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COMPARISON OF EFFICACY AND SAFETY SILODOSIN 8 MG ONCE DAILY AND SILODOSIN 4 MG TWICE DAILY IN BPH PATIENTS WITH LUTS Diansyah, Ramzie Nendra; Renaldo, Johan; Djatisoesanto, Wahjoe; Hakim, Lukman
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.552

Objective: This study was aimed to compare the efficacy and side effect of silodosin 8mg once daily and silodosin 4mg twice daily in BPH-LUTS patients after 4 and 12 weeks. Material & Methods: Single blind randomized controlled trials in 60 male patients aged ≥45 years with BPH-LUTS from July 2017 to October 2017 was divided into groups who received 8mg of silodosin once daily and those who received 4mg of silodosin twice daily. Efficacy and adverse events were evaluated after 4 and 12 weeks of treatment. Results: There was no significant difference of mean age of the two groups was 67.93 ± 6.49 years and 69.07 ± 6.28 years respectively (p 0.49). Both doses of this drug decreased the International Prostate Symptom Score (IPSS) and significantly increased the maximum urinary flow (Qmax) (p<0.05) but there was no significant differences between the two groups (p>0.05). Ejaculation disorder was the most common side effect in all groups (6.7% and 5%) and there was no significant difference between the two groups (p>0.05). Conclusion: The administration of 8mg of once daily silodosin has similar efficacy as 4mg twice daily silodosin. There were no adverse events differences in the two groups. Ejaculation disorder is the most common adverse event of silodosin administration.

THE EFFECT OF THE DURATION OF INHALED NICOTINE EXPOSURE TO THE NUMBER OF LEYDIG, SPERMATOGONIUM, AND SERTOLI CELLS ON THE SPRAGUE-DAWLEY STRAIN WHITE RATS Hoesain, Fadil Pramudhya; Soebadi, Doddy M.; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.596

Objective: To analyze the differences of the number of Leydig, spermatogonium, and Sertoli cells in mice, after being given nicotine inhalation, and the effect of recovery when nicotine stopped. Materials & Methods: This is experimental studies with a post-test only control group design. The sample used was 36 adult male mice (10-12 weeks) (Rattus Norvegicus) Sprague-Dawley strain, which were divided into three groups. P1 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days, P2 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days and was free of treatment for 15 days. The control group (NC) has no treatment at all. Histological examination and calculation of Sertoli cells, Leydig cell, and spermatogonium were processed within 1 hour after terticular sample collection. Then carried out to statistical analysis. 100x and 400x magnification is used to obtain the histopathological. Results: Post-hoc LSD test for each variable (Leydig cells, Sertoli cells, and spermatogonium), showed that the NC group had a significantly higher number compared to group P1. P2 group has a significantly higher number compared to group P1. There is no significant difference between the NC group and the P2 group. There was a structural difference in the sample testicles which exposed to nicotine. Conclusion: Nicotine exposure with a dose of 4 mg/kg/day for 15 days has a significant effect on decreasing the number of Leydig cells, spermatogonium cells, and Sertoli cells in rats and giving a free-treatment period for 15 days, giving the testis time to do recovery and regeneration (the reversible damage of testicular structure).

COMPARISON OF PAIN PERCEPTION BETWEEN INTRAVENA TRAMADOL INJECTION WITH PERIPROSTATIC LIDOCAINE INJECTION IN TRANSRECTAL ULTRASONOGRAPHY GUIDED PROSTATE BIOPSY PATIENT Sawal, Zuhri; Djatisoesanto, Wahjoe; Djojodimedjo, Tarmono
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.646

Objective: To compare the pain perception between intravenous tramadol administration and PNB technique using lidocaine in TRUS guided prostate biopsy. Material & Methods: The design of this study is a prospective randomized clinical trial. The population of this study is BPH patients who will undergo TRUS guided prostate biopsy procedure according to the indication in our center. Randomization was done for the determination of groups 1 and 2. Group 1 was given tramadol injection 100 mg intravenously, while group 2 was given a local injection of lidocaine periprostatic. The Wong-Baker scale directly determined pain perception during the procedure. Results: The total samples in this study were 20 samples that met the inclusion and exclusion criteria with 10 samples in each group. The lidocaine group had a lower Wong Baker’s pain scale in both probe USG insertion and prostate biopsy than the tramadol group. However, it’s not statistically significant (p=0.089; p=0.125, respectively). Conclusion: The use of intravenous tramadol can be used as an alternative anesthetic/analgesic method in prostate biopsy patients. The pain scale of the intravenous tramadol can be compared with periprostatic lidocaine with lesser complications compared to periprostatic lidocaine.

