Article Per Year (5 Year)
p-Index From 2020 - 2025
1.978
P-Index
This Author published in this journals
All Journal Journal of Nutrition and Health Nurse Media Journal of Nursing Jurnal Kedokteran Diponegoro Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Medica Hospitalia Jurnal Penyakit Dalam Indonesia Journal of Mental Health
Innawati Jusup
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
THE COMPARISON OF PLASMA MALONDIALDEHYDE LEVELS AMONG OSTEOPOROTIC AND NON-OSTEOPOROTIC POSTMENOPAUSAL WOMEN Innawati Jusup; Putri Theresia LA Bancin; Santoso Jaeri; Banundari Rachmawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29337

Abstract

Introduction: Osteoporosis is a bone metabolic disorder due to decreased of bone matrix and minerals. Oxidative stress refered as an elevation of reactive oxygen species (ROS) in the cells causing structural damages and functional loss, is contributed in the process of osteoporosis, but its association still in controversy. Herewith we report the comparison of the plasma malondialdehyde (MDA) levels, one of oxidative stress markers among osteoporotic postmenopausal women and without osteoporosis. Methods: An observational analytic study with cross-sectional approach among 40 postmenopausal women, grouped into two groups, osteoporosis (n=20) and non-osteoporosis (n=20) based on bone mineral density (BMD) score. The plasma MDA levels were measured from venous blood using ELISA. The difference between plasma MDA levels among both groups was analyzed using an independent T-test. Results: The characteristics of demography and clinic among both groups are relatively similar. However, there is a difference in the body weight and BMI. Furthermore, there is no significant differences of MDA levels between the two groups (292,03±61,02ng/ml for group with osteoporosis, and 315,25±73,86ng/ml for non-osteoporosis, p=0,286). Conclusions: There is no significant difference in plasma MDA levels among osteoporosis and non-osteoporosis postmenopausal women.
PENGARUH EKSTRAK BUAH KIWI (ACTINIDIA DELICIOSA) TERHADAP KADAR ENZIM HEPAR TIKUS WISTAR TERINDUKSI PARASETAMOL Naufal Fauzan Ihsan; Innawati Jusup; Amallia Nugettsiana Setyawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.413 KB) | DOI: 10.14710/dmj.v6i2.18600

Abstract

Latar Belakang : Kasus efek samping obat parasetamol berupa kerusakan hepar sekitar 9,5% akibat pemberian parasetamol  yang melebihi dosis terapeutik. Metabolit aktif obat ini akan memicu pembentukan stress oksidatif. Kerusakan hepar dapat dideteksi dini melalui enzim hepar (ALT dan AST). Buah kiwi (Actinidia deliciosa) memiliki potensi sebagai hepatoprotektor karena kaya akan vitamin C dan senyawa polifenol.Tujuan : Membuktikan pengaruh pemberian ekstrak Actinidia deliciosa terhadap kadar enzim hepar tikus wistar terinduksi parasetamol.Metode : Penelitian true experimental dengan metode post test only with control group design. Penelitian ini menggunakan lima kelompok, kelompok kontrol negatif yang diberi pakan standar (K1), kelompok kontrol positif yang diberi pakan standar dan induksi parasetamol (K2), dan kelompok perlakuan yang diberi pakan standar, induksi parasetamol, dan ekstrak Actinidia deliciosa 100 mg/kgBB (P1), 200 mg/kgBB (P2), serta 400 mg/kgBB (P3).Hasil : Kadar ALT kelompok K1 72,08 ± 4,56 ng/dL, kelompok K2 325,61 ± 82,80 ng/dL, kelompok P1 311,67 ± 89,80 ng/dL, kelompok P2 474,15 ± 94,21 ng/dL, dan kelompok P3 444,61 ± 131,83 ng/dL. Kadar AST kelompok K1 128,43 ± 6,85 ng/dL, kelompok K2 388,35 ± 84,83 ng/dL kelompok P1 239,65 ± 76,75 ng/dL, kelompok P2 597,00 ± 46,70 ng/dL, dan kelompok P3 556,20 ± 98,61. Terdapat perbedaan kadar ALT bermakna antarkelompok (p = 0,040) dan AST bermakna antarkelompok (p = 0,003).Kesimpulan : Terdapat pengaruh ekstrak Actinidia deliciosa 100 mg/kgBB terhadap kadar enzim hepar tikus wistar terinduksi parasetamol.
HUBUNGAN KADAR VITAMIN D DENGAN FUNGSI KOGNITIF PADA LANSIA Nihayatul Istianah; Dwi Ngestiningsih; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.297 KB) | DOI: 10.14710/dmj.v8i1.23350

