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All Journal Global Medical and Health Communication YARSI Medical Journal Diklat Review : Jurnal manajemen pendidikan dan pelatihan Makara Journal of Science
Susi Endrini
Department of Biochemistry, School of Medicine, YARSI University, Jakarta
Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : YARSI Medical Journal

 1 
PENGARUH PEMBERIAN EKSTRAK DAUN KOLA (COLA NITIDA) PADA KUALITAS SPERMA MANUSIA IN VITRO Susmiarsih, T.; Endrini, Susi
Jurnal Kedokteran YARSI Vol 21, No 1 (2013): JANUARI - APRIL 2013
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.797 KB) | DOI: 10.33476/jky.v21i1.15

Abstract

Studi terhadap tanaman yang berpengaruh terhadap proses reproduksi masih menjadi skala prioritas. Salah satunya adalah Kola (Cola  nitida), yang dikenal mempunyai efek stimulan. Telah dilakukan studi untuk mengetahui pengaruh ekstrak daun Kola terhadap viabilitas, motilitas dan integritas membran spermatozoa manusia in vitro. Sampel sperma diperoleh dari 20 orang pria dengan kategori normozoospermia. Sampel semen dibagi menjadi 1 kelompok kontrol ( kontrol negatif) dan 2 kelompok perlakuan dengan ekstrak daun Kola (0.05% dan 0.025%). Hasil penelitian menunjukkan bahwa ekstrak daun Kola tidak berpengaruh terhadap viabilitas spermatozoa tetapi secara bermakna meningkatkan motilitas dan integritas membran spermatozoa (p 0.05). Hasil ini mengindikasikan bahwa ekstrak daun Kola berpengaruh terhadap kualitas spermatozoa manusia in vitro.Study on medicinal plants that have potential effect on  reproductive process is still important to be done. One of the plant is Kola (Cola nitida) that has a stimulant effect. This study evaluated  the effects of Kola  leaf  extract  toward viability, motility and membrane integrity on human sperm in vitro. Normozoospermia semens from  twenty volunteers were taken and divided into 3 groups: 1 group  was  treated  as control  and 2 groups were treated with Kola leaf extracts  (0.05% dan 0.025%). The results showed that Kola leaf extract  had no significant effect in viability but increased significantly (p 0.05) the motility and membrane integrity. It indicates that Kola leaf extract influences human semen quality in vitro.
EFFECTS OF STROBILANTHES CRISPUS EXTRACT ON THE APOPTOTIC PATHWAY OF HUMAN LIVER CARCINOMA CELL LINES Endrini, Susi; Suherman, Suherman; Rahmat, Asmah; Ismail, Patimah; Taufiq-Yap, Y.H; Othman, Fauziah
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.011 KB) | DOI: 10.33476/jky.v15i1.998

Abstract

Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effectof S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.
AKTIVITAS ANTIOKSIDAN DAN EFEK SITOTOKSIK EKSTRAK KOLA (COLA NITIDA) PADA KULTER SEL KANKER HATI (HEPG-2) Endrini, Susi; Marsiati, Himmi; J, Suherman; O, Fauziah; R, Asmah
Jurnal Kedokteran YARSI Vol 17, No 1 (2009): JANUARI - APRIL 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.103 KB) | DOI: 10.33476/jky.v17i1.195

Abstract

Liver cancer is one among cancers with increasing incidence in the world. Cola fruit (Cola nitida) is a fruit that is rich in properties and has been known since the Dutch colonial era. This fruit contains ingredients such as those contained in tea and chocolate such as methylxanthine and its derivatives. This study aims to determine the content of antioxidants and cytotoxic effects of cola fruit extracts obtained from Indonesia and Malaysia on liver cancer cell lines. Antioxidant content of fruit extracts of cola was assessed using DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) and cytotoxic effects were studied using MTT (3 - (4,5-Dimethylthiazol-2-Yl)diphenyltetrazolium bromide -2.5) on human liver cancer cell lines (HepG2). The results showed that cola fruit from Malaysia contained high antioxidant with the IC50 value of 37.2 ?g/mL whereas IC50 of value of its Indonesia?s cola fruit was 66.0 ug / mL. The similar results have been shown in the cytotoxic test using HepG-2 liver cancer cell lines. Malaysia?s cola fruit extract has a smaller IC50 value of 6.5 ?g / mL while the fruit extract of Indonesia?s cola showed IC50 value of 39.5 ?g / mL. These values indicates that the fruit extract of cola is a potential anticancer activities especially on liver cancer. Further studies are required to clarify this hypothesis.
ANTIOXIDANT ACTIVITY AND ANTICARCINOGENIC PROPERTIES OF “SISIK NAGA”(DRYMOGLOSSUM PILOSELLOIDES PRESL.) Endrini, Susi
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.777 KB) | DOI: 10.33476/jky.v17i2.201

Abstract

The research was conducted to determine the anticarcinogenic properties of ?sisik naga?(Drymoglossum piloselloides Presl.), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependenthormone (MCF-7) cell lines. The preliminary results showed that the ?sisik naga? extract displayed the cytotoxic effects against MCF-7 with IC50 value of 83.63µg/ml. The antioxidative activity of the extracts which could contribute to their cytotoxic properties was also studied. The ?sisik naga? extract was found to have high antioxidant activity with IC50-value of 4.229 ppm. The strong cytotoxic properties of the ?sisik naga? extract could be due to its high antioxidant activity.
Co-Authors Agung Novianto, Agung Arrahmani, Betharie Cendera Asmah Rahmat Batubara, Lilian Fauziah Othman Hanna Sari Widya Kusuma, Hanna Sari Widya Irfan Syarif, Irfan J, Suherman Juniarti . Marlita, Lora Marsiati, Himmi Nafik, Said Nasution, Azlaini Yus Nunung Ainur Rahmah O, Fauziah Patimah Ismail Pratiwi, Denia R, Asmah Sri Utami Susmiarsih, T. Syamsul Arifin Taufiq-Yap, Y.H WAHYU WIDOWATI Wardaniati, Isna Y.H. Taufiq-Yap Yuhernita, Yuhernita