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All Journal EKSAKTA: Journal of Sciences and Data Analysis CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Indonesian Journal of Chemistry Proceeding of International Conference Health, Science And Technology (ICOHETECH)

Ritmaleni, Ritmaleni

Faculty Of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia.

Author-ID : 2920924

Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 18 Documents Claim Missing Document

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Articles

Title

EFFECT OF BENZALDEHYDE EXCESS IN THE SYNTHESIS OF LR-2 AND CYTOTOXIC ACTIVITY OF LR-2 AGAINTS HeLa CELL Ritmaleni, Ritmaleni; Arifin, Muhammad Fajar; Laksmiani, Ni Putu Linda; ., Rumiyati; ., Sismindari
INDONESIAN JOURNAL OF PHARMACY Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

LR-2(4-phenyl-3,4-dihydro-indeno[2â,1â]pyramidine-2(1H)- thione;Â LeniÂ RitmaleniÂ 2),Â whichÂ designedÂ andÂ assumedÂ toÂ have biologicallyÂ activityÂ asÂ anticancer,Â hasÂ beenÂ successfully synthesizedÂ byÂ usingÂ theÂ BiginelliÂ reaction.Â ThisÂ researchÂ was aimedÂ toÂ investigateÂ theÂ effectÂ ofÂ benzaldehydeÂ excessÂ inÂ the synthesisÂ ofÂ LR-2Â andÂ toÂ evaluateÂ theÂ cytotoxicÂ activityÂ ofÂ LR-2against HeLa cancer cell lines. The synthesis was done by reacting benzaldehyde, 2-indanone and togetherÂ with thiourea at one time asÂ saidÂ asÂ oneÂ potÂ reactionÂ syntheticÂ methodologyÂ andÂ the reaction was acid catalysed. The mole equivalent of benzaldehyde wasÂ inÂ excessÂ compareÂ toÂ others.Â TheÂ effectÂ ofÂ benzaldehydeÂ in excess is the higher the mole of benzaldehyde, the lower the yield ofÂ LR-2.Â TheÂ cytotoxicityÂ ofÂ LR-2Â wasÂ doneÂ byÂ usingÂ MTTÂ method and the LC50 was 268.15 Î¼M.Key words : LR-2, benzaldehyde, cytotoxic, HeLaÂ

Cytotoxicity of Tetrahydropentagamavunon-0 (THPGV)-0 and Tetrahydropentagamavunon-1 (THPGV-1) in Several Cancer Cell Lines Ikawati, Muthi; Purwanto, Heri; Imaniyyati, Niar Nurul; Afifah, Anis; Sagiyo, Marrita Langgeng; Yohanes, Jasson; Sismindari, Sismindari; Ritmaleni, Ritmaleni
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tetrahydropentagamavunon-0 (THPGV-0) and Tetrahydro-pentagamavunon-1 (THPGV-1), are analogs of a curcumin metabolite, tetrahydrocurcumin, and a derivate of Pentagama-vunon-0 (PGV-0) and Pentagamavunon-1 (PGV-1), respectively.Â THPGV-0 and THPGV-1 have been successfully synthesized and are investigated for their anticancer potency.Â Cytotoxic assays were performed toward several cancer cell lines to determine values of the IC50 against those cell lines. Assessing cytotoxicity in Vero normal cell line showed the selectivity of those compound.Â THPGV-1 showed highest cytotoxic activity in lymphoma Raji cells, a suspension cell line, with an IC50 of 180mM.Â Both THPGV-0 and THPGV-1 showed similar potencies in T47D breast cancer cell line with IC50 values of 250-270mM.Â Regardless their high selectivity, however, cytotoxic activities of THPGV-0 and THPGV-1 were lower compared to PGV-0 and PGV-1 in HeLa cervical, T47D breast, and WiDr colon cancer cell lines.Â Further study using different types of cancer cell lines and confirmation of cell viability by another assays and apoptosis detection may give more benefit.Â

Synthesis of 4-phenyl-3,4-tetrahydro-indeno [2,1]-pyrimidin-2-one (LR-1) Ritmaleni, Ritmaleni; Nurcahyani, Wahyu
Indonesian Journal of Pharmacy Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The synthetic compound 4-phenyl-3,4-tetrahydro-indeno[2,1]- pyrimidin-2-one 20a (LR-1) was synthesised using Biginelli reaction method. The reaction involved benzaldehyde 6, 2-indanone 2 and urea 7 in acid condition. This condensation reaction yielded 15 % of the product 20, at 133,4-135,0oC of melting point and 0.15 (Et2O : CHCl3 = 1 : 3) of RfÂ value.Keywords : benzaldehyde, indenone-2, urea

