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All Journal Medicina E-Jurnal Medika Udayana Sari Pediatri Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Cardiology Indonesian Journal of Global Health research Pediatric Sciences Journal Jurnal Indonesia Sosial Sains Seroja Husada: Jurnal Kesehatan Masyarakat
Eka Gunawijaya
Departemen/KSM Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : Pediatric Sciences Journal

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Challenging diagnostic of juvenile systemic sclerosis in limited sources: a case report Ronaldi, Melissa; Wati, Ketut Dewi Kumara; Gunawijaya, Eka; Yantie, Ni Putu Veny Kartika; Anandasari, Pande Putu Yuli
Pediatric Sciences Journal Vol. 5 No. 1 (2024): (Available online: 1 June 2024)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v5i1.88

Abstract

Background: Juvenile Systemic Sclerosis (JSSc) is a rare chronic-autoimmune rheumatic disease leading to potential delay in diagnosis, especially in limited sources due to lack of knowledge and facility. This case report aimed to present a rare case of JSSc in limited sources of medical facilities. Case presentation: A 15-year-old girl was earlier suspected of having congenital heart disease due to the presentation of bluish fingers without any detectable clinical heart disease manifestation, including normal electrocardiography as well as echocardiography. The patient experienced pain and difficulty executing wrist endorotation, representing limited joint movement action. Further physical examinations showed pale, cold fingers and toes, bluish color in the peripheral represented sclerodactyly and arthritis. Skin showed multiple erythema-hypopigmentation papuls, in accordance with gottorn papule, gottorn sign. The antinuclear antibody titer was 1:320. Chest CT-Scan result was a fibrotic line at the inferior lobe of the left lung with the left diaphragm tenting due to a chronic inflammatory process. Skin biopsy shows an acanthotic epidermis, dermafibrocollagenous tissue with extensive fibrosis, and sclerosis with vascular proliferation. These findings meet JSSc PRES, ACR, and EULAR standard classification criteria, including 1 major and 4 minors. The treatment regimen was started with methylprednisolone 2 mg/kg/day, then tapering off once clinical manifestation alleviated, methotrexate 10 mg/BSA, and folic acid 1 mg a day. Long-term monitoring plans are also scheduled. Conclusion: Recognizing early symptoms of JSSc would provide a better outcome.
Unveiling associated factors related to congenital heart disease in children: A case-control study Wijaya, Lisa Amelia; Yantie , Ni Putu Veny Kartika; Gunawijaya, Eka
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.125

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Background: Congenital heart diseases (CHDs) remain a significant global health burden and a leading cause of child mortality. However, limited evidence exists regarding the factors associated with CHDs, particularly in Indonesia. This study aims to identify factors associated with congenital heart defects (CHDs) in children. Methods: A case-control study was conducted using secondary data from pediatric cardiology patients at Ngoerah Hospital between 2021 and 2023, extracted from pedcardiobali.com. Patients aged 0–18 years who were diagnosed with CHD via echocardiography were included in the case group. Those with normal echocardiographic findings comprised the control group. Patients with incomplete medical records were excluded from the study. A total of 300 eligible subjects were selected, with 150 assigned to each group using a combination of purposive and random sampling methods. Multivariate logistic regression analysis was performed using SPSS version 29.0. Results: Among the 300 subjects, low birth weight (<2,500 grams) was significantly associated with CHDs (OR 3.365; 95% CI: 1.48–7.65; P = 0.004). Prematurity, maternal alcohol consumption, and congenital anomalies were identified as potential confounding factors (OR 1.19; 95% CI: 0.61–2.35; P = 0.61; OR 1.65; 95% CI: 0.45–6.06; P = 0.45; OR 1.98; 95% CI: 0.56–6.94; P = 0.29, respectively). No significant associations were found with maternal or paternal age, multiparity, multiple gestation, smoking, family history of CHDs, or maternal infection. Conclusion: Low birth weight is a dominant factor associated with CHDs. Early prenatal care and targeted interventions are crucial in reducing this risk. Further research is warranted to investigate the underlying mechanisms and genetic contributions to coronary heart disease (CHD).
Co-Authors AA Sg Mas Meiswaryasti Putra, AA Sg Mas Meiswaryasti Abdul H. S. Adi Purnami, Adi Alvin Alvelino Putra Sutrisna Anak Agung Ayu Dwi Adelia Yasmin Anak Agung Ngurah Ketut Putra Widnyana Anggreini, Faradilla Novita Armand Setiady Liwan Ayu Setyorini Mestika Mayangsari Bagus Ari Pradnyana Bagus Ngurah Putu Arhana Defranky Theodorus Dewangga, Made Satria Yudha Dewi Sutriani Mahalini Dewi, Luh G.A.P. Djoko, Sri Wahyuni Dyah Kanya Wati Eko Kristanto Kunta Adjie Elizabeth Joan Salim Hendra Santoso I Gusti Agung Trisna Windiani I Gusti Ayu Made Dwisri Okadharma I Gusti Lanang Sidiartha I Gusti Ngurah Sanjaya Putra I M Widia I Nyoman Budi Hartawan I Wayan Gustawan Ida Bagus Subanada Kadek Wini Mardewi Ketut Ariawati Ketut Dewi Kumara Wati Ketut Putu Yasa Komang Ayu Witarini Laurentia Utari Wibisono, Laurentia Utari Liwan, Armand Setiady Made Dwi Purnami, Made Dwi Made Gede Dwi Lingga Utama Maharini, Kadek Ni Made Ayu Agustini Ni Nyoman Margiani Ni Nyoman Utami Wijayaswari Pande, Ni Nyoman Utami Wijayaswari Ni Putu Veny Kartika Yanti, Ni Putu Veny Kartika Ni Putu Veny Kartika Yantie, Ni Putu Veny Kartika Ni Putu Wirantari NP Veny Kartika Yantie Pande Putu Yuli Anandasari Putu Ayu Widyanti Ria, Natal Ronaldi, Melissa Soetjiningsih Soetjiningsih Sukmapermata, Bunga Suryani Malik, Suryani Tri Yuliantini Wijaya, Lisa Amelia Yantie , Ni Putu Veny Kartika Yuwono, Elien