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All Journal Jurnal Sain Veteriner Jurnal Medik Veteriner Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Asian Journal of Social and Humanities Jurnal Medika Veterinaria
Nuzul Asmilia
Laboratorium Klinik Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Veterinary

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Toxicity Test of Flavonoid Compounds from Ethyl Acetate Extract of Malacca Leaves with Brine Shrimp Lethality Test Zakwan, Muhammad; Sutriana, Amalia; Nurliana, Nurliana; Asmilia, Nuzul; Ammar, Muhammad; Novianti, Arindita Niatazya
Jurnal Medik Veteriner Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Scien
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss3.2023.15-19

Abstract

Flavonoids are a group of polyphenolic compounds produced in plants as secondary metabolites. Flavonoids have favorable biochemical effects on multiple diseases and other bioactivities. This study aimed to isolate the active compounds contained in malacca (Phyllanthus emblica) leaves and analyze toxic properties using the Brine Shrimp Lethality Test (BSLT) method in Artemia salina leach shrimp larvae. This study used malacca leaf powder with ethyl acetate solvent then macerated. Ethyl acetate extract was concentrated and fractionated, then toxicity tests were carried out. Extracts from the evaporation results were further fractionated using solvent petroleum ether, diethyl ether, and ethyl acetate. Then the ethyl acetate fraction was hydrolyzed using reflagged with 7% sulfuric acid for two hours, then the filtrate was extracted with ethanol solvent. The obtained fraction washed with aquades and dried using a vacuum desiccator. The toxicity test results showed that the flavonoid compound of malacca leaves was not toxic with a value of LC50 > 1000 ppm, an increase in the concentration of the extract was followed by an increase in the average mortality of larvae.
Effect of Ethyl Acetate Extract of Malacca Leaf (Phyllanthus emblica) on the Growth of Plasmodium falciparum in Vitro Sir, Habibah Annum; Asmilia, Nuzul; Armansyah TR, T.
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.42732

Abstract

This study aimed to determine the antiplasmodium activity of ethyl acetate extract of malacca leaf (Phyllanthus emblica L.) on Plasmodium falciparum in vitro. In this study, five treatment groups with extract dosage of 100, 75, 50, 25, and 5 g / ml were used. For positive control, antimalarial drug artesdiaquine was given. Plasmodium culture used the candle-jar method and the antiplasmodium activity test was carried out by microculture method in vitro. This research used a complete randomized design (RAL), data was analyzed using analysis of variance (ANOVA) and continued with Duncan's tests. The inhibition concentration (IC50) of malacca leaf extract was analyzed using PROBIT SPSS. Antiplasmodium activity was expressed by IC50 value which is the ability to inhibit 50% of Plasmodium growth. The results showed that the IC50 value of the extract was 17,849 g/ml. It can be concluded that the ethyl acetate extract of malacca leaf had good activity as antiplasmodium and the best concentration was 25 g / ml.
Potential Anticholesterol Infusion of Malaca Leaf (Phyllanthus Emblica) In Mice (Mus Musculus) Hypercholesterolemia Silvana, Sartika; Asmilia, Nuzul; TR, T. Armansyah; Rasmaidar, Rasmaidar; Isa, M
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.86890

Abstract

The aim of this research was to find out infusion test of malaka leaves (Phyllantus emblica) to mice (Mus musculus) blood cholesterol rate which hypercholesterolemic mice. Twenty male mice with the age of 3 month and clinically healthy were used in this research. All mice were randomly divided into 4 treatment groups, 5 mice each. K1 was negative control group. K2 was positif control group, fed with hypercholesterolemic feed. K3 and K4 group were fed with hypercholesterolemic feed and infusion of malaka leaves with the doses of 0,04 and 0,08 mg body weight respectively. The result of statistic analysis showed that infusion of malaka leaves significantly effect (P<0,01) on the decrease of cholesterol level of male mice inducedby hypercholesterolemic feed. The treatment of infusion of malaka leaves 0,04 mg and 0,08 mg was able to decrease the cholesterol level ofmice induced by hypercholesterolemic feed. The advance test showed that the treatment K1 significantly effect (P<0,01) compare to K2 and K3. The K2 treatment significantly effect (P<0,01) with K1, K3, and K4. The K3 treatment showed no significanly effect compare to K4 (P<0,05). In conclusion, the administration of infusion of malaka leaves with the dose of 0,04 and 0,08 mg reduce cholesterol level.
INHIBITORY POWER TEST OF N-HEXANE EXTRACT OF MALAKA LEAVES (Phyllanthus emblica) ON GROWTH Microsporum canisIN-VITRO Miranda, Lola Almira; Asmilia, Nuzul; Fakhrurrazi, Fakhrurrazi; Rusli, Rusli; Amiruddin, Amiruddin; Jalaluddin, M.
The International Journal of Tropical Veterinary and Biomedical Research Vol 10, No 1 (2025): Vol 10 (1) May 2025
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v10i1.48192

