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All Journal Indonesian Journal of Urology Indonesian Journal of Biotechnology Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Medicine Jurnal Ners Jurnal Impresi Indonesia Buletin Kedokteran dan Kesehatan Prima
Mukti, Ade Indra
Universitas Prima Indonesia Medan, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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TESTICULAR CANCER IN SOETOMO HOSPITAL SURABAYA: RETROSPECTIVE STUDY Mukti, Ade Indra; Hakim, Lukman; Djatisoesanto, Wahjoe; Hardjowijoto, Sunaryo
Indonesian Journal of Urology Vol 25 No 1 (2018)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v25i1.386

Abstract

Objective: The aim of this study was to determine the characteristics of the testicular cancer that were managed in Soetomo Hospital. Materials & Methods: This was a retrospective descriptive study. We reviewed the medical records of patient with testicular tumor admitted in Soetomo Teaching Hospital Surabaya, from January 2008 until December 2013. The data regarding demographic characteristics, clinical presentation, grading and staging based on pathological examination result, and the management of the cancer. Data was presented in tabular and narrative in order to know the number and percentage of testicular cancer in Surabaya. Results: There were 46 patients with testicular cancer with mean age of 27.1 ± 7.9 years. Peak incidence was 15–35 years old (54%). Testicular mass was the most frequent clinical presentation in 42 patients (91%), abdominal mass and other complaints in 4 patients (9%). Most of the patients live outside Surabaya in 34 patients (72%). Location of the tumor was more frequently in scrotum, which occured in 42 patients (91%). A total of 4 patients (9%) were found to have a history of UDT. Based on the TNM staging, patients with stage pT3 were as many as 20 patients (43%), pT4 11 patients (24%), pT2 7 patients (15%) and pT1 4 patients (9%). In regional lymph nodes staging (N) N3 were as many as 26 patients (57%), N0 9 patients (20%), N2 5 patients (11%) and N1 2 patients (4%). Metastase staging (M) M0 was found in 27 patients (58%) and M1 tumor was found 42%. The major pathological finding was seminoma in 37 patients (80%), Yolk sac tumor in 4 patients (9%), Embryonal Ca in 1 patient (2%), Teratoma in 1 patient (2%) and mixed germ cell tumor in 3 patients (7%). The most widely theraphy was underwent orchidectomy followed by PEB chemotheraphy in 29 patients (64%), 3 patients (6%) underwent EBRT and PEB chemotheraphy, 5 patients (11%) underwent PEB chemotheraphy, There were 9 patients (19%) underwent orchidectomy alone. Group of seminoma tumor show normal limit of tumor marker α-FP and β-HCG and increased in non seminoma. Conclusion: Testicular cancer mostly appears in younger males. Most of testicular cancer was seminoma, diagnosed in advanced stage with metastase 42% of the patient. Most of the patients received orchidectomy followed by PEB chemotheraphy.
TINGKAT PENGETAHUAN IBU HAMIL TENTANG INFEKSI SALURAN KEMIH (ISK) DI DESA SIBOLANGIT Indah Sherbina Br Tarigan; Ade Indra Mukti; Ok Yulizal
Jurnal Impresi Indonesia Vol. 2 No. 11 (2023): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v2i11.3803

