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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Bioscientia Medicina : Journal of Biomedicine and Translational Research Prosiding Balai Arkeologi Jawa Barat Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Theodorus Theodorus
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING Haidar Ali Hamzah; Junoretta Haviva Ernanto; Putri Mahirah Afladhanti; Theodorus Theodorus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.789

Abstract

Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (Mpro) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green tea leaves as a COVID-19 Mpro inhibitor using molecular docking. 12 compounds and lopinavir were used. Lipinski analysis was carried out to assess potential compounds as a drug. Docking was carried out by Autodock Tools 1.5.6 and Autodock Vina. The visualization was carried out by Discovery Studio v16. The results showed that all compounds compiled the criteria as a drug based on Lipinski rules. Catechin and epicatechin have the same energy bond as lopinavir with a binding energy of -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest energy bond with a binding energy of -9.0 and -8.2 kcal/mol. All compounds bind in the active site of the COVID-19 Mpro so they are competitive inhibitor. Catechin gallate is the strongest inhibitors.
Co-Authors Adriansyah, H Adriansyah, H Afkur Mahesa Nasution Alia Desmalia Andi Miarta Chairil Anwar Cindy Kesty Citra Dewi Dalilah Dalilah Diana Sari Ellyzar Ellyzar F Heru Irwanto Febri Jaya Gunawan Haidar Ali Hamzah Hapzi Ali Henny Sulastri Irsan Saleh Joko Marwoto Junoretta Haviva Ernanto Kamaludin, M.T.2 Kamaludin, M.T.2 Krisna Murti Kusuma Harimin Lidya Fransisca Martadiansyah, Abarham Mimi Marleni MT Kamaluddin MT. Kamaluddin Muhammad Bahori Myrna Alia Nita Parisa Nursiah Nasution Nuswil Bernolian Peby M. Lestari Peby Maulina Lestari, Peby Maulina Putri Mahirah Afladhanti Putri Mirani Resiana Resiana Samantha Ferlin Boentara Sari Mulia Sofjan Effendi Sri Nita Sulastri, H Sulastri, H tian kaprianti Wisman Tjuandra Yulia Iriani, Yulia Yundari, Yundari Zarkasih Anwar