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All Journal Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Katalisator Jurnal Farmasi Higea Indonesian Journal of Pharmaceutical and Clinical Research Borneo Journal Of Pharmascientech JAFP (Jurnal Akademi Farmasi Prayoga)
Asra, Ridho
Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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ANALISIS KUANTITATIF NATRIUM BENZOAT PADA KECAP KEDELAI MANIS PRODUKSI LOKAL DI KOTA PADANG DENGAN METODE SPEKTROFOTOMETRI ULTRAVIOLET-VISIBLE QUANTITATIVE ANALYSIS OF SODIUM BENZOATE FROM SOYBEAN SWEET SAUCES IN PADANG CITY BY USING ULTRAVIOLET-VISIBLE SPECTROPHOTOMETRY Ridho Asra; Zulharmita Zulharmita; Isa Rondasi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 3 No 1 (2019): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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Abstract

ABSTRAK Analisis kuantitatif natrium benzoat pada kecap kedelai manis produksi lokal di kota Padang dengan metode spektrofotometri ultraviolet-visible telah dilakukan. Sampel kecap diekstraksi menggunakan pelarut dietil eter kemudian ekstrak diidentifikasi dengan reaksi esterifikasi, reaksi warna dan uji nyala. Hasil penelitian menunjukan bahwa ketiga sampel kecap kedelai manis positif terdapat pengawet asam benzoat. Penetapan kadar pengawet asam benzoat ditentukan dengan menggunakan metode spektrofotometri ultraviolet-visible pada max 271,6 nm. Dari hasil pengukuran didapatlah kadar natrium benzoat sampel A 982 mg/kg, sampel B 960 mg/kg dan sampel C 914 mg/kg dan penggunaan pengawet asam benzoat pada sampel tidak melebihi batas maksimum penggunaan menurut BPOM RI No. 36 Tahun 2013 yaitu 1000 mg/kg bahan. Kata Kunci: Pengawet Benzoat, Kecap Manis, Spektrofotometri Ultraviolet-visibel ABSTRACT Quantitative analysis of sodium benzoate from soybean sweet sauces in Padang city with ultraviolet-visible spectrophotometry method has been studied. The samples were extracted with diethyl ether, and identified by using esterification reaction, colour reaction and flame test. The result of this study showed three samples positive contained benzoic acid. The determination of benzoic acid preservative concentration was determined by using ultraviolet-visible spectrophotometric method at max 271.6 nm. The contents of benzoic acid were sample A 982 mg/kg, sample B 960 mg/kg and sample C 914 mg/kg. In this study preservatives in the sample did not exceed the threshold that have been stipulated in BPOM RI No. 36, 2013 is 1000 mg/kg. Keywords: Preservative benzoate, Soy Sauce, Spectrophotometry Ultraviolet-visible.
ANALISIS KANDUNGAN NATRIUM BENZOAT PADA BAWANG MERAH GILING (Allium cepa L.) MENGGUNAKAN SPEKTROFOTOMETRI ULTRAVIOLET Ridho Asra; Fery Yasma; Zulharmita Zulharmita
Jurnal Akademi Farmasi Prayoga Vol 4 No 1 (2019): Jurnal Akademi Farmasi Prayoga
Publisher : Jurnal Akademi Farmasi Prayoga

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Abstract

Penetapan kadar Natrium Benzoate didalam bawang merah giling telah ditentukan. Sampel diperoleh dari tiga lokasi yang berbeda yaitu Pasar Gaung (A1, A2, A3), Pasar Batu Sangkar (B1, B2, B3), dan Pasar Solok Selatan (C1, C2, C3). Sampel kemudian dianalisis secara kualitatif dan diperoleh tiga sampel yang mengandung Natrium Benzoat adalah A1, A2 dan B1. Sampel diekstraksi menggunakan etanol sebagai pelarut dan kemudian diukur kadarnya menggunakan spektrofotometri ultraviolet. Natrium Benzoate dalam sampel dianalisis menggunakan persamaan regresi y = 0,0097x – 0,0721 dengan r = 0,9999. Batas Deteksi (BD) dan Batas Kuantitasi (BK) adalah 4,8247 ppm dan 16,08 ppm. RSD yang dihitung adalah 0,0156. Hasil penelitian menunjukkan bahwa kandungan Natrium Benzoat didalam tiga sampel yaitu A1=1,481g/kg, A2=1,347 g/kg, B1=1,209g/kg. Kadar yang diperoleh berada di atas nilai maksimum dari kandungan Natrium Benzoat yang ditetapkan oleh badan pengawas obat dan makanan Indonesia yaitu 1 g/kg.
Perbandingan Akrilamidakopi Bubuk Tradisional Dan Luwak Dengan Metode HPLC Ridho Asra; Rusdi Rusdi; Sofia Nofianti; Nessa Nessa
Jurnal Katalisator Vol 4, No 2 (2019): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jk.v4i2.4644

