Nurul Ratna Mutu Manikam
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia

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Journal : World Nutrition Journal

Correlation of Beta Carotene and Nutrition Status With Malondialdehyde Levels in Breastfeeding Mother Katya Saphira; Nurul Ratna Mutu Manikam; Dwirini Retno Gunarti
World Nutrition Journal Vol. 3 No. 1 (2019): Volume 03 Issue 1 Include Supplements Oral Presentation Abstracts of 14th Sympo
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i1.0011

Abstract

Background : Malondialdehyde (MDA), one of the products of polyunsaturated fatty acid (PUFA) peroxidation detected in breast milk (BM). MDA levels depicted BM’s oxidative status. BM oxidative balance could prevent oxidative stress in babies. MDA could be influenced by antioxidant food source such as beta carotene as well as body mass index (BMI).Objective: To analyze beta carotene intake and BMI and their correlation with BM MDA levels in nursing motherMethods: Eighty breastfeeding mothers who were 20–40 years old, came to Cilincing and Grogol Petamburan Public Health Centre February–April 2019 and had 1–6 months old babies were enrolled in this cross-sectional study. The BM was extracted in the next day. Mothers were asked to empty one of the breast 2 hours prior to extraction. Beta carotene intake was assessed using semi quantitative food frequency (SQ-FFQ). Body weight and height was measured on the first day. The BM MDA levels were assessed using thiobarbituric acid reactive substance (TBARS) assay. The correlation of beta carotene intake and MDA as well as BMI and MDA was assessed using Spearman test with level of significance of p<0.05.Results: Subject’s median age was 27 (20-35) years old, median BMI was 23.21 (15.25-39.55) kg/m2. Beta carotene’s median intake was 8039.8 (1697.7–34028) mg/day with 72.5% of the subjects were considered low intake. BM MDA level’s median was 1.953 (0.739-4.928) nmol/ml. Beta carotene intake (r = 0.247, p = 0.027) and BMI (r = 0.285, p = 0.010[DN4] ) had a weak correlation with BM MDA level.Conclusion: The beta carotene intake and the BMI of the subjects correlate significantly with the BM MDA level. It showed that the mother’s intake and body composition contribute to the oxidant level in BM, therefore influenced the level of oxidative stress transferred to the babies.
Body Mass Index And Survival Rate in Nasopharyngeal Cancer Patient: An Evidence-based Case Report Yohannessa Wulandari; Metta Satyani; Marvin Marino; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 3 No. 2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i2.0005

Abstract

Introduction: Nasopharyngeal cancer is the most common type of head and neck cancer with prevalence of 6.2/100000 population. Recently, study of prognostic factors for nasopharyngeal cancer still becomes one of research focuses. Several studies have tried to find the relationship between nutritional status (body mass index/BMI) and nasopharyngeal cancer patients’ survival rate, but the results are still inconsistent.                    Objective: To find the relationship between nutritional status represented by BMI and nasopharyngeal cancer patients’ survival rate.Methods: Electronic literature searches were performed in Cochrane®, Scopus®, and Pubmed®. Mesh term and title/abstracts were screened based on inclusion and exclusion criteria before relevant journals were reviewed.Results: Two articles were selected based on the eligibility criteria and relevancy to the clinical question. In the study of Huang et al., the subject was nasopharyngeal cancer patient stage III and IV was included as subject of the study. In the study of Lin et al., nasopharyngeal cancer patient with metastases was also included. Patient with higher BMI has better survival rate than underweight BMI category.Conclusion: Increasing BMI in underweight cancer patient simproves nasopharyngeal cancer patient’ survival rate.
Effect of isoflavone consumptions on the recurrence and survival rate among breast cancer patients: an evidence-based case report Meilianawati Meilianawati; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 4 No. 1 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i1.0010

Abstract

Background: isoflavones possess both anti-estrogenic and estrogenic-like properties. Tempeh is a traditional dish from Indonesia which rich in isoflavone content. It remains controversial whether women diagnosed with breast cancer should be advised to avoid or increase the intake of food products that contain isoflavone to improve survival.Objective: to identify the association between post-diagnosis isoflavone food consumption with the recurrence and survival rate among women with breast cancer. Methods: the search was conducted with advanced searching on PubMed, Cochrane, Scopus, and ProQuest according to the clinical question. The screening of title and abstract using inclusion and exclusion criteria, filtering double, and reading full text led to six useful articles. The selected studies were critically appraised for validity, importance, and applicability.Results: five prospective cohort studies and one meta-analysis were found with comparable validity. Women at the high level of isoflavone intake (>10 mg/day) had a significant reduction in the risk of recurrence and mortality of breast cancer.Conclusion: isoflavone food intake is associated with better survival, low recurrence, and low mortality among breast cancer patients.   
Effect of vitamin D supplementation to prevent acute respiratory tract infection : an evidence-based case report Oki Yonatan Oentiono; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 4 No. 1 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i1.0002

Abstract

Background: One of the frequent health problems that regularly occurs in Indonesia, as a tropical country is an acute respiratory tract infection, including influenza. Since immunological benefit of vitamin D already proven, hypothetically, vitamin D can be used as protective agent to prevent influenza or other respiratory tract infections. Objective: This evidence-based case report was focused on the evaluation of protective ability of vitamin D supplementation to prevent influenza or other acute respiratory tract infections.Methods: Literature searching was conducted on PubMed data base and Cochrane Library using the related keyword combinations.Results: Two randomized-clinical trials (RCTs) and a meta-analysis study were fulfilled the eligibility criteria. Vitamin D supplementation did not reduce the incidence of influenza but reduce the incidence of non-influenza infection. High-dose vitamin D supplementation had no effect on the reduction of acute respiratory tract infection incidence. The meta-analysis concluded that vitamin D supplementation reduced the risk for acute respiratory tract infection and the stronger effects occurred on low-levels of vitamin D serum.Conclusion: Vitamin D supplementation may prevent acute respiratory tract infections, especially in subjects with low-levels of vitamin D serum.
Vitamin D and immune responses: how much is too much? Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 5 No. S3 (2022): Selected conference proceedings of the Nutri Virtual Symposium 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S3.0019

Abstract

Vitamin D is a sunshine vitamin that is widely known for bone health. The main source of vitamin D from exposure to ultraviolet B radiation, whereas only 20% from natural and fortified food. Recent studies concluded that vitamin D has a putative role in reducing the risk of viral respiratory infection by suppressing pro-inflammatory cytokines and delaying increasing anti-inflammatory cytokines response. Whereas, vitamin D regulates innate immunity through macrophage and dendrite cell activity as well as an adaptive immune response through lymphocyte T cells response.
External validation test of body height estimation on outpatient radiotherapy clinic of Dr. Cipto Mangunkusumo General Hospital Wiji Lestari; Fiastuti Witjaksono; Nurul Ratna Mutu Manikam; Wahyu Ika Wardhani; Krisadelfa Sutanto
World Nutrition Journal Vol. 6 No. 2 (2023): Volume 06 Issue 2, February 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.i2.0007

Abstract

Background : Stature is required to calculate body mass index and determine the energy needs of patients in nutritional medical therapy. Difficulty was found to obtain stature data in patients who are unable to stand. Therefore, there are some height estimation formula to predict the actual height using knee height. This study aimed to validate the Chumlea formula on outpatient clinic of Dr. Cipto Mangunkusumo General Hospital, Indonesia. Methods : This cross-sectional study used 90 respondents selected by consecutive sampling. Actual height, knee height, age and gender data were collected. Estimated height using the three of Chumlea formula. Pearson correlation was used to see the correlation between actual height and estimated height. Paired t-test were used to determine the difference significance. Results : The average age of the subjects was 45±10 years old with actual height 157±10 cm, and knee height 48.8±3.5 cm. A strong positive correlation was found between actual height with all estimated height on male (p=0.000; r > 0.8) and female subjects (p=0.000; r > 0.6). However, comparison between actual height and estimated height showed no significant differences only in Chumlea L1 formula (p=0.087) and Chumlea L3 formula (p=0.824) on the male subjects. Conclusions : Chumlea L1 and Chumlea L3 formula was a valid fomulation for calculating the estimated body height in adult male patients. There was no valid Chumlea’s formulation to estimate body height in female patients.
Medical nutrition therapy in hospitalized patients with pemphigus vulgaris Bintari Anindhita; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 7 No. 01 (2023): Volume 07 Issue 1, August 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/10.25220/WNJ.V07.i1.0004

