Garuda - Garba Rujukan Digital

Phytochemistry and antifatigue activities of Carica papaya leaf from geothermal, coastal and urban areas, Indonesia Candra, Aditya; Fahrimal, Yudha; Yusni, Yusni; Azwar, Azwar; Santi, Tahara D.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.321

Fatigue, a condition of lack of energy and motivation resulting in the feeling of extreme tiredness or exhaustion, is usually prevented and treated with ergogenic aids, such as in the form of nutritional supplements. Papaya (Carica papaya) may be a potential candidate for ergogenic aids, considering its healthy secondary metabolite properties and number of metabolite compounds that could be affected by the location where the plant growing. The aim of this study was to identify the phytochemicals of papaya leaves from three different locations: geothermal, coastal, and urban areas in Aceh province, Indonesia. Concentrations of papaya leaf with the highest number of secondary metabolite compounds were tested in rats to measure blood lactate acid concentrations after strenuous exercise. The number of chemical compounds identified from the three locations was 24 compounds; 23 compounds and 17 compounds, respectively. The highest concentration of chemical compounds that have antifatigue activity contained in all papaya leaf samples were neophytadiene, linolenic acid, gamma tocopherol, hexadecanoic acid, vitamin E, carpaine, octadecatrienoic acid, nor lean-12-ene, squalene, and phytol. Furthermore, most of the compounds' highest concentrations were found in papaya leaves from the coastal area and, therefore, tested on the animal model. Treatment was provided in 12 male rats with different doses of papaya powder supplements for 15 days. The results showed that lactic acid levels of rats received a dose of 400 mg/kg of papaya leaf extract reduced the lactic acid concentration (p=0.014) compared with the control group. This study highlights that papaya leaves from the coastal area have the most potential activities as ergogenic herbal aid and were able to reduce lactic acid levels in rats after strenuous exercise.

The Use of Sour Soup (Annona murricata) Seed Powder as Acaricide on Cow and Goat Fahrimal, Yudha; Daud, Razali; Chandra, Adi; Iqbal, Syauki; Roslizawaty, Roslizawaty
Jurnal Kedokteran Hewan Vol 4, No 1 (2010): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v4i1.9797

This research was aimed to study curative effect of sour soup seed powder on cattle invested with ticks and goat infected with scabies. This study was using 12 cattle invested with ticks and 12 goats with scabies. The cattle divided into 4 groups (S1, S2, S3 and S4) while goats were divided into 3 groups (K1, K2, and K3) equally. For cattle with ticks group S1 received water (control group), while group S2, S3, and S4 received 1%, 5%, and 10% sour soup powder respectively. Ticks that fell to the ground and not engorged were collected and identified. Statistical analysis showed that all concentrations of sour soup were effective in paralyzing and or killing ticks of the genera Boophilus sp. and Dermacentor sp. but were not effective against Rhipicepalus sp. For goats with scabies, groups K1, K2, and K3 received 1, 5 and 10% sour soup powder respectively mixed with water applied to whole area of infected and uninfected skin surrounding infected area. Number of mites per cm2 before and after treatment was counted. Statistical analysis showed that 1, 5, and 10% sour soup powder effective in reducing the number of scabies mites on day 1 and 7 after treatment and were significantly different from those number of mites before treatment (P0.01). Statistical analysis also showed that no significant difference among concentration of sour soup seed powder in decreasing the number of mites (P0.05).

ANTI-TRYPANOSOMA ACTIVITY OF ETHANOLIC EXTRACT OF NEEM LEAF (Azadirachta indica) ON Trypanosoma evansi IN RATS (Rattus norvegicus) Fahrimal, Yudha; Maghfirah, Siti; Rinidar, Rinidar; Azhar, Al; Asmilia, Nuzul; Erina, Erina
Jurnal Kedokteran Hewan Vol 11, No 1 (2017): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v11i1.5450

The aim of this study was to determine the effect of neem leaf extract (Azadirachta indica) on parasitemia of rats infected with Trypanosoma evansi (T. evansi) Aceh local isolate. A total of 24 male rats aged three months were used in this study and randomly divided into six treatment groups equally. The negative control group (K0) without T. evansi infection and neem leaf extract, the positive control group (K1) was infected with T. evansi but no neem leaf extract given, group K2, K3, K4, and K5 were infected with 5x104 T. evansi and were given neem leaf extract after patent infection with dose of 50, 100, 400, and 800 mg/kg BW respectively. The extract was given orally for three consecutive days. On the fourth day, rat blood was drawn for parasitemia examination. The results showed that no T. evansi detected in rats in negative control group (K0), while parasitemia in group K1; K2; K3; K4; and K5 was 12,295 x106/mL; 10,495 x106/mL; 9,360 x106/mL; 5,080x106/mL; and 2,398x106/mL of blood, respectively. Percentage of inhibition of parasitemia in K2, K3, K4, and K5 reached 14.64, 23.78, 58.68, and 80.50%, respectively. Based on the result of the study, neem leaf extract of 800 mg/kg BW gave the highest reduction of parasitemia in rats infected with T. evansi.

