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All Journal Jurnal Penelitian Kesehatan Suara Forikes Journal Of Vocational Health Studies Window of Health : Jurnal Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) COMMUNITY : Jurnal Pengabdian Kepada Masyarakat International Journal of Advanced Health Science and Technology HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Pengabdian Kepada Masyarakat Mulawarman Analis Kesehatan Sains (e-Journal) Jurnal Laboratorium Khatulistiwa
Edy Haryanto
Poltekkes Kemenkes Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Glucose Oxidase–Peroxidase Aminoantipyrine Sebagai Metode Pemeriksaan Glukosa yang Akurat Terhadap Heksokinase pada Pasien Diabetes Mellitus Tipe 2 Pangesti, Rice Kusuma; Haryanto, Edy; Puspitasari, Ayu
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 3 (2025): Juli-September 2025
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf16319

Abstract

Diabetes mellitus is a chronic disease characterized by high blood glucose levels. The number of diabetes mellitus patients is increasing day by day, thus increasing the need for blood glucose testing. This test is commonly used as an initial screening to detect diabetes mellitus. Among the methods for measuring blood glucose levels are Point of Care Testing (POCT), Glucose Oxidase-Peroxidase Aminoantipyrine (GOD PAP), and hexokinase. This study aimed to analyze the differences and accuracy of blood glucose test results using the POCT and GOD PAP methods against hexokinase in patients with type 2 diabetes mellitus. This study was an observational, correlational analytic study, involving 33 patients with type 2 diabetes mellitus selected by purposive sampling method. Blood glucose levels were examined using the POCT, GOD PAP, and hexokinase methods. The POCT-based glucose test results had a bias value (d%) of 34.52% and a recovery value of 86.32%, indicating a significant deviation from hexokinase. In contrast, the GOD-PAP-based glucose test results had a bias value of 4.27 and a recovery value of 102%, meaning they were still within the acceptable range. A t-test showed no significant difference between POCT and GOD-PAP results for hexokinase. Furthermore, it was concluded that the GOD-PAP method is accurate for blood glucose testing in patients with type 2 diabetes mellitus.Keywords: accuracy; blood glucose; Point of Care Testing (POCT), Glucose Oxidase-Peroxidase Aminoantipyrine (GOD-PAP), hexokinase; type 2 diabetes mellitus ABSTRAK Diabetes melitus adalah penyakit kronis yang ditandai dengan tingginya kadar glukosa pada darah. Pasien diabetes melitus semakin hari meningkat, maka kebutuhan pemeriksaan kadar glukosa darah meningkat. Pemeriksaan ini umum digunakan sebagai skrining awal untuk mendeteksi diabetes melitus. Di antara metode pengukuran kadar glukosa darah adalah Point of Care Testing (POCT), Glucose Oxidase-Perokxidase Aminoantipyrine (GOD PAP) serta heksokinase. Penelitian ini bertujuan untuk menganalisis perbedaan dan akurasi hasil pemeriksaan glukosa darah menggunakan metode POCT dan GOD PAP terhadap heksokinase pada pasien diabetes melitus tipe 2. Penelitian ini termasuk jenis observasional analitik korelasional, dengan melibatkan 33 pasien diabetes mellitus tipe 2 yang dipilih dengan metode purposive sampling. Pemeriksaan kadar glukosa darah dilakukan menggunakan metode POCT, GOD PAP dan heksokinase. Hasil pemeriksaan glukosa berbasis POCT memiliki nilai bias (d%) adalah 34,52% dan nilai recovery adalah 86,32%, berarti menyimpang cukup besar dari heksokinase. Sebaliknya, hasil pemeriksaan glukosa berbasis GOD-PAP memiliki nilai bias adalah 4,27 dan nilai recovery adalah 102%, berarti masih berada dalam rentang yang dapat diterima. Berdasarkan uji t, perbedaan hasil POCT dan GOD PAP terhadap heksokinase adalah tidak signifikan. Selanjutnya disimpulkan bahwa metode GOD PAP adalah akurat dalam pemeriksaan glukosa darah pasien diabetes mellitus tipe 2.Kata kunci: akurasi; glukosa darah; Point Of Care Testing (POCT), Glucose Oxidase-Perokxidase Aminoantipyrine (GOD PAP), heksokinase; diabetes mellitus tipe 2
Comparison of Glucose, AST, and Cholesterol Test Results Using Plain Vacutainer Tubes and Clot Activator Vacutainer Tubes Kholidah Zafirah Inas Fatin; Edy Haryanto; Ayu Puspitasari
Jurnal Laboratorium Khatulistiwa Vol 9, No 2 (2026): MEI 2026
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v9i2.2083

