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Journal : Jurnal Farmasi Indonesia

Efek Antihiperlipidemia Kombinasi Ektrak Kelopak Bunga Rosella dan Ekstrak Daun Bawang Kucai Dwi Ningsih; Samuel Budi Harsono; Anas Diah Kusumawati; Dinda Nur Mahmudah
Jurnal Farmasi Indonesia Vol 14 No 1 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.518 KB) | DOI: 10.31001/jfi.v14i1.359

Abstract

Research was conducted to determine the antihyperlipidemic activity of the combination of Roselle Petal AndGarlic Chives Leaves ethanol extracton hyperlipidemic rats. To determine the potential effects of a combination of garlic chives leaves and rosella, the test animals were divided into seven treatment groups consisting of a hyperlipidemic control group, rosella group (500 mg / KgBW), garlic chives leaves group (110 mg / KgBW), the combination of Roselle Petal And Garlic Chives Leaves respectively 125 : 82.5 mg / KgBW, 250 : 55 mg / KgBW, and 375 : 27.5 mg / KgBW.Total cholesterol test results obtained percent reduction in total cholesterol rosella group (500 mg / KgBW) amounted to 11.49%, garlic chives leaves group (110 mg / KgBW) amounted to 13.70%, the combination of roselle petal and garlic chives leaves125 : 82.5 mg / KgBW, 250 : 55 mg / KgBW, and 375 : 27.5 mg / KgBW, respectively by 40.60%; 46.80% and 32.80%. The test results obtained percent decrease in triglyceride levels of triglyceride levels rosella group (500 mg / KgBW) amounted to 16.40%, garlic chives leaves group (110 mg / KgBW) amounted to 27.68%, combination of roselle petal and garlic chives leaves 125 :82.5 mg / KgBW, 250 : 55 mg / KgBW, and 375 : 27.5 mg / KgBW, respectively by 18.67%; 45.24% and 15.76%.The combination of roselle petal and garlic chives leaves250 : 55 mg / KgBW more effective to reduce total cholesterol and triglyceride blood of test animals than others.
Uji Aktivitas Antipiretik Dan Kandungan Flavonoid Total Ekstrak Daun Pepaya Dwi Ningsih; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1122.568 KB) | DOI: 10.31001/jfi.v15i2.451

Abstract

Demam adalah peningkatan suhu tubuh diatas normal (98,6oF/ 37oC). Demam merupakan respon fisiologis tubuh terhadap penyakit yang di perantarai oleh sitokin dan ditandai dengan peningkatan suhu pusat tubuh dan aktivitas kompleks imun. Untuk mengatasi keluhan demam, diberikan obat obat antipiretik. Daun pepaya, dipercaya mempunyai efek antipiretik. Tujuan penelitian ini adalah untuk menguji aktivitas antipiretik dan menentukan kadar flavonoid total ekstrak etanol daun pepaya. Hewan uji dikelompokkan menjadi 5 kelompok yang terdiri dari kelompok kontrol demam, kontrol obat ibuprofen 18 mg/KgBB, ekstrak daun papaya (EDP) dosis 100 mg/KgBB, 200 mg/KgBB, dan 400 mg/KgBB. Hewan uji tikus jantan galur Wistar diinduksi demam dengan vaksin DPT-Hb 0.2 mL secara subkutan. Perlakuan diberikan setelah hewan uji mengalami demam, dilihat dari kenaikan suhu rectal. Suhu tubuh hewan uji diamati setiap 30 menit. Uji kandungan flavonoid total dilakukan untuk mengetahui kadar flavonoid total. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun papaya dosis 100 mg/KgBB, 200 mg/KgBB, dan 400 mg/KgBB mempunyai aktivitas antipiretik pada tikus jantan galur wistar yang diinduksi vaksin DPT-Hb. Aktifitas antipiretik dari ketiga dosis tidak berbeda secara signifikan dengan kontrol ibuprofen.
Pengaruh Pemberian Ekstrak Adas (Foeniculum vulgare Mill ) Pada Tikus Laktasi Terhadap Sel Neuroglia Anak Tikus Dwi Ningsih
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.794

Abstract

Breast Milk is a natural baby food that is rich in nutrients and contains higher immunological factors compared to formula milk. Foeniculum vulgare Mill plants have long been used by the community as enhancing the production of breast milk (ASI). The purpose of this study was to determine the effect of lactogogum extracts of Foeniculum vulgare Mill leaves and stems in lactation mice, as seen from mouse neuroglia cells. Foeniculum vulgare Mill extract was made by maceration method using 96% ethanol solvent. The test animals used in the study were white rats, divided into 6 groups namely, normal control, control without drugs (cmc-na 0.5%), comparison of asifit drugs (67.86 mg / KgBB), ethanol extract groups of leaves and stems fennel dosage 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight. The results of the research that have been done show that the ethanol extract of Foeniculum vulgare Mill leaves and stems dose 315 mg / kg body weight, 630 mg / kg body weight, and 945 mg / kg body weight have a lactagogum effect seen from the parameters of the number of glia cells in the brains of breastfed mice. The effect increase is not as large as the dose increase given. The ethanol extract of Adas leaves and stems of 630 mg / kg BW has an optimal lactagogum effect equivalent to drug control on the market as seen from the parameters of the number of glia cells in the brains of breastfed rat.