Article Per Year (5 Year)
p-Index From 2021 - 2026
3.355
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Udayana Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Indonesian Journal of Pharmaceutical Science and Technology Al-Khidmah BULETIN AL-RIBAATH PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Fajar Nugraha
Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Jl. Prof. Dr. H. Hadari Nawawi Kota Pontianak 78124, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Identification of Paracetamol in Jamu Using Thin Layer Chromatography Analysis Method Iga Yastiara; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15284

Abstract

Jamu is one of the Indonesian traditional medicine. Jamu is efficacious for health so it is widely consumed by the society. The high level of consumption causes trade competition from jamu industry in various regions, including in Pontianak City, West Kalimantan. However, several jamu industries in Pontianak have violated the law by adding medicinal chemicals to jamu. The most widely added medicinal chemical in jamu is paracetamol. Paracetamol which indicates as an analgesic-antipyretic can be harmful for health because it increases liver hepatotoxicity if consumed continuously.This study aims to identify paracetamol in herbal medicine. A total of 10 samples were obtained in Pontianak City, West Kalimantan by purchasing directly or from an online shop. This study used thin layer chromatography as an instrument of qualitative analysis. The results of the analysis using thin layer chromatography were Rf samples A, B, and G were 0.675, respectively; 0.6625; 0.6625 which is close to the standard Rf value for comparison of paracetamol, which is 0.675. Those three samples contained paracetamol because they had a different Rf value 0.05 from the standard Rf value.
Identify the Rhodamin B on lipsticks in the market Using Thin Layer Chromatography (TLC) Method Nurul Fajriani; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15392

Abstract

Rhodamine B is a synthetic dye used as a dye for paper and textiles. This dyeis prohibited from being used in cosmetics including lipstick because it can cause skin irritation, irritation to the digestive tract, poisoning, and can cause cancer. The research aims to identify Rhodamine B contained in lipstick circulating in the market area of Pontianak City. Sampling was carried out using purposive sampling technique, obtained 7 samples of lipstick circulating in the market area of Pontianak City. The analysis of Rhodamine B in this lipstick was carried out by Thin Layer Chromatography method using silica gel plate GF 254 and the mobile phase is a mixture of n-butanol, ethyl acetate, and ammonia in a ratio (10:4:5). The results of this study obtained 2 positive samples containing Rhodamine B, namely samples A and E. The Rf values in the samples were 0.75 and 0.675, which were close to the Rf value for the comparison of Rhodamine B, which was 0.7375. The identification results showed that from 7 lipstick samples there were 2 samples positive for Rhodamine B dye. 
Analysis of Hydroquinone Content in Whitening Cream by Spectrophotometry UV-Vis Method Efprio Nensa Kurniawan; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15285

Abstract

Hydroquinone is an ingredient that is often added in whitening creams with the aim of whitening the skin. According to BPOM Regulation No.23 of 2019, hydroquinone has been banned from its use as a bleach or lightener in cosmetics. The use of hydroquinone can only be used for nails with a level of 0.02%, as well as hair dye oxidizers with a maximum level of 0.3%. The mechanism of hydroquinone in whitening the skin is the toxic effect of hydroquinone on melanocytes, and through inhibition of the process of melanin formation. This study aims to identify and determine the levels of hydroquinone contained in whitening creams circulating in Pontianak City. The research method used in this study is descriptive non-experimental, where as many as 10 samples of whitening cream circulating in Pontianak City were obtained using purposive sampling techniques. Identification of hydroquinone is carried out qualitatively using FeCl3 1% reagent, and benedict reagent. Determination of hydroquinone levels in the sample is done quantitatively using a UV-Vis spectrophotometer. Based on the calculation of validation parameters, the equation y = 0.0251x – 0.0029, linearity value with relation coefficient (r) of 0.9999, %recovery of 100.15%, precision with a value of %RSD of 0.4899%, LOD of 0.2742 ppm and LOQ of 0.9140 ppm. Based on the results obtained, as many as 8 samples of positive whitening creams contained hydroquinone with a sample level of A of 3.1630%; sample B of 2.7322%; C sample of 2.5335%; sample D of 2.3216%; G sample is 2.5118%; H sample of 3.3171%; sample I was 2.4409 and sample J was 0.5571%.
Uji Kualitatif dan Penetapan Kadar dengan Metode Spiking pada Logam Pb di Dalam Minuman Kopi Kaleng Husnafa Patriani; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15802