Abstract

Penelitian ini dilakukan untuk memahami tingkat pengetahuan ibu hamil terkait Infeksi Saluran Kemih (ISK) di Desa Sibolangit, sebuah kebutuhan mendalam mengingat dampak serius ISK pada kesehatan maternal dan neonatal. Lokasi penelitian dipilih di Desa Sibolangit untuk mendapatkan gambaran representatif mengenai pengetahuan ibu hamil terkait ISK di lingkungan pedesaan. Data ini diharapkan dapat menjadi dasar untuk perencanaan program intervensi kesehatan masyarakat yang lebih efektif dan terarah guna meningkatkan pengetahuan ibu hamil, mencegah risiko ISK, serta meningkatkan kesehatan ibu dan bayi di Desa Sibolangit. Tujuan penelitian ini adalah mengetahui tingkat pengetahuan ibu hamil tentang ISK di Desa Sibolangit, dengan menggunakan penelitian kuantitatif dan pendekatan cross-sectional. Hasil penelitian menunjukkan sebagian besar ibu hamil di Desa Sibolangit berusia 20-30 tahun dengan tingkat pengetahuan cukup tentang ISK sebesar 64.6%. Uji chi-square menunjukkan tidak ada hubungan signifikan antara usia dan tingkat pengetahuan ISK, sementara tingkat pendidikan dan pekerjaan ibu hamil menunjukkan hubungan yang signifikan dengan tingkat pengetahuan. Penelitian ini menyoroti risiko ISK pada usia 21-28 tahun, berbeda dengan teori usia reproduktif sehat. Faktor pendidikan dan pekerjaan memainkan peran penting, dengan tingkat pendidikan rendah dikaitkan dengan pengetahuan ISK yang kurang. Temuan ini menekankan perlunya perhatian khusus terhadap pendidikan formal dan status pekerjaan untuk meningkatkan pengetahuan ibu hamil tentang ISK di Desa Sibolangit, guna meningkatkan kesehatan maternal dan neonatal.
Moringa oleifera leaf extract ameliorates collagen degradation via the inhibition of MMP‐3 expression in UVB‐induced rats Riska Rachmania; Titiek Sumarawati; Agung Putra; Nurul Hidayah; Iffan Alif; Sofian Azalia Husain; Ade Indra Mukti; Reynaldi Suryajaya; Salma Yasmine Azzahara
Indonesian Journal of Biotechnology Vol 29, No 3 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.77538

Abstract

Prolonged exposure to high‐intensity UVB induces the formation of reactive oxygen species (ROS) in skin tissue, triggering an increase in matrix metalloproteinase‐3 (MMP‐3) enzyme production and leading to collagen degradation. Moringa oleifera (MO) contains bioactive compounds known for ROS‐scavenging and anti‐inflammatory properties. However, the precise molecular mechanism of action remains unclear, requiring the inhibition of MMP‐3 activation and regulation of collagen deposition. This study aims to elucidate the potential effect of MO leaf extract‐based gel in restoring collagen deposition by reducing MMP‐3 activation in UVB irradiate‐induced collagen loss in rats. This study employed a completely randomized design, comprising four groups: a healthy group without UVB radiation, a negative control group subjected to UVB radiation and receiving a placebo, and two treatment groups exposed to UVB radiation with 5% or 10% moringa leaf extract‐based gel (MO‐5% or MO‐10%), respectively. Results showed that MO‐5% and MO‐10% significantly reduced MMP‐3 gene expression and increased collagen density compared to the negative control group (p < 0.05). Moringa oleifera leaf extract ameliorates collagen degradation by inhibiting MMP‐3 expression in UVB‐induced rats, suggesting its potential as a pharmacological and cosmetic agent for UVB‐induced skin damage.
Laporan kasus: Karsinoma sel skuamosa paru dengan temuan sitologi dan histopatologi Lina, Juliana; Fadillah, Qori; Nadapdap, Marshall Jeremia; Mukti, Ade Indra; Novita, Cut Elvira
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5564

