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Hubungan Kadar Apelin dengan Disfungsi Diastol pada Penderita Gagal Jantung dengan Fraksi Ejeksi Normal Rostiati, Dini; Erwinanto, -; Yahya­, Achmad Fauzi; Achmad, Chaerul; Tedjokusumo, Pintoko; Hidayat, Syarief; Purnomowati, Augustine; Aprami, Toni Mustahsani
Majalah Kedokteran Bandung Vol 47, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.167 KB)

Abstract

Apelin merupakan peptida yang berperan dalam mempertahankan performa jantung pada beban tekanan kronik. Penelitian ini bertujuan menilai hubungan antara kadar apelin dan disfungsi diastol pada penderita gagal jantung dengan fraksi ejeksi normal. Analisis statistik korelasi Spearman-Rank. Penelitian dilakukan di Instalasi Rawat Jalan Jantung dan Divisi Diagnostiik Noninvasif Departmen Kardiologi dan Kedokteran Vaskular Rumah Sakit Dr. Hasan Sadikin Bandung periode Januari–April 2014. Hasil penelitian didapatkan 50 penderita laki-laki sebanyak 24 (48%) dan perempuan 26 (52%), usia rata-rata 58,72 (11,02) tahun, durasi hipertensi 1–30 tahun, median 5 tahun. Indeks massa tubuh rata-rata 24,13 kg/m2. Median tekanan darah sistol 130 (120–180) mmHg, median tekanan darah diastol 90 (70–110)mmHg. Fraksi ejeksi median 65 (49–77%), pengobatan dengan Angiotensin converting enzyme inhibitor (ACEI) sebanyak 48%, calcium channel blocker (CCB) 27%, beta bloker 6%, angiotensin receptor blocker (ARB) 3%, dan diuretik 1%. Pengukuran fungsi diastol, tissue doppler imaging (TDI) rata-rata 10,32, deceleration time rata-rata 228,2 detik, median rasio E/A (early/atrial (late) ventricular filling velocities) 0,77 (0,43–1,53), median isovolumic relaxation time (IVRT) 92 (60–177) detik. Median kadar apelin 1080,5 (993,2–1113) pg/mL. Sebagai simpulan, terdapat korelasi positif antara kadar apelin dan disfungsi diastol yang dihitung dengan TDI (R=0,3445, p=0,014). Apelin dapat digunakan untuk menilai gejala dan prognosis pada penderita gagal jantung dengan fraksi ejeksi normal karena kadarnya meningkat pada beban tekanan disertai fibrosis yang  sedikit dan menurun pada beban tekanan disertai fibrosis yang luas.[MKB. 2015;47(2):91–5]Kata kunci: Apelin, disfungsi diastol, fraksi ejeksi normal, gagal jantung, TDICorrelation between Plasma Apelin Level and Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction AbstractApelin ia a novel multifunction peptide implicated in cardiovascular performance regulation in chronic pressure overload. Plasma apelin level and its correlation to diastolic dysfunction in patient heart failure with preserved ejection fraction were investigated. Hypertensive patients with heart failure but without coronary artery disease, atrial fibrillation, obese, and diabetes mellitus were enrolled in this study. Each patients underwent plasma apelin measurement and echocardiographic assessment of left ventricular diastolic function. Statistical analysis was conducted using Spearman Rank. Fifty patients,  24 males (48%) and 26 females (52%),  met the inclusion criteria.  The mean age of the participants was 58.72 (11.02) years with a duration of hypertension between 1–30 years, median 5 year. Mean body mass index was 24.13 kg/m2. Systolic blood pressure median was 130 (120–180)mmHg while the diastolic blood pressure median was 90 (70–110)mmHg. Left ventricular ejection fraction median was 65 (49–77)%, treatment with Angiotensin converting enzyme inhibitor (ACEI) was 48%, calcium channel blocker (CCB) was 27%, beta blocker was 6%, angiotensin receptor blocker (ARB) was 3%, and diuretic was 1%. Diastolic function assessment with tissue doppler imaging (TDI) resulted in a mean of 10.32, deceleration time mean of 228.2, E/A (early/atrial (late) filling velocities) ratio median of 0.77 (0.43–1.53),and IVRT (isovolumic relaxation time) median of 92 (59–177). Plasma apelin measurement median was 1080.5 (993.2–11) pg/mL. In conclusion, there is a positive correlation between plasma apelin level and diastolic function (TDI) (R=0.3445, p=0.014). There is no significant correlation between plasma apelin level and diastolic function using other criteria. In conclusion, apelin can be used for assessing symptoms and prognosis of heart failure patients with preserved ejection fraction because apelin level is upregulated when pressure overload occurs with less fibrosis and down-regulated when pressure overload occurs with marked fibrosis. [MKB. 2015;47(2):91–5]Key words: Apelin, diastolic dysfunction, heart failure, preserved ejection fraction DOI: 10.15395/mkb.v47n2.459
Visualization of Carotid Doppler in Patients with Ischemic Stroke at Dr. Hasan Sadikin General Hospital Bandung Year 2016-2019 Olivia Olivia; Ahmad Rizal Ganiem; Syarief Hidayat
Althea Medical Journal Vol 8, No 3 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n3.2285