Abstract

Background and Aim: Malacca leaves are one of the medical plants that can be used in traditional medicine. Malacca leaves contain several active compounds that can be effective in inhibiting fungal growth. This study aims to investigate the inhibition of n-hexane Malacca leaves extract on Microsporum canis growth in vitro.Materials and Methods: The method used in this study is Kirby-Bauer disc diffusion with 5 treatments, namely P1 (25% Malacca leaves n-hexane extract), P2 (50% Malacca leaves n-hexane extract), P3 (75% Malacca leaves n-hexane extract), P4 (control (+): ketoconazole) and P5 (control (-): carboxymethylcellulose (CMC) 1%) with 3 replications. The clear zone formed around the disc was measured using a caliper.Results : The results showed that there was no clear zone formed around the disks of the n-hexane extract of Malacca leaves. It can be concluded that the n-hexane extract of Malacca leaves could not inhibit the growth of Microsporum canis.Conclusion: The findings of this study indicate that the n-hexane extract of Malacca leaves, at concentrations of 25%, 50%, and 75%, does not exhibit antifungal activity against Microsporum canis in vitro, as evidenced by the absence of inhibition zones. Therefore, n-hexane may not be an effective solvent for extracting antifungal compounds from Malacca leaves against this fungal species.
Histopathologic Features of Trachea and Lungs in Chickens with Chronic Respiratory Disease Annisa, Aiza; Darmawi, Darmawi; Etriwati, Etriwati; Balqis, Ummu; Salim, M. Nur; Nazaruddin, Nazaruddin; Aliza, Dwinna; Aisyah, Siti; Awaluddin, Awaluddin; Hasan, Denny Irmawati; Akmal, Muslim; Helmi, T. Zahrial; Asmilia, Nuzul
Jurnal Medika Veterinaria Vol 18, No 1 (2024): J.Med.Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i1.37429

Abstract

The purpose of this case study is to determine the changes that exist in chickens infected with Chronic Respiratory disease (CRD). A broiler male chicken aged 40 days was found dead in a chicken basket at Ulee Kareng chicken slaughterhouse in a state of feather loss and feces attached to cloaca, on January 6th, 2023. The chicken was brought to pathology laboratory of Faculty of Veterinary Medicine, Universitas Syiah Kuala for necropsy and organ collection. Organs associated with CRD cases were trachea and lungs and histopathological preparations were carried out, stained with Haematoxylin Eosin, and observed under a microscope. The results of histopathological examination showed hemorrhage and hyperplasia of the tracheal epithelium. Hemorrhage was caused by edema which causes increased vascular permeability and epithelial cell hyperplasia occured due to the body's response to infection or inflammation. In the lungs there was bleeding due to damage to the blood vessel wall which caused increased vascular permeability, so that fluid and blood plasma come out of the blood vessels. Fibrinogen then underwent polymerization which resulted in fibrinous thrombi. Congestion happened as the result of fluid accumulation in a location that occured in a passive process so the fluid failed to escape. Because of the accumulation of fluid (congestion), the blood supply to the lung tissue is interrupted, resulting in several points of necrosis in the lungs.
Total Plate Numbers and Coliforms in The Processing of Milkfish Without Spines (Chanos Chanos) in Household Indusrty in Banda Aceh Nurliana, Nurliana; Aftari, Nailul; Sutriana, Amalia; Asmilia, Nuzul; Sari, Wahyu Eka
Jurnal Medika Veterinaria Vol 17, No 2 (2023): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v17i2.34843

Abstract

Microbial contamination of fish has the potential to cause product quality degradation and cause fishborne disease. Microbial contamination can occur at any stage of fish processing. This study aimed to determine the total plate count and coliform at each stage process of milkfish (Chanos chanos) boneless. Milkfishes were obtained from three processing stage, namely raw material (fresh fish) stage, the fish bone removal stage and the baking fish stage. The parameters observed were the number of colonies growing as total plate count and coliform as the most probable number (MPN). The results showed that the highest ALT contamination was found at the bone removal stage with an average of 1.7x104 CFU/g but this figure did not exceed the standard limit and the lowest was at the firing stage with an average of 1.2x103 CFU/g. The highest coliform was found in the fresh fish stage, namely 129 MPN/g and the lowest was 3 MPN/g. From this research, it can be concluded that the total microbial plate number does not exceed the SNI 7288: 2009 standard and the coliform exceed the SNI 7388: 2009 standard.
THE EFFECT OF AEROB AND ANAEROBIC CONDITION AND ADDITION OF CaCO3 ON THE GROWTH AND ANTIBACTERIAL ACTIVITY OF LACTIC ACID BACTERIA ISOLATED FROM LAYER HENS INTESTINE AFTER ADMINISTRATED OF AKBISprob Nurliana, Nurliana; Khairunisa, Fauzia; Musni, Nailah; Vanda, Henni; Rasmaidar, Rasmaidar; Hasan, Muhammad; Asmilia, Nuzul; Sari, Wahyu Eka; Isa, Muhammad
Jurnal Kedokteran Hewan Vol 17, No 3 (2023): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i3.20309

Abstract

This study aimed to determine the effect of aerobic and anaerobic incubation, and the addition of CaCO on the growth and antibacterial activity of Lactic Acid Bacteria (LAB) isolated from laying hens intestines (strain ISA Brown) after given 4% AKBISprob. The LAB used in this study was the isolates strains that produced the strongest antibacterial activity with inhibition zone 5 mm. The treatments consisted of two incubations condition (aerobic and anaerobic) with five concentrations of CaCO3 (1%, 2%, 3%, 4%, and 5%). Each treatment consisted of three repetitions. Total Plate Count (TPC) method and the agar diffusion method were used to calculate the amount of LAB and antibacterial activity, respectively. The results showed that anaerobic conditions had a significant effect (P0.05) on the increase of LAB growth, but both of aerobic and anaerobic conditions (P0.05) did not show significant effect on antibacterial activity. The addition of CaCO3 had a significant effect (P0.05) on the increase in growth and antibacterial activity of LAB. Based on the results of the study, it can be concluded that anaerobic incubation can increase the growth of two isolate of LAB isolates (P31S72 and P31H62), however aerobic and anaerobic incubation have no effect on antibacterial activity. In addition, the administration of 3% CaCO3 can increase the growth and antibacterial activity of all LAB isolates.
THE EFFECT OF WHOLE SEED (Barringtonia racemosa) WATER EXTRACT ON ERYTHROCYTE, HEMOGLOBIN AND HEMATOCRITE COUNT OF WHITE RAT (Rattus norvegicus) EXPOSED TO CIGARETTE SMOKE Dasrul, D; Aliya, Yayang Nuri Al; Sutriana, Amalia; Asmilia, Nuzul; Daud, Razali
Jurnal Kedokteran Hewan Vol 17, No 2 (2023): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i2.25424

Abstract

This study aims to determine the effect of Barringtonia racemosa seed extract on the number of erythrocytes, hemoglobin levels, and the percentage of hematocrit in white rats (Rattus norvegicus) exposed to cigarette smoke. A total of 25 white rats Wistar strain, aged 3-4 months, male, weighing 180-200 g, were randomly divided into 5 treatment groups, each group consisting of 5 rats. Positive control group (KP) without exposure to cigarette smoke and without administration of Barringtonia racemosa seed extract, negative control group (KN) exposed to cigarette smoke without administration of Barringtonia racemosa seed extract. Treatment groups P1, P2, P3 were exposed to cigarette smoke and given Barringtonia racemosa seeds with doses of 50, 100, and 150 mg/kg BW/day, respectively. The extract was administered orally for 30 days. Blood collection in all groups was carried out via the orbital vein using a hematocrit pipette after the rats had been sedated with 0.2 mL of ketamine. Erythrocyte, hemoglobin, and hematocrit values were calculated using a hematology analyzer. Data were analyzed using one-way pattern analysis of variance (ANOVA). The results showed that giving Barringtonia racemosa seeds at doses of 50, 100 and 150 mg/kg/day had a significant effect (P0.05) in increasing the values of erythrocytes, hemoglobin, and hematocrit of white rats exposed to cigarette smoke compared to the control group which was not given the extract. In conclusion, the administration of Barringtonia racemosa seed extract can increase the number of erythrocytes, hemoglobin levels, and the percentage of hematocrit exposed to cigarette smoke.
EFFECT OF ETHANOL EXTRACT FROM MALACCA LEAVES (Phyllanthus emblica) ON THE SPERM QUALITY OF MICE Thasmi, Cut Nila; Asmilia, Nuzul; Suryani, Elfi Satria; Hafizuddin, Hafizuddin; Adam, Mulyadi; Sayuti, Arman; Nazaruddin, Nazaruddin; Panjaitan, Budianto
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.27246

