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All Journal HAYATI Journal of Biosciences Microbiology Indonesia Media Penelitian dan Pengembangan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Biotek Medisiana Indonesia Medical Journal of Indonesia Sari Pediatri Paediatrica Indonesiana Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) The Indonesian Journal of Infectious Diseases Eksakta : Berkala Ilmiah Bidang MIPA Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Makara Journal of Science Journal of Clinical Microbiology and Infectious Diseases Jurnal Kefarmasian Indonesia
Fera Ibrahim
Departemen Mikrobiologi Fakultas Kedokteran Universitas Indonesia/KSM Mikrobiologi Klinik RSUPN Dr Cipto Mangunkusumo, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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TROUBLESHOOTING IN EXPRESSION AND PURIFICATION OF RECOMBINANT SEVERE ACUTE RESPIRATORY SYNDROME-ASSOCIATED CORONAVIRUS NUCLEOCAPSID PROTEIN IN Escherichia coli BL21 Yasmon, Andi; Ibrahim, Fera; Bela, Budiman
Makara Journal of Science Vol. 14, No. 2
Publisher : UI Scholars Hub

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Abstract

Uji In Vitro Beberapa Kombinasi Antibiotik Antipseudomonas terhadap Pseudomonas aeruginosa yang Resisten terhadap Karbapenem Prasetyo, Dimas Seto; Herna, Herna; Mursinah, Mursinah; Ibrahim, Fera; Bela, Budiman
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5008

Abstract

Lower respiratory tract, sepsis, or urinary tract infection caused by the multidrug resistance Pseudomonas aeruginosa is common in the hospital, especially in the ICU wards. The treatment against this bacteria requires combination of antibiotics with different mechanism of actions. In this study, several combinations of antibiotics were evaluated in vitro against carbapenem-resistant P. aeruginosa isolated from the ICU of Cipto Mangunkusumo Hospital. The combination of antibiotics tested were ceftazidime-amikacin, ceftazidime-ciprofloxacin, and ciprofloxacin-amikacin. Checkerboard assay to the combination of antibiotics was conducted to assess the in vitro synergistic activity. A total of 22 P. aeruginosa isolates were collected, 16 of them were resistant to ceftazidime, ciprofloxacin, amikacin, as well as carbapenem. The result revealed that the combination of ceftazidime and amikacin showed promising synergistic activity. Conversely, no synergitic activities were shown by the combination of ceftazidime-ciprofloxacin and ciprofloxacin-amikacin. The combination of ceftazidime-amikacin may has potential effect againsts carbapenem-resistant P. aeruginosa in vitro.
Application of Nipah Pseudovirus System for Development of Antibody Neutralization Assay Anna, Shoffiana Noor; Fera Ibrahim
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 01 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss01/569

Abstract

Nipah virus (NiV) is a type of virus that can make people and many animals very sick.  It can cause serious breathing problems and brains welling.  Because of how dangerous and deadly it is, the World Health Organization (WHO) sees NiV as a global healthrisk.  It needs to be handled in special labs that have the highest safety measures, called Biosafety Level-4 (BSL-4) facilities.  Rightnow, there isn't a good vaccine or treatment available for NiV.  It could be a health risk for Indonesia since it has been found in nearby countries. Indonesia doesn't have a BSL-4 lab yet. So, we need a way to evaluation NiV vaccine that can be done in a BSL-2 lab.  The NiV pseudovirus (PV NiV) has special proteins that help it attach to and enter mammal cells.  It is made using a system based on HIV and includes a signal detector.  This setup can help create tests to measure how well antibodies work against NiV.  It can also be used to monitor infections, check community immunity, develop NiV vaccines, and research new treatments to fight NiV infections.
Daya Anti Bakteri Kombinasi Fosfomisin dan Sulbaktam-sefoperazon terhadap Bakteri Pseudomonas aeruginosa Syahrurachman, Agus; Ibrahim, Fera; Atna Permana
Majalah Kedokteran Indonesia Vol 69 No 12 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.12-2019-164

Abstract

Introduction: Pseudomonas aeruginosa may cause infections in various organs. Due to increase resistance, single antibiotic option for treatment of those infections is more limited.Objective: to elcucidate in vitro antibacterial effect of fosfomycin and sulbactam-cefoperazone alone and its combination against clinical isolates of Pseudomonas aeruginosa.Methods: Minimal Inhibitory concentration of fosfomycin and cefoperazone-sulbactam as a single drug and their combination was determined in liquid media against 30 clinical isolates of the Pseudomonas aeruginosa. Effect of antibiotic combination was calculated by Fraction Inhibitory Index. Time-kill curve was plotted according to the number of viable bacteria after antibiotic exposure.Results: The proportion of susceptible isolate to sulbactam-cefoperazon alone was 66.7% and increased to 90 % to combined antibiotics. Proportion of susceptible bacteria to fosfomycin alone was 10 % and increase to 20 % to combined antibiotics. Synergistic, indifferent and antagonistic effects were found in 60%,36.7% and 3.3% strains respectively. Rapid bacterial death occurred within the first 4 hours of exposure.Conclusion : Combination of sulbactam-cepoferazone and fosfomycin have sinergism in majority of tested strain of Ps aeruginosa and only one strain show antagonistic effect.
Potential of endophytic bacteria as producers of antibiotics: A literature review Scania, Alifah Evi; Ibrahim, Fera
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art13