Abstract

Lead (Pb) is a heavy metal that is naturally present in the earth’s crust. This metal is dispersed in nature in small amounts through natural processes. Lead that accumulates in the environment is not biodegradable and its toxicity does not change. Contamination of lead (Pb) meta; in canned drinks can occur due to imperfect packaging, damage or rust. Lead metal is obtained from soldering tools. This study aims to identify the presence of Pb metal in canned coffee drinks. In addition, to find out the method of preparation that was carried out correctly the spiking method was used. Samples were taken in Pontianak City with purposive sampling technique. The sample of this research is canned coffee drinks with 3 different brands (brands A, B and C) circulating in the city of Pontianak. The qualitative test was carried out using 0.5 N KI reagent and 2 M HCl which was dropped into the sample. A positive result on a sample that was dripped with 0.5 N KI reagent was a yellow precipitate, while a positive result on a sample that was dripped with 2 M HCl reagent was a white precipitate. The spiking method was carried out by adding 0.3 mL of 1000 ppm Pb standard solution and adding the sample to a volume of 2 mL. Then, wet digestion was carried out using 10 mL HNO3 and 2 mL H2O2 as solvent. The results of the qualitative test showed that all samples with 0.5 N KI reagent were clear and black precipitate formed. All samples that were dropped with 2 M HCl reagent were clear and no precipitate was formed. In assay by spiking method, the levels obtained are 73.54 mg/kg and % recovery is 86.667%. All tested samples did not contain Pb metal and the preparation method used was correct.
Karakterisasi Bobot Jenis dan Identifikasi Kalsium Pada Susu Kedelai Bart Agus Raya; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15830

Abstract

Soy milk is a drink that is good for health because it contains protein, unsaturated fatty acids, vitamins, carbohydrates and important minerals needed by the body such as calcium. Calcium functions to help the process of forming bones and teeth, blood clotting, muscle contraction, transmitting nerve cell signals, maintaining bone density, supplements in lowering LDL cholesterol levels. This study aims to determine the density characteristics of soy milk produced and to identify the calcium content qualitatively in soy milk drinks circulating in Pontianak City. The research method used in this study is descriptive non-experimental using 3 samples of soy milk circulating in Pontianak City with purposive sampling technique. Sample preparation in this study was carried out by wet digestion using HNO3 65% p.a solvent. Qualitative identification of calcium content was carried out using 5% ammonium oxalate reagent. The presence of a white precipitate after the addition of 5% ammonium oxalate indicates a positive calcium in the sample. Characterization of the specific gravity of soy milk was carried out using a pycnometer. The results obtained in this study are samples of soy milk A, B and C are positive for calcium because they form a white precipitate when soy milk samples are added with 5% ammonium oxalate reagent and the density of soy milk A, B and C is 1, respectively. ,00894905 g/mL, 1.008108836 g/mL and 1.008789684 g/mL.
Penetapan Kadar Paracetamol dalam Jamu di Kota Pontianak Menggunakan Instrumen Spektrofotometri UV-Vis Fajar Nugraha; Hadi Kurniawan; Iga Yastiara
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.18876

Abstract

Jamu is a traditional medicine used for generations in Indonesia. There are many regulations for jamu in Indonesia, one of which is the Regulation of the Minister of Health number 7 of 2012. The Minister of Health regulates the prohibition of distribution of jamu containing medicinal chemicals (BKO) that can endanger health. However, there are still many herbs containing BKO circulating in Indonesia, one of which is paracetamol. This study aims to verify the analytical method and measure the levels of paracetamol of jamu in Pontianak City, West Kalimantan. The verification of the analytical methods in this study is the measurement of linearity, accuracy, precision, Limit of Detection (LOD), and Limit of Quantification (LOQ). 3 (three) samples with different brands and indications were obtained through purchases from online shops. UV-Vis spectrophotometry used as a quantitative analytical instrument. The results of the linearity test obtained an r value of 0.999 and an r2 value of 0.999 which met the requirements of ICH, SNI, AOAC, and Eurachem. The results of the accuracy test have a %recovery range of 97.1986-102.2856% which meets the AOAC requirements. The results of the precision test have a %RSD range of 1.8197-7.7966% which meets the AOAC and Horwitz requirements. The results of the LOD calculation are 0.3273 ppm and the LOQ value is 0.9918 ppm. The results of the analysis using UV-Vis spectrophotometry were samples A, B, and C containing paracetamol with levels of 5.1667% each; 18.9809%; and 22,9167%.
Identifikasi Timbal dan Verifikasi Destruksi dengan Metode Spiking Pada Sampel Kangkung Darat Di Kota Pontianak Virgilius Alleandro Tuah Talu; Hadi Kurniawan; Fajar Nugraha
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.18891

Abstract

Water spinach is a vegetable that is rich in benefits, apart from the benefits it has, it can also be a mediator for the spread of heavy metals to humans. One of the contaminants that can contaminate Water spinach is lead (Pb). Lead (Pb) is a pollutant that occurs in big cities and has toxic properties. Lead (Pb) contamination in water spinach can occur due to the influence of motor vehicle exhaust, waste, fertilizers and pesticides containing metals. Lead (Pb) contamination in vegetables such as Water spinach can have adverse effects on health such as poisoning and can cause various kinds of disorders such as digestive tract disorders. This study aims to identify lead (Pb) in Water spinach and find out whether the sample preparation method used is good and correct by using spiking method. The samples used in this study amounted to 5 samples spread at different market locations in Pontianak city using the technique purposive sampling. Water spinach samples were prepared using the wet destruction method, then qualitatively tested using 1N NaOH reagent. Method Spiking carried out by taking a standard solution of 1,000 ppm lead (Pb) as much as 1 ml and putting it into the sample to be prepared. The sample that has been prepared is then measured and the value is calculated %Recovery. The results of the qualitative test showed that after the sample was dripped using 1N NaOH reagent there was no white precipitate. The Result obtained in verification of destruction using the spiking method were concentration of 18.7515 ppm and a value %Recovery of 106.8833%. All samples of Water spinach that were tested qualitatively did not contain lead (Pb) and the preparation method used for analysis of ground kale was good and correct.
Identifikasi Natrium Siklamat dan Karakterisasi Bobot Jenis Pada Sampel Minuman Jajanan yang Dijual di Kota Pontianak Andi Andi; Hadi Kurniawan; Fajar Nugraha
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.18877

Abstract

Food additives are materials that are added in the food and beverages which has function to influence the quality and form of the food. Sodium cyclamate is one of a food additives that commonly used as a sweeteners in beverages, but the excessive and continuous use can cause dangerous effects to the body. The purpose in this study are to identify sodium cyclamate content qualitatively and to determine the density characteristics of the beverages that are sold in the Pontianak city. The method that are used in this reseacrh is descriptive non-experimental using 5 samples of beverages that are sold in the Pontianak City with purposive sampling technique. Identification of sodium cyclamate in beverages samples is carried out qualitatively using HCl, BaCl2, and NaNO2. Samples which positively contain sodium cyclamate will make white precipitate after the reaction. Characterization of the density of beverages samples is carried out using a pycnometer. The qualitative test result in this research indicate that there are 3 out of 5 samples positive containing sodium cyclamate which is samples of beverages C, D, and E. Density result in sample of beverages C, D, and E respectively are 1,0073 g/mL, 1,0075 g/mL dan 1,0086 g/mL.
Identifikasi Kandungan Natrium Nitrit Pada Jajanan Ayam Krispi Pedagang Kaki Lima Harli Frimana; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15746

