiving sulfonylurea medications for the preceding six months. The data were collected from medical records and interviews with the T2DM patients who received treatment at the Internal Medicine Clinic of Dr. Soetomo General Academic Hospital from January to June 2022. Results: Most patients were 46–65 years old (73.2%), female (51.2%), and had been diabetic for over 15 years (48.8%). The predominant medications administered to the patients were glimepiride (41.4%) and a combination of glibenclamide 5 mg, metformin 500 mg, and acarbose 100 mg (19.5%). Almost all patients took their medications in the morning before meals (92.6%). The average weight gain was 4.6 kg, with the glibenclamide and metformin combination resulting in a 17% incidence. Conclusion: T2DM patients who use sulfonylureas generally gain weight and exhibit specific traits, including being middle-aged, female, and diabetic for multiple years. The most commonly used sulfonylureas are glimepiride for monotherapy and glibenclamide for combination therapy with metformin and acarbose. Future research is required to understand weight gain in T2DM patients treated with sulfonylureas more comprehensively. Highlights: 1. This study investigated weight changes in type 2 diabetes mellitus (T2DM) patients receiving sulfonylureas, with a special focus on the emergence of weight gain as a new problem in T2DM management. 2. The importance of this study pertains to its findings regarding weight gain in T2DM patients treated with sulfonylureas, offering additional data that aids in preventing adverse effects of the medications.

The Role of Lumbar CT Scan Anthropometric Parameters to Predict the Height of Indonesian Adults Afriliani, Nurmilia; Setiawati, Rosy; Violetta, Lenny
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14225

Anthropometry, the study of human body measurements, is crucial in estimating stature, which is valuable in medical research, forensic science, anthropology, and ergonomic design. While various methods exist for estimating stature, lumbar spine measurements make a significant contribution to this estimation. This study aimed to analyze the relationship between lumbar spine dimensions and stature in the Indonesian population using three-dimensional computed tomography (3D CT) scan data. This analytical observational study, employing a cross-sectional approach, was conducted at the Department of Radiology, Dr. Soetomo General Academic Hospital, Surabaya, from August to September 2023. The key measurements included heights of the posterior, anterior, and central vertebral bodies from lumbar 1 to lumbar 5 (L1 to L5), transverse pedicle diameter, pedicle axis length, vertical pedicle diameter, and overall stature. The study included 66 subjects (30 males and 36 females). Males had an average height of 165.86 cm, while females had an average height of 155.85 cm. Significant gender differences were observed in heights of the posterior vertebral body (HPVB), heights of the central vertebral body (HCVB), and pedicle axis length (PAL) measurements. HPVB of L1 can be used as a predictor of height in females (p<0.001), whereas PAL of L5 can be used as a predictor of height in males (p=0.006). Lumbar spine dimensions measured using 3D CT scans provide reliable stature predictions, with specific measurements such as HPVB from L1 in females and PAL from L5 in males showing high accuracy. These findings support the development of population-specific anthropometric tools and enhance understanding of factors influencing stature in Indonesia.

Clinical and Radiological Characteristics of Pneumonia in COVID-19 Patients at First Admission of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021 Pradnyandari, Anak Agung Sagung Putri; Hasan, Helmia; Setiawati, Rosy; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 2 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I22025.115-121

Highlights: This was the first study that described the radiological features of pneumonia in COVID-19 patients at first admission to Dr. Soetomo General Academic Hospital, Surabaya, during the Delta wave. This study presented the gastrointestinal symptoms of COVID-19 patients with pneumonia. Abstract Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease (COVID-19) pandemic. Pneumonia in COVID-19 can cause acute respiratory distress syndrome (ARDS), which could lead to damage to end organs. This study aimed to describe the clinical and radiological profile of pneumonia in COVID-19 patients at first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021. Methods: This was a single-center, descriptive study of COVID-19 patients with pneumonia (n=193) at their first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, from June to August 2021. The demographic data, pre-existing comorbidities, clinical signs and symptoms, and radiological findings were collected from the electronic medical record and analysed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26. Results: Out of all the COVID-19 patients included in the study (n=193), most of them were 18-64 years old (86.0%), and the majority were males (50.8%). Of 193 patients, 51.3% had pre-existing comorbidities. Most patients (95.9%) experienced pulmonary symptoms, with shortness of breath being the most common. On chest radiograph, 60.1% patients showed consolidation with central and peripheral predominance (60.6%) and bilateral lung involvement (91.2%). Conclusion: This study presented a description of the clinical and radiological findings in COVID-19 patients with pneumonia. Most of which showed extensive lesions on chest radiograph along with dyspnea, which may suggest that most patients were suffering from late-stage and severe COVID-19 with pneumonia. To confirm this suggestion, further research is needed.

