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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JITEK (Jurnal Ilmiah Teknosains) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Journal of Halal Science and Research Journal of Food and Pharmaceutical Sciences Prosiding Seminar Nasional Unimus Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia
Diniatik Diniatik
Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Borneo Journal of Pharmacy

 1 
Standardized Herbal Extract for Wound Healing: A Comparative Study of Centella asiatica, Curcuma domestica, and Heterotrigona itama Honey Combination in Rabbits Diniatik, Diniatik; Kustiawan, Paula Mariana; Suryadini, Halida
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.5803

Abstract

Centella asiatica and Curcuma domestica are recognized for their wound-healing properties. This study investigated the synergistic effects of combining these plant extracts with stingless bee (Heterotrigona itama) honey on wound healing in rabbits. Ethanolic extracts of C. asiatica and C. domestica were prepared in a 1 : 10 ratio. Blended formulations containing 20% plant extracts and 80% honey were created in two ratios: 1 : 1 and 2 : 1. The total flavonoid and tannin content of the plant extracts were quantified. Male rabbits were subjected to a wound-healing model, and the formulations were applied topically for seven days. Wound healing was assessed, and the results were compared to a positive control. The ethanolic extracts of C. asiatica and C. domestica were rich in flavonoids and tannins. The blended honey formulations exhibited promising wound-healing effects, with Formula 2 (2 : 1 ratio of plant extracts) demonstrating slightly superior results compared to Formula 1 and the positive control. These findings suggest the potential of the combined extracts of C. asiatica, C. domestica, and H. itama honey as effective wound-healing agents.
Co-Authors Ade Rusman Agus Siswanto Aman Suyadi Ana Andriani Ana Hidayati Mukaromah Anjar Mahardian Kusuma Annisa, Rully Arif Budiman Deby Inda Lestari Dewi Anggraeni Dewi ANGGRAENI Diah Permatasari, Diah Dwi Hartanti Dyah Kusumaningrum Egi Laila Solichati, Egi Laila Feni Nurul Hidayanti, Feni Nurul Githa Fungie Galistiani Halida Suryadini Ibnu Amar Ibnu Amar, Ibnu Ika Yuni Astuti Inna Marfu’ah, Inna Iryani, Yeyen Dwi Katerina Zielda Deviana Marsha, Ardiana Mr Suparman, Mr Mr Yulianto, Mr Muslimah Muslimah Nervita Noor Izzati, Nervita Noor Nina Yuniawati, Nina Okti Purwaningrum, Okti Paula Mariana Kustiawan Pri Iswati Utami Reny Apriani, Reny Rosiana Sofia Anggraeni Rusman, Ade Sabikis Sabikis, Sabikis Sudarso Sudarso suparman suparman Suparman Suparman Syarifa, Hasna Maulida Tresna Asih Santoso, Tresna Asih Wiranti Sri Rahayu Wulansari, Eka Yeyen Dwi Iryani Zulfa Ika Setyaningsih