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All Journal Jurnal Kesehatan Masyarakat Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Harsini
Departement Of Pulmonology And Respiratory Medicine, Medical Faculty, Universitas Sebelas Maret, Surakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Tuberculin Skin Test and T-SPOT.TB for Latent Tuberculosis Infection detection in healthcare workers Yusup Subagio Sutanto; Paulus Arka Triyoga; Harsini Harsini; Reviono Reviono; Hendra Kurniawan
Jurnal Kesehatan Masyarakat Vol 18, No 4 (2023)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i4.39528

Abstract

Healthcare Workers (HCWs) have a higher risk of getting Tuberculosis (TB) than the general population. This study analyzed effectiveness of Tuberculin Skin Test (TST) and T-SPOT.TB for detection prevalence of Latent Tuberculosis Infection (LTBI) among HCWs and the correlation between work locations and HCW duties. A trial study with a cross-sectional study design in Dr. Moewardi Hospital, Surakarta, in December 2018. The sampling technique used consecutive sampling with 30 subjects. Data analysis was performed using SPSS 21 for Windows. The appropriate levels of TST and T-SPOT indicated substantial TB (K = 0.603, p 0.001). The sensitivity and specificity of T-SPOT.TB with close contact was 60% and 86.7%. The sensitivity and specificity of TST with close contact were 33.3% and 93.3%. T-SPOT.TB was a significant correlation between the work location, the pulmonary care ward r = 0.436 and p = 0.008 (p 0.05). T-SPOT.TB has a slightly better sensitivity than TST.
Comparison of NEWS, SIRS, and qSOFA Score as Predictors of Mortality and Length of Stay in Patients Pneumonia with Sepsis Harsini Harsini; Aditya Alfarizi; Jatu Aphridasari; A Farih Raharjo; Reviono Reviono
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.505

Abstract

Background: Pneumonia is a major health problem in all age groups and often related with sepsis. In 2021, Surviving Sepsis Campaign Guidelines mentioned several clinical scoring systems to identify patients with potentials of developing sepsis, such as systemic inflammatory response syndrome (SIRS), national early warning score (NEWS), quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA). The guideline stated that there is no gold standard for diagnosing sepsis, contradicting The Sepsis-3 Guideline in 2016 that mentioned SOFA score as a gold standard for diagnosing sepsis.Methods: Subjects were all patients with pneumonia and sepsis who were treated in Dr.Moewardi Hospital within 1 January to 31 December 2022. Data from subjects’ medical records were collected to assess their NEWS, SIRS, qSOFA, and SOFA score on the day of admission. Since evaluation of SOFA score needs a number of components requiring laboratory results and takes longer time so they made a simpler tool called qSOFA to avoid delayed treatment of the patients.Results: NEWS is more consistent with SOFA compared to SIRS and qSOFA (Kappa value = 0.726 vs 0.320 vs 0.22; respectively). NEWS, SIRS, and qSOFA were all significantly correlated with mortality (P<0.001) with NEWS having the strongest correlation (r=0.482 vs 0.216 vs 0.175; respectively). Only NEWS showed significant correlation with the length of stay (r=0.129; P<0.001).Conclusion: NEWS was the most consistent score to SOFA compared to SIRS and qSOFA. NEWS was also the best predictor for mortality and was the only score correlated with length of hospital stay.
Hubungan Kategori Level Xpert MTB/RIF dengan Waktu Konversi Kultur Sputum Pasien TB Resisten Obat (TB RO) Samuel; Jatu Apridasari; Reviono; Yusup Subagio Sutanto; Harsini
Cermin Dunia Kedokteran Vol 47 No 9 (2020): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i9.565