COMPARISON OF PAIN PERCEPTION BETWEEN INTRAVENA TRAMADOL INJECTION WITH PERIPROSTATIC LIDOCAINE INJECTION IN TRANSRECTAL ULTRASONOGRAPHY GUIDED PROSTATE BIOPSY PATIENT Sawal, Zuhri; Djatisoesanto, Wahjoe; Djojodimedjo, Tarmono
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.646

Objective: To compare the pain perception between intravenous tramadol administration and PNB technique using lidocaine in TRUS guided prostate biopsy. Material & Methods: The design of this study is a prospective randomized clinical trial. The population of this study is BPH patients who will undergo TRUS guided prostate biopsy procedure according to the indication in our center. Randomization was done for the determination of groups 1 and 2. Group 1 was given tramadol injection 100 mg intravenously, while group 2 was given a local injection of lidocaine periprostatic. The Wong-Baker scale directly determined pain perception during the procedure. Results: The total samples in this study were 20 samples that met the inclusion and exclusion criteria with 10 samples in each group. The lidocaine group had a lower Wong Bakerâ€™s pain scale in both probe USG insertion and prostate biopsy than the tramadol group. However, itâ€™s not statistically significant (p=0.089; p=0.125, respectively). Conclusion: The use of intravenous tramadol can be used as an alternative anesthetic/analgesic method in prostate biopsy patients. The pain scale of the intravenous tramadol can be compared with periprostatic lidocaine with lesser complications compared to periprostatic lidocaine.

THE EFFECT OF VITAMIN E (α- TOCOPHEROL) AS NEPHROPROTECTOR ON BLOOD UREA NITROGEN AND SERUM CREATININE LEVEL OF STRAIN WISTAR RATS AFTER CISPLATIN TREATMENT: IN VIVO STUDY Affandi, Yohan; Djatisoesanto, Wahjoe; Hakim, Lukman
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.649

Objective: To analyze the differences in kidney function of Wistar strain rats that received a combination of vitamin E and cisplatin, compared with cisplatin alone. Material & Methods: An experimental prospective study with post-test only control design, using male Wistar strain rats (Rattus norvegicus). Rats were randomized using the simple randomized sampling method. Treatment was given in the form of exposure to cisplatin 5 mg/kg (positive control group), with a combination of vitamin E 100 mg/kg and 200 mg/kg (treatment group), to evaluate its effect on kidney function as measured by blood urea nitrogen (BUN) and creatinine serum. Results: Statistical analysis of Mann Whitney showed that there were no differences in BUN levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p>0.05). Further analysis showed that there was no significant difference between treatment group 1 (Vitamin E 100 mg/kg) and treatment group 2 (Vitamin E 200 mg/kg). There was no difference in serum creatinine levels in the positive control group compared to a treatment group that received both vitamin E 100 mg/kg and the vitamin E 200 mg/kg (p>0.05). further analysis revealed no significant difference in serum creatinine levels between the group that receives vitamin E 100 mg/kg and 200 mg/kg. Conclusion: Vitamin E at doses of 100 mg/kg and 200 mg/kg did not have the nephroprotective feature in cisplatin-exposed Wistar rats.

THE EFFECT OF VITAMIN E (Î±- TOCOPHEROL) AS NEPHROPROTECTOR ON BLOOD UREA NITROGEN AND SERUM CREATININE LEVEL OF STRAIN WISTAR RATS AFTER CISPLATIN TREATMENT: IN VIVO STUDY Affandi, Yohan; Djatisoesanto, Wahjoe; Hakim, Lukman
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.649

Objective: To analyze the differences in kidney function of Wistar strain rats that received a combination of vitamin E and cisplatin, compared with cisplatin alone. Material & Methods: An experimental prospective study with post-test only control design, using male Wistar strain rats (Rattus norvegicus). Rats were randomized using the simple randomized sampling method. Treatment was given in the form of exposure to cisplatin 5 mg/kg (positive control group), with a combination of vitamin E 100 mg/kg and 200 mg/kg (treatment group), to evaluate its effect on kidney function as measured by blood urea nitrogen (BUN) and creatinine serum. Results: Statistical analysis of Mann Whitney showed that there were no differences in BUN levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p>0.05). Further analysis showed that there was no significant difference between treatment group 1 (Vitamin E 100 mg/kg) and treatment group 2 (Vitamin E 200 mg/kg). There was no difference in serum creatinine levels in the positive control group compared to a treatment group that received both vitamin E 100 mg/kg and the vitamin E 200 mg/kg (p>0.05). further analysis revealed no significant difference in serum creatinine levels between the group that receives vitamin E 100 mg/kg and 200 mg/kg. Conclusion: Vitamin E at doses of 100 mg/kg and 200 mg/kg did not have the nephroprotective feature in cisplatin-exposed Wistar rats.

