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All Journal E-Jurnal Medika Udayana Indonesian Journal of Urology Folia Medica Indonesiana Health Notions JBN (Jurnal Bedah Nasional) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Narra J
wahjoe djatisoesanto
Department Of Urology, Faculty Of Medicine, Universitas Airlangga, Dr Soetomo Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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COMPARISON OF EFFICACY BETWEEN LASER AND PNEUMATIC LITHOTRIPSY FOR URETERAL STONE MANAGEMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS Wicaksono, Dillon Martino; Soebadi, Doddy Moesbadianto; Djatisoesanto, Wahjoe; Rizaldi, Fikri
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.743

Abstract

Objective: This study aimed to evaluate the efficacy of ureteroscopy lithotripsy (URS) using laser lithotripsy compared to pneumatic lithotripsy for ureteral stone management. Material & Methods: A systematic search was conducted in PubMed and ScienceDirect. The search and screening process in this study followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline to include relevant RCTs. The included studies were assessed for their risks of bias using the Cochrane risk of bias tool 2 (RoB 2). The comparison of outcomes, which includes stone-free rate, DJ-Stent use, and mean fragmentation time between laser and pneumatic lithotripsy was analyzed using Review Manager 5.4. Results: A total of 11 RCTs evaluating a total of 235 patients with ureteral stone were analyzed in this review. Compared to pneumatic lithotripsy, laser lithotripsy has a significantly higher stone-free rate (OR 2.39, 95% CI 1.78-3.21, p < 0.001), longer mean fragmentation time (MD 4.11, 95% CI 3.17-5.04, p < 0.001), and lower DJ stent use rate (OR 0.53, 95% CI 0.36-0.76) based on the forest plot analysis. Conclusion: Patients undergoing laser lithotripsy have a higher stone-free rate, a lower DJ stent use rate, and albeit a longer mean fragmentation time compared to pneumatic lithotripsy.
THE EFFECTIVENESS OF TNF-Α INHIBITOR THERAPY IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS Kholis, Ahmad; Soetojo; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.744

Abstract

Objective: To evaluate the effectiveness of TNF-α inhibitor therapy in Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) patients compared to placebo, assessed using Global Response Assessment (GRA). Material & Methods: A systematic review and meta-analysis. Subjects were patients with moderate to severe diagnosis of BPS/IC who were given TNF-α inhibitor versus placebo, with the Global Response Assessment (GRA) (patient-reported self-reported BPS/IC treatment response scale). A systematic literature search was carried out on the English databases PubMed/MEDLINE and Science Direct, published until September 2020. Data were extracted independently and assessed the bias and quality of each selected article. Results: Initially there were 124 studies. After further selection, 2 RCT studies were included in the criteria for this study. The number of samples obtained was 85 patients. There is 1 study that used 400 mg of certolizumab pegol subcutaneously and 1 study used adalimumab 80 mg subcutaneously and followed by 40 mg subcutaneously for 2 weeks. Both studies had statistically low heterogeneity with I2 = 0% (P = 0.34), so fixed effect statistical model was used to determine the result. Furthermore, there was no significant difference (P = 0.32) between the number of GRA responders from the TNF-α inhibitor and placebo therapy groups, with odds ratio of 1.61 (CI = 0.65-4.00). Conclusion: TNF-α inhibitor therapy did not increase GRA responders when compared to placebo.
THE EFFICACY COMPARISON OF MIRABEGRON AS A MONOTHERAPY VERSUS ITS COMBINATION WITH SOLIFENACIN IN OVERACTIVE BLADDER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Madani, Hasan; Soetojo; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.748

Abstract

Objective: This review aimed to evaluate the efficacy and safety of mirabegron as monotherapy and its combination with solifenacin for patients with overactive bladder (OAB). Material & Methods: A systematic search was conducted in PubMed, Google Scholar, and Science Direct using the keywords Overactive bladder or OAB and mirabegron or beta-3 agonist or β3 adrenoreceptor agonist and solifenacin or antimuscarinic based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline to include relevant randomized controlled trials (RCT)s. The included studies were assessed for their risks of bias using the Cochrane risk of bias tool for randomized controlled trials. Quantitative analysis using forest plot was performed in Review Manager 5.4. Results: A total of 4 RCTs were included from 227 studies. A fixed-effects model was chosen due to the low level of heterogeneity between the studies (I2 = 0%). The average micturition volume of patients in the combination group is higher compared to the monotherapy group (MD 17.13, 95% CI 12.78 - 21.48, p < 0.00001). The mean micturition frequency (MD - 0.54, 95% CI - 0.73 - -0.34, p < 0.00001) and incontinence incidence (MD -0.30, 95% CI -0.48 - -0.12, p = 0.001) in the combined group are significantly lower compared to the monotherapy group. Conclusion: The combination of mirabegron and solifenacin has better efficacy compared to mirabegron as monotherapy for OAB patients with a therapy duration of less than 12 weeks based on the micturition volume, micturition frequency, and incontinence incidence. The administration of combination therapy would not increase adverse event incidence compared to monotherapy.
The Correlation of Prostate Volume with Uroflowmetry and International Prostatic Symptoms Score (IPSS) on Patient with Benign Prostatic Hyperplasia without Urinary Retention Arif Rananda; Reny I’tishom; Wahjoe Djatisoesanto; Soetojo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15613

