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All Journal Pharmaciana: Jurnal Kefarmasian Pharmascience Jurnal Surya Medika JMM (Jurnal Masyarakat Mandiri) Jurnal Peduli Masyarakat Jurnal Insan Farmasi Indonesia Borneo Journal of Pharmacy
Evi Mulyani
Universitas Muhammadiyah Palangkaraya
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Physics Public Health Other

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Journal : Pharmascience

 1 
Formulasi dan Evaluasi Gel Topikal Antibakteri Fraksi Aktif Akar Kuning (Arcangelisia flava Merr.) Evi Mulyani; Suratno Suratno; Mohammad Rizki Fadhil Pratama
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8081

Abstract

ABSTRAK Akar kuning (Arcangelisia flava Merr.) merupakan salah satu tanaman yang tumbuh di Kalimantan Tengah dan secara turun temurun digunakan sebagai pilihan pengobatan beberapa penyakit kulit dan terbukti mempunyai aktivitas antibakteri. Pembuatan sediaan topikal antibakteri berbahan fraksi aktif A. flava sangat potensial dilakukan untuk mengoptimalkan penggunaan dalam pengobatan sekaligus meningkatkan nilai ekonomis dari A. flava. Tujuan penelitian ini untuk mendapatkan formula gel fraksi aktif A. flava sebagai antibakteri yang paling baik secara fisik.Formula gel dibuat dengan variasi jenis dan konsentrasi gelling agent.Gel fraksi aktif A. flava diuji secara fisika, kimia, dan biologi seperti organoleptis, homogenitas, daya sebar, pH, daya lekat, dan daya hambat terhadap Staphylococcus aureus. Hasil formulasi sediaan gel fraksi aktif A. flava dengan basis NaCMC memenuhi syarat sifat fisik dan zona hambatan 11,6 mm pada Formula 1 dan 13,4 mm pada Formula 2, sedangkan sediaan gel dengan basis Carbophol 943 pada Formula 1 dan 2 memenuhi syarat sifat fisik dan zona hambat 10,9 mm pada Formula 2.Formula gel yang memenuhi kriteria secara fisik adalah Formula 2 dengan Carbophol 1,5% sebagai gelling agent. Kata Kunci: Akar kuning, antibakteri, gel, Staphylococcus aureus  ABSTRACT Akar kuning (Arcangelisia flava Merr.) is a plant that grows in Central Kalimantan and has been used as a treatment option for several skin diseases and has been shown to have antibacterial activity. The making of topical antibacterial preparations made from the active fraction of A. flava is very potential to be done to optimize the use in treatment while increasing the economic value of A. flava. The purpose of this study was to obtain the active A. flava fraction gel formula as the best natural antibacterial. The gel formula was made with variations in the type and concentration of the gelling agent. Arcangelisia flava Merr. active fraction gel was tested physical, chemical, and biological, such as organoleptic, homogeneity, spreadability, pH, adhesion, and bacterial inhibitionagainst Staphylococcus aureus. The results of the formulation of the active gel of A. flava based on NaCMC base fulfills physical condition requirements and shows an inhibition zone of 11.6 mmin Formula 1 and 13.4 mm in Formula 2, while gel preparation based on Carbophol 943 Formula 1 and 2 fulfill the physical characteristic requirements and show the inhibition zone of 10.9 mm in Formula 2.Gel formula that meets the physical criteria is Formula 2, with 1.5% Carbophol as a gelling agent. Keywords: Akar kuning, antibacterial, gel, Staphylococcus aureus
Rambusa (Passiflora foetida L) vs. Free Radicals: In Vitro Study with DPPH Method Dewi Sari Mulia; Evi Mulyani; Muhammad Ikhwan Rizki; Mohammad Rizki Fadhil Pratama
Jurnal Pharmascience Vol 6, No 2 (2019): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7344

Abstract

ABSTRAK             Rambusa (Passiflora foetida L) adalah tumbuhan obat yang banyak terdapat di berbagai daerah di Indonesia, termasuk di Kalimantan Tengah. Beberapa bagian tumbuhan dari rambusa diketahui memiliki aktivitas antioksidan termasuk di bagian daunnya. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari daun rambusa yang berasal dari Kalimantan Tengah. Metode yang digunakan adalah metode 2,2-diphenyl-1-picrylhydrazyl (DPPH) yang diukur serapannya dengan Spektrofotometer UV Vis. Hasil yang diperoleh menunjukkan nilai IC50 dari ekstrak etanol daun rambusa senilai 93,269 μg/mL. Meskipun nilai IC50 yang diperoleh lebih rendah dibandingkan senyawa antioksidan standar seperti kuersetin, nilai IC50 dari ekstrak etanol daun rambusa asal Kalimantan Tengah masih lebih tinggi dibandingkan daun rambusa yang diperoleh dari daerah lain Kata Kunci—antioksidan, DPPH, Kalimantan Tengah, Passiflora foetida, rambusa  ABSTRACT Rambusa (Passiflora foetida L) is a medicinal plant that is widely found in various regions in Indonesia, including in Central Kalimantan. Some parts of the plant of rambusa are known to have antioxidant activities including in the leaves. This study aims to determine the antioxidant activity of rambusa leaves from Central Kalimantan. The method used was 2,2-diphenyl-1-picrylhydrazyl (DPPH) method which was measured by UV Vis spectrophotometer. The results obtained showed IC50 values of ethanol extract of rambusa leaves worth 93.269 μg/mL. Although the IC50 values obtained were lower than the standard antioxidant compounds such as quercetin, the IC50 value of the ethanol extract of the leaves of rambusa from Central Kalimantan was still higher than that of the rambusa leaves obtained from other regions or some other medicinal plant extracts. Keywords— antioxidants, DPPH, Central Kalimantan, Passiflora foetida, rambusa
Co-Authors Ade Irawati Aditama Reyhan Agung Pribadi Ahmad Asmadi Aminuyati Asma'ul Ayuriska Sari Bersiani Bersiani Chandra Putra Dewi Sari Mulia Drenikha Sikhe R Endang Darmawan Endang Darmawan Guntur Satrio Pratomo Halida Suryadini Husna Fauzia Mohammad Rizki Fadhil Pratama Muhammad Ikhwan Rizki Muhammad Priyadi Mustofa Mustofa Nurmila Dewi Nurul Chusna Nurul Qamariah Rismadani Safitri Rizka Rahmadina Putri Suratno Suratno Suratno Suratno Susi Novaryatiin