PROFIL DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINFEKSIKAN Trypanosoma evansi DAN DIBERIKAN EKSTRAK KULIT BATANG JALOH (Salix tetrasperma Roxb) Fahrimal, Yudha; E, Eliawardani; Rafina, Afira; Azhar, Al; Asmilia, Nuzul
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2654

Penelitian ini bertujuan mengetahui gambaran darah (hematokrit, eritrosit, leukosit, dan diferensial leukosit) tikus yang diinfeksi Trypanosoma evansi (T. evansi) dan diberi ekstrak kulit batang jaloh (Salix tetrasperma Roxb). Duapuluh lima ekor tikus jantan dibagi secara acak ke dalam 5 kelompok perlakuan yang masing-masing terdiri atas 5 ekor tikus. Kelompok 0 (K0) tanpa perlakuan, kelompok I (K1) hanya diinfeksikan dengan 103 T. evansi, kelompok II (K2) diinfeksikan dengan 103T. evansi dan diberikan ekstrak kulit batang jaloh 30 mg/kg bobot badan, kelompok III (K3) diinfeksikan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 45 mg/kg bobot badan, dan kelompok IV (K4) diinfeksi dengan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 60 mg/kg bobot badan. Infeksi T. evansi dilakukan secara intraperitoneal sedangkan ekstrak diberikan secara oral selama 3 hari berturut-turut. Hasil penelitian menunjukkan bahwa rata-rata SD nilai hematokrit dan eritrosit tikus dari K1, K2, K3 dan K4 lebih rendah dari K0. Sebaliknya, rata-rata SD jumlah leukosit (103/l) lebih tinggi dari K0. Diferensial leukosit menunjukkan jumlah masing-masing sel leukosit semua tikus dalam kelompok perlakuan meningkat setelah pemberian ekstrak kulit batang jaloh kecuali eosinofil dan limfosit yang justru menurun. Dari penelitian dapat disimpulkan bahwa Infeksi T. evansi menurunkan kadar hematokrit dan eritrosit namun meningkatkan kadar leukosit tikus dan pemberian ekstrak kulit batang jaloh dosis rendah dalam waktu yang singkat mampu mengembalikan profil darah tikus mendekati nilai normal.

PROFIL DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINFEKSIKAN Trypanosoma evansi DAN DIBERIKAN EKSTRAK KULIT BATANG JALOH (Salix tetrasperma Roxb) Fahrimal, Yudha; E, Eliawardani; Rafina, Afira; Azhar, Al; Asmilia, Nuzul
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2653

Penelitian ini bertujuan mengetahui gambaran darah (hematokrit, eritrosit, leukosit, dan diferensial leukosit) tikus yang diinfeksi Trypanosoma evansi (T. evansi) dan diberi ekstrak kulit batang jaloh (Salix tetrasperma Roxb). Duapuluh lima ekor tikus jantan dibagi secara acak ke dalam 5 kelompok perlakuan yang masing-masing terdiri atas 5 ekor tikus. Kelompok 0 (K0) tanpa perlakuan, kelompok I (K1) hanya diinfeksikan dengan 103 T. evansi, kelompok II (K2) diinfeksikan dengan 103T. evansi dan diberikan ekstrak kulit batang jaloh 30 mg/kg bobot badan, kelompok III (K3) diinfeksikan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 45 mg/kg bobot badan, dan kelompok IV (K4) diinfeksi dengan 103 T. evansi dan diberikan ekstrak kulit batang jaloh 60 mg/kg bobot badan. Infeksi T. evansi dilakukan secara intraperitoneal sedangkan ekstrak diberikan secara oral selama 3 hari berturut-turut. Hasil penelitian menunjukkan bahwa rata-rata SD nilai hematokrit dan eritrosit tikus dari K1, K2, K3 dan K4 lebih rendah dari K0. Sebaliknya, rata-rata SD jumlah leukosit (103/l) lebih tinggi dari K0. Diferensial leukosit menunjukkan jumlah masing-masing sel leukosit semua tikus dalam kelompok perlakuan meningkat setelah pemberian ekstrak kulit batang jaloh kecuali eosinofil dan limfosit yang justru menurun. Dari penelitian dapat disimpulkan bahwa Infeksi T. evansi menurunkan kadar hematokrit dan eritrosit namun meningkatkan kadar leukosit tikus dan pemberian ekstrak kulit batang jaloh dosis rendah dalam waktu yang singkat mampu mengembalikan profil darah tikus mendekati nilai normal.