Abstract

Background: Various pathological changes in both the intra and extracranial arteries that supply the brain can cause disturbance of cerebral blood flow and perfusion leading to cerebral dysfunction. Doppler ultrasound is able to assess these changes. This study was performed to evaluate the anatomical and physiological changes found in the carotid arteries of patients with ischemic stroke using Doppler ultrasound.Methods: The cross-sectional descriptive study design with total sampling method was conducted on the medical records of ischemic stroke patients who had carotid Doppler ultrasound at the Department of Cardiology and Vascular Medicine Dr. Hasan Sadikin General Hospital Bandung from 2016 to 2019. Demographic data, such as stroke diagnoses and plaque characteristics recorded in the Doppler reports were collected.Results: There were 38 data sets collected. The distribution and characteristics of atherosclerotic plaques were similar between the two carotid systems, with the same percentage of plaque being found in the right (31.6%) and left (36.8%) carotid system. The most common type of plaque found was type III and was located in the common carotid artery. Thrombus was absent in all patients. Intimal media thickening was found in 13.2% right system and 15.8% left system. Stenosis was present in 34.2% of patients, and most had <50% stenosis. Peak systolic velocity increased (>125 cm/s) in 5.3% of the right system and 7.9% of the left system of the internal carotid artery.Conclusions: Most of the atherothrombotic and thromboembolic type of ischemic stroke patients in this study have normal carotid Doppler ultrasound features. Further study on the presence of plaque in ischemic stroke patients in Indonesia is needed.
Prevalence of oral habits in homeless children under care of Yayasan Bahtera Bandung Gildasya Gildasya; Eriska Riyanti; Syarief Hidayat
Dental Journal (Majalah Kedokteran Gigi) Vol. 39 No. 4 (2006): December 2006
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.705 KB) | DOI: 10.20473/j.djmkg.v39.i4.p165-167

Abstract

Oral habits, comprising of thumb and lip sucking, lip and nail biting, tongue thrusting and mouth breathing are commonly caused by disturbance in mental development. These persistent habits may lead to disturbance in physical growth, causing disorders such as malocclusion. Homeless children are prone to this condition. The purpose of this descriptive research was to present the prevalence of oral habits in homeless children under care of Yayasan Bahtera Bandung, by survey technique. The sample consisted of 92 children collected by purposive sampling. This research was conducted through interviews and clinical examnations of the oral cavity to elucidate signs of oral habits. The result showed 50% of homeless children performed oral habits, consisting of 26 boys (55,32%) and 20 girls (44.44%). The prevalence of thumb sucking habit was 21.74%, lip sucking or biting was 17.37%, tongue thrusting was 4,35%, nail biting and mouth breathing tied at 3,26%. The research concluded that a part of homeless children had oral habits, with boys as slight majority, and thumb sucking was the most performed.
Gambaran erupsi gigi pada anak kembarDescription of tooth eruptions in twins Cindy Putri Amelia; Eka Chemiawan; Syarief Hidayat
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 28, No 2 (2016): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.687 KB) | DOI: 10.24198/jkg.v28i2.18703