Abstract

Latar Belakang: Jumlah penduduk lanjut usia semakin meningkat dari tahun ke tahun . Pada orang lanjut usia cenderung terjadi penurunan dari fungsi kogntif dan rendahnya kadar vitamin D dalam tubuh akibat rendahnya sintesis vitamin D di kulit dan juga rendahnya vitamin D dari asupan makanan. Reseptor vitamin D tersebar luas di jaringan otak dan bentuk aktif vitamin D [1,25(OH)2D3] menunjukkan efek neuroprotektif bagi otak yang berpotensi penting untuk pencegahan penurunan fungsi kognitif. Studi terbaru dari negara-negara Barat menunjukkan adanya hubungan antara tingkat vitamin D yang lebih rendah dengan penurunan fungsi kognitif pada lansia . Tujuan: Mengetahui hubungan kadar vitamin D dengan fungsi kognitif pada lansia. Metode: Penelitian yang dilakukan adalah observasional belah lintang dengan subjek lansia berusia diatas 60 tahun di beberapa posyandu lansia di Kota Semarang pada bulan Mei - Oktober 2018. Subjek penelitian sebanyak 38 sampel dengan teknik randomization sampling. Data yang digunakan adalah data primer dimana fungsi kognitif diperiksa menggunakan kuesioner MMSE (Mini Mental State Examintaion), dan kadar vitamin D diukur dengan menggunakan ELISA (Enzyme linked immunosorbent assay).Uji hipotesis menggunakan uji Somer’s D Hasil: Tidak didapatkan hubungan antara kadar vitamin D dengan fungsi kognitif pada lansia ( p=0,418 , r = 0,109) maupun dengan domain orientasi, registrasi, atensi, memori,bahasa dan visuospasial. Didapatkan hubungan yang bermakna antara tingkat pendidikan dan fungsi kognitif pada lansia (p= 0,009). Tidak didapatkan hubungan bermakna antara usia dan pekerja dengan fungsi kogntiif pada lansia Kesimpulan: Tidak terdapat hubungan antara kadar vitamin D dengan fungsi kognitif pada lansiaKata Kunci: Vitamin D, fungsi kognitif, lansia
Proportion of Depression Symptoms and Its Relationship with ARV Therapy: A Study at the VCT Clinic, Dr. Kariadi General Hospital Sofro, Muchlis Achsan Udji; Raharja, Tommy; Haidati, Titis; Sari, Linda Kartika; Jusup, Innawati
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Indonesia has the second largest HIV burden in Asia. The prevalence of depression in HIV/AIDS is 2-10 times higher than the general population, influenced by biological, environmental, psychological, and demographic factors. Data on the proportion of depression symptoms in HIV/AIDS patients and their relationship to biological factors are still limited, which needed for better treatment of HIV/AIDS. This study aimed to determine the prevalence of depression and its relationship to the biologic factors of ARV therapy (ART) in HIV/AIDS patients.Methods. Cross-sectional study was conducted among 142 HIV/AIDS patients undergoing ARV treatment at RSUP. Dr. Kariadi in January – March 2021. Demographic data, ART, ART type, side effects, ARV use duration, viral load, and CD4 cell count were obtained from medical records. The incidence of depression was assessed by the Beck Depression Inventory II (BDI-II).Results. The proportion of depression symptoms was 48.6%, consisting of mild depression (26.1%), moderate depression (17.6%), and severe depression (4.9%). Multivariate analysis resulted a significant relationship between the incidence of depression and biological factors, consisting of ART side effects, ART use duration, and CD4 cell count. Meanwhile, there was no significant relationship between the incidence of depression with the ART type and viral load. Conclusion. The proportion of depression symptoms in HIV patients undergoing ART is 48.6%. It is concluded that biological factors can affect the proportion of depression in patients with ART.
HUBUNGAN INTENSITAS PENGGUNAAN SITUS JEJARING SOSIAL DENGAN KECEMASAN PADA MAHASISWA AKHIR Yethie Hillda Pranata; Natalia Dewi Wardani; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.474 KB) | DOI: 10.14710/dmj.v5i4.15988

Abstract

Latar Belakang Mahasiswa menggunakan situs jejaring sosial sebagai alat komunikasi dan juga sebagai fungsi hiburan untuk menghindari stres. Kegagalan mekanisme koping dan adaptasi dapat menyebabkan gangguan kecemasan pada mahasiwa. Namun, penggunaan situs jejaring sosial yang berlebihan atau dengan intensitas yang tinggi dapat menyebabkan dampak negatif seperti kecemasan. Gejala adanya gangguan kecemasan tersebut dapat berupa gejala fisik, psikologis, dan perilaku.Tujuan Mengertahui adakah hubungan intensitas penggunaan situs jejaring sosial dengan tingkat kecemasan pada mahasiswa tingkat akhir.Metode Penelitian ini merupakan penelitian observasional analitik desain cross sectional. Sebanyak 215 mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Diponegoro angkatan 2012 Calon subyek penelitian yang masuk kriteria inklusi dikumpulkan dan dimintai kesediaannya untuk menjadi subyek penelitian dengan mengisi informed consent dengan benar. Kemudian subyek penelitian diminta untuk mengisi kuesioner demografi, kuesioner Social Network Time Usage Scale (SONTUS) dan kuesioner Zung Self-rating Anxiety Scale (ZSAS). Analisis hubungan menggunakan uji korelasi Spearman.Hasil Responden memiliki faktor demografi yang bervariasi. Sebanyak 74 responden (35,1%) memiliki intensitas penggunaan situs jejaring sosial rendah, 99 responden (46,9%) memiliki intensitas sedang, 36 responden (17,1%) memiliki intensitas tinggi, dan sisanya sejumlah 2 responden (0,9%) memiliki intensitas sangat tinggi. Terdapat 96 responden (45,5%) tidak mengalami gangguan cemas, 114 responden (54%) mengalami kecemasan ringan, satu responden (0,5%) mengalami kecemasan sedang, dan tidak terdapat responden yang mengalami kecemasan berat. Terbukti adanya hubungan yang signifikan antara intensitas penggunaan situs jejaring sosial dan kecemasan pada mahasiswa tingkat akhir dengan koefisien signifikansi sebesar 0,000 serta koefisien korelasi sebesar 0,537.Kesimpulan Terdapat hubungan yang bermakna antara intensitas penggunaan situs jejaring sosial dan kecemasan.
The Effect of Folic Acid Supplementation on the Liver Function in Chronic Schizophrenia Patients Fitrikasari, Alifiati; Asady, Julianata; Jusup, Innawati; Asikin, Hang Gunawan
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 17 No 2 (2023): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v17i2.5941

Abstract

Oxidative stress caused by free radicals and long-term antipsychotic use in chronic schizophrenic patients may result in liver cell damