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All Journal Indonesian Journal of Pharmaceutical Science and Technology Padjadjaran Journal of Dentistry Cakradonya Dental Journal Malacca Pharmaceutics
Sri Fitriyani
Department of Dental Materials, Faculty of Dentistry, Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Studi Pelepasan Monomer Sisa Dari Resin Akrilik Heat Cured Setelah Perendaman Dalam Akuades Diansari, Viona; Fitriyani, Sri; Haridhi, Fazliyanda Maria
Cakradonya Dental Journal Vol 10, No 1 (2018): Februari 2018
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v10i1.10466

Abstract

Resin akrilik heat cured merupakan campuran monomer metil metakrilat dan polimer polimetil metakrilat yang dipolimerisasi dengan cara pemanasan. Proses polimerisasi tidak sempurna dan menghasilkan monomer sisa. Kandungan monomer sisa yang tinggi dapat menyebabkan iritasi atau alergi terhadap jaringan rongga mulut. Pengurangan jumlah monomer sisa dapat dilakukan dengan perendaman resin akrilik heat cured dalam akuades. Penelitian ini bertujuan untuk mengetahui pengaruh durasi perendaman resin akrilik heat cured dalam akuades terhadap pelepasan monomer sisa. Penelitian ini menggunakan resin akrilik QC-20 berbentuk disk (ukuran d = 50 mm, t = 3 mm) sebanyak 10 spesimen direndam dalam akuades dengan durasi 1, 2, 3, 4, 5, 6, 7, dan 8 hari pada suhu 37C. Perendaman setiap 24 jam dilakukan pergantian akuades (tiap perlakuan menggunakanspesimen yang sama). Pengukuran jumlah monomer sisa dilakukan setiap 24 jam menggunakan alat Spektrofotometer UV-VIS. Perhitungan jumlah monomer sisa dalam bentuk konsentrasi menggunakan persamaan garis lurus y = 9.2543x - 0.0027. Persamaan garis lurus didapat dari kurva absorban dan konsentrasi larutan standar metil metakrilat 0.1%, 0.075%, 0.050%, 0.025%, dan 0.010%. Analisis statistik data hasil penelitian dilakukan dengan uji Friedman dan uji lanjut Wilcoxon (p0.05). Hasil uji Friedman menunjukkan bahwa terdapat perbedaan bermakna (p=0.000) antara durasi perendaman terhadap jumlah monomer sisa. Hasil uji lanjut Wilcoxon menunjukkan bahwa terdapat perbedaan bermakna pada perendaman resin akrilik selama 24 jam (hari ke-1) dibandingkan dengan hari berikutnya (perendaman hari ke-1 melepaskan monomer sisa dengan jumlah tertinggi). Perendaman antara hari ke-6, 7, dan 8 terdapat perbedaan yang tidak bermakna (uji Wilcoxon p0.05). Dapat disimpulkan bahwa terdapat pengaruh durasi perendaman resin akrilik heat cured dalam akuades terhadap pelepasan jumlah monomer sisa.
Effect on color stability and surface roughness of nanofiller dental composite after soaking in Bidara leaf (Ziziphus mauritiana Lam) ethanol extract: an experimental study fitriyani, Sri; Nazilla, Cut Syahla; sundari, Iin; Diansari, Viona; Subhaini, Subhaini; Ningsih, Diana Setya; Rahmayani, Liana; Qamaruzzaman, Jasmina Binti
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.61351