Abstract

Pendahuluan: Erupsi gigi meliputi perubahan posisi gigi melalui beberapa tahap secara berturut-turut dari awal pembentukan benih gigi sampai gigi muncul ke arah oklusal dan mencapai titik kontak dengan gigi antagonisnya.Erupsi gigi pada anak kembar berada dibawah kontrol dan pengaruh yang kuat dari faktor genetik. Tujuan penelitian ini untuk melihat gambaran erupsi gigi pada anak kembar. Metode: Penelitian bersifat deskriptif dan pengambilan sampel dengan menggunakan accidental sampling sebanyak 35 pasang kembar yang terdiri dari 24 pasang kembar identik dan 11 pasang kembar tidak identik. Penelitian dilakukan dengan menghitung jumlah gigi erupsi dan dilihat kesamaannya antara kembar identik maupun kembar tidak identik. Hasil: Hasil penelitian menunjukkan bahwa erupsi gigi pada anak kembar, baik identik ataupun tidak identik memiliki tingkat kesesuaian lebih dari 50%, yaitu 68,57%. Simpulan: Penelitian ini menunjukan bahwa erupsi gigi pada anak kembar memiliki kecenderungan sesuai, baik kembar identik ataupun tidak identik dalam tahapan gigi sulung, gigi campuran, maupun gigi permanen.Kata kunci: Erupsi gigi, anak kembar, tahapan gigi.  ABSTRACTIntroduction: Tooth eruption involves changing the position of the tooth through several successive stages from the beginning of the formation of the tooth until the tooth appears in the occlusal direction and reaches the point of contact with its antagonistic teeth. Tooth irritation in twins is under control and strong influence of genetic factors. The purpose of this study was to look at the description of tooth eruption in twins. Methods: Descriptive research and sampling using accidental sampling as many as 35 pairs of twins consisting of 24 pairs of identical twins and 11 pairs of twins are not identical. The study was conducted by calculating the number of erupted teeth and seen the similarity between identical twins and twins is not identical. Results: The results showed that tooth eruption in twins, either identical or not identical had a suitability level of more than 50%, which was 68.57%. Conclusion: This study shows that tooth eruption in twins has an appropriate tendency, both identical or not identical twins in the stages of primary teeth, mixed teeth, or permanent teeth.Keywords: Tooth eruption, twins, tooth stage.
Pola karies pada anak kembarDental caries patterns in twins Amilia Nabhila; Syarief Hidayat; Yetty Herdiyati
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 1 (2017): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.049 KB) | DOI: 10.24198/jkg.v29i1.18606

Abstract

Pendahuluan: Karies merupakan penyakit gigi yang paling banyak dikeluhkan masyarakat. Etiologi karies multifaktorial, antara lain faktor genetik dan lingkungan. Penelitian dengan mempertimbangkan faktor tersebut dapat dilakukan pada anak kembar. Tujuan penelitian untuk memperoleh data mengenai pola karies pada anak kembar yaitu apakah terdapat kemiripan. Metode: Penelitian deskriptif dengan sampel penelitian menggunakan metode accidental sampling sebanyak 30 pasang anak kembar yang tinggal di Kota Bandung. Indikator yang digunakan berdasarkan ICDAS. Hasil: Hasil penelitian menunjukkan bahwa pola karies pada anak kembar terdapat 13,33% memiliki pola karies memiliki kemiripan, 13,33% memiliki pola karies dengan banyak kemiripan, 33,33% memiliki pola karies dengan sedikit kemiripan, sedangkan sisanya 40% memiliki pola karies yang tidak mirip. Simpulan: Pola karies pada anak kembar lebih banyak tidak ada kemiripan dan sedikit kemiripan dibandingkan yang memiliki kemiripan dan banyak kemiripan.Kata kunci: Anak kembar, pola karies ABSTRACTIntroduction: Caries is a dental disease that most people complain about. Etiology of multifactorial caries, including genetic and environmental factors. Research by considering these factors can be done in twins. The research objective was to obtain data regarding caries patterns in twins, namely whether there were similarities. Methods: A descriptive study with a sample of research using the accidental sampling method as many as 30 pairs of twins living in the city of Bandung. Indicators used based on ICDAS. Result: The results showed that caries patterns in twins had 13.33% had a similar caries pattern, 13.33% had a caries pattern with many similarities, 33.33% had a caries pattern with little resemblance, while the remaining 40% had a pattern unequal caries. Conclusion: Caries patterns in twins have no more similarities and less similarities than those who have similarities and many similarities.Keywords: Twins, dental caries patterns.
Compliance evaluation of removable space maintainer or space regainer usage Revanti Ramadhani; Syarief Hidayat; Risti Saptarini Primarti
Padjadjaran Journal of Dentistry Vol 24, No 1 (2012): March 2012
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.067 KB) | DOI: 10.24198/pjd.vol24no1.15383