Correlation between Length-to-width Ratio of Gallbladder and Gamma-glutamyl Transferase Value in Biliary Atresia Elmanar, Ryan; Violetta, Lenny; Setiawati, Rosy
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Biliary atresia represents one of the most prevalent etiologies for neonatal cholestasis. Unmanaged biliary atresia can be fatal. Ultrasonography is the primary diagnostic test because it's accurate, cost-effective, and available. Various ultrasound findings can assist in diagnosing biliary atresia; the length-to-width ratio of the gallbladder is a particularly advantageous method, offering a short examination time, objectivity, and ease of use, with an accuracy rate of 78.9%. In cases with unconventional ultrasound findings, gamma-glutamyl transferase is believed to be able to complete the diagnostic process with an accuracy rate of up to 80%. The optimal cut-off value differs between studies, making it challenging to use as a benchmark for biliary atresia detection. In this study, researchers aim to further investigate the relationship between length-to-width ratio and gamma-glutamyl transferase in cases of biliary atresia, compared to the liver biopsy results in these patients and the optimal cut-off. This study employed an observational analytic approach with a retrospective design. The sample population consisted of all patients with neonatal cholestasis who underwent laboratory and ultrasonographic examinations at Dr. Soetomo Academic General Hospital Surabaya between 2019 and 2023. The study population comprised 82 patients. A significant relationship (p-value<0.001) was observed between the length-to-width ratio of the gallbladder and biliary atresia, as well as between gamma-glutamyl transferase and biliary atresia (area under the curve: 0.7–0.8). However, the analysis between the length-to-width ratio of the gallbladder and the value of gamma-glutamyl transferase showed p-value=0.066, which means no significant relationship was observed between the length-to-width ratio and gamma-glutamyl transferase. DOI: https://doi.org/10.29313/gmhc.v12i3.14170

The Role of Lumbar CT Scan Anthropometric Parameters to Predict the Height of Indonesian Adults Afriliani, Nurmilia; Setiawati, Rosy; Violetta, Lenny
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14141

Anthropometry, the study of human body measurements, is crucial in estimating stature, which is valuable in medical research, forensic science, anthropology, and ergonomic design. While various methods exist for estimating stature, lumbar spine measurements make a significant contribution to this estimation. This study aimed to analyze the relationship between lumbar spine dimensions and stature in the Indonesian population using three-dimensional computed tomography (3D CT) scan data. This analytical observational study, employing a cross-sectional approach, was conducted at the Department of Radiology, Dr. Soetomo General Academic Hospital, Surabaya, from August to September 2023. The key measurements included heights of the posterior, anterior, and central vertebral bodies from lumbar 1 to lumbar 5 (L1 to L5), transverse pedicle diameter, pedicle axis length, vertical pedicle diameter, and overall stature. The study included 66 subjects (30 males and 36 females). Males had an average height of 165.86 cm, while females had an average height of 155.85 cm. Significant gender differences were observed in heights of the posterior vertebral body (HPVB), heights of the central vertebral body (HCVB), and pedicle axis length (PAL) measurements. HPVB of L1 can be used as a predictor of height in females (p<0.001), whereas PAL of L5 can be used as a predictor of height in males (p=0.006). Lumbar spine dimensions measured using 3D CT scans provide reliable stature predictions, with specific measurements such as HPVB from L1 in females and PAL from L5 in males showing high accuracy. These findings support the development of population-specific anthropometric tools and enhance understanding of factors influencing stature in Indonesia.

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