Abstract

Dysphagia due to involvement of the oral, pharyngolaryngeal, and esophageal mucosa and increased catabolism due to epidermal shedding can contribute to a decline in nutritional status in pemphigus vulgaris (PV) patients. On the other hand, decreased lean body mass is associated with immune system impairment, increased risk of infection, and delayed wound healing in PV patients, therefore, nutritional screening and assessment are necessary. Medical nutritional therapy in PV patients aims to overcome the metabolic response to the insults, prevent further malnutrition, modulate the immune system, and accelerate wound healing process. An aggressive nutritional support to minimize protein loss during the phase of mucocutaneous lesion healing is needed in patients with PV. Aside from macronutrient adequacy, micronutrients including vitamin A supplementation can be considered to accelerate wound healing process. Medical nutritional therapy including provision of adequate macronutrients, micronutrients, addressing dehydration and electrolyte imbalances should be the cornerstone of multidisciplinary treatment in PV patients.
Perioperative nutrition : ERAS special group discussion Luciana B Sutanto; Nurul Ratna Mutu Manikam; Adianto Nugroho
World Nutrition Journal Vol. 7 No. S1 (2023): Selected conference proceedings of the Nutri Symposium 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/V07.S1.0016

Abstract

Nutrition is one of the vital role in improving the healing and recovery after surgery, either preoperative (before surgery), intraoperative (during surgery), or postoperative (after surgery). The Enhanced Recovery After Surgery (ERAS) Society has published a multidisciplinary approach to perioperative care aimed at achieved early recovery for patients undergoing major surgery.
Validity test of the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria compared with the American Society for Parenteral and Enteral Nutrition (ASPEN) criteria in inpatients at Dr. Cipto Mangunkusumo hospital: A cross-sectional study Oentiono, Oki Yonatan; Manikam, Nurul Ratna Mutu
World Nutrition Journal Vol. 8 No. i1 (2024): Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0008

Abstract

Background: Malnutrition experienced by numerous inpatients is linked to various complications. The Global Leadership Initiative on Malnutrition (GLIM), which established the latest malnutrition criteria, recommends a two-step methodology for diagnosing malnutrition in adult inpatients. This study aims to evaluate the validity of the GLIM criteria for the diagnosis of malnutrition in hospitalized patients at Cipto Mangunkusomo Hospital Jakarta by comparing them with the ASPEN criteria. Methods: This cross-sectional study was conducted at Cipto Mangunkusomo Hospital, Jakarta. Secondary data was taken from 100 inpatients from October 2021 to February 2022 selected by consecutive sampling technique. The diagnosis of malnutrition in the patients applied the ASPEN and GLIM criteria. Furthermore, data were analyzed using Cohen's Kappa and chi-square tests. Results: Of 100 inpatients, 63% were diagnosed with malnutrition according to the GLIM diagnostic criteria. Meanwhile, 48% of them were found to be malnourished according to the ASPEN criteria. The GLIM criteria have a specificity of 69.2%, a sensitivity of 97.9%, a PPV of 74.6%, and an NPV of 97.3%. Conclusion: The GLIM diagnostic criteria are valid as an instrument for diagnosing malnutrition but require further research to assess the severity of malnutrition.
Known facts: iron deficiency in Indonesia Manikam, Nurul Ratna Mutu
World Nutrition Journal Vol. 5 No. S1 (2021): Special Issue : The role and importance of iron
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S1.0001

Abstract

More than half cases of anemia are due to iron deficiency. Anemia is a major and global public health problem that affects maternal and child mortality, child cognitive development and eventually productivity. Infancy, adolescence, and pregnancy are particularly at risk. Indonesia is a low middle country with the prevalence of anemia as high as 48.9% in pregnant women and 38.5% in children under 5 years old. It is even higher among adolescents aged 12-18 years, especially in rural areas. Low income and level of education seem to also contribute to iron deficiency. Indonesia government aims to prevent anemia in young and pregnant women by providing iron pills. Still, the etiology of anemia in Indonesia is various and many elements are preventing Indonesia women to consume pills and/or iron-rich foods. We aim to review the prevalence, risk factors associated with iron deficiency especially among women of reproductive age in Indonesia, including the socio-determinant influence on iron deficiency. We will also discuss the management of iron deficiency in Indonesia in comparison with international guideline to identify the potential gaps.