Abstract

Premature loss could cause a problem with the tooth arrangement or the dental arch size. A space left by the primary tooth loss could cause migration of the adjacent teeth. As a result, space will be narrowed and undermined the eruption of the permanent teeth. The success of the space maintainer or space regainer usage due to the premature loss marked by space for the replacement of the permanent teeth. The purpose of this research was to evaluate the compliance of children in wearing a space maintainer or space regainer after insertion at Pedodontics Installation of Faculty of Dentistry Universitas Padjadjaran Dental Hospital, Bandung, Indonesia. The research method was descriptive survey technique. The sample consisted of 30 patients selected using the total sampling technique. Data were obtained with a questionnaire and statistically analyzed. The results showed that majority of the children uses the removable space maintainer or the space regainer daily was only about 23,3% overall. Most of the children only use the removable space maintainer or the space regainer for sometimes. The research concluded that the low rate of pedodontic patients compliance at Pedodontics Installation of Faculty of Dentistry Universitas Padjadjaran Dental Hospital in the usage of the removable space maintainer or the space regainer was usually caused by pain or discomfort. This fact was evidence of a low awareness of parents in preventing malocclusion to their children.
Prevalence of Carotid Artery Atherosclerosis Plaque in Systemic Lupus Erythematosus in Hasan Sadikin Hospital Bandung in 2017-2018 Irham Rasyid; Syarief Hidayat; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i2.129

Abstract

Background. Systemic Lupus Erythematosus (SLE) is an autoimmune disease involving many organs including the cardiovascular system such as accelerated atherosclerosis or premature atherosclerosis. Atherosclerotic plaque can cause coronary heart disease, ischemic stroke and peripheral arterial disease, which are the main causes of death in the world. The purpose of this study was to determine the prevalence of carotid artery atherosclerosis plaques in patients with SLE. Method. This research is a descriptive study with a cross-sectional design. Carotid artery atherosclerosis plaques in SLE patients were assessed by analysing results of carotid ultrasound examinations that were conducted in 2017-2018. The inclusion criteria of this study were SLE patients who had undergone carotid doppler ultrasound B mode examination on the carotid artery for the period of 2017-2018. The exclusion criteria in this study were SLE patients with a history of stroke, peripheral arterial disease, and significant coronary artery disease. Result. This study involved 88 SLE patients who met the inclusion criteria. Results showed that there were 10 SLE patients (11.4%) who had atherosclerotic plaques. SLE patients with atherosclerosis plaque were mostly in the age range of 35-44 years (16%) and 45-54 years (22.2%). There were 2 patients (15.3%) with atherosclerotic plaque from a total of 11 patients had high triglyceride levels (≥150 mg/dL). Chi square analysis of lipid profiles (cholesterol, LDL, HDL, triglycerides) in patients with atheroclerotic plaque revealed not significant (p>0.05). These findings could be caused by several factors, such as the small number of samples in this study and the non-traditional factors in the formation of atherosclerotic plaque as well as other traditional factors Conclusion. The prevalence of carotid artery atherosclerosis plaques in patients with SLE in Dr. Hasan Sadikin General Hospital in 2017-2018 is 11.4%.
Upaya Pembangkitan Rasa Nasionalisme Siswa Tingkat Sekolah Dasar Melalui Kegiatan Lomba Cerdas Cermat Di Desa Bicak Hutabarat, Debora; Dwiyanti, Tsabitah Mariyah; Mahisa, Delvia Shafa; Aulia, Disya Jasmine; Hidayat, Syarief
Jurnal Pengabdian Sosial Vol. 1 No. 10 (2024): Agustus
Publisher : PT. Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/3c80vr93

