Article Per Year (5 Year)
p-Index From 2021 - 2026
2.612
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL FARMASIMED (JFM) MONSU'ANI TANO Jurnal Pengabdian Masyarakat Jurnal Farmagazine Jurnal Ilmiah Medicamento Jurnal Insan Farmasi Indonesia Journal of Fundamental and Applied Pharmaceutical Science Jurnal Abdiraja International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Megawati, Sefi
Universitas Muhammadiyah A.R. Fachruddin
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : JURNAL FARMASIMED (JFM)

 1 
Test Of Antibacterial Activity and GC-MS analysis of ethyl acetate and N-hexane fractions of Kenitu leaves (Chrysophyllum cainito L.) Megawati, Sefi; Meta Safitri; Rangkuti, Saru Noliqo; Luthfiyyatul Makiyyah; Arum Mawarni, Nur Indah
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2421

Abstract

Background: As a result of the large number of infectious diseases, every year 3.5 million people die. The more microorganisms that are resistant to antibiotics, the search for and research into new antibacterials must be carried out from medicinal plant extracts such as the kenitu leaf plant, whose antibacterial activity is still rarely researched. Objectives: to analyze the factors that influence the management of solid media waste of hazardous and toxic materials at RSUD.Kumpulan Pane, Tebing Tinggi City. Research method: This research is a type of laboratory experiment using the semi-polar solvent ethyl acetate and the non-polar solvent n hexane from kenitu (Chrysophyllum cainito L.) leaves to test their antibacterial activity using the disk diffusion method. In this study there were six treatment groups: positive control (+) ciprofloxacin, negative control (-) DMSO 10%, as well as four concentration variations, namely K1: 25 mg/ml, K2: 50 mg/ml, K3: 100 mg/ml, and K4: 500 mg/ml. Results: The results of the ANOVA test of the antibacterial activity test of the Bacillus subtilis fraction against the ethyl acetate fraction obtained a p value <0.001. From the results of the homogeneity test, a significant value of p = 0.023 was obtained. These values ??are in accordance with the criteria (p <0.05), meaning that the concentration treatment has a significant impact on the diameter of the inhibition zone. Based on the results of the two tests, the data obtained in this study were analyzed using the non-parametric Kruskal-Wallis statistical test showing that there was a difference in the average Asymp value in each treatment. Sig. = 0.005 (p <0.05). The results of the Mann-Whitney test of the ethyl acetate fraction on Bacillus subtilis bacteria stated that it had a significant difference in providing an inhibition zone. Conclusion: the analysis stated that there were 27 compounds that were identified in the ethyl acetate fraction and 19 compounds that were identified in the n-hexane fraction of kenitu leaves. The results of testing regarding antibacterial activity stated that the kenitu leaf fraction from ethyl acetate solvent was only able to inhibit the growth of Bacillus subtilis and Staphylococcus aureus bacteria at a concentration of 500 mg/ml, for the kenitu leaf fraction from n-hexane solvent stated that all concentrations were not possible. able to inhibit the growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis.
The Effect of Genjer Leaf Extract Ointment (Limnocharis flava) on Incision Wounds in Male New Zealand White rabbits Megawati, Sefi; Saru Noliqo Rangkuti; Ilmi Hidayat; Avianti Eka Dewi Aditya Purwaningsih
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tfpm7z77

Abstract

Background: Incision wounds are a common type of open wound that require proper treatment to prevent infection and accelerate the healing process. The use of natural products as alternative wound therapy has been increasingly developed, one of which is yellow velvetleaf (Limnocharis flava), known to contain active compounds such as flavonoids, tannins, and saponins that have anti-inflammatory and wound healing properties. Objective: This study aimed to determine the effect of ethanol extract ointment of Limnocharis flava leaves on incision wound healing in male New Zealand White rabbits and to identify the most effective extract concentration. Methods: Limnocharis flava leaves were extracted using 70% ethanol by maceration with a ratio of 1:10, then formulated into ointments with concentrations of F1 (5%), F2 (7.5%), F3 (10%), F4 (negative control), and F5 (positive control using povidone-iodine). Results: The evaluation results showed that all ointment formulations met the physical requirements, including good homogeneity, stable form and color, pH compatible with skin pH, as well as optimal spreadability and adhesion. Observation of wound healing indicated an increase in the percentage of wound closure with higher extract concentrations and longer treatment duration. Statistical analysis using Two-Way ANOVA showed a p-value < 0.05, indicating a significant effect of extract concentration and duration of treatment on incision wound healing. Conclusion: Quantitatively, the 10% concentration group (F3) showed the highest percentage of wound closure and the fastest healing time compared to other groups, with effectiveness approaching the positive control. The 10% Limnocharis flava leaf extract ointment is the most effective formulation for accelerating incision wound healing.
Co-Authors Abdul Latif Junaedi ABDULLOH Agil Restudiarti Anna Febriyanti Ari, Muhamad Ilham Ariadin Nurfi Arini Aprilliani Arini Aprilliani Arum Mawarni, Nur Indah Azzahra Fernanda Carolina, Febby Dania Maretiana Daulay, Meilyn A.K. Debya Wahyuningtyas Dewi Kurniasih Dinda Nisa S.Farm Djoko Wahyono Djoko Wahyono Elsa Agustyani Sukma Soleha Ervina Damayanti Oktavia Fathonah, Nuriyatul Fita Rahmawati Fita Rahmawati Fitri Hidayati Fitria Budi Utami Fitria Novfrianti Musrizal Ilmi Hidayat Luthfiyyatul Makiyyah M, Fajrin Noviyanto3 Meta Safitri Nia Wati Nita Rusdiana S.Farm., M.Sc, Apt Nur&#039;aini 4 Nuraini Nuraini Nuraini Nuraini Nuriyatul Fhatonah Nur’aini Nur’aini Purwaningsih, Avianti Eka Dewi Aditya Radooti Merlin Sagala Rangkuti, Saru Noliqo Rasydy, La Ode Akbar Reni Rahmawati Rini Rumantir Saru Noliqo Rangkuti Selpina Kurniasih Septiandu indransyah1 Setiawan, Abdul Aziz Setiawan, Abdul Aziz Sopiahani, Syifa Stiani, Sofi Nurmay Sujera, Lulu Sylvia, Diana Trisna Lestari Ulis, Ulis Wahyu Laras Setyani Yuniarto, Ari