Abstract

Introduction: Dental composite resins offer aesthetic appeal and high wear resistance; however, their physical properties may diminish after exposure to colored foods or mouthwashes. We explore Bidara leaf (Ziziphus mauritiana Lam) extract as an alternative mouthwash due to its rich content of bioactive compounds. The study aims to analyze the color change and surface roughness of nanofiller composite resins after immersion in Bidara leaf ethanol extract. Methods: This research was an experimental study. The resin composite samples were divided into four groups; each group consisted of 3 specimens (n=3): Group 1 (negative control) immersed in distilled water; Group 2 (positive control) immersed in 0.2% chlorhexidine; and Groups 3 and 4 soaked in 4.5% and 20% ethanol extracts of Bidara leaf, respectively. The specimens were cylindrical with a diameter of 10 mm and a thickness of 2 mm. All specimens were the same size, shape, and color, with flat surfaces and no cracks or stains. Samples were immersed for two minutes daily over one month. Color changes were analyzed using a stereomicroscope and the CIELab color system with Adobe Photoshop, while surface roughness was assessed using atomic force microscopy (AFM). Results: Color changes show ΔE>3.3 indicating a visible difference. The most significant color change occurrs in Group 4, followed by Groups 3, 2, and 1. One-way ANOVA shows a statistically significant color change (p<0.05). Surface roughness also increases, with Group 4 (0.138±0.066 μm) displaying the greatest roughness compared to Group 3 (0.122±0.061 μm), Group 2 (0.122±0.076 μm), and Group 1 (0.054±0.012 μm).  Based on the one-way ANOVA test, the results show no significant differences (p>0.05) between the pre- and post-immersion. Conclusion: Although changes in surface roughness were not statistically significant, the ethanol extract of Bidara leaf influences the color and surface roughness of the nanofiller dental composite.
A Systematic Review on the Transformation of Bone Waste into Valuable Dental Biomaterials Diansari, Viona; Idroes, Rinaldi; Sunarso, Sunarso; Fitriyani, Sri
Malacca Pharmaceutics Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v4i1.385

Abstract

Bone waste is a sustainable, calcium-rich resource for the production of hydroxyapatite (HA), a biomaterial widely used in dental and bone tissue engineering. This systematic review evaluates recent advances in the extraction, transformation, and biological performance of HA derived from bone waste. A total of 20 records were initially identified, of which 11 full-text articles met the eligibility criteria and were included in the qualitative synthesis. The reviewed studies demonstrate that bone waste can be effectively converted into HA through several routes, including thermal-based extraction (calcination, annealing, and sintering at 600–1000°C), alkaline hydrolysis, and hydrothermal or microwave-assisted methods, enabling the production of micro- and nano-sized HA with high purity. Post-extraction functionalization, such as ion doping (Mg²⁺, Na⁺, Co²⁺), drug loading, and composite formation, further enhances osteogenic, antimicrobial, and mechanical properties. Physicochemical characterization using XRD and FTIR consistently confirmed the formation of non-stoichiometric, ion-substituted HA with Ca/P ratios ranging from 1.6 to 1.9, closely resembling biogenic apatite. The presence of multiscale porosity (25–65%) and nano-scale features promotes protein adsorption, ion exchange, and cellular interactions. In vitro studies confirmed cytocompatibility, while ALP activity and mineralization assays demonstrated strong osteogenic potential. Overall, bone waste–derived HA offers biomimetic, functional, and environmentally sustainable alternatives for dental and maxillofacial applications.
Effects of Mesenchymal Stem Cell Secretome on Cardiac Histopathological Changes in Doxorubicin-Induced Rats Putri, Liza Aulia; Syahrizal, Dedy; Husna, Fauzul; Ridwan, Muhammad; Fitriyani, Sri
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69258

Abstract

Doxorubicin is an anthracycline chemotherapeutic agent widely used in clinical practice, but its application is limited by cardiotoxicity that damages myocardial structure and function. Mesenchymal stem cell secretome contains diverse bioactive molecules, including cytokines, growth factors, and extracellular vesicles, which contribute to tissue protection and cellular repair. This study aimed to evaluate the preventive and curative effects of secretome administration on histopathological changes in the hearts of doxorubicin-induced rats. Twenty-four rats were divided into four groups: without treatment (KS), cardiotoxicity group (KK), preventive secretome (P1), and curative secretome (P2). Histopathological assessment included degeneration, inflammatory infiltration, congestion, and necrosis using semi-quantitative scoring. Results showed no significant differences in degeneration, inflammatory infiltration, or congestion among groups. In contrast, necrosis scores differed significantly (p = 0.002), with the highest values observed in the KK group. Secretome administration in the P2 group demonstrated the most pronounced improvement, reflected by a greater reduction in necrosis scores compared to other groups. In conclusion, curative-phase secretome treatment provided the most effective histological improvement by reducing myocardial necrosis, indicating a stronger tissue repair response than preventive administration.
Co-Authors Dedy Syahrizal Diana Setya Ningsih, Diana Setya Haridhi, Fazliyanda Maria Husna, Fauzul Iin Sundari Liana Rahmayani Muhammad Ridwan Nazilla, Cut Syahla Poppy Andriany Putri, Liza Aulia Qamaruzzaman, Jasmina Binti Rinaldi Idroes Rizki Dumna, Rizki Subhaini, Subhaini Sunarso Sunarso Viona Diansari