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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Indonesian Journal of Biotechnology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Keperawatan Padjadjaran Journal of Indonesian Dental Association
Rebriarina Hapsari
Department Of Microbiology, Faculty Of Medicine, Diponegoro University, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Relationship Between Leucocytes and Bacterial Count in The Wound Swab Sample with Colony Counting In Wound Tissue Infection Maria Estela Karolina; Mujahidah Mujahidah; Rebriarina Hapsari; Subakir Subakir
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 4 (2023): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i4.22061

Abstract

ABSTRACT Background: Wound tissue infection is a problem in developing countries. The cause of the infection must be known, so that appropriate antibiotics are given for that required microbiological examination. The number of Polymorphonuclear leukocytes (PMN) >25/HPF and the number of colonies >105/Colony Forming Unit (CFU) determine the occurrence of infection. Proving the relationship between the number of leukocytes and bacteria in the wound swab sample to the number of colonies in superficial Surgical site infection (SSI). Methods: This study was an Observational analytical research design with 35 samples of superficial SSI. Microscopic examination: gram stain to see the number of leukocytes and bacteria in a large field of view. Culture examination: number of colonies, identification of microorganisms, and patterns of antibiotic sensitivity with automatic machines. Statistical analysis for the relationship between the number of leukocytes and bacteria to the number of colonies was Chi-square and logistic regression. Results: Superficial SSI samples were more common at the age <60 years, with malignancy comorbid. The most common cause of infection is Escherichia coli. The results of the Chi-square test showed that the number of leukocytes (p=0.017) and the number of bacteria (p=<0.01) were related to the number of colonies, and logistic regression tests found that the number of bacteria was significant to the number of colonies (p=0.010, 95% C1: 0.030–0.624). Conclusion: The number of bacteria associated with the number of bacterial colonies in patients with superficial SSI.
Comparison of SARS-CoV-2 Variant Screening and Whole Genome Sequencing at an Indonesian Tertiary Hospitals Hapsari, Rebriarina; Kesumayadi, Irfan; Sari, Desvita; Anjarwati, Dwi Utami; Alfiyuliani, Nesia Hani; Mujahidah, Mujahidah; Sari, Iva Puspita; Hadi, Purnomo
Journal of Biomedicine and Translational Research Vol 9, No 3 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i3.19147

Abstract

Background: The global COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), experienced a surge in cases with the emergence of the Omicron variant. Despite increasing vaccination coverage, Indonesia witnessed peaks in COVID-19 cases. Variant screening and whole genome sequencing (WGS) play a crucial role in identifying SARS-CoV-2 variants and monitoring their spread.Objective: The objective of this study was to compare variant screening results with WGS data, assess the prevalence of subvariants, and analyze their correlation with demographic and cycle threshold (CT) values.Methods: Between November 7th and 18th, 2022, variant screening and WGS were conducted on samples with CT values below 30. Variant screening utilized the mBioCov-19+ VarScreen assay, while WGS was performed on the Oxford Nanopore Technologies (ONT) platform. Bioinformatics analysis was performed using epi2melabs. Demographic data and CT values were analyzed. Results: Out of 89 subjects, all tested positive for the Omicron variant through variant screening. The variant screening identified two subvariants: Omicron BA.2 (64%) and Omicron B.1.1.529.1 (36%). WGS revealed that the XBB subvariant was the most dominant (52.8%), followed by BQ.1 (22.5%) and BA.5 (13.5%). When VarScreen indicated BA.2, the majority of WGS results showed XBB (82.5%), while for B.1.1.529.1, the majority of WGS results were BQ.1 (59.4%), followed by BA.5 (37.5%). XBB was the most prevalent variant in both females and males, while BQ.1 was more dominant in females (80%). No infections were detected among children aged 1-5 years. All variants had CT values below 24.Conclusion: Variant screening provides accurate and quick results for detecting the Omicron variant in laboratories without WGS capacity. However, it is important to continuously update the screening methodology based on the prevailing circulating variants. During the study period, XBB emerged as the predominant subvariant of the Omicron variant.
Antibacterial Activity of Euphorbia tirucalli against Lactobacillus acidophilus: An In Vitro Study Bang, Vania Christina Budiono; Hapsari, Rebriarina; Kusuma, Ira Anggar
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86604