Abstract

This study aims to analyze the effect of administering Malacca leaves (Phyllanthus emblica) extract on the sperm quality of mice. This leaf extract was administered orally using gavage method once daily for 21 days. There were four treatment groups: the control group (P0) received distilled water while the first (P1), second (P2), and third (P3) treatment groups received 300 mg, 600 mg, and 1200 mg of Malacca leaf ethanol extract/kg body weight, respectively. Each groups consisted of four mice and was evaluated for sperrm motility, viability, morphology, and concentration. The results showed that sperm motility, viability, morphology and sperm concentration tended to decrease after administration of Malacca leaf ethanol extract for all parameters, although there was no significant difference (P0.05). It was concluded that the administration of Malacca leaf ethanol extract tends to reduce the sperm quality of mice. ___________________________________________________________
DETERMINATION OF THE BEST ROSELLA (Hibiscus sabdarifa L.) FILTRATE CONCENTRATION IN EGG YOLK CITRATE DILUENT Sayuti, Arman; Mayuri, Herdina; Asmilia, Nuzul; Arifin, Tazul; Adam, Mulyadi
Jurnal Kedokteran Hewan Vol 15, No 4 (2021): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i4.22398

Abstract

The aim of this research was to determine if the substitution of rosella filtrate (Hibiscus sabdarifa L.) in citrate-based diluent and egg yolks with the ratio 4:1 (16 mL citrate + 4 mL yolk) would help maintain the progressive motility of Kacang goat spermatozoa at room temperature. This study used a male Kacang goat with an average sperm quality of approximately 205 x 107 spermatozoa/mL and motility of 81.6%. An electro-ejaculator was used once a week to collect the semen. The treatments were labelled as follows: P0 was the negative control group, treatment P1 was given 5% rosella filtrate, treatment P2 was given 10% rosella filtrate, and treatment P3 was given 15% rosella filtrate. Examination of the motility of the spermatozoa was carried out at room temperature. The examination was carried out once every four hours. It was concluded that the rosella filtrate could maintain the progressive motility of spermatozoa of the Kacang goat at optimal concentrations. The optimal motility percentage was found at a concentration of 15% at a storage life of 0-4 hours.
Co-Authors - Fakhrurrazi Afira Rafina, Afira Aftari, Nailul Al Azhar Aliya, Yayang Nuri Al Amalia Sutriana Amiruddin Amiruddin Amiruddin Amiruddin Anita Esfandiari Annisa, Aiza Arifin, Tazul Arman Sayuti Armansyah TR, T. Awaluddin Awaluddin budianto panjaitan Cut Dahlia Iskandar Cut Nila Thasmi, Cut Nila Darmawi . Dasrul, D Daulay, Lingga Surya Maret Dwinna Aliza Eliawardani E, Eliawardani Erdiansyah Rahmi Erina Erina Etriwati E Febrianto, Niko Gholib G, Gholib Hafizuddin Hafizuddin Hamdan Hamdan Hamny H, Hamny Hasan, Denny Irmawati Helmi, T. Zahrial Henni Vanda IETJE WIENTARSIH Indriany, Sudi Isa, M Joharsyah J, Joharsyah Juli Melia Khairunisa, Fauzia Lina Noviyanti Sutardi M. Jalaluddin, M. M. Nur Salim Maghfirah, Siti Maret Daulay, Lingga Surya Mayuri, Herdina Miranda, Lola Almira Muhammad Ammar Muhammad Hambal Muhammad Hasan Muhammad Isa Mulyadi Adam, Mulyadi Muslim Akmal Musni, Nailah N. Nazaruddin Novianti, Arindita Niatazya NURLIANA NURLIANA R. Rusli Rasmaidar Rasmaidar Razali Daud Rinidar R, Rinidar Rinidar Rinidar, Rinidar Roslizawaty r Rosmaidar Rosmaidar, Rosmaidar Sari, Wahyu Eka Silvana, Sartika Sir, Habibah Annum Siti Aisyah Sri Wahyuni Sugito - Sugito Sugito Suriadi S, Suriadi Suryani, Elfi Satria Syafruddin s T. Armansyah Tongku Nizwan Siregar TR, T Armansyah Ummu Balqis Yudha Fahrimal Zainuddin Z Zakwan, Muhammad