Abstract

Sodium nitrite is a food additive that is often used as a preservative in processed meats such as crispy chicken, but excessive and continuous use can cause toxic effects on the body. The purpose of this study was to identify sodium nitrite in crispy chicken in Pontianak city with limits determined by the Regulation of the Head of BPOM RI No 36 of 2013. The research method used in this study was descriptive non-experimental, where as many as 5 samples of crispy chicken were samples A, B, C, D, and E sold by several street vendors in Pontianak City were obtained using purposive sampling technique. Identification of sodium nitrite was carried out qualitatively using BaCl2, AgNO3, and Griess reagents. A positive result for the BaCl2  if it contains sodium nitrite will result in no precipitate forming, a positive result for the AgNO3 will produce a white precipitate, while a positive result for the griess reagent will produce a red-purplish color. The results of the qualitative test using BaCl2 and AgNO3 showed that none of the 5 samples tested were positive for sodium nitrite, while the qualitative test using griess reagent showed that out of the 5 samples tested there were 2 samples containing positive sodium nitrite, namely samples A and D, so that it can be concluded that samples A and D contained positive sodium nitrite in crispy chicken sold by several street vendors in Pontianak city
ANALISIS KADAR MINERAL BESI (Fe) DALAM KULIT LABU SIAM (Sechium edule (Jacq.) Sw.) DAN LABU AIR (Lagenaria siceraria (Mol.) Standley) DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM: ANALYSIS MINERAL CONTENT OF IRON (Fe) IN CHAYOTE PEEL (Sechium edule (Jacq.) Sw.) AND WATER GOURD (Lagenaria siceraria (Mol.) Standley) USING ATOMIC ABSORPTION SPECTROPHOTOMETRY Daffa Hana Alifia; Pratiwi Apridamayanti; Fajar Nugraha
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.666

Abstract

Mikronutrien ialah zat esensial atau molekul kecil yang dibutuhkan organisme atau makhlukhidup dalam jumlah kecil yang digunakan untuk pertumbuhan dan perkembangan tubuh secaranormal. Defisiensi mikronutrien dapat mempengaruhi kurang lebih 2 miliar individu dariberbagai umur di negara industri maupun di negara berkembang. Pengkonsumsian labu siamdan labu air sangat berguna bagi tubuh jika dikonsumsi dalam jumlah yang cukup karena labusiam dan labu air banyak mengandung sejumlah mineral didalamnya. Riset ini bertujuan untukmenetapkan kadar mineral besi yang terdapat di dalam kulit labu air dan labu siam. Mineralbesi dipilih karena merupakan mikromineral yang bila dikonsumsi dalam jumlah kecil dapatmembantu proses metabolisme dari reaksi kimia di dalam tubuh. Fungsi mineral besi pentingdalam metabolisme tubuh ialah sebagai zat yang berperan untuk membentuk sel darah merahdari proses sintesis hemoglobin dan sebagai sistem imunitas tubuh dengan mengaktifkanenzim penyusun antibodi. Metode riset yang dipergunakan pada riset berikut ialah penelitianeksperimental menggunakan metode analisis kuantitatif dengan instrumen SpektrofotometriSerapan Atom. Metode SSA digunakan karena dapat menganalisis unsur logam dengankonsentrasi yang kecil dan sangat kecil, memiliki kepekaan dan ketelitian yang tinggi,sederhana, cepat, dan minim interferensi. Penentuan kadar sampel diperoleh hasil kadar besirata-rata untuk labu air yaitu sebesar 46,416 ± 0,09 mg/kg dan kadar rata-rata besi pada labusiam sebesar 65,700 ± 0,02 mg/kg. Kata kunci : mikronutrien, SSA, labu air, labu siam
Co-Authors Adelita Ahyanurri Adnan Pramudio Andhi Fahrurroji Andi Andi Apridamayanti, Pratiwi Aulia Faradilla Bambang WIJIANTO Bart Agus Raya Daffa Hana Alifia Dwi I. Prayitno Efprio Nensa Kurniawan Fajriaty, Inarah Hadi Kurniawan Hafrizal Riza Hariyanto IH Harli Frimana Husnafa Patriani Iga Yastiara Iga Yastiara Khalishah, Hana Laksono Trisnantoro Liza Pratiwi Melania Niken Safira Muhammad Akib Yuswar Novia Novia Nurul Fajriani Pratiwi Apridamayanti Rico Arianto Ropiqa, Meri Safrilla Anggraeni Shoma Rizkifani Siti Nani Nurbaeti Thamrin Usman Tiara Bella Pratiwi Virgilius Alleandro Tuah Talu Winda Rahmalia Yuda Pratama K