IDENTIFIKASI LEUKOSIT POLYMORPHONUCLEAR (PMN) DALAM DARAH SAPI ENDOMETRITIS YANG DITERAPI DENGAN GENTAMISIN, FLUMEQUIN, DAN ANALOG PGF2 Melia, Juli; a, Amrozi; Tumbelaka, Ligaya Ita; Fahrimal, Yudha
Jurnal Kedokteran Hewan Vol 6, No 2 (2012): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v6i2.342

Penelitian ini bertujuan mengetahui persentase leukosit polymorphonuclear (PMN) dalam preparat ulas darah sapi endometritis. Enam ekor sapi endometritis dibagi dalam dua kelompok perlakuan. Kelompok I (n=3) diterapi dengan 250 mg gentamisin/ekor, 250 mg flumequin/ekor, dan PGF2 sebanyak 12,5 mg/ekor secara intra uteri. Kelompok II (n=3) diterapi dengan menggunakan antibiotik dengan dosis dan cara pemberian yang sama seperti pada Kelompok I. Hasil penghitungan leukosit diferensial sebelum terapi menunjukkan persentase jumlah limfosit yang lebih tinggi dibandingkan bentuk leukosit lainnya pada Kelompok I dan II masing-masing adalah 62,501,17 dan 63,662,35, sedangkan persentase jumlah neutrofil pada Kelompok I dan II masing-masing adalah 29,330,94 dan 27,330,94. Setelah terapi, tidak ada perbedaan persentase (P0,05) bentuk leukosit antara kedua kelompok perlakuan. Terapi kombinasi antibiotik dan PGF2 pada sapi penderita endometritis tidak menghasilkan perubahan diferensial leukosit termasuk PMN.

GAMBARAN KLINIS SAPI PIOMETRA SEBELUM DAN SETELAH TERAPI DENGAN ANTIBIOTIK DAN PROSTAGLANDIN SECARA INTRA UTERI Sayuti, Arman; Melia, Juli; a, Amrozi; s, Syafruddin; r, Roslizawaty; Fahrimal, Yudha
Jurnal Kedokteran Hewan Vol 6, No 2 (2012): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v6i2.310

Penelitian ini bertujuan mengetahui gambaran klinis sapi pyometra sebelum dan setelah diterapi dengan antibiotik dan prostaglandin. Dalampenelitian ini digunakan enam ekor sapi betina yang didiagnosis menderita piometra berdasarkan pemeriksaan secara klinis dan ultrasonografi pada organ reproduksi. Sapi tersebut dibagi ke dalam dua kelompok perlakuan, masing-masing 3 ekor sapi untuk tiap kelompok. Kelompok I diterapi dengan 5 ml antibiotik (gentamicine, flumequine) ditambah 15 ml NaCl fisiologis dan PGF2 (Luprostiol) 12,5 mg secara intra uteri,sedangkan kelompok II diterapi hanya dengan menggunakan antibiotik. Hasil penelitian menunjukkan pada sapi yang didiagnosis piometra ditemukan adanya cairan yang penuh mengisi uterus (100%), korpus luteum persisten pada salah satu ovarium (100%), discharge di sekitar ekor, perineum, dan vulva yang berwarna kuning (50%), krem (33,3%), dan hijau keabu-abuan (16,6%). Sapi yang diterapi dengan antibiotik dan PGF2 menyebabkan pengeluaran leleran yang lebih cepat dan lebih banyak dibandingkan sapi yang diterapi hanya dengan antibiotik.

Gastrointestinal Parasites in Birds at Taman Rusa, Aceh Besar Sari, Rahmah; Dwitama, Fajri; Fahrimal, Yudha; Daud, Razali; Riandi, Lian V.; Hasan, M.; Helmi, Teuku Z.
Aceh Journal of Animal Science Vol 10, No 3 (2025): December 2025
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13170/ajas.10.3.47533

Captive animals are not immune to infectious diseases, including parasitic infections that can be fatal. Prolonged periods of captivity can increase the likelihood of transmission between animals and humans. This study was conducted to identify and document the parasites that infect birds housed at Taman Rusa in the Aceh Besar District. The collected fecal samples were placed in labeled sample bottles containing formalin and stored in ice boxes. Fecal samples were collected, preserved in 10% formalin, and examined using flotation, sedimentation, formol-ether, and modified Ziehl-Neelsen techniques. The data obtained from the examination of the fecal samples were tabulated and descriptively analyzed. The results of fecal sample examinations carried out on 60 birds (representing 28 species) indicated that 39 birds (19 species) were infected with parasites. The nematode class included Heterakis sp. (3.33%), Capillaria sp. (13.3%), Trichuris sp. (6.67%), and Strongyloides sp. (8.3%). The cestode class included Hymenolepis sp. (10%), while the trematode class included Neodiplostomum sp. (1.67%). Additionally, the class Conoidasida protozoa included Eimeria sp. (33.3%) and Isospora sp. (1.67%). The highest prevalence of helminth infection was observed in Capillaria sp. infection (13.3%), while Eimeria sp. exhibited the highest prevalence of protozoan infection (35%). The findings deliver valuable guidance for veterinary health management, disease surveillance, and biosecurity strategies in avian conservation facilities. The identification of parasites with established pathogenic and zoonotic potential, including Strongyloides sp. and Capillaria sp., highlights the significance of these results for both avian health and potential public health risks.

Title

Found 8 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 8 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 8 Documents
Search