Abstract

Laboratory examinations play a crucial role in supporting disease diagnosis; therefore, laboratory test results must be accurate, valid, and reliable. However, errors may occur during various stages of the examination process, including the selection of blood collection tubes, which can influence test outcomes. In clinical chemistry testing, red-capped vacutainer tubes are commonly used, either plain tubes or tubes containing clot activators. The addition of clot activators should not affect the quality of analyte measurements. This study aimed to compare glucose, AST, and cholesterol levels in serum samples collected using plain vacutainer tubes and vacutainer tubes with clot activators. Serum samples were obtained from 16 respondents and analyzed at a primary healthcare laboratory in Surabaya. This study employed an analytic observational method with a cross-sectional and comparative study design. Data normality was assessed using the Shapiro–Wilk test, followed by the Independent t-test for normally distributed data and the Mann–Whitney test for non-normally distributed data. The results showed no significant differences (p > 0.05) in glucose, AST, and cholesterol levels between serum collected in plain vacutainer tubes and serum collected in vacutainer tubes with clot activators. Therefore, both types of vacutainer tubes can be used interchangeably for these clinical chemistry examinations.
PRECISION AND ACCURACY OF NORMAL AND ABNORMAL CREATININE LEVELS OF JAFFE METHOD AGAINST ENZYMATIC METHODS Fa'iqotul Azharil Jauharoh; Anik Handayati; Museyaroh; Edy Haryanto
Journal of Vocational Health Studies Vol. 10 No. 1 (2026): July 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V10.I1.2026.56-62

Abstract

Background: The Jaffe method is still applied with semi-automated analyzers based on picric acid reaction in many laboratories, whereas the enzymatic method is more frequently used as a reference in primary laboratories and hospitals. Purpose: To evaluate the accuracy of the Jaffe method in comparison with the enzymatic method and to assess its precision in measuring normal and abnormally high serum creatinine levels under routine laboratory conditions. Method: The study employed an analytical observational manner at the East Java Province Hajj Hospital and Bakti Analysa Laboratory. Serum samples were obtained from 30 patients with normal creatinine levels and 25 pre-dialysis patients with abnormally high creatinine levels. Accuracy was evaluated by comparing the results of the Jaffe method with those obtained using the enzymatic method, while precision was assessed by repeating the measurements 10 times for each sample. Result: The inaccuracy of the Jaffe method for normal creatinine levels was 19.20%, while for abnormally high creatinine levels, it was -9.33%. The precision value (coefficient of variation) for normal creatinine levels was 5.86%, whereas for abnormally high creatinine levels, it was 1.13%. Conclusion: The Jaffe method for measuring normal creatinine levels demonstrated poor accuracy because the inaccuracy value exceeded the ±10% limit. In contrast, the measurement of abnormally high creatinine levels showed good accuracy because the inaccuracy value remained within the ±10% range. Both normal and abnormally high creatinine measurements using the Jaffe method demonstrated good precision, as the coefficient of variation values were lower than the maximum CV limit of 6%.
In Silico Analysis of Antiviral Activity and Pharmacokinetic Prediction of Brazilein Sappan Wood (Caesalpinia sappan L.) Against SARS-CoV-2 Spike Glycoproteins Dwi Krihariyani; Edy Haryanto; Retno Sasongkowati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1854