Abstract

Akrilamida merupakan senyawa kimia terdapat pada kopi yang disangrai pada suhu diatas 120 ˚C, berpotensi menyebabkan kanker pada manusia. Tujuan dari penelitian ini adalah untuk membandingkan kandungan akrilamida dalam kopi bubuk tradisional dan kopi  luwak dengan metode Kromatografi Cair Kinerja Tinggi.  Fase gerak yang digunakan asetonitril: aquabidest (15: 85, v/v), dengan detektor Photodioday-Array (PDA) pada ℷ   200 nm. Akrilamida dalam sampel kopi bubuk teridentifikasi pada waktu retensi (tR) ± 6,8 menit. Metode ini terbukti valid dengan linearitas y = 356468 + 293761 x, koefisien korelasi (r) = 0,9993, batas deteksi 1,9901 µg/mL dan batas kuantitasi 6,6337 µg/mL, presisi dengan % SBR = 0,207 %, akurasi dengan % perolehan kembali kopi bubuk tradisional dan kopi bubuk luwak 99 % dan 104 %. Kadar akrilamida dalam sampel kopi bubuk 1 sampai 6 berturut-turut adalah 1115 ± 12,17 µg/g sampel (1), 687 ± 7,58  µg/g sampel (2), 1461 ± 63,89 µg/g sampel (3), 221 ± 3,54 µg/g sampel (4), 128 ± 3,24 µg/g sampel (5), 195 ± 1 µg/g sampel (6). Dari keenam sampel kopi bubuk menunjukkan bahwa kadar akrilamida masing-masing sampel berkisar antara 128 sampai 1461 µg/g. Kadar yang diperoleh melebihi batas aman konsumsi akrilamida yang dikeluarkan oleh WHOAcrylamide is a chemical compound found in roasted coffee at temperatures above 120 ˚C which can potentially cause cancer in humans. The purpose of this research was to analyze acrylamide contents in traditional ground coffee and civet ground coffee by using High Performance Liquid Chromatography (HPLC) method. This analysis was carried out by isocratic elution system, the mobile phase of acetonitrile : aquabidest (15 : 85, v/v), using the stationary phase of the Shimadzu Shimpack ODS C18 column (250 × 4.6 mm), flow rate of 0.5 mL/minute, injection volume 20 µL, with a Photodioday-Array (PDA) detector at a wavelength of 200 nm. Acrylamide in ground coffee samples was identified at retention time (tR) ± 6.8 minutes. This method is proved valid with the linearity y = 356468 + 293761 x, correlation coefficient (r) = 0.9993, limit of detection 1.9901 µg / mL and limit of quantitation 6.6337 µg / mL, precision with % RSD = 0.207 %, acuracy with % recovery of traditional ground coffee and luwak ground coffee 99 % and 104 %. Acrylamide levels in 1 to 6 ground coffee samples in a row is 1115 ± 12.17 µg / g samples (1), 687 ± 7.58 µg / g samples (2), 1461 ± 63.89 µg / g samples (3), 221 ± 3.54 µg / g sample (4), 128 ± 3.24 µg / g sample (5), 195 ± 1 µg / g sample (6). Of the six ground coffee samples showed that the acrylamide levels of each sample ranged from 128 to 1461 µg / g. The levels obtained exceed the safe limits of acrylamide consumption released by WHO
Determination of Dexamethasone in Unregistered Herbal Weight Gain Using HPTLC-Densitometry Ridho Asra; Zulharmita; Nopitri Yuliatim
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (829.05 KB) | DOI: 10.32734/idjpcr.v1i2.331

