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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical and Clinical Research Reswara: Jurnal Pengabdian Kepada Masyarakat Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik) Jurnal Natural Grimsa Journal of Science Engineering and Technology Jurnal Pengabdian Mahakarya Masyarakat Indonesia
Misrahanum Misrahanum
Jurusan Farmasi FMIPA Universitas Syiah Kuala
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Journal : Jurnal Natural

 1 
ACTIVITY TEST OF Abrus precatorius L. LEAF EXTRACT AGAINST CLINICAL Streptococcus pneumonia GROWTH* Misrahanum Misrahanum; Cut Intan Annisa Puteri; Cut Yulvizar
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.235 KB) | DOI: 10.24815/jn.v17i1.7260

Abstract

Abstract. Saga (Abrus precatorius L.) have been used by Indonesian community as a traditional medicine. The research aims to determine the activity of the methanol extract of saga leaves to inhibit the growth of clinical Streptococcus pneumoniae growth. Inhibition tests was done with casting cup method. The results showed that the methanol extract of saga leaves at a concentration of 37,5; 50; 62,5; 75 and 87,5 mg/mL formed growth inhibition zone of clinical S. pneumoniae with consecutive average of 0,5; 1,75; 2,82; 4,00; and 4,82 mm. Based on the results of the research can be concluded that the methanol extract of saga leaves had activity in inhibiting the growth of clinical S. pneumoniae isolates with low category.  Key words: Abrus precatorius L., Clinical Streptococcus pneumoniae, Methanol extract*Judul ini telah dipresentasikan pada Seminar Nasional: Indonesian Students Conference on Science and Mathematics(ISCSM) 11-12 November 2015, Banda Aceh Indonesia
FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.739 KB) | DOI: 10.24815/jn.v19i2.12151

Abstract

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of  25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli. 
GAS CROMATOGRAPHIC ANALYSIS OF ORGANOPHOSPATE AND PYRETROID COMPOUNDS IN MOSQUITO COILS Sadli Sadli; Misrahanum Misrahanum
Jurnal Natural Volume 11, Number 2, September 2011
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.066 KB)

Abstract

Mosquito coils contain active compounds such as chlorpyriphos, dichlorphos, and d-alletrhrin which may be hazardous to the health. As majority of pesticides are stable heat, they can be changed into stable vapor state by column.  a gas chromatographic method of analysis was developed. Gas chromatography for organophosphate compounds, namely chlorpyriphos and dichlorphos, with a OV-17 packed column, and a flame photometry detector equipped by filter for phosphor, which detecs phosphor containing compounds exclusively, avoiding any interference of other non phosphor compounds present in the sample matrix. Gas chromatography for a pyrethoid compound, d-allethrin, utilizes a HP-1 capilarry column with a flame ionization detector, and detect, any ionizable compound. The research was initiated by adjustment of the condition of gas chromatography system to obtain an appropiate separation of compounds a good shape of chromatogram and a tolerable retention time.  With a flow rate of nitrogen 55 ml/min, column temperatures of 210oC, a detector and injector temperature of 230oC, the method gave a retention times chlorpyriphos of 6,47 minute and that of dichlorphos of 0,73 minute . The difference in retention time of chlorpyriphos and that of dichlorphos was caused by the difference in molecular weight of both compounds, thin dichlorphos with a smaller molecular weight (220, 98) was eluted faster than chlorpyriphos (350,6). For  d-allethrin whit a flow rate of nitrogen gas of 40 ml/min, a column temperature  of 180oC, a detector and injector temperature of 210oC, a retention time of d-allethrin of 3,28 minutes was obtained. The mosquito coils tested did not contain any chlorpyriphos nor dichlorphos, and some contained d-allethrin. The d-allethrin content obtained in one of the sample was beyond the tolerated limit.
ACTIVITY TEST OF Abrus precatorius L. LEAF EXTRACT AGAINST CLINICAL Streptococcus pneumonia GROWTH* Misrahanum Misrahanum; Cut Intan Annisa Puteri; Cut Yulvizar
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v17i1.7260

Abstract

Abstract. Saga (Abrus precatorius L.) have been used by Indonesian community as a traditional medicine. The research aims to determine the activity of the methanol extract of saga leaves to inhibit the growth of clinical Streptococcus pneumoniae growth. Inhibition tests was done with casting cup method. The results showed that the methanol extract of saga leaves at a concentration of 37,5; 50; 62,5; 75 and 87,5 mg/mL formed growth inhibition zone of clinical S. pneumoniae with consecutive average of 0,5; 1,75; 2,82; 4,00; and 4,82 mm. Based on the results of the research can be concluded that the methanol extract of saga leaves had activity in inhibiting the growth of clinical S. pneumoniae isolates with low category.  Key words: Abrus precatorius L., Clinical Streptococcus pneumoniae, Methanol extract*Judul ini telah dipresentasikan pada Seminar Nasional: Indonesian Students Conference on Science and Mathematics(ISCSM) 11-12 November 2015, Banda Aceh Indonesia
FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i2.12151

Abstract

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of  25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli. 
Co-Authors Amalia Amalia Arpini, Mifta Ayuningsih, Cut Mutia Chairul Fahmi Cut Yulvizar Cut Yulvizar Cut Yulvizar Essy Harnelly Hilda Maysarah Hilda Maysarah Hira Helwati Humaira, Cut Jessica Irhamni Irhamni Irma Sari Isnaini, Nadia Masykur, Masykur Meutia Faradilla Meutia Faradilla, Meutia Murniana Murniana Muslem, Abdul Halim Oktaviana, Nurul Puteri, Cut Intan Annisa Putra, Ferry Syah Rezeki, Rena Novita Sadli Sadli Sadli Sadli Sadli Sadli Sugiarti Sugiarti Syaifullah Muhammad Syarifah Dhea Almunawwarah Tedy Kurniawan Bakri Yulia Sari Ismail Yulia Sari Ismail Zahratul Safarah Zaidiyah Zaidiyah Zulkarnain Zulkarnain