Abstract

Penanganan TB yang tidak tepat dan tidak sesuai standar dapat menimbulkan masalah TB resisten obat (TB RO). Penelitian ini bertujuan mengetahui hubungan antara kategori level hasil Xpert MTB/RIF dan waktu konversi kultur sputum pasien TB RO. Data berasal dari rekam medik mulai bulan September 2012 sampai dengan bulan Oktober 2015; didapatkan 198 pasien TB RO, 112 laki-laki (56,6%) dan 86 perempuan (43,4%). Usia rerata 38,87 ± 12,41 tahun. Seluruh pasien TB RO merupakan pasien TB paru dengan memiliki riwayat pengobatan OAT kategori 1. Hasil pemeriksaan Xpert MTB/RIF menunjukkan sebagian besar pasien TB RO berada pada kategori low (43,9%). Konversi kultur terbanyak pada minggu ke-4 sampai ke-8 pengobatan sebesar 59,1%. Tidak ada perbedaan bermakna antara kategori Xpert MTB/RIF dan waktu konversi kultur sputum pasien TB RO (CI 95%, p = 0,572). Tidak ada korelasi bermakna antara kategori level gene X-pert dan waktu konversi kultur sputum pasien TB RO (CI 95%, r = 0,061; p = 0,392). nadequate TB management can cause the emergence of drug resistant tuberculosis. This study is to determine the correlation between Xpert MTB/RIF levels category with sputum culture conversion time in drug resistant tuberculosis patients. This retrospective cohort study was conducted in PMDT clinic at Dr. Moewardi General Public Hospital, Surakarta from September 2012 until October 2015. The respondents were 198 drug resistant tuberculosis patients; 112 males (56.6%) and 86 females (43.4%), mean age 38.87 ± 12.41 years old. All were pulmonary TB patients with category 1 anti-TB treatment. The Xpert MTB/RIF levels were mostly low category (43.9%). Culture conversion showed that 59.1% had conversion between the fourth and eighth week of drug resistant tuberculosis treatment. No statistically significant difference between Xpert MTB/FIR level category and sputum culture conversion time (CI 95%, p = 0.572). No statistically significant correlation between Xpert MTB/RIF level category and sputum culture conversion time (CI 95%, r = 0.061; p = 0.392)
Comparative Analysis of Copeptin, IL-6, and TNF-α as Predictive Biomarkers for Clinical Outcome in Moderate to Severe COVID-19 Patients Harsini Harsini; Jatu Aphridasari; Sihsusetyaningtyas Tiominar Siregar
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v46i1.1114

Abstract

Background: Cytokine release syndrome (CRS) plays a central role in disease progression, driven by pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), as well as neuroendocrine stress markers such as copeptin. Perbandingan langsung biomarker copeptin, IL-6, dan TNF-α sangat penting untuk mengidentifikasi prediktor hasil COVID-19 yang paling andal, terutama pada kasus sedang hingga berat. This retrospective clinical study aimed to evaluate the correlation of copeptin, IL-6, and TNF-α levels with the clinical outcomes of patients with moderate to severe COVID-19. Methods: The study included patients who met the selection criteria and provided written informed consent. A sample size of 41 was determined via power analysis to achieve 80% power at a 0.05 significance level. Consecutive sampling was employed to select participants. The study utilized medical records of patients with moderate to severe COVID-19 who underwent copeptin, IL-6, and TNF-α testing. Correlation analyses and Bonferroni corrections were performed using SPSS® ver. 21. Results: Results revealed a moderate positive correlation between copeptin levels and patient outcomes (Bonferroni correlation=0.597; P<0.001). A weak positive correlation was observed between IL-6 levels and outcomes (Bonferroni correlation=0.239; P=0.055), while a negligible positive correlation was found for TNF-α levels (Bonferroni correlation=0.140; P=0.177), which was not statistically significant. Conclusion: Copeptin emerged as a more sensitive biomarker for predicting the outcomes of COVID-19 patients. Elevated copeptin levels were associated with a poorer prognosis. Furthermore, its stability in serum renders copeptin a more sensitive biomarker than IL-6 and TNF-α.
Co-Authors . Isdaryanto . Muthmainah . Muthmainah . Suradi Aditya Alfarizi Aditya Sri Listyoko Agung Prasetyo Aisya Fikritama Aditya Aninda Dwi Anggraeni Anisa Nur Rahma Aphridasari, Jatu Arif Suryawan Arthrien Adiputri Artrien Adhiputri Brigitta Devi Anindita Hapsari Farih Raharjo Hendra Kurniawan Hie Sukiyanto Ita Haryatie Jatu Apridasari Jatu Apridasari Jusuf Soebagyo Kresentia Anita Raniputri Leli Saptawati Leonardo H. Simandjuntak Lusiana Susilo Utami Marwoto Marwoto Novi primadewi Olivia Dwimaswasti Paulus Arka Triyoga Reviono Reviono - Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Risky Irawan Rullyano Hardian Samuel Samuel - Sarah Nadya Roosana Sihsusetyaningtyas Tiominar Siregar Suradi Suradi SURYAWATI, BETTY Umarudin, Umarudin Yusup Subagio Sutanto Zefania Yonisa