Abstract

Brazilein is one of the secondary sappan wood metabolites which can be used empirically as an antivirus. The SARS-CoV-2 spike (S) glycoproteins play significant roles in attaching and entering the virus into the host cell. This study aims to predict the antiviral activity and pharmacokinetic properties of brazilein of the sappan wood against the in-silico SARS-CoV-2 S glycoproteins with vitamin C as the reference compound. Molegro Virtual Docker 5.5 was used to predict antiviral activity by docking process. SARS-CoV-2 S glycoprotein with NAG ligand available in Protein Data Bank (PDB) (PDB ID: 7C01) was the receptor used. The pkCSM online tool was used to predict the pharmacokinetic properties and toxicity of brazilein. Data were analyzed on the target receptors by comparing the docking bond energies between NAG, brazilein, and vitamin C. The smaller the ligands’ bond energy to the target receptor, the more stable the bonds are. The bond energy of NAG, brazilein, and vitamin C was -59.2864 kcal/mol, -65.8911 kcal/mol, and -53.9093 kcal/mol, respectively. These results suggested that brazilein has a greater capacity as an antivirus compared to NAG and vitamin C. In silico test using the pkCSM online tool demonstrated that brazilein had strong pharmacokinetic properties and relatively low toxicity.
Relationship of Albumin Concentrations with Sodium, Potassium, in CAPD (Continuous Ambulatory Peritoneal Dialysis) Patients at PHC Hospital Surabaya Dian Anggraini; Edy Haryanto; Syamsul Arifin; Ayu Puspitasari
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.3252

Abstract

Kidney failure is caused by a permanent decline in kidney function and requires renal replacement therapy, one of which is Continuous Ambulatory Peritoneal Dialysis (CAPD). This study aimed to determine the relationship between albumin concentrations and sodium and potassium concentrations in CAPD patients. The study was carried out between January to May 2022. Cross-sectional research methodology is used in this study. It included 60 chronic kidney failure patients who had CAPD as therapy at PHC Surabaya Hospital. Then, patients were divided into three groups with an age interval of 40-50 years, 51-60 years, and 61-70 years in. The results of grouping CAPD patients according to the characteristics based on the age of CAPD patients aged 61-70 years had low albumin concentrations and low sodium concentrations A total of 12 people (66.67%), patients with large CAPD aged 51-60 years, had low albumin and potassium concentrations, namely 11 people (61.11%). CAPD patients aged 51-60 years mostly had low albumin and sodium concentrations in 13 people (72.22%). the conclusion is that in patients with renal failure on CAPD therapy, there is a decrease in albumin and sodium-potassium concentrations due to peritonitis (inflammation) which is associated with a measurable excess of fluid (overhydration) which causes more dilute sodium, causing hyponatremia and hypokalemia.
PERBANDINGAN NILAI LED MENGGUNAKAN ANTIKOAGULAN EDTA DENGAN NATRIUM SITRAT 3,8% PADA PASIEN DIABETES MELITUS TIPE 2 Nurul Aini Maghfiroh; Edy Haryanto; Wisnu Istanto; Gesang Jukadiarko
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 3 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i3.13514