THE EFFECT OF CONDITIONED-MEDIUM HUMAN ADIPOSE-DERIVED MESENCHYMAL STEM CELL IN APOPTOSIS OF BLADDER CANCER CELLS Mawdudi, Ari Alauddin; Hidayatullah, Furqan; Bachtiar, Indra; Rachman, Arif; Putri, Indri Lakhsmi; Castiglione, Fabio; Djatisoesanto, Wahjoe; Hakim, Lukman
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.653

Objective: To determine the effect of conditioned medium human Adipose-Derived Mesenchymal Stem Cells (CM-hADMSC) on apoptosis of urothelial bladder cancer cells. Material & Methods: Bladder (5637) cancer cell lines cultured in conditioned media harvested from human adipose-derived mesenchymal stem cells (hADMSC). Flow cytometry tests were carried out using the Flowcytometry Acquisition cell sorting (FACS) Calibur to measure apoptosis. Results: There was a significant difference in the percentage of late apoptosis in the group receiving culture medium treatment: CM-hADMSC 1: 1 to the entire study group. Further analysis revealed no difference in the average percentage of late apoptosis in groups exposed to culture medium: CM-hADMSC 1: 2 and culture medium: CM-hADMSC 1: 4 (p> 0.05). Conclusion: CM-hADMSC at a 1: 1 dose concentration to culture medium obtain a significant increase of apoptosis in bladder cancer cells.

COMPARISON OF PAIN INTENSITY BETWEEN LIDOCAINE GEL AND INTRAURETRAL TRAMADOL WITH LIDOCAINE GEL IN THE DJ STENT REMOVAL Wijayanto, Cahyo; Doddy M. Soebadi; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.696

Objective: To determine the difference in pain intensity between the administration of a combination of tramadol and intraurethral lidocaine gel with only lidocaine gel during the removal of DJ stents. Material & Methods: This study was a prospective randomized clinical trial with 22 patients that were divided into 2 groups. Group 1 was given a combination of tramadol and lidocaine gel urethral injection 3 to 5 minutes before DJ stent removal, whereas group 2 was given lidocaine gel urethral injection 3-5 minutes before the removal. The inclusion criteria in this study was all patients with a DJ stent placement with 1 to 3 months prior to release who were willing to participate. The Wong-Baker scale was used directly to determine the scale of pain during the procedure. Mann Whitney analysis was used to analyze the findings. Results: Most patients in group 1 are shown to have a pain rating of 2. There are 2 patients with a high pain rating scale of 6 and 7. In group 2, most patients claimed that the procedure was painless. The average Wong-Baker pain scale in group 1 (2.9) compared to group 2 (0.36) was significantly different. Conclusion: The combination of intraurethral tramadol and 2% lidocaine gel can significantly decrease pain during DJ stent removal more effectively than sole intraurethral 2% lidocaine gel based on the Wong-Baker pain scale.

NEFROPROTECTOR EFFECT OF CURCUMIN (CURCUMA LONGA) AND VITAMIN E (α-TOCOPHEROL) IN WISTAR STRAIN RATS AFTER CISPLATIN TREATMENT Sirait, Binsar Marshall Maranatha; Wahjoe Djatisoesanto; Soetojo
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.704

Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin.

COMPARATIVE EFFICACY OF COMBINED LOW-INTENSITY EXTRACORPOREAL SHOCKWAVE THERAPY AND ORAL THERAPY VS ORAL THERAPY ALONE FOR CHRONIC PELVIC PAIN SYNDROME: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIAL Nurakbariansyah, Rocky; Soebadi, Doddy M.; Djatisoesanto, Wahjoe; Renaldo, Johan
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.741

Objective: This study aimed to compare the efficacy of Low-Intensity Extracorporeal Shockwave Therapy (Li-ESWT) and oral therapy combination compared to sole oral therapy for reducing symptoms in CP/CPPS patients. Material & Methods: A systematic search was conducted from the electronic database including PubMed, Clinicaltrial.gov, and Cochrane Library, published up to July 2020 following the PRISMA guideline. We screened RCTs with the inclusion criteria and assessed the quality with the Cochrane Risk of Bias tool. The primary outcome was the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and subgroup analysis for triple therapy users was conducted to improve interpretability. The analysis was performed using Review Manager 5.3. Results: A total of 2 RCTs consisted of 91 CP/CPPS patients were analyzed. Pooled analysis showed that compared to the oral therapy only group, combination therapy had a significant lower NIH-CPSI total score at the endpoint of the treatment (MD -7.46, 95% CI -9.85 to -5.07, p<0.001) and NIH-CPSI component pain score (MD -3.48, 95% CI -5.04 to -1.93, p<0.0001), urinary symptoms score (MD -0.96, 95% CI -1.47 to -0.45, p<0.001), and quality of life (QoL) impact score (MD -2.94; 95% CI -3.68 to -2.20, p=<0.001). Conclusion: This review revealed that patients undergoing combination Li-ESWT therapy have lower total NIH-CPSI scores than patients receiving oral therapy alone, this finding is consistent with each component of the score: pain, urinary symptoms, and impact on QoL.

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