Abstract

Objective: To value the correlation of Prostate Volume with Uroflowmetry and IPSS on patients with BPHwithout urinary retention that would be conducted at Dr. Soetomo 2015-2017. Method: This research usedretrospective descriptive study using secondary data from medical records to determine the relationshipbetween Prostate Volume (PV) and Uroflowmetry and the International Prostatic Symptom Score (IPSS)of Benign Prostate Hyperplasia (BPH) patients without urinary retention. Uroflowmetry basic parametersis Qmax, Vvoid, and PVR. The sampling technique used the total sampling method that used all existingdata in a certain period. Result: 86 medical records of BPH patients, the age range 45-64 years: 52 patients(60.46%), and the age range> 65 years: 34 patients (39.54%). PV statistical test with Qmax (r = 0.012;p = 0.913), the correlation was not significant. PV with Vvoid (r = 0.112; p = 0.305), the correlation wasnot significant. PV with PVR (r = -0.015; p = 0.892), the correlation was not significant. PV with IPSS (r= 0.048; p = 0.660), the correlation was not significant. Conclusion: There is no correlation on ProstateVolume with Uroflowmetry and IPSS on patient with BPH without urinary retention.
Characteristics of Renal Cell Carcinoma Patients in RSUD Dr Soetomo Surabaya in 2014-2017 Ferdiansyah Rusdhy; Wahjoe Djatisoesanto; Dyah Erawati; Dyah Fauziah
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn31206

Abstract

Renal Cell Carcinoma is a type of malignant renal tumour. According to GLOBOCAN 2012 data, it ranked 17th on the most common malignancy in Indonesia with an incidence rate of 1.5 per 100000 citizens. Mortality rates for men is 1.6 per 100000, while it is 0.8 per 100000 case for women. The clinical symptoms of flank pain, flank mass, and hematuria, are usually only found in patients with later stages of cancer development. This descriptive study aims to present data on characteristics of Renal Cell Carcinoma patients. Data were collected from histopathological medical records of RSUD Dr. Soetomo Surabaya. We found that 25 of 40 patients are male, with most patients aged between 50 to 59 at time of diagnosis. Majority of patients worked as a private sector worker, and had high school level education. They presented with stage 2 tumour, with Clear Cell Renal Cell Carcinoma subtype. All 40 patients were treated by Radical Nephroctomy. Keywords: renal cell carcinoma; characteristics
FAKTOR PREDIKTOR KEGAGALAN KEMOTERAPI BLEOMYCIN, ETOPOSIDE DAN CISPLATIN PADA PASIEN DENGAN SEMINOMA TESTIS PENELITIAN KOHORT RETROSPEKTIF Ida Bagus Putra Pramana; Lukman Hakim; Wahjoe Djatisoesanto
E-Jurnal Medika Udayana Vol 8 No 6 (2019): Vol 8 No 6 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.34 KB)