Abstract

A method was described for the simultaneous determination of dexamethasone in herbal weight gain. Three unregistered herbal weight gains (sample A, B, and C) were analyzed by using HPTLC-densitometry method. Samples were extracted as bases into methanol, separated by HPTLC silica gel 60 F254plate using chloroform: methanol (9:1) as mobile phase followed by densitometry measurement of its spot. The result showed that the detector response was linear for concentrations between 100-500 mg/mL (r =0.998). The limits of detection and quantitation were 9.19 mg/mL and 30.64 mg/mL, respectively. Dexamethasone contents from samples were analyzed. The result showed that two samples (sample A and B) were positively containing dexamethasone and the other one showed a negative result. The average contents of dexamethasone from both samples were 0.23% and 0.25%, respectively.
Determination of Heavy Metal Contaminations of Lead and Cadmium in Selected Lipstick Products Sold in Padang City Using Atomic Absorption Spectrophotometry Ridho Asra; Rusdi; Robi Budi Yandra; Nessa
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.618 KB) | DOI: 10.32734/idjpcr.v2i1.743

Abstract

The study was aimed at assessing the levels of some toxic metals of lead and cadmium in selected lipstick products sold in Padang city. Four brands of lipsticks were taken which were BL, NK, PS and WD. The lipsticks were grinded and analyzed for heavy metals (lead and cadmium) using atomic absorption spectrophotometry. Each sample was destructed by nitric acid and perchloric acid (3:1). Destructed samples were added with sodium hydroxide to liberate ammonia and filtered into a 25 mL volumetric flask. The concentrations of heavy metal were measured by using atomic absorption spectrophotometry. The results showed that lead heavy metal contamination was not detected. Whereas, the heavy metal contamination of cadmium in lipstick brands BL, NK, PS and WD were 0.2287, 0.2000, 0.1796 and 0.1220 mg/kg, respectively. The study results showed that all metal contaminations of lead and cadmium were not over the limit which were regulated by National Agency of Drug and Food Control of the Republic of Indonesia.
Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi: Physicochemical Study of Betacyanin from Dragon Fruit Rind and Its Application as Natural Dye for Pharmaceutical Dosage Form Asra, Ridho; Yetti, Rina Desni; Rusdi, Rusdi; Audina, Selly; Nessa, Nessa
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.638 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13498

Abstract

The rind of dragon fruit (Hylocereus lemairel (Hook.) Britton & Rose) is a waste material that has not been optimally utilized. The rind contains betacyanin pigment that has many benefits in pharmaceutical products. The study aimed to characterize the physicochemical properties, to evaluate the stability and to apply betacyanin in dragon fruit rind as a natural dye. The extraction process was done by using water as solvent which was sonicated at 50 kHz for 30 minutes at 25 °C. Extract was freeze dried for 48 hours. The dried extract was purified by using preparative TLC and physicochemically analyzed by using UV-Vis and FTIR spectrophotometer. The stability of betacyanin extract against pH and temperature was examined and applied as a dye in tablet imprinting. The result of this study indicated that betacyanin was found at Rf value of 0.6 same as the betacyanin standard. The maximum wavelength of betacyanin was obtained at 534 nm and the IR spectra showed similarity with betacyanin standard with the same functional groups between 4000-600 cm-1 although there was a slight shift in the wavenumber but it still in the range. The stability study were stable at temperature below 40 °C and at range pH 4-6. Betacyanin applications as natural dye of tablet have been successfully carried out with good color stability during 3 months of storage at room temperature.
Co-Authors Aisyah Agustina Arifin, Putut Astuty, Widya Audina, Selly Boy Chandra Boy Chandra Boy Chandra Desi Ratnasari Elsa Febrianti Fery Yasma Festires Kurnia Harefa Harrizul Rivai I Gusti Bagus Wiksuana Isa Rondasi Laksono Trisnantoro Maisitoh Maisitoh Misfadhila, Sestry Muhammad Amrul N. Nessa Nadya Arta Mevia Nessa Nessa Nessa Nessa, N. Nessa, Nessa Nize Ria Azni Nopitri Yuliatim Putut Arifin R. Rusdi Rezza Puspita Sari Riri Nofrianti Robi Budi Yandra Rusdi Rusdi Rusdi Rusdi Rusdi Selly Audina Sofia Nofianti Via Lovita Riani Widya Astuty Yetti, Rina Desni Zikra Azizah Zikra Azizah Zulharmita Zulharmita Z Zulharmita Zulharmita