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All Journal journal of internal medicine Geological Engineering E-Journal Jurnal Kreativitas PKM Medical and Health Science Journal Community Service Journal of Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Indonesia Berdaya International Islamic Medical Journal Journal of Health Community Service JGEN : Jurnal Pengabdian Kepada Masyarakat
Danny Irawan
Badan Geologi KESDM
Religion Arts Humanities Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : International Islamic Medical Journal

 1 
Effect of Oral Administration of Mytragina Speciosa on Blood Ketone Level and Glomerular Histology in Streptozotocin Induced Diabetic Mice choirotussanijjah, Choirotussanijjah; Salim, Hotimah Masdan; Bintarti, Tri Wahyuni; Irawan, Danny
Jurnal Medis Islam Internasional Vol 6 No 1 (2024): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v6i1.5232

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disease characterized by increased sugar levels that cause serious damage to various organs. Diabetic ketoacidosis is one of the complications of diabetes mellitus. It is characterized by a decrease in the patient's consciousness, increased blood sugar levels, and the presence of acidic ketone bodies. It is a serious condition that can cause a coma or even death. Mytragina Speciosa,  known as kratom, is a plant often found in Southeast Asia, including Indonesia. This herb is frequently used as a stimulant to treat fatigue and help improve productivity. Based on previous research, Mytragina Speciosa is rich in alkaloids, flavonoids, and phenols. These compounds are very useful for inhibiting the activity of α-glucosidase and lipase enzymes in the pancreas, so they have a potential effect on diabetes mellitus. However, there has been no research related to the administration of Mytragina Speciosa its effect on blood ketone levels and glomerular diameter. Objective: to determine whether there is an effect of Mytragina Speciosa on blood ketone levels and glomerular diameter in mice with a diabetes mellitus model. Methods: Hyperglycemia is induced by Streptozotocin. On the 14th day, the mice will be checked for hyperglycemia and blood ketone levels. Administration of Mytragina Speciosa begins on day 15 for 2 weeks. At the end of the second week, the mice will be checked for blood ketone levels using a special kit to detect ketone bodies. Furthermore, the glomerular diameter will also be assessed. Results: In this study, treatment for 2 weeks only caused an increase in blood sugar levels in mice, but did not cause an increase in blood ketone levels in the diabetes group or other treatment groups (p > 0.05). Histological preparation of the Glomerulus showed a decline in glomerular diameter. Conclusions: The administration of Mitragyna speciosa extract did not result in a significant increase in blood ketone levels in diabetic mice. Many factors are involved in increasing blood ketone. It is necessary to monitor ketone levels during treatment as well as have a longer treatment time to see the effect of Mitragyna speciosa on ketones
The Relationship between The Characteristics of Type 2 Diabetes Mellitus Patients and The Chronic Kidney Disease Stage during The COVID-19 Pandemic at RSI Jemursari Surabaya Irawan, Danny; Effendi; Donastin, Adyan; Agustiandani, Rifka Windi; Tsabita, Andhien Syifa’; Iryawan, Rifky Dwi Aditya; Oktaviana, Betta Mega; Muhammad, Akbar Reza
Jurnal Medis Islam Internasional Vol 5 No 2 (2024)
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v5i2.5606

Abstract

Introduction: The prevalence of diabetes mellitus has risen globally, posing a substantial health challenge, with a marked increase reported in both developed and developing nations. Diabetes is a primary contributor to the global prevalence of Chronic Kidney Disease (CKD). During the pandemic, there is a considerable challenge, especially for CKD patients, including a loss in health services, vulnerability to COVID-19 infection, stressful events during social distancing, and a decrease in therapy adherence. Hence, the COVID-19 pandemic may give rise to various characteristics in individuals with chronic kidney disease. Objective: To investigate the correlation between the characteristic of patients with type 2 diabetes mellitus and the chronic kidney disease (CKD) stage at RSI Jemursari Surabaya during the COVID-19 pandemic. Methods: An observational analytical cross-sectional study was conducted on individuals with chronic kidney disease (CKD) previously diagnosed with diabetes mellitus (DM) during the COVID-19 pandemic from 2020 to 2022. A total of 169 samples were obtained using a simple random sampling method. The variables considered include age, gender, HbA1c, blood pressure, cardiovascular comorbidities, Pulmonary comorbidities, and history of COVID-19. Results: The study demonstrated a significant correlation between blood pressure and kidney function tests, including blood creatine level, BUN, and eGFR, with CKD stage (P<0.05). Randomised blood glucose also has a significant correlation to the CKD stage. No notable correlation was observed among age, gender, HbA1c levels, cardiovascular comorbidities, pulmonary comorbidities, and history of COVID-19. Conclusions: The presence of hypertension and abnormal kidney function test results correlate with the stage of chronic kidney disease (CKD) during a pandemic.
Co-Authors -, Rusdianingseh Aditya Iryawan, Rifky Dwi Agustiandani, Rifka Windi Ali P, Abraham Ahmad Alifiyah Pramesti, Rosandhy Arfianto V Avicenna, Adrian Awwalia, Evi Sylvia Bambang Edi Suwito Bintarti, Tri Wahyuni Bramantono Bramantono, Bramantono Choiriya, Dian Dakwatul Choirotussanijjah Donastin, Adyan Dwi Handayani Effendi Hadi Nugroho Hadi U Hamidah - Hatmanti, Nety Mawarda Hendry Tri Pradipta Putra Imamatul Faizah Irmawan Farindra Iryawan, Rifky Dwi Aditya Lailatul Khusnul Riski Magna, Chaedar Sufy Muhammad, Akbar Reza Nasronudin Nasronudin Nuari, Nuzlan Oktaviana, Betta Mega Pramistyowati , Magda Budi Purwati - Puspitasari, Mia Ratna Yunita Rohmawati, Riska Rusdi, Warda El Maida Salim, Hotimah Masdan Sari, Ratna Yunita Savitri, Ardyarini Dyah Septianingrum, Yurike Soewandojo E Soleha, Umdatus Suharto - Triyono EA Tsabita, Andhien Syifa’ Ulum F, Ahmad Misbahul Yanis Kartini Yoga Aribowo Yuli, Aizah Ari Setyana Yunita Sari, Ratna Zahran, Sadira Zhavira, Rahmadinah Diva