Abstract

Di Amerika serikat sekitar 8400 orang mengalami kanker testis dan 280 orang meninggal karena penyakit ini. Germ cell tumor meningkat diseluruh dunia. Di Amerika angka prevalensinya pada pasien usia 15 – 49 tahun meningkat dari 2,9 per 100.000 pada tahun 1975 menjadi 5,1 per 100.000 pada tahun 2004. Prevalensinya meningkat dari 55 % pada tahun 1973 menjadi 73 % pada tahun 2001. Insiden kasus seminoma lebih tinggi dibandingkan dengan non-seminoma. Untuk mengetahui faktor – faktor prediktor kegagalan kemoterapi bleomycin, etoposide dan cisplatin (BEP) pada pasien dengan seminoma testis yang mendapat terapi di Rumah Sakit dr Soetomo Surabaya. Penelitian ini merupakan penelitian kohort retrospektif. Karakteristik pasien seperti umur, stadium, kadar serum tumor marker, adjuvant kemoterapi, efek samping dari kemoterapi dan respon kemoterapi didapatkan dari rekam medis pasien di RSUD dr Soetomo Surabaya pada Januari 2008 – Desember 2015. Data dianalisis dengan deskriptif analitik, faktor faktor yang mempengaruhi kegagalan kemoterapi seperti patologi staging tumor (pT), penyebaran regional lymph node (N), metastasis (M), dan level serum tumor marker preoperatif seperti Lactic Dehydrogenase (LDH), human chorionic gonadotrophin (hCG), dan Alpha-Fetoprotein (AFP) dianalisis dengan menggunakan Binary Logistic Regression.Terdapat 55 pasien dengan seminoma testis dengan rata rata umur 32,43±13,3 tahun. Dari 55 pasien hanya 41 pasien yang hanya mendapat adjuvant kemoterapi BEP. Faktor faktor seperti pT, N dan M yang signifikant secara statistik sebagai faktor prediktor kegagalan kemoterapi. Pasien dengan staging pT3 dan pT4 memiliki 8,25 kali faktor resiko yang lebih besar dibandingkan pT1 dan pT2 untuk terjadinya kegagalan kemoterapi (OR=8,250, p=0,005 dan IK95%=1,87 – 36,38). Pasien dengan N2 dan N3 memiliki resiko 4,812 kali lebih besar untuk mengalami kegagalan kemoterapi dibandingkan N0 dan N1 (OR = 4,812, p=0,036, IK95% = 1,105 – 20,95). Pasien dengan M1 (M1a atau M1b) memiliki resiko 6,4 kali lebih besar mengalami kegagalan kemoterapi jika dibandingkan dengan M0 (OR = 6,40, p = 0,015, CI = 1,44 – 28,443). Seminoma testis merupakan tumor yang kemo-sensitif. Staging tumor primer (pT), regional lymph nodes (N) dan Metastasis (M) dapat digunakan sebagai faktor prediktor kegagalan kemoterapi pada pasien dengan seminoma testis. Keywords : Germ Cell Tumors, Testicular Seminoma, Kemoterapi BEP.
Bladder Chondrosarcoma in A Male: A Rare Case Report Muhammad Husni Tamrin; Wahjoe Djatisoesanto
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.41 KB) | DOI: 10.20473/fmi.v57i3.25208

Abstract

Chondrosarcoma is a rare variant of bladder tumor and one of the rare types of soft tissue sarcoma. This case happened on a 36-year-old male who complained of lumps in his lower abdomen, accompanied by difficulties in passing urine and painful urination, without hematuria. We performed TURBT and histopathological examination showed low-grade chondrosarcoma. The patient was diagnosed with low-grade bladder chondrosarcoma. The patient was treated for chemotherapy and radiotherapy. However, after undergoing one cycle of chemotherapy, the patient refused to continue the therapy.
Duplication and Multiseptate Urinary Bladder: A Rare Case Report Muhammad Fawzi Zulfikar; Wahjoe Djatisoesanto; Tarmono Tarmono
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.952 KB) | DOI: 10.20473/fmi.v57i3.25269

Abstract

The multiseptate bladder is a congenital bladder anomaly that is very rare and often accompanied by other congenital abnormalities. This condition could result in intravesical obstruction and kidney failure in more serious conditions. A 3-year-old girl without any complaint was consulted by the Pediatric Surgery Department with postoperative cloacal type malformation anorectal (MAR) postero-sagittal anorecto-vagino-urethroplasty (PSARVUP) + sigmoidectomy. Magnetic Resonance Imaging (MRI) of the pelvis showed the appearance of four interconnected multiple fluid lesions. Cystoscopy was performed and found many septa with varied positions and forms. From the cystography during the operation, it was seen duplication of the right and left bladder. There was no further operative treatment in the field of urology because no urinary tract obstruction and normal renal function were found in this study.
Prostate-Specific Antigen and Time to PSA Nadir as Prognostic Significance in Castration-Resistant Prostate Cancer Firmantya Hadi Pranata; Wahjoe Djatisoesanto; Doddy M. Soebadi
Folia Medica Indonesiana Vol. 58 No. 1 (2022): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1117.7 KB) | DOI: 10.20473/fmi.v58i1.32649