Abstract

ABSTRACT Erythrocyte sedimentation rate (ESR) is a hematological parameter widely used to assess inflammatory processes, including chronic inflammation in patients with type 2 diabetes mellitus. Although 3.8% sodium citrate is recommended as the standard anticoagulant for the Westergren ESR method, EDTA is more commonly used in clinical laboratories because of its practicality, which may influence ESR measurements. Therefore, this study aimed to compare ESR values obtained using EDTA and 3.8% sodium citrate anticoagulants in patients with type 2 diabetes mellitus. This comparative observational study with a cross-sectional design involved 34 patients with type 2 diabetes mellitus selected through purposive sampling. ESR measurements were performed using the Westergren method on paired blood samples collected in EDTA and 3.8% sodium citrate anticoagulants. The results showed that the mean ESR value was 34.32 ± 20.85 mm/hour (median: 32 mm/hour) for EDTA samples and 32.59 ± 21.57 mm/hour (median: 31 mm/hour) for 3.8% sodium citrate samples. Statistical analysis using the paired sample t-test revealed a significant difference between the two anticoagulants (p = 0.016). These findings indicate that the type of anticoagulant significantly affects ESR measurements in patients with type 2 diabetes mellitus. Therefore, 3.8% sodium citrate remains the preferred anticoagulant for the Westergren ESR method because it better preserves the physiological characteristics of blood samples and supports more accurate clinical interpretation of ESR results. ABSTRAK Pemeriksaan laju endap darah (LED) merupakan salah satu parameter hematologi yang sering digunakan untuk menilai proses inflamasi, termasuk pada pasien diabetes melitus tipe 2 yang umumnya mengalami inflamasi kronis. Meskipun natrium sitrat 3,8% direkomendasikan sebagai antikoagulan standar pada pemeriksaan LED metode Westergren, penggunaan EDTA masih banyak dijumpai di laboratorium karena lebih praktis sehingga berpotensi menghasilkan perbedaan nilai pemeriksaan. Penelitian ini bertujuan untuk menganalisis perbedaan hasil pemeriksaan LED menggunakan antikoagulan EDTA dan natrium sitrat 3,8% pada pasien diabetes melitus tipe 2. Penelitian menggunakan desain observasional komparatif dengan rancangan cross-sectional yang melibatkan 34 pasien diabetes melitus tipe 2 yang dipilih secara purposive. Pemeriksaan LED dilakukan menggunakan metode Westergren pada sampel darah yang mengandung antikoagulan EDTA dan natrium sitrat 3,8%. Hasil penelitian menunjukkan rerata nilai LED sebesar 34,32 mm/jam dengan median 32 mm/jam pada sampel EDTA, sedangkan pada natrium sitrat 3,8% diperoleh rerata sebesar 32,59 mm/jam dengan median 31 mm/jam. Hasil uji Paired Sample t-Test menunjukkan nilai signifikansi sebesar 0,016 (p < 0,05), yang menandakan adanya perbedaan signifikan antara hasil pemeriksaan LED menggunakan kedua antikoagulan. Temuan ini menunjukkan bahwa jenis antikoagulan memengaruhi hasil pemeriksaan LED, sehingga natrium sitrat 3,8% tetap lebih direkomendasikan untuk pemeriksaan LED metode Westergren karena mampu mempertahankan kondisi sampel yang lebih mendekati keadaan fisiologis dan mendukung ketepatan interpretasi hasil laboratorium pada pasien diabetes melitus tipe 2.
AKURASI KADAR LDL METODE INDIRECT TERHADAP METODE DIRECT Marina Putri Rahajeng; Anik Handayati; Musholli Himmatun Nabilah; Edy Haryanto
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14483

Abstract

Lipid profile examination is used to help assess the risk of cardiovascular disease. LDL level examination can be performed using the indirect method (Friedewald Formula) and the direct method (homogeneous test). The indirect method is more economical and is still frequently used in laboratories, but its accuracy is starting to be questioned at high triglyceride levels. This study aims to determine the accuracy of LDL levels using the indirect method (Friedewald Formula) compared to the direct method (homogeneous test) at triglyceride levels of 200-300 mg/dL. This study used a comparative analytical quantitative design with a paired cross-sectional approach. The study sample used primary data, namely the serum of patients with triglyceride levels of 200-300 mg/dL examined using the indirect and direct methods on the same sample. Data analysis was performed using the Wilcoxon test, mean %Bias, Bland-Altman, and linear regression. The results showed that there was no significant difference between the indirect and direct methods with a significance value (p > 0.05). The average %Bias value of -0.3962% still meets the acceptance limits of the National Cholesterol Education Program (NCEP). Bland-Altman analysis showed that most of the data were within the limits of agreement. Based on the results of the study, the indirect method (Friedewald Formula) has good accuracy and relatively comparable results with the direct method (homogeneous testing) at triglyceride levels of 200-300 mg/dL. ABSTRAK Pemeriksaan profil lipid digunakan untuk membantu menilai risiko penyakit kardiovaskular. Pemeriksaan kadar LDL dapat dilakukan menggunakan metode indirect (Friedewald Formula) dan metode direct (homogeneous assay). Metode indirect lebih ekonomis dan masih sering digunakan di laboratorium, tetapi akurasinya mulai diragukan pada kadar trigliserida tinggi. Penelitian ini bertujuan untuk mengetahui akurasi kadar LDL metode indirect (Friedewald Formula) terhadap metode direct (homogeneous assay) pada kadar trigliserida 200–300 mg/dL. Penelitian ini menggunakan desain kuantitatif analitik komparatif dengan pendekatan cross-sectional berpasangan. Sampel penelitian menggunakan data primer, yaitu serum pasien dengan kadar trigliserida 200–300 mg/dL yang diperiksa menggunakan metode indirect dan metode direct pada sampel yang sama. Analisis data dilakukan menggunakan uji Wilcoxon, mean %Bias, dan Bland-Altman. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna antara metode indirect dan metode direct dengan nilai signifikansi (p > 0,05). Nilai mean %Bias sebesar -0,3962% masih memenuhi batas keberterimaan National Cholesterol Education Program (NCEP). Analisis Bland-Altman menunjukkan sebagian besar data berada dalam batas kesepakatan. Berdasarkan hasil penelitian, metode indirect (Friedewald Formula) memiliki akurasi yang baik dan hasil yang relatif sebanding dengan metode direct (homogeneous assay) pada kadar trigliserida 200-300 mg/dL.
PERBEDAAN KADAR ELEKTROLIT MENGGUNAKAN BAHAN UJI SERUM DENGAN BAHAN UJI PLASMA HEPARIN Linatur Rosyidah; Edy Haryanto; Anik Handayati; Gesang Jukadiarko
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14622