Abstract

Dental caries is a common oral disease that occurs due to excessive interaction between tooth structure, bacterial biofilm, and glucose. Lactobacillus acidophilus is the main cause of dentin dental caries, which can be prevented using anticaries agents. However, current anticaries agents may cause some side effects. Therefore, there is a need for natural anticaries agents with minimal side effects. Euphorbia tirucalli contains flavonoids, tannins, and saponins that contribute to its antibacterial activity. This study aimed to determine the antibacterial activity of E. tirucalli against L. acidophilus bacterial growth. This was an in-vitro study with a post-test-only control group design, divided into three groups. The positive control group received 0.2% chlorhexidine digluconate, the negative control group received aquadest, and the intervention groups received extracts with concentrations of 10 mg/mL, 20 mg/mL, 30 mg/mL, 40 mg/mL, and 100 mg/mL. Minimum Inhibitory Concentration (MIC) was examined post-treatment using the agar dilution method. The differences in colony growth were analyzed using Cramer's V and Fisher's Exact Test, with p<0.05 considered significant. E. tirucalli extracts showed antibacterial effects against L. acidophilus with a concentration of 40 mg/mL as the MIC. Extract groups with concentrations of 40 mg/mL and 100 mg/mL showed significant differences in L. acidophilus growth compared to the negative control group (p<0.001). The study concluded that E. tirucalli extract has antibacterial activity against the growth of L. acidophilus, with MIC of 40 mg/mL.
Effect of Immersion Time in Sweet Orange and Tangerine Peel Juice on Teeth Whitening (In Vitro Study) Puspitaningrum, Putri Febiana; Hapsari, Rebriarina; Vidyahayati, Indah Lestari
Journal of Indonesian Dental Association Vol 7 No 2 (2024): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v7i2.1079

Abstract

Introduction: Tooth discoloration is an aesthetic problem that greatly affects appearance. The use of chemicals to treat tooth discoloration requires high cost and can cause tooth hipersensitivity. Sweet orange peel and tangerine peel contain organic acids and d-limonene which have the potential to be alternative bleaching agents. Objective: To determine the effect of immersion time in sweet orange peel juice (Citrus sinensis (L.) Osbeck) and tangerine peel juice (Citrus reticulata Blanco) on teeth whitening. Methods: This research was an experimental in vitro study using 30 post-extraction maxillary first premolars divided into 3 groups. Group 1 was soaked in sweet orange peel juice, group 2 was soaked in tangerine peel juice, and group 3 (negative control) was soaked in distilled water. Samples were soaked in coffee solution for 7 days and then soaked according to groups for 1 hour, 3 hours, and 5 hours. Color changes were observed with blinding method using the VITAPAN classical shade guide. Data were analyzed using Wilcoxon Sign Rank Test and Kruskal Wallis Test. Results: Sweet orange peel juice, tangerine peel juice, and distilled water showed significant differences in the observed values ​​(p<0.05) after 1 hour, 3 hours, and 5 hours of immersion. The biggest difference on the observed value was obtained after 5 hours of immersion in sweet orange peel juice and tangerine peel juice. Based on the Kruskal Wallis test and the Post Hoc Test, there are no significant differences on the average value of tooth color observations (p>0.05) between sweet orange peel juice and tangerine peel juice after 1 hour, 3 hours, and 5 hours of immersion. Conclusion: The longer the immersion time in sweet orange peel juice and tangerine peel juice, the greater the effect of teeth whitening.
Co-Authors Alfi Dian Uly Noor Alfiyuliani, Nesia Hani Anugrah Riansari Bang, Vania Christina Budiono Benediktus Yohan Desvita Sari, Desvita Dionisius Denis Dwi Utami Anjarwati Edi Dharmana Failasuf Wibisono Firdaus, Nadilla Shafa Helmia Farida Indah Lestari Vidyahayati, Indah Lestari Indah Sri Wahyuningsih Ira Anggar Kusuma Janitra, Fitria Endah Jonathan Alvin Nugraha Halim Kesumayadi, Irfan Kusuma, Ira Anggar Maria Estela Karolina Maryani Maryani Masfiyah Masfiyah, Masfiyah Meita Hendrianingtyas Muhammad Mahfud Muhammad Thifan Satyagraha Mujahidah Mujahidah Mujahidah Mujahidah Mujahidah, Mujahidah Nahwa Arkhaesi Nani Maharani Purnomo Hadi Puspitaningrum, Putri Febiana R. Tedjo Sasmono Rahayu Rahayu Sari, Iva Puspita Sarinti Sarinti Setiawati, Setiawati Sotianingsih Haryanto Stefanie Natalia Halim Subakir Subakir Thania Lathifatunnisa Putri Agusti Titik Nuryastuti Tri Nur Kristina V. Rizke Ciptaningtyas Winarto Winarto