Abstract

Kanker paru-paru sel skuamosa merupakan tantangan klinis yang signifikan dengan prognosis yang buruk. Laporan kasus ini menyajikan seorang pasien dengan gejala khas kanker paru-paru sel skuamosa. Hasil histopatologi mendukung temuan sitologi yakni tampak sebaran dan kelompokan sel epitel skuamous yang atipik dan pleomorfik, inti sel bentuk bulat dan oval, N/C ratio meningkat, kromatin kasar dengan anak inti menonjol, sitoplasma minimal dan eosinofilik. Untuk diagnosa yang lebih pasti dibutuhkan pemeriksaan imunohistokimia p40, p63, CK7, CK5/6 untuk prognosis dan terapi. Namun, sampel jaringan yang sangat sedikit dan tidak cukup untuk prosesing di laboratorium berikutnya, sehingga membutuhkan waktu yang lebih lama untuk tindakan berikutnya pada pasien. Kasus ini menyoroti pentingnya deteksi dini dan penatalaksanaan yang tepat untuk meningkatkan prognosis pasien. Laporan kasus ini memberikan wawasan berharga tentang karakteristik klinis dan tantangan dalam pengelolaan kanker paru-paru sel skuamosa.
The Effect of Hordeum Vulgare on Spermatogenesis and Testical Histopathology in Diabetes Mellitus Rats Clarisa Eka Putri Sihombing; Ade Indra Mukti; Edlin Edlin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.55293

Abstract

Diabetes dapat memicu kerusakan pada sistem reproduksi pria dan merupakan salah satu faktor penyebab infertilitas pada pria. Tujuan dari penelitian ini adalah untuk menguji pengaruh Hordeum vulgare terhadap spermatogenesis pada tikus diabetes. Penelitian ini menggunakan desain penelitian True Experimental Pretest dan Posttest Control Group Design. Sampel tikus adalah tikus Wistar jantan (Rattus norvegicus), dengan berat sekitar 200 gram, dan berusia sekitar 2 bulan. Variabel independen dalam penelitian ini adalah Hordeum vulgare dan variabel dependennya adalah motilitas sperma dan ciri-ciri histopatologis testis tikus. Data akan diolah menggunakan uji Kruskal Wallis dengan SPSS. Hasil penelitian menunjukkan bahwa tidak ada perbedaan yang signifikan dalam spermatogenesis tikus antar kelompok. Pengaruh Hordeum vulgare pada skor rata-rata Johnsen dan gambaran histopatologis testis tikus diabetes menunjukkan bahwa kelompok tikus diabetes yang diberi makan Hordeum vulgare memiliki banyak spermatozoa tetapi epitel germinal tidak teratur yang ditandai dengan exfol.
Hubungan Lama Waktu Duduk dan Posisi Duduk Terhadap Keluhan Low Back Pain Pada Pekerja Kantoran di Kabanjahe Kabupaten Karo Tarigan, Grace Angelina Br; Edlin , Edlin; Mukti, Ade Indra
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.34421

Abstract

Salah satu masalah kesehatan yang paling sering dikeluhkan masyarakat ialah sakit punggung bagian bawah atau dikenal juga sebagai Low back pain (LBP), dikarenakan duduk dalam jangka waktu yang lama.Salah satu penyebab nyeri punggung bawah, yang merupakan penyakit musculoskeletal yang salah satu penyebabnya adalah postur tubuh yang salah, seperti duduk atau berdiri dalam waktu lama, terlalu banyak membungkuk atau melakukan gerakan berulang-ulang saat bekerja. Penelitian ini memiliki tujuan untuk menilai hubungan durasi waktu duduk dan posisi duduk terhadapa keluhan low back pain. . Jenis Penelitian yang digunakan ialah kuantitatif dengan pendekatan cross-sectional, metode penelitian ini melibatkan survei dengan 100 orang pegawai kantoran di Kabanjahe Kabupaten Karo yang berusia 25-56 tahun. Lokasi Penelitian ini dilakukan di Gedung Badan Kepegawaian dan Pengembangan Sumber Daya Manusia Kabupaten Karo. Analisis data yang digunakan pada penelitian ini yaitu menggunakan SPSS (Statistical Package for the Social Sciences). Hasil penelitian ini menunjukkan bahwa terdapat adanya hubungan signifikan antara posisi duduk dan keluhan low back pain.
Profile of urinary tract infections in the Urology Polyclinic of Imelda Pekerja Indonesia General Hospital Matondang, Lasma Ani Giot Marito; Ade Indra Mukti; Edlin, Edlin
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5807