Abstract

Electrolyte examination is performed to assess the levels of the major electrolytes in the blood. This examination is used to help establish the diagnosis of fluid balance disorders and acid-base imbalances in the body. The test materials commonly used for electrolyte examination are serum and heparinized plasma. Differences in the type of test material may affect the results of electrolyte examinations. This study aimed to determine the differences in electrolyte levels, including sodium, potassium, chloride, and ionized calcium, between serum and heparinized plasma test materials. This study employed a quantitative approach with an analytical observational design and a cross-sectional design. A total of 15 samples were obtained from patients undergoing electrolyte examinations at Muhammadiyah Babat General Hospital in February 2026. Electrolyte examinations were performed using the Erba Electrolyte Analyzer with the direct Ion-Selective Electrode (ISE) method. The results showed that the mean sodium levels were 139.29 mmol/L in serum and 136.49 mmol/L in heparinized plasma, the mean potassium levels were 3.79 mmol/L in serum and 3.58 mmol/L in heparinized plasma, the mean chloride levels were 106.77 mmol/L in serum and 105.63 mmol/L in heparinized plasma, and the mean ionized calcium levels were 1.00 mmol/L in serum and 0.89 mmol/L in heparinized plasma. The examination results were analyzed using the paired t-test and the Wilcoxon signed-rank test according to the data distribution. The results showed significant differences in sodium, potassium, and ionized calcium levels between serum and heparinized plasma test materials, with significance values of p < 0.05. Meanwhile, chloride levels showed no significant difference between serum and heparinized plasma test materials, with a significance value of p > 0.05. Based on the data analysis that had been conducted, significant differences were found in sodium, potassium, and ionized calcium levels between serum and heparinized plasma test materials, whereas chloride levels showed no significant difference. ABSTRAK Pemeriksaan elektrolit merupakan pemeriksaan untuk menilai kadar elektrolit utama di dalam darah. Pemeriksaan ini digunakan untuk membantu menegakkan diagnosis adanya gangguan keseimbangan cairan maupun ketidakseimbangan asam-basa dalam tubuh. Bahan uji yang umum digunakan pada pemeriksaan elektrolit adalah serum dan plasma heparin. Perbedaan jenis bahan uji dapat memengaruhi hasil pemeriksaan elektrolit. Penelitian ini dilakukan untuk mengetahui adanya perbedaan kadar elektrrolit, meliputi kadar natrium, kalium, klorida, dan kalsium terionisasi antara bahan uji serum dengan bahan uji plasma heparin. Penelitian ini menggunakan pendekatan kuantitatif observasional analitik dengan desain cross-sectional. Jumlah sampel sebanyak 15 sampel dari pasien yang menjalani pemeriksaan elektrolit di RSU Muhammadiyah Babat pada bulan Februari 2026. Pemeriksaan elektrolit dilakukan menggunakan alat Erba Electrolyte Analyzer dengan metode Ion Selective Electrode (ISE) secara langsung. Hasil pemeriksaan menunjukkan bahwa rerata kadar natrium pada serum sebesar 139,29 mmol/L dan plasma heparin sebesar 136,49 mmol/L, kadar kalium pada serum sebesar 3,79 mmol/L dan plasma heparin sebesar 3,58 mmol/L, kadar klorida pada serum sebesar 106,77 mmol/L dan plasma heparin sebesar 105,63 mmol/L, serta kadar kalsium terionisasi pada serum sebesar 1,00 mmol/L dan plasma heparin sebesar 0,89 mmol/L. Data hasil dari pemeriksaan elektrolit akan dianalisa menggunakan uji T-dependen dan uji Wilcoxon sesuai dengan distribusi data. Hasil uji pada kadar natrium, kalium, dan kalsium terionisasi antara bahan uji serum dengan bahan uji plasma heparin menunjukkan adanya perbedaan bermakna, dengan nilai signifikansi (p < 0,05). Sedangkan, pada kadar klorida tidak terdapat perbedaan bermakna antara bahan uji serum dan bahan uji plasma heparin dengan nilai signifikansi (p > 0,05). Berdasarkan analisis data yang telah dilakukan, ditemukan perbedaan yang bermakna pada kadar natrium, kalium, dan kalsium terionisasi antara bahan uji serum dengan plasma heparin, sedangkan kadar klorida tidak menunjukkan perbedaan bermakna.
PENDAMPINGAN KADER POSYANDU DALAM PENGOLAHAN KERUPUK FORTIFIKASI SEBAGAI EDUKASI PANGAN BERGIZI UNTUK MENDUKUNG KESEHATAN JANTUNG Wisnu Istanto; Edy Haryanto; Era Fitria Yunita
COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/community.v6i2.14889