Synthesis of Tetrahydro Pentagavunon-0 Ritmaleni, Ritmaleni; Simbara, Ari
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Curcumin, tetrahydrocurcumin, and monoketone curcumin analogue, pentagamavunone-0 (PGV-0), have been investigated as antioxidant, antiinflammatory and anticancer. This research was aimed to synthesise the Tetrahydropentagamavunone-0 (THPGV-0) compound which assumed as an active metabolite of PGV-0. The hydrogenation reaction was applied to the synthesis of THPGV-0 from PGV-0 using Pd/C 10 % as catalyst at room temperature. The structure elucidation was analysed by using spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.Key words: pentagamavunone-0, Tetrahydropentagamavunone-0, hydrogenation

Curcumin Analogs Induce Apoptosis and G2/M Arrest In 4T1 Murine Triple-Negative Breast Cancer Cells Retno Murwanti; Azmi Rahmadani; Ritmaleni Ritmaleni; Adam Hermawan; Bambang Sulistiyo Ari Sudarmanto
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp11

Chemotherapy is the first-line treatment for triple-negative breast cancer (TNBC), yet toxicity and resistance effects have been the current problems. Curcumin,a natural compound, has been reported to exert anti-proliferative effects on various cancer cells, including breast carcinoma cells. However, the β-diketone moiety influences the stability of curcumin. Curcumin analogs, pentagamavunon-0 (PGV-0), and pentagamavunon-1 (PGV-1) were synthesized to improve the stability and activity of curcumin by modified the β-diketone moiety into mono-ketone pentanone. In this study, we evaluated the cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis of curcumin and its analogs (PGV-0 and PGV-1) in murine triple-negative breast cancer 4T1 cell line. The cytotoxic evaluation was done by MTT assay, while apoptosis induction and cell cycle evaluation was performed by annexin V staining and detected by flow cytometry. Curcumin and its analogs, PGV-0, and PGV-1, significantly inhibit the viability of 4T1 breast cancer cells with an IC50 value of 34.34µg/mL, 13.76µg/mL and 38.21μg/mL, respectively. Apoptosis analysis with a dose of 10µg/mL and 15µg/mL in 4T1 breast cancer cells showed that curcumin and its analogs effectively induce apoptotic in a dose-dependent manner. In cell cycle analysis using a dose of 15µg/mL, curcumin inhibited the cell cycle progression in the S phase, whereas PGV-0 and PGV-1 inhibited the cell cycle in the G2/M phase. It could be concluded that curcumin analogs, PGV-0 and PGV-1, have higher potential to be developed as anti-cancer agents by inducing cell cycle arrest and apoptosis in triple-negative breast cancer.

Inhibitory effect of THPGV-0 on the histamine release from antigen-induced RBL-2H3 cells Agung Endro Nugroho; Ritmaleni Ritmaleni; Novrizal Abdi Sahid; Kazutaka Maeyama
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tetrahydropentagamavunon-0 (THPGV-0) is assumed to be main metabolite product of biotransformation process of PGV-0. THPGV-0 was synthesized by converting PGV-0 to the compound by hydrogenation with Pd/C as a catalyst. PGV-0 potently inhibited the histamine release from rat mast cells in vitro and in vivo, however, ironically only traces amount of compound was found in the blood. THPGV-0 is assumed to have important roles in the biological effects of PGV-0 in vivo. In present study, we investigated the antiallergy effect of THPGV-0 in compare to this of PGV-0 in vitro. The study was performed by using rat basophilic leukemia (RBL-2H3) cell line, a tumor analog of mucosal mast cells. DNP-BSA, an antigen, was used as an inducer for stimulating the histamine release from mast cells. In present study, THPGV-0 at low concentration did not succeed to inhibit the histamine release, but at higher concentration (30 and 100 M) showed strong effects. THPGV-0 at concentration of 100 M depleted the histamine release by 96.10 0.51%. In compare to PGV-0, THPGV-0 has higher efficacy but less potent. In the study, the possibilities of the spontaneous release from RBL-2H3 cells by the compounds were also observed. All concentrations of THPGV-0 as well as PGV-0 showed low spontaneous histamine release, less than 10 % of the total histamine contained in RBL-2H3 cells.Key words: tetrahydropentagamavunon-0, allergy, histamine, RBL-2H3 cells