Abstract

Urinary tract infection (UTI) is one of the most common infectious diseases in the world, affecting 150 million people every year.The purpose of this study was to determine the profile of urinary tract infection patients in the urology polyclinic at Imelda Pekerja Indonesia General Hospital.The type of research used in this study was observational analytic with a cross sectional study design. In this study, the population and sample included patients who experienced UTI infection at Imelda Pekerja Indonesia General Hospital. Univariate and bivariate analyses were performed. The results showed that sex was a significant risk factor for UTI. High-risk female gender can increase risk of UTI 4.442 times. Age was not a significant risk factor for UTI. Occupation was not a significant risk factor for UTI. A history of DM was not a significant risk factor for UTI. High-risk patients with a history of DM can increase risk of UTI 1.462 times, this risk was not statistically significant. A history of BSK is a significant risk factor for UTI. High-risk patients with a history of UTI can increase risk of UTI 4.929 times, this risk is statistically significant. Sex and a history of BSK were significant risk factors for UTI. Age, occupation, and history of DM were not significant risk factors for UTI.
Common injuries among Brazilian Jiu Jitsu practitioners in Medan City Lazuardi, Maulana Umar; Edlin, Edlin; Mukti, Ade Indra
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5727

Abstract

Brazilian Jiu Jitsu (BJJ) is a martial art that focuses on floor fighting and was first popularized in Brazil. The BJJ originally focused on entertainment, health, and self-development. These goals changed when practitioners began participating in competitions in which there was a significant increase in the number of BJJ injuries. A pre-survey in the field indicated that many jiu jitsu practitioners were affected by common injuries. The type of research in this study is a descriptive survey with a cross-sectional approach conducted at Ryu Dojo Martial Arts Center, Musi Jiu Jitsu, and PBJI Medan City in March 2024. Data were collected in the form of questionnaires, interviews, and medical records of practitioners diagnosed with injuries who were sampled. Univariate analysis was used to obtain the frequency distribution of respondents for each variable, namely age, gender, belt level, weight, training frequency, and competitor status. The results of the study were analyzed using SPSS version 27.0. The results showed that the highest number of practitioners was in the late teenage group (53.8%), the highest gender was male (92.3%), and the highest number of practitioners was white belt (69.2%). Based on body weight, the highest number of practitioners was in the Light Feather category (< 64 kg/141 lbs) with a percentage of 26.9%, and the most training hours were 3-5 hours 16 (30.8%). Lower Back Pain was the most common injury with a total of 25 practitioners. A total of 75% of the practitioners stated that their daily activities were disrupted because of their injuries. It can be concluded that the majority of BJJ participants were in their late teens, male was the most common gender, and white belts were the most common practitioners. The most common injury was lower back pain due to the amateur competitor status. Most respondents stated that their injuries interfered with their daily activities.
Determinant Analysis of Hypertension in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study in Medan, North Sumatera, Indonesia Tjendera, Mariaman; Gusbakti; Chiuman, Linda; Mukti, Ade Indra; Sartika, Dewi
Indonesian Journal of Medicine Vol. 10 No. 2 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.831

Abstract

Background: Type 2 diabetes mellitus (T2DM) and hypertension are two chronic conditions that frequently co-occur and pose a significant health burden. At Padang Bulan Primary Healthcare Center in Medan, out of 260 Prolanis participants, 117 T2DM patients sought treatment, and 90 of them were diagnosed with hypertension. This study aimed to analyze the determinants of hypertension in T2DM patients receiving care at Padang Bulan Primary Healthcare Center in Medan. Subjects and Method: An analytical cross-sectional study was conducted on 100 T2DM patients selected through consecutive sampling. Data were collected using structured question¬naire, anthropometric measurement, and blood pressure and blood glucose examinations. The variables studied included sociodemographic characteristics (gender, education, occupation, marital status) and clinical characteristics (body mass index, duration of T2DM, blood glucose levels, family history). Data analysis was performed using Chi-square test. Results: The majority of respondents were women (62%), highly educated (79%), and obese (87%). The prevalence of hypertension in T2DM patients was notably high (>70%) across all groups. However, bivariate analysis showed no statistically significant relationship between any of the studied variables and the incidence of hypertension (p>0.05). Conclusion: There was no significant relationship between sociodemographic and clinical factors with the incidence of hypertension in T2DM patients. Nevertheless, the high prevalence of hypertension indicates the importance of a comprehensive approach in managing both conditions
Prevalensi Penyakit Gagal Ginjal Kronik Di Kalangan Usia Produktif Akibat Gaya Hidup Di Rumah Sakit Royal Prima Medan Agatha, Callista Della; Mukti, Ade Indra; Girsang, Ermi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i8.61340

