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All Journal Damianus Journal of Medicine Majalah Patologi Indonesia Journal of Urban Health Research Neurona Journal of Medicine and Health Cermin Dunia Kedokteran
Ecie Budiyanti
Department Of Histology, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Neuroscience Public Health

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Aplikasi Metode Whole Chromosome Painting untuk Mendeteksi Aberasi Kromosom pada Tumor Padat Budiyanti, Ecie; Suryani, Des; Pawitan, Jeanne Adiwinata
Majalah Patologi Indonesia Vol. 23 No. 1, Januari 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

In solid tumor, conventional cytogenetic method usualy fails to detect chromosomal aberation due to failure in obtaining good quality metaphases. Therefore, special technique is required to get the karyotype of solid tumors. Whole chromosome painting (WCP) is a method to paint the chromosomes using Fluorescence In Situ Hybridization (FISH) technique. Application of WCP, both using one and multiple colors (mFISH or SKY) or their modifications can be used to identify chromosomal aberrations, which are valuable in helping to attain a diagnosis, to determine the prognosis and management, and to predict the response to therapy. Key words: chromosomal aberation, FISH, solid tumor, whole chromosome painting.
Co-Authors Anastasia, Cindy Christopher Tan Cindy Anastasia Clara Stephanie Paul Des Suryani Des Suryani Divara Ariesta Sekar Suryadi, Made Edward Surjono Erwin Yantho Eunike Jennifer Tandiono Evi Ulina Margareta Situmorang Fan, Tan Fei Hendrik, Antonia J Jeanne Adiwinata Pawitan Jimmy Fransisco Abadinta Barus Jonny Setiawan Linawati Hananta, Linawati Linda Suryakusuma Lonah Lonah, Lonah Mariani Santosa, Mariani Nur Rizqiyah Muhandis Sandy Vitria Kurniawan Sasmita, Poppy K. Wijaya, Mayckel Joey Yantho, Erwin Yuda Turana Yuliana Yuliana Yuliana Zita Arieselia