SYNTHESIS OF TETRAHYDROHEXAGAMAVUNON-5 AND TETRAHYDROHEXAGAMAVUNON-7 Ritmaleni Ritmaleni; Ian Praditya; Haryono Wibowo; Sardjiman Sardjiman
Indonesian Journal of Pharmacy Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Synthesis of Tetrahydrohexagamavunon-5 (THHGV-5) and Tetrahydrohexagamavunone-7 (THHGV-7) were prepared by catalytic hydrogenation reaction on Hexagamvunon-5 (HGV-5) and Hexagamavunone-7 (HGV-7) by using gas H2 as source of hydrogen gas, Pd/C 10 % as metal catalyst and methanol as solvent at room temperature. The products were characterized by IR Spectroscopy, Gas Chromatography-Mass Spectroscopy (GCMS), 1D-NMR (1H-NMR and 13C-NMR) and 2D-NMR (1H-13C HMQC) Spectroscopy to determine the product structure molecules. According to the data of IR, GC-MS, 1H-NMR, 13C-NMR and 1H-13C HMQC spectra, the products are THHGV-5 and THHGV-7 as white crystalline powders. Key words:Tetrahydrohexagamavunon-5, Tetrahydrohexagamavunone-7, Hexagamvunon-5, Hexagamavunone-7

Synthesis and cytotoxicity test of LR-2 on breast cancer cell line T47D Ritmaleni Ritmaleni; Dina Anitasari; Sinta Susanti; Sismindari .
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in Faculty of Farmacy, Universitas Gadjah Mada. This reserach was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cancer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaldehyde, 2-indanone and thiourea were reacted together for 6hours in acid catalyst. The cytotoxicity test was carried by using breast cancer cell line the MTT assay method and the LC50 was ditermined by using the probit analysis with Miller and Tainter method. The product was isolated by using preparative TLC in 54 % yield. The structure was elucidated by spectroscopymethods (UV-Vis, H-NMR, IR and GC-MS).The LC50 is 159 µM.Keywords : LR-2, benzaldehyde, 2-indanone, thiourea, T47D

Synthesis of Phenethyl-aza-ß-Lactam (1,2-Dimethyl4(R,S)-Phenethyl-[1,2]Diazetidin-3-One) Ritmaleni Ritmaleni; Varinder K Anggarwal
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Racemic spiro-epoxide, (7RS, 1RS, 3RS)-phenethyl-10-oxa-1,3-dithiaspiro[6,7]octane 1,3-dioxide 12, can be synthesised in four step reactions, sequences starting from the commercially available 1,3-dithiane 8. The synthesis of aza ß-lactam, 1,2-dimethyl-4(R,S)-phenethyl-[1,2]diazetidin-3one 13, was successfully carried out by opening the epoxide by 1,2-dimethyl hydrazine salt in moderate yield. Keywords : epoxide, aza-ß-lactam

ATTEMPTED SYNTHESIS OF BIS-SPIROEPOXIDE DITHIANEDIOXIDE Ritmaleni Ritmaleni; Varinder K. Aggarwal
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The bis-spiroepoxide dithiane dioxide has been attempted to be synthesised as its role as an intermediate in the synthesis of diaminopimelic acid (DAP). The first method was carried out by reacting the 3-dithiane-2-diethylphosphonate 4 with an aqueous solution of the commercially available glutaraldehide resulting the bis-ketene dithiane dioxide 5. The second alternative method was involving the ozonolysis of cyclopentene 7 in the synthesis of bis-ketene dithiane dioxide 5 in four step reactions which gave moderate to good yield. Unfortunately, epoxidation process for the bis-ketene dithiane dioxide 5 was still unsuccess yet.Key words: synthesis, diaminopimelic acid, bis-spiroepoxide dithiane dioxide

Co-Authors Abdul Karim Zulkarnain Adam Hermawan Afifah, Anis Agung Endro Nugroho Ahmad Marzuki Arifin, Muhammad Fajar Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Desy Ayu Irma Permatasari Dina Anitasari Haryono Wibowo Ian Praditya Iip Izul Falah Imaniyyati, Niar Nurul Kazutaka Maeyama M. Utoro Yahya Megawati Parmasari Muthi Ikawati Ni Putu Linda Laksmiani Novrizal Abdi Sahid Nurcahyani, Wahyu Purwanto, Heri Rahmayani, Almira Retno Murwanti Retno Wahyuningrum Rumiyati, Rumiyati Sagiyo, Marrita Langgeng Sardjiman Sardjiman Simbara, Ari Sinta Susanti Sismindari . Sismindari . Sismindari, Sismindari Subagus Wahyuono Syach, Muhammad Ferdian Takushi Kaneko Tatang Irianti Titik Nuryastuti Varinder K Anggarwal Varinder K. Aggarwal Woro Anindito Sri Tunjung Yohanes, Jasson

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