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All Journal Dentika Dental Journal Indonesian Journal of Pharmaceutical Science and Technology Padjadjaran Journal of Dentistry Cakradonya Dental Journal Malacca Pharmaceutics Jurnal of Syiah Kuala Dentistry Society
Sri Fitriyani
Department Of Dental Materials, Faculty Of Dentistry, Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effects of Mesenchymal Stem Cell Secretome on Cardiac Histopathological Changes in Doxorubicin-Induced Rats Putri, Liza Aulia; Syahrizal, Dedy; Husna, Fauzul; Ridwan, Muhammad; Fitriyani, Sri
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69258

Abstract

Doxorubicin is an anthracycline chemotherapeutic agent widely used in clinical practice, but its application is limited by cardiotoxicity that damages myocardial structure and function. Mesenchymal stem cell secretome contains diverse bioactive molecules, including cytokines, growth factors, and extracellular vesicles, which contribute to tissue protection and cellular repair. This study aimed to evaluate the preventive and curative effects of secretome administration on histopathological changes in the hearts of doxorubicin-induced rats. Twenty-four rats were divided into four groups: without treatment (KS), cardiotoxicity group (KK), preventive secretome (P1), and curative secretome (P2). Histopathological assessment included degeneration, inflammatory infiltration, congestion, and necrosis using semi-quantitative scoring. Results showed no significant differences in degeneration, inflammatory infiltration, or congestion among groups. In contrast, necrosis scores differed significantly (p = 0.002), with the highest values observed in the KK group. Secretome administration in the P2 group demonstrated the most pronounced improvement, reflected by a greater reduction in necrosis scores compared to other groups. In conclusion, curative-phase secretome treatment provided the most effective histological improvement by reducing myocardial necrosis, indicating a stronger tissue repair response than preventive administration.
Co-Authors Aldita Dwy Gustya Dedy Syahrizal Diana Setya Ningsih Diana Setya Ningsih, Diana Setya Fazliyanda Maria Haridhi Haridhi, Fazliyanda Maria Husna, Fauzul Iin Sundari Iin Sundari Intan Yumanita Liana Rahmayani Liana Rahmayani Muhammad Kahlil GIBRAN Muhammad Ridwan Nazilla, Cut Syahla Poppy Andriany Poppy Andriany Putri, Liza Aulia Qamaruzzaman, Jasmina Binti Rinaldi Idroes Rizki Dumna Rizki Dumna, Rizki Subhaini SUBHAINI Subhaini, Subhaini Sunarso Sunarso Suzanna Sungkar, Suzanna Viona Diansari Viona Diansari