Abstract

The potential of Desa Ketetang, Kecamatan Kwanyar, Kabupaten Bangkalan on fishery and local food products which are not optimally utilised as a product that has a nutritional and economic value is still limited by the capacity of the Posyandu mothers in food processing and business management. The community service activity is intended to increase the knowledge and skills of the participants in developing food products from moringa leaves and lemuru fish and to strengthen the entrepreneurial capacity of households. The program used a participatory approach with a one-group pretest-posttest evaluation design involving 40 cadre mothers and Posyandu members. The activity was conducted in January- August 2026. The implementation includes needs identification, education on food fortification and heart health, production demonstrations and practices, packaging, cost price calculations, simple book-keeping, digital marketing, and introduction to food legality and safety. The evaluation process is carried out through knowledge tests, activity observations, and satisfaction questionnaires. The average score of knowledge increased from 51.50 ± 14.20 to 86.88 ± 7.13, with an increase of 35.38 points and a group N-gain of 0.73 in the high category. After the mentoring, all participants achieved a Good or Very Good knowledge level. The average satisfaction score was 91.8 ± 5.2 (maximum=100). 95.0% of respondents were Very Satisfied, and 5.0% were Satisfied. The highest rating was assigned to the willingness to recommend the program. This program shows that the synergy between health education, local food processing practices, and entrepreneurship mentoring can improve knowledge and program acceptance. The sustainability of the activities requires product standardisation, quality and safety testing, legal compliance, and monitoring of production, marketing and income of the participants. ABSTRAK Desa Ketetang, Kecamatan Kwanyar, Kabupaten Bangkalan memiliki potensi hasil perikanan dan pangan lokal yang belum dimanfaatkan secara optimal menjadi produk bernilai gizi dan ekonomi, sedangkan kapasitas kader Posyandu dalam pengolahan pangan dan pengelolaan usaha masih terbatas. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan keterampilan peserta dalam mengembangkan produk pangan berbasis ikan lemuru dan daun kelor serta memperkuat kemampuan kewirausahaan rumah tangga. Program menggunakan pendekatan partisipatif dengan desain evaluasi one-group pretest–posttest yang melibatkan 40 ibu kader dan anggota Posyandu. Kegiatan dilaksanakan pada bulan Januari–Agustus 2026. Pelaksanaan mencakup identifikasi kebutuhan, edukasi fortifikasi pangan dan kesehatan jantung, demonstrasi dan praktik produksi, pengemasan, perhitungan harga pokok produksi, pembukuan sederhana, pemasaran digital, serta pengenalan legalitas dan keamanan pangan. Evaluasi dilakukan melalui tes pengetahuan, observasi kegiatan, dan kuesioner kepuasan. Rata-rata skor pengetahuan meningkat dari 51,50 ± 14,20 menjadi 86,88 ± 7,13 dengan peningkatan 35,38 poin dan N-gain kelompok sebesar 0,73 yang termasuk kategori tinggi. Setelah pendampingan, seluruh peserta berada pada kategori pengetahuan Baik atau Sangat Baik. Rata-rata kepuasan mencapai 91,8 ± 5,2 dari skor maksimum 100; sebanyak 95,0% peserta termasuk Sangat Puas dan 5,0% termasuk Puas. Kesediaan untuk merekomendasikan program memperoleh penilaian tertinggi. Program ini menunjukkan bahwa integrasi edukasi kesehatan, praktik pengolahan pangan lokal, dan pendampingan kewirausahaan dapat meningkatkan pengetahuan serta keterterimaan program. Keberlanjutan kegiatan memerlukan standardisasi produk, pengujian mutu dan keamanan, pemenuhan legalitas, serta pemantauan produksi, pemasaran, dan pendapatan peserta.
HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI Sofiyah Sofiyah; Anik Handayati; Suhariyadi Suhariyadi; Edy Haryanto
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.15860

