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Hari Wijayanto
Departemen Statistik, FMIPA Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : ARRUS Journal of Mathematics and Applied Science

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Metabolite-Group Selection On Temu Ireng (Curcuma Aeruginosa) Contains Related To Toxicity Activity By Using Group Lasso Regression H S, Rahmat; Afendi, Farit Mochamad; Wijayanto, Hari
ARRUS Journal of Mathematics and Applied Science Vol. 4 No. 2 (2024)
Publisher : PT ARRUS Intelektual Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/mathscience3626

Abstract

Metabolites are expressed in mass-to-charge ratio (m/z) on mass spectrometry experiments. They can be identified more than once. Some of m/z representing same metabolites can be considered as a group of metabolites. Evaluation of metabolite effects can be considered based on the groups. Group least absolute shrinkage and selection operator (group lasso) regression can be used to evaluate these groups. It shrinks some coefficients of regression exactly to be zero by adding intermediate penalty on ordinary least square (OLS) objective function. The purposes of this study were to estimate groups of metabolite contains of Curcuma aeruginosa (Temu ireng) affecting toxicity activity by using group lasso regression and to compare it to partial least square regression (PLSR). The data used were toxicity activity and metabolite contain, obtained from LC-MS, of temu ireng from three areas in Java. The groups of metabolites which affected toxicity activity, of group lasso regression by using dedicated software of R with gglasso package, were groups of m/z 238.150, 250.165, 262.128, 264.144, 312.275, and 456.183. The estimates of metabolites that affected of group lasso regression and PLSR had similarities. Based on the goodness of fit, group lasso regression was better than PLSR to estimate the affecting groups.
Co-Authors . Aunuddin . Barizi . Gunawan Aan Kardiana Afnan, Irsyifa Mayzela Agus Mohamad Soleh Aji Hamim Wigena Akhmad Fauzi Aldi Cahyanugroho Anadra, Rahmi Anang Kurnia Andres Purmalino Anggraini Sukmawati Aqmar, Nurzatil Arief Hendarto Arif Handoyo Marsuhandi Aruddy Aruddy ASEP SAEFUDDIN Astridina, Astridina Aunuddin Aunuddin Baba Barus Bagus Sartono Bambang Hendro Trisasongko Barizi . Basita G. Sugihen Bertho Tantular Boedi Tjahjono Budi Susetyo Cici Suhaeni Cut Zaraswati DAHRUL SYAH Darjono, Agus Heru Dede Dirgahayu Domiri Dedi Budiman Hakim Dyah R Panuju Dyah R. Panuju Dyah R. Panuju Edi Abdurrachman Eko S. Pribadi Erfiani Erfiani Erliza Noor Fachry Abda El Rahman Farit Mochamad Afendi Farly Shabahul Khairi fatimah Fatimah Fitria Hasanah Fitrianto, Anwar H S, Rahmat Hikmah, Zetil I K Marla Lusda I Made Sumertajaya Ilma, Meisyatul Ina Widayanty Indahwati Irzaman, Irzaman Istiqlaliyah Muflikhati Jajah K. Wagiono Jayawarsa, A.A. Ketut Kapiluka, Kristuisno Martsuyanto Khairil Anwar Notodiputro Kurnia Suci Indraningsih Kusman Sadik La Ode Abdul Rahman Leny Maryesa Lilik Noor Yuliati Luvy Mayanda M. Syamsul Maarif Mahmud A. Raimadoya Mahmud A. Raimadoya Mualifah, Laily Nissa Atul Muhammad Nur Aidi Musa Hubeis Nunung Nurjanah Nurrahman, Fathu Panca Wiputra Pang S. Asngari Pannu, Abdullah Prabowo Tjitrpranoto Riana Riskinandini Rizal Bakri Rizky Nurkhaerani Rysda Rysda Sachnaz Desta Oktarina Siti Hafsah Suhaeni, Cici Ujang Sumarwan Utami Dyah Syafitri Yarah, Helena Ramadhini Yenni Angraini Yuni Suci Kurniawati Zaenal, Mohamad Solehudin