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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Bioscientia Medicina : Journal of Biomedicine and Translational Research Prosiding Balai Arkeologi Jawa Barat Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Theodorus Theodorus
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Kadar Tumor Necrosis Factor Alpha (TNF-α )Sebagai Prediktor Demam Berdarah Dengue Pada Hari Ketiga Myrna Alia; Yulia Iriani; Zarkasih Anwar; Theodorus Theodorus
Majalah Kedokteran Sriwijaya Vol 46, No 3 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i3.2701

Abstract

Demam berdarah dengue (DBD) pada  fase awal sakit memiliki gejala yang tidak khas dan mirip dengan demam dengue (DD) atau demam karena infeksi lain (other febrile illness/OFI). Adanya perembesan plasma merupakan penanda DBD yang terjadi setelah fase awal ini. TNF-α merupakan salah satu sitokin yang berperan dalam mekanisme perembesan plasma pada DBD. Tujuan: Penelitian ini bertujuan untuk melihat hubungan antara TNF-α  dengan DBD. Penelitian ini merupakan suatu case control yang dilakukan pada bulan Maret-September 2011 pada RS Moh Hoesin, RSUD Palembang Bari dan RS Muhammadiyah Palembang dan Puskesmas Pembina. Kelompok kasus terdiri dari subjek dengan DBD dan kelompok kontrol subjek non DBD (DD dan OFI) sebanyak dua kali lipat yang dimatching menurut usia dan jenis kelamin. Pengambilan sampel darah untuk pemeriksaan TNF-α dilakukan pada hari ke tiga demam. Sebanyak 54 subjek yang terdiri dari 18 subjek dengan DBD dikelompokkan sebagai kasus dan masing-masing 18 subjek dengan DD dan OFI sebagai kontrol. Rerata kadar TNF-α pada DBD, DD dan OFI adalah 52,71±22,58 pg/mL,  39,79±9,57 pg/mL dan 35,98±8,07 pg/mL dan uji statistik menunjukkan terdapat perbedaan bermakna (p=0,002; uji Kruskal-Wallis). Titik potong kadar TNF-α yang optimal adalah 37,6 pg/mL. Uji Fisher menunjukkan adanya hubungan yang bermakna antara kadar TNF-α dan DBD dibanding DD (p=0,027;OR=8), OFI (p=0,00;OR=28) dan non DBD/DD+OFI (p=0,00; OR=14,145). Terdapat hubungan yang bermakna antara kadar TNF-α dan DBD.
Efek Antiinflamasi Ekstrak Air Daun Mali-mali (Leea indica) Terhadap Jumlah Leukosit Pada Tikus Putih Jantan Galur Wistar Afkur Mahesa Nasution; MT. Kamaluddin; Theodorus Theodorus
Majalah Kedokteran Sriwijaya Vol 49, No 3 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i3.8507

Abstract

Selama ini pengobatan inflamasi umumnya didominasi oleh obat-obat AINS (Antiinflamasi Nonsteroid). Penggunaannya yang kerap tidak tepat dapat memunculkan keluhan-keluhan berupa gangguan pencernaan, hati, dan ginjal. Saat ini, penelitian yang bertujuan untuk mencari alternatif pengobatan inflamasi yang bersumber dari bahan alami sudah banyak dilakukan. Ekstrak air daun Mali-mali (Leea indica) mengandung senyawa flavonoid, terpenoid, tannin, alkaloid, dan saponin. Kandungan flavonoid ini yang diduga berperan pada proses antiinflamasi. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak air daun Mali-mali sebagai antiinflamasi. Penelitian eksperimental, in vivo dengan metode Pre-test and Post-test.  Penelitian dilakukan sejak 27 Desember 2016 sampai 7 Januari 2017 di Laboratorium Bio Sains Riset. Sampel berupa 30 ekor tikus putih jantan yang memenuhi kriteria inklusi, dibagi menjadi 5 kelompok perlakuan menggunakan Kalium Diklofenak sebagai kontrol positif dan aquades sebagai kontrol negatif, serta ekstrak air daun Mali-mali (Leea indica) yang dibagi ke dalam 3 konsentrasi dosis, yaitu: 100 mg/KgBB, 200 mg/KgBB dan 400 mg/KgBB. Uji antiinflamasi dilakukan dengan cara membandingkan jumlah leukosit darah tikus sebelum dan sesudah diberi perlakuan.Ekstrak air daun Mali-mali (Leea indica) mempunyai efek antiinflamasi dimulai dari dosis terkecil 100 mg/KgBB sampai dosis terbesar 400 mg/KgBB. Uji kesetaraan menunjukkan ekstrak air daun Mali-mali 16,514 mg/KgBB setara dengan 5,56 mg/KgBB Kalium Diklofenak.Ekstrak air daun Mali-mali (Leea indica) mempunyai efek antiinflamasi, dilihat dari jumlah leukosit darah tikus yang turun setelah diberikan perlakuan. 
Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury Febri Jaya Gunawan; F Heru Irwanto; Andi Miarta; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.58