Abstract

Highlight:Assessing the survival rate in castration-resistant prostate cancer was descriptived.PSA level between survivor and non survivor was significant but not for PSA nadir level, TTN and TTC.Initial PSA level can predict survival prognosis rate of castration-resistant prostate cancer patients. Abstract:High mortality rates was often found in castration-resistant prostate cancer (CRPC). Our aim on this research was to assess the PSA level and time to PSA nadir as a prognostic tool for survival in CRPC patients. Several factors are considered to be useful as prognostic marker in CRPC patients. This study was a descriptive study assessing the survival rate in castration-resistant prostate cancer. Evaluation data included sex, age, initial PSA level, final PSA level, time to PSA nadir (TTN), time to CRPC progression (TTC), and survival status. A total of 24 patients with CRPC were evaluated in this study. There was significant difference found of initial PSA level between survivor (445.7 + 165.6 ng/mL) and non-survivor (200.7 + 144.9 ng/mL). There were no significant differences were also found in PSA nadir level, TTN and TTC between survivor and non-survivor groups. This study revealed that there was association between initial PSA level on survival rate of CRPC patients. Initial PSA level could be used to predict survival prognosis in CRPC patients.
CORRELATION BETWEEN SERUM TISSUE POLYPEPTIDE SPECIFIC ANTIGEN LEVEL AND PROSTATE VOLUME IN BPH Mahrany Graciella Bumbungan; Endang Retnowati; Wahjoe Djatisoesanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1136

Abstract

Volume prostat menjadi informasi yang penting karena dapat memperkirakan kematian pada Benign Prostatic Hyperplasia (BPH).Volume prostat diukur menggunakan TRUS (Transrectal Ultrasonography) sebagai baku emas namun TRUS mempunyai beberapakekurangan. Dibutuhkan suatu tolok ukur lain yang dapat memperkirakan volume prostat. Tissue Polypeptide Specific Antigen (TPS)yang terdeteksi di peredaran terdiri dari fragmen sitokeratin yang terdapat dalam jaringan dan menunjukkan status proliferasi. Selepitel di BPH yang mengandung sitokeratin 18 akan mengalami hiperplasia sehingga dapat terdeteksi dengan pemeriksaan TPS. Tujuanpenelitian ini adalah membuktikan adanya kenasaban antara kadar TPS serum dan volume prostat. Subjek penelitian terdiri dari 28pasien BPH yang datang berobat ke Poli Rawat Jalan Urologi RSUD Dr. Soetomo Surabaya. Volume prostat diukur menggunakan alatTRUS. Kadar TPS serum diukur menggunakan metode ELISA (TPS® ELISA IDL Biotech). Kadar TPS serum berkisar antara 82,45–1771,5U/L (195,35±349,79 U/L). Volume prostat beragam antara 20,7-87,4 cm (34,70±15,31 cm). Tidak terdapat kenasaban positif yangbermakna antara kadar TPS serum dan volume prostat (p=0,404; r=0,164).
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Azis Affandi, Yohan Affandi, Yohan Ahmad Kholis Anton Hermawan Arif Rachman Arif Rananda Aryati Aryati Castiglione, Fabio Diansyah, Ramzie Nendra Doddy M Soebadi Doddy M. Soebadi Doddy M. Soebadi Doddy M. Soebadi Dyah Erawati DYAH FAUZIAH, DYAH Endang Retnowati Ferdiansyah Mahyudin Firmantya Hadi Pranata Furqan Hidayatullah HASAN MADANI Hoesain, Fadil Pramudhya Holyness Nurdin Singadimedja I'tishom, Reny Ida Bagus Putra Pramana Indra Bachtiar Indri Lakhsmi Putri, Indri Lakhsmi Johan Renaldo Kristian Yoci Santoso Yoci Santoso Laksita, Tetuka B. Lukman Hakim Lukman Hakim Lukman Hakim M. Asro Abdih Mahrany Graciella Bumbungan maliki, ahmad Mawdudi, Ari Alauddin Muhammad Fawzi Zulfikar Muhammad Husni Tamrin Mukti, Ade Indra Nindra Prasadja Nugroho, Achmad Nugroho, Ahmad Nurakbariansyah, Rocky Rezia, Dian Kartika Rizaldi, Fikri Rizka Fitriani Sabilal Alif Sawal, Zuhri Sawal, Zuhri Setianingsih, Yennie A. Sirait, Binsar Marshall Maranatha Soebadi, Doddy Moesbadianto Soebadi, Mohammad A. Soetojo Soetojo Soetojo Sunaryo Hardjowijoto Tarmono Djojodimedjo Tri Wulanhandarini Wicaksono, Dillon Martino Widodo J Pudjirahardjo Widodo J Pujiraharjo Wijayanto, Cahyo Zulfian Hasibuan