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All Journal HAYATI Journal of Biosciences The Journal of Pure and Applied Chemistry Research Alchemy Jurnal Penelitian Kimia Jurnal Kewirausahaan dan Bisnis Molekul: Jurnal Ilmiah Kimia
Desi Suci Handayani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Antioxidant, Antidiabetic, and Antibacterial Activities of Terminalia bellerica Seed Extracts in Various Solvent Polarities Atmira Sariwati; Fita Sari; Venty Suryanti; Desi Suci Handayani; Ichiro Kamei; Ninis Yuliati
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.854-866

Abstract

Terminalia bellerica is well-known for producing edible fruits with pharmacotherapeutic properties. Traditional healers use these species to treat and control diabetes mellitus, its side effects, and other illnesses. Involved in this disease's pathophysiological process, extensive research has been conducted to validate and comprehend these bioactive claims scientifically. This research aims to ascertain the bioactive metabolite contents of different solvent polarities, including ethyl acetate, hexane, distilled water, and methanol. The phenol concentration was determined using the Follin-Ciocalteu procedure to be between 23.45 and 160.41 mg GAE/g. The aluminum chloride colorimetric technique measured flavonoid concentration from 88.52 to 7.12 mg QE/g. The quantitative values of tannic acid, which spanned from 0.78 to 5.32 mg TAE/g, were determined by spectrophotometry UV-VIS. The extracts' capacity to reduce free radical damage ABTS (2, 2' azinobis (3-ethylbenzene-thiazoline-6-sulfonic-acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) was examined. The extract ethyl acetate exhibited the most significant level of antioxidant activity, with IC50 values for DPPH and ABTS of 28.17 and 22.22 g/ml, respectively. Staphylococcus aureus (23 mm) and were tested for antibacterial and antifungal activity in a methanol extract (21 mm). In vitro, antidiabetic activities were assessed using α-glucoside and α-amylase inhibition. The ethyl acetate extract has α-glucoside inhibition IC50 of 23.04 g/ml and α-amylase inhibition IC50 of 25.35 g/ml. T. bellerica seed includes secondary metabolites that show promise as lead chemicals in creating potent medications.
Co-Authors Abu Masykur Atmira Sariwati Chairil Anwar Dewi Marliyana, Soerya Dian Endah Kusuma Astuti, Dian Endah Dwi Siswanta edi pramono Fajar Rakhman Wibowo Fita Sari I.F. Nurcahyo I.F. Nurcahyo Ichiro Kamei Jumina Jumina Laksono Trisnantoro Maulidan Firdaus Muhammad Widyo Wartono, Muhammad Widyo Mustofa Mustofa Ninis Yuliati Pranoto Pranoto Qurotul Aini Rakhman Wibowo, Fajar Respati ., Respati Riska Azizawati Sholikh, Riska Azizawati Soerya Dewi Marliyana Tahara, Alfia Uke Triana Kusumaningsih Venty Suryanti Venty Suryanti Windrawati Windrawati, Windrawati Witri Wahyu Lestari Yuni Lestari Yuniawan Hidayat Zainal Arifin Almaqqomul Amin, Zainal Arifin