Abstract

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI. Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury. Methods : There’re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18% Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum. Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity
The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats Nita Parisa; MT Kamaluddin; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.62

Abstract

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05). Results There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.
Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury Febri Jaya Gunawan; F Heru Irwanto; Andi Miarta; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.58

Abstract

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI. Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury. Methods : There’re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18% Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum. Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity
The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats Nita Parisa; MT Kamaluddin; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.62

Abstract

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05). Results There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.
Level of maternal zinc serum as risk factor of preeclampsia Tian Kaprianti; Putri Mirani; Abarham Martadiansyah; Peby M. Lestari; Theodorus Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 4 Oktober 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i4.1616

Abstract

Objective : To know the relationship of serum zinc levels with preeclampsia (PE) Method: This observational research uses a type of case control research. The population of this study is all pregnant women with a single pregnancy, gestational age of 28-42 weeks who were treated at the Department of Obstetrics and Gynecology of RSUP Dr. Mohammad Hoesin Palembang from August 2020 to November 2020. The study divided into 2 group, a case group of 30 pregnant women with PE and a control group of 60 pregnant women non PE. Serum zinc level examination is performed on all samples that match the research criteria. The data is processed by using SPSS software program version 20.0 Windows. Result: Both case and control groups had no meaningful differences to the general characteristics of the patient. There were significant differences in average zinc levels of maternal serum in both research groups (p=0.013; 43.90 plus-minus 15.79 pg/dL). The value of serum zinc levels that have the best sensitivity and specificity is at 45.5 pg/dL. Conclusion: There is a meaningful relationship between serum zinc levels and PE events. Pregnant women with serum zinc levels greater than or equal to 45.5 pg /dL were significantly at 3.2 times more risk of PE than pregnant women with serum zinc levels less than or equal to 45.5 pg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia. Keywords: preeclampsia, zinc, case-control studies
POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING Haidar Ali Hamzah; Junoretta Haviva Ernanto; Putri Mahirah Afladhanti; Theodorus Theodorus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.789

Abstract

Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (Mpro) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green tea leaves as a COVID-19 Mpro inhibitor using molecular docking. 12 compounds and lopinavir were used. Lipinski analysis was carried out to assess potential compounds as a drug. Docking was carried out by Autodock Tools 1.5.6 and Autodock Vina. The visualization was carried out by Discovery Studio v16. The results showed that all compounds compiled the criteria as a drug based on Lipinski rules. Catechin and epicatechin have the same energy bond as lopinavir with a binding energy of -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest energy bond with a binding energy of -9.0 and -8.2 kcal/mol. All compounds bind in the active site of the COVID-19 Mpro so they are competitive inhibitor. Catechin gallate is the strongest inhibitors.
DRUG PATTERN STUDY ON ANGIOTENSIN II RECEPTOR BLOCKER IN OUTPATIENTS AT MOHAMMAD HOESIN HOSPITAL PALEMBANG Samantha Ferlin Boentara; Nita Parisa; Theodorus Theodorus
Majalah Kedokteran Sriwijaya Vol 54, No 4 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i4.19664