Abstract

Hypertension is a chronic disease that may increase the risk of cardiovascular disease. Elevated uric acid levels are known to contribute to oxidative stress and inflammatory processes, while high-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker used to assess cardiovascular disease risk. This study aimed to determine the relationship between uric acid and hs-CRP levels among hypertensive Prolanis patients at Farmalab Medical Laboratory, Bangkalan Regency. This study employed a quantitative observational analytic design with a cross-sectional approach. Serum samples were obtained from 30 hypertensive Prolanis patients. Uric acid levels were measured using an Homogenus Enzymatic Colometric method, while hs-CRP levels were measured using Fluorescence Immunoassay (FIA). Data were analyzed using the Shapiro-Wilk test and Spearman correlation. The mean uric acid level was 5.913 mg/dL and the mean hs-CRP level was 2.560 mg/L. Spearman correlation analysis showed no significant relationship between uric acid and hs-CRP levels (r = -0.218; p = 0.246). The correlation coefficient indicated a very weak negative relationship. In conclusion, uric acid levels were not significantly associated with hs-CRP levels among hypertensive Prolanis patients. ABSTRAK Hipertensi merupakan penyakit kronis yang berkaitan dengan peningkatan risiko penyakit kardiovaskular dan melibatkan proses inflamasi serta gangguan metabolik. Kadar asam urat yang meningkat diduga berkaitan dengan inflamasi sistemik, yang dapat dinilai melalui pemeriksaan high-sensitivity C-reactive protein (hs-CRP). Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dan hs-CRP pada pasien Program Pengelolaan Penyakit Kronis (PROLANIS) hipertensi di Laboratorium Medis Farmalab, Kabupaten Bangkalan. Penelitian ini menggunakan desain kuantitatif analitik observasional dengan pendekatan cross-sectional. Sampel penelitian terdiri atas 30 pasien perempuan berusia 40–65 tahun yang dipilih menggunakan teknik purposive sampling. Pemeriksaan asam urat menggunakan metode homogeneous enzymatic colorimetric, sedangkan hs-CRP menggunakan metode fluorescence immunoassay (FIA). Analisis data dilakukan menggunakan uji normalitas Shapiro–Wilk dan korelasi Spearman. Hasil penelitian menunjukkan rata-rata kadar asam urat sebesar 5,913 mg/dL dan hs-CRP sebesar 2,560 mg/L. Uji korelasi Spearman menunjukkan koefisien korelasi sebesar −0,218 dengan nilai p = 0,246. Dengan demikian, tidak terdapat hubungan yang signifikan antara kadar asam urat dan hs-CRP pada pasien PROLANIS hipertensi.
Co-Authors Anggraini, Anita Dwi Ayu Pramita Desty Ratna Ayu Puspitasari Dian Anggraini Endah Astuti, Sri Sulami Era Fitria Yunita Evy Diah Woelansari Fa'iqotul Azharil Jauharoh Gesang Jukadiarko Handayati, Anik Istanto, Wisnu Kartika Rahayuningsih, Christ Kholidah Zafirah Inas Fatin Krihariyani, Dwi Linatur Rosyidah Marina Putri Rahajeng Museyaroh, Museyaroh Musholli Himmatun Nabilah Nurul Aini Maghfiroh Pangesti, Rice Kusuma Sadgassusi Hera Samudra Sasongkowati, Retno Sofiyah Sofiyah Suhariyadi Syamsul Arifin Syamsul, Arifin Tania, Aulia Rachma Thoyib, Agus Muhammad Yunarsih, Yunarsih