Abstract

Microbial infection is a significant contributing aspect to the development of diseases, posing ongoing challenges in - healthcare. Numerous synthetic antibiotic agents have been used as therapeutic interventions; however, many microorganisms exhibit resistance to these synthetic agents. The rate at which microbes developed resistance to antibiotics has outpaced the discoveries and study of new treatments. The potential of endophytic bacteria to produce bioactive compounds or metabolites that can serve as the basis for developing new antibiotic drugs is promising is promising. This review aims to explore the metabolite potential of endophytic bacteria as a source of antibiotics. Understanding the mechanism and potential of endophytic bacteria offers opportunities for the advancing therapeutic interventions to mitigate the negative effects of various strains of antibiotic-resistant pathogenic bacteria.
Effect of matrix metalloproteinase-9 inhibitors in hepatitis B virus replication Kalista, Kemal Fariz; Harimurti, Kuntjoro; Immanuel, Suzanna; Iskandriati, Diah; Lesmana, Cosmas Rinaldi Adithya; Ibrahim, Fera; Gani, Rino Alvani
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257895

Abstract

BACKGROUND Hepatitis B virus (HBV) remains difficult to eradicate due to the persistence of covalently closed circular DNA (cccDNA). Matrix metalloproteinase-9 (MMP-9) enhances HBV replication, but the effects of its inhibition remain unexplored. This study aimed to investigate the effects of MMP-9 inhibitors on HBV replication markers. METHODS Primary hepatocyte cultures were obtained from the livers of 6 Tupaia javanica. Cultures were infected with HBV from human sera and divided into control and intervention groups. The intervention group received MMP-9 inhibitors at 1, 3, and 7 nM. The control group received phosphate-buffered saline. Levels of hepatitis B surface antigen (HBsAg), HBV DNA, cccDNA, MMP-9, interferon alpha and beta receptor subunit 1 (IFNAR1), and interferon beta (IFN-β) were measured in both groups before and 72 hours post-intervention. RESULTS MMP-9 inhibitor administration at 1, 3, and 7 nM consistently reduced HBsAg, HBV DNA, cccDNA, and MMP-9 levels, though not statistically significant. Median HBV DNA levels at 1, 3, and 7 nM were 7.05, 5.29, and 5.98 ×103 copies/ml, respectively. Mean cccDNA levels at 1, 3, and 7 nM were 14.15, 11.04, and 13.94 ×103 copies/ml, respectively. The 3 nM dose increased IFNAR1 levels, while the 7 nM dose increased IFN-β, but neither change was significant. Among the tested doses, 3 nM showed the most favorable effects despite the lack of significance. CONCLUSIONS MMP-9 inhibitor suppressed HBsAg, HBV DNA, cccDNA, and MMP-9 while increasing IFNAR1 and IFN-β in vitro.
Co-Authors . Andriansjah . DARMINTO . DARMINTO Ade P.R. Simaremare Agus Sjahrurachman Agus Sjahrurachman Agus Sjahrurachman Agus Sjahrurachman Agus Suwandono Agus Suwandono Agus Suwandono Agus Syahrurachman Akrom, Akrom Amin Soebandrio Andi Yasmon Andrijono Andrijono Andrijono Andrijono Anna, Shoffiana Noor Ardiana Kusumaningrum Ariyani Kiranasari Aroem Naroeni Aroem Naroeni Atna Permana Beti Ernawati Dewi Betty Ernawati Budiman Bela C Rinaldi A Lesmana Cliff Clarence Haliman Conny R Tjampakasari DIAH ISKANDRIATI Dimas Seto Prasetyo Elisna Syahruddin Endang R. Sedyaningsih Fithriyah Fithriyah Fithriyah Fithriyah Gatot Purwoto GINA SAMAAN Hartiyowidi Yuliawuri Herna Herna Herna, Herna Iin Maemunah Kemal Fariz Kalista, Kemal Fariz Ketut Tuti Parwati Krisna N.A. Pangesti Kuntjoro Harimurti Lola Febriana Dewi Louisa Ivana Utami Made Setiawan Made Setiawan Made Setiawan Mardiastuti H Wahid Mardiastuti Mardiastuti Melinda Remelia Mirna Robert D.R. van Beest Holle Muhammad F Aziz Muhammad F Aziz Mursinah Mursinah Mursinah Mursinah Mursinah, Mursinah NI LUH PUTU INDI DHARMAYANTI NI LUH PUTU INDI DHARMAYANTI Ni Luh Putu Indi Dharmayanti Ni Made Adi Tarini Ni Nengah Dwi Fatmawati Pratiwi Pujilestari Sudarmono Rela Febriani Rino Alvani Gani RISA INDRIANI Samsuridjal Djauzi Scania, Alifah Evi Silvia Tri Widyaningtyas Simon Yosonegoro Liem Subangkit Subangkit Suzanna Immanuel T Mirawati Sudiro Tiffani, Wely L Tjahjani M. Sudiro Tjahyani M. Sudiro Tofan W Utami Tofan W Utami VIVI SETIAWATY Vivi Setiawaty Wely L Tiffani Yeva Rosana Yulia Rosa Saharman YULIANTY MUHAYAR Yuliar Budi Hartanto Yuyun Soedarmono