Abstract

Hypertension is a global health problem due to its increasing prevalence. Hypertension is a condition where there is a persistent increase in blood pressure exceeding 140/90 mmHg. Among the many choices of antihypertensive drug classes, ARB is one of the first-line drug classes for the treatment of hypertension. Inappropriate ARB administration can reduce the effectiveness of treatment and harm the patient. This study aims to determine the pattern of ARB use in hypertensive patients. This drug pattern study has been done on October – November 2021 at the Outpatient Department of Dr. Mohammad Hoesin Central Public Hospital Palembang. The sample was using the medical record data of all hypertensive patients’ period of July – December 2020 who met the inclusion criteria, with a total of 171 data. The data was processed by using the SPSS v25 and presented in the form of a table with a descriptive explanation referring to the research variables. This study found that the prevalence of ARB use was 59.0% with the highest was in male (30.4%) and age group 41-60 years (29.2%). The most widely used ARB is candesartan (94.0%) at a dose of 16 mg (52.6%), frequency once a day (97.9%) and duration more than one month (93.7%). The drug prescribed to the patient mostly didn’t have interaction with ARB (33.0%). The prevalence of ARB administration is high in hypertensive patients (59.0%) with the most commonly used ARB is candesartan (94.0%).
THE DIAGNOSTIC METHODS OF PLACENTA ACCRETA SPECTRUM DISORDERS Alia Desmalia; Nuswil Bernolian; Abarham Martadiansyah; Theodorus Theodorus; Citra Dewi; Putri Mirani; Peby Maulina Lestari; Cindy Kesty
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.19655

Abstract

Placenta Accreta Spectrum Disorder (PASD) is abnormal trophoblast invasion of part or all of the placenta into the myometrium of the uterine wall. Magnetic resonance imaging (MRI) examination is one of the tools that can help diagnosing PASD earlier, so that maternal morbidity and mortality can be reduced. This study aims to determine the prevalence, risk factors of PASD and the accuracy of Placenta Accreta Index Score (PAIS) and MRI, with histopathological examination in diagnosing PASD at dr. Mohammad Hoesin General Hospital (RSMH) Palembang during the 2018–2021. A descriptive study with a survey design on pregnant and intrapartum women with suspected PASD was performed at Department of Obstetrics and Gynecology at RSMH Palembang from 2018 until 2021. There were 72 study subjects who met the inclusion criteria. The relationship between the independent and dependent variables was analyzed using Chi Square and Fisher Exact. The cut-off point of the PAIS scores was analyzed using the Receiver Operating Curve (ROC). The comparison of the diagnostic value of PAIS and MRI scores used the Youden Index. Data was analyzed with SPPS version 22.0 From 72 subjects, 60 subjects (83.3%) were PASD and 12 subjects (16.7%) were not PASD. The risk factors of PASD in this study was surgical history more than once (PR = 4.600 (95% CI 1.261–16.781); p = 0.037). Youden Index values and PAIS accuracy were 0.782 and 0.953 while Youden Index values and MRI accuracy were 0.333 and 0.886. PAIS and MRI could be considered as diagnostic tools for PASD. However, overall, PAIS had a better diagnostic value than MRI.
Co-Authors Adriansyah, H Adriansyah, H Afkur Mahesa Nasution Alia Desmalia Andi Miarta Chairil Anwar Cindy Kesty Citra Dewi Dalilah Dalilah Diana Sari Ellyzar Ellyzar F Heru Irwanto Febri Jaya Gunawan Haidar Ali Hamzah Hapzi Ali Henny Sulastri Irsan Saleh Joko Marwoto Junoretta Haviva Ernanto Kamaludin, M.T.2 Kamaludin, M.T.2 Krisna Murti Kusuma Harimin Lidya Fransisca Martadiansyah, Abarham Mimi Marleni MT Kamaluddin MT. Kamaluddin Muhammad Bahori Myrna Alia Nita Parisa Nursiah Nasution Nuswil Bernolian Peby M. Lestari Peby Maulina Lestari, Peby Maulina Putri Mahirah Afladhanti Putri Mirani Resiana Resiana Samantha Ferlin Boentara Sari Mulia Sofjan Effendi Sri Nita Sulastri, H Sulastri, H tian kaprianti Wisman Tjuandra Yulia Iriani, Yulia Yundari, Yundari Zarkasih Anwar