Abstract

Dalam rangka memperingati HUT Kemerdekaan Indonesia yang ke-79, mahasiswa Kuliah Kerja Nyata (KKN) Kelompok 4 Universitas Pembangunan Nasional “Veteran” Jawa Timur berinisiatif menyelenggarakan kegiatan lomba cerdas cermat dengan tema nasionalisme. Kegiatan ini bertujuan untuk membangkitkan dan meningkatkan rasa nasionalisme siswa sekolah dasar di Desa Bicak melalui metode yang interaktif dan edukatif. Kami menggunakan metode deskriptif, observasi, dan dokumentasi dalam pelaksanaan lomba cerdas cermat yang melibatkan siswa kelas 6 dari tiga sekolah dasar di Desa Bicak, Mojokerto. Lomba ini berlangsung selama tiga hari yang terdiri dari babak penyisihan, semi final, dan final dengan peraturan permainan dan skor poin hingga menghasilkan juara berdasarkan akumulasi poin. Pelaksanaan kegiatan lomba cerdas cermat di Desa Bicak, Kec. Trowulan, Kab. Mojokerto, berjalan dengan baik dalam membangkitkan jiwa nasionalisme siswa sekolah dasar melalui antusiasme dan keaktifan mereka dalam berpikir cepat dan kritis
Effect of short one-third lower face toward mastication performance in Deutero Malay Anggraeni, Dian; Oewen, Roosje Rosita; Runkat, Jakobus; Hidayat, Syarief
Padjadjaran Journal of Dentistry Vol 26, No 3 (2014): November 2014
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.055 KB) | DOI: 10.24198/pjd.vol26no3.14010

Abstract

The one-third lower face height belongs to ideal proportion, ratio 1:1:1, of vertical face height. The one-third lower face height could be influenced by mastication. The one-third lower face height that shorter than normal ratio is generally followed by deep bite which may lead to temporomandibular disfunction even so eustachian tube disfunction, this condition may interfere mastication function, which can be measured by mastication performance. The research objective was to determine the effects of short lower face height to the mastication performance based on overbite. The research method was a cross-sectional study with epidemiology survey type. Research subjects 12-15 years old junior high school with Deutero Melayu Sub races in Bandung. Sampling technique used multistage random sampling by determining the size of the sample based on potluck sample and gained 24 children (group 1) with the normal ratio of vertical face height and 27 children with short lower facial height which were 11 children overbite normal (group 2) and 16 children deep bite (group 3). Mastication performance by 20 times chewing artificial test food then followed by sieving test. Mastication performance value represented by the median particle size (MPS) and the distribution of the particle distribution (b). The results of average MPS and b between group 1, 2 and 3 used statistical analysis MPS with ANOVA test which Fhit=5.56 and pvalue=0.0075, b which Fhit=3.41 and pvalue=0.0430 showed significant differences. Continued with group T test MPS (value = 0.0925) dan b (value = 0.2076) between group 1 and 2 showed a non significant differences. While between group 1 and 3 showed a highly significant differences in MPS (value = 0.0037 and  = 0,01) and a significant differences in b (value = 0.0141 and  = 0,05). Conclusions of this study were children with short lower face height and normal overbite did not decrease the mastication performance while children with deep bite decrease the mastication performance.
Eight to thirteen years old children fear at dental treatment Aryani, Dwi Destaria; Gartika, Meirina; Hidayat, Syarief
Padjadjaran Journal of Dentistry Vol 25, No 2 (2013): July 2013
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol25no2.26792

Abstract

Introduction: Fear is an emotion occurring in situation of stress and uncertainty and can make the person experience the threatened or helpless feeling. The etiology of child dental fear consist of personal factor, external factor, and dental factor. The purpose of this study was to describe the child fear at 8-13 years of age toward dental treatment and find the most dominant etiology of fear. Methods: A descriptive survey was conducted amongs 53 childs in MI Cikapayang Islamic Elementary School who had ever gotten the dental treatment using CFSS-DS and questionnaire. The sampling method was total sampling. Results: The result shows that the description of child fear at 8-13 years of age to the dental treatment is not afraid at all (45,3%), a little afraid (33%), a fair amount afraid (15,2%), pretty much afraid (4%), and the most little is very afraid (2,5%). The etiology of child dental fear consist of personal factor (52,8%), external factor (7,5%), and dental factor (39,6%). Conclusion: Majority of child fear at 8-13 years of age to the dental treatment in MI Cikapayang Islamic Elementary School feel not afraid at all to the dental treatment (45,3%) and the most dominant etiology is personal factor (52,8%).