Abstract

Penyakit Gagal Ginjal Kronik ( CKD ) adalah penyakit yang menyebabkan kerusakan ginjal secara progresif yang ditandai dengan penurunan laju filtrasi glomerulus (glomerular filtration rate) kurang dari 60 mL/menit/1,73 m² yang berlangsung selama lebih dari tiga bulan, salah satu penyebab dari penyakit gagal ginjal kronik ini kurangnya memperhatikan gaya hidup. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan penyakit gagal ginjal kronik di usia kalangan produktif akibat gaya hidup di RS Royal Prima Medan Tahun 2024 . Jenis penelitian ini adalah deskriptif retrospektif dengan desain cross-sectional. Populasi pada penelitian ini adalah seluruh pasien penderita gagal ginjal kronik dengan usia produktif (usia 15-59) didapati 240 pasien. Sampel pada penelitian ini diambil dengan cara total sampling. Data penelitian ini ditampilkan dalam bentuk tabel distribusi frekuensi serta dilakukan uji chi-square untuk mengetahui hubungan. Berdasarkan hasil penelitian diperoleh bahwa penderita penyakit gagal ginjal kronik di RS Royal Prima Medan didominasi oleh usia 51-59 thn (46.7%), berjenis kelamin laki laki sebanyak (58,3%), riwayat penyakit terbanyak hipertensi (49,2%), gaya hidup yang menjadi kebiasaan pasien terbanyak riwayat jarang minum air putih (63.7%), riwayat konsumsi minuman kemasan (61.7%), riwayat merokok (53,8%), ,riwayat konsumsi obat anti nyeri (45%). Pada hasil uji chi-square diperoleh p-value <0,05 yang berarti terdapat hubungan bermakna antara riwayat penyakit seperti hipertensi, diabetes, dan batu saluran kemih dengan penyakit gagal ginjal kronik. Diperoleh p-value <0,05 pada hasil uji chi-square gaya hidup riwayat konsumsi minuman kemasan, riwayat konsumsi obat anti nyeri, riwayat jarang minum air putih yang berarti terdapat hubungannya dengan penyakit gagal ginjal kronik, dan p-value >0,05 untuk gaya hidup merokok yang berarti tidak terdapat hubungannya secara statistik tetapi meningkatkan resiko terjadinya penyakit gagal ginjal kronik.
Co-Authors Agatha, Callista Della Agung Putra Chiuman, Linda Clarisa Eka Putri Sihombing DEWI SARTIKA Edlin , Edlin Edlin Edlin Edlin, Edlin Fadillah, Qori Girsang, Ermi Gusbakti Iffan Alif Indah Sherbina Br Tarigan Lazuardi, Maulana Umar Lina, Juliana Lukman Hakim Matondang, Lasma Ani Giot Marito Nadapdap, Marshall Jeremia Novita, Cut Elvira Nurul Hidayah Reynaldi Suryajaya Riska Rachmania Salma Yasmine Azzahara Sofian Azalia Husain Sunaryo Hardjowijoto Tarigan, Grace Angelina Br Titiek Sumarawati Tjendera, Mariaman wahjoe djatisoesanto Yulizal, Ok