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All Journal HAYATI Journal of Biosciences VALENSI The Journal of Pure and Applied Chemistry Research Alchemy Jurnal Penelitian Kimia Jurnal Kewirausahaan dan Bisnis SEMAR Molekul: Jurnal Ilmiah Kimia
Desi Suci Handayani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Antioxidant, Antidiabetic, and Antibacterial Activities of Terminalia bellerica Seed Extracts in Various Solvent Polarities Atmira Sariwati; Fita Sari; Venty Suryanti; Desi Suci Handayani; Ichiro Kamei; Ninis Yuliati
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.854-866

Abstract

Terminalia bellerica is well-known for producing edible fruits with pharmacotherapeutic properties. Traditional healers use these species to treat and control diabetes mellitus, its side effects, and other illnesses. Involved in this disease's pathophysiological process, extensive research has been conducted to validate and comprehend these bioactive claims scientifically. This research aims to ascertain the bioactive metabolite contents of different solvent polarities, including ethyl acetate, hexane, distilled water, and methanol. The phenol concentration was determined using the Follin-Ciocalteu procedure to be between 23.45 and 160.41 mg GAE/g. The aluminum chloride colorimetric technique measured flavonoid concentration from 88.52 to 7.12 mg QE/g. The quantitative values of tannic acid, which spanned from 0.78 to 5.32 mg TAE/g, were determined by spectrophotometry UV-VIS. The extracts' capacity to reduce free radical damage ABTS (2, 2' azinobis (3-ethylbenzene-thiazoline-6-sulfonic-acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) was examined. The extract ethyl acetate exhibited the most significant level of antioxidant activity, with IC50 values for DPPH and ABTS of 28.17 and 22.22 g/ml, respectively. Staphylococcus aureus (23 mm) and were tested for antibacterial and antifungal activity in a methanol extract (21 mm). In vitro, antidiabetic activities were assessed using α-glucoside and α-amylase inhibition. The ethyl acetate extract has α-glucoside inhibition IC50 of 23.04 g/ml and α-amylase inhibition IC50 of 25.35 g/ml. T. bellerica seed includes secondary metabolites that show promise as lead chemicals in creating potent medications.
Synthesis and Characterization of Copoly(Anethole-Stearyl Acrylate) as Phenol Adsorbent Handayani, Desi Suci; Pramono, Edi; Dewi, Anita Kusuma
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46484

Abstract

This study aims to synthesize copoly (Anethole-stearyl acrylate, SA) through cationic polymerization at room temperature (28–36°C) under a nitrogen atmosphere. The synthesis was carried out without a solvent using BF3O(C2H5)2 as the initiator. SA was added in varying weights of 2%, 4%, and 6% relative to anethole. The product obtained from the synthesis was then applied as a phenol adsorbent using the batch method at different contact times. FTIR (Fourier Transform Infrared) analysis showed that methoxy group (-OCH3) termination occurred at wavenumber 1147 cm-1, followed by the loss of vinyl group (C=C) at 1633–1654 cm-1. In addition, the loss of =C-H vinyl bending and stretching group absorption occurred at 964–998 cm-1 and 3025–3095 cm-1, respectively. Structural analysis using 1H-NMR showed the loss of the vinyl group proton signal at a chemical shift (δH) of 5.8–39 ppm. The addition of 2%, 4%, and 6% SA led to an increase in intrinsic viscosity of 26.891, 41.093, and 55.336, respectively. The morphology of copoly showed the presence of various cavities. The degradation temperature of the product increased with the addition of SA. During the application of copoly as a phenol adsorbent, the 6% (w/w) concentration had the largest adsorption capacity of 2.22 mg/g.
Usaha Peningkatan Standar Mutu UMKM Jamu Herbal Ratu Botani Solo di Surakarta Fauziyah Azhari; Rita Rakhmawati; Widya Mudyantini; Soerya Dewi Marliyana; Nestri Handayani; Titi Wahyuni; Esti Suryani; Desi Suci Handayani; Siti Baroroh Zakiyatul Islah; Fahrul Zikri; Yeni Ermaningsih; Witri Wahyu Lestari
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 14, No 2 (2025): November
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v14i2.105220

Abstract

 Industri jamu Indonesia memiliki potensi ekonomi besar dengan pasar domestik Rp 20 triliun, ekspor Rp 16 triliun. Namun, UMKM jamu masih menghadapi tantangan signifikan terkait standarisasi mutu, keamanan produk, dan kepatuhan terhadap regulasi. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kapasitas UMKM Jamu Ratu Botani Solo (RBS), Surakarta melalui penguatan standar mutu produk, khususnya dalam aspek uji mutu produk dan pengemasan. Metode pelaksanaan meliputi tiga tahap: (1) Pra-kegiatan dilakukan dengan FGD untuk identifikasi kebutuhan dan tantangan mitra; (2) Pelatihan penyuluhan empat materi yaitu pemilihan bahan herbal, metode ekstraksi, implementasi teknik ekstraksi skala industri, penandaan obat bahan alam. Kegiatan ini disertai pemberian bantuan alat pengemasan dan analisis mutu produk di laboratorium (3) Evaluasi keberlanjutan untuk mengukur dampak dan keberlanjutan implementasi oleh mitra. Hasil kegiatan menunjukkan peningkatan signifikan pemahaman peserta (80–100%) pada seluruh materi pelatihan, terutama terkait penandaan produk sesuai ketentuan BPOM. Mitra kini mampu mengimplementasikan teknik ekstraksi yang sesuai standar, seperti remaserasi dan digesti, dalam proses produksi jamu. Mitra juga telah memiliki akses terhadap layanan uji mutu (logam berat, kadar air, dan mikrobiologi) di laboratorium UPT UNS. Kegiatan ini berhasil memberdayakan RBS dalam memproduksi jamu berstandar nasional, meningkatkan daya saing, dan mendukung keberlanjutan usaha berbasis herbal. 
Co-Authors Abu Masykur Atmira Sariwati Chairil Anwar Dewi Marliyana, Soerya Dewi, Anita Kusuma Dian Endah Kusuma Astuti, Dian Endah Dwi Siswanta Edi Pramono edi pramono Esti Suryani Fahrul Zikri Fajar Rakhman Wibowo Fauziyah Azhari Fita Sari I.F. Nurcahyo I.F. Nurcahyo Ichiro Kamei Jumina Jumina Laksono Trisnantoro Maulidan Firdaus Muhamad Widyo Wartono Mustofa Mustofa Nestri Handayani Ninis Yuliati Pranoto Pranoto Qurotul Aini Rakhman Wibowo, Fajar Respati ., Respati Riska Azizawati Sholikh, Riska Azizawati Rita Rakhmawati Siti Baroroh Zakiyatul Islah Soerya Dewi Marliyana Soerya Dewi Marliyana Tahara, Alfia Uke Titi Wahyuni Triana Kusumaningsih Venty Suryanti Venty Suryanti Widya Mudyantini Windrawati Windrawati, Windrawati Witri Wahyu Lestari Witri Wahyu Lestari Yeni Ermaningsih Yuni Lestari Yuniawan Hidayat Zainal Arifin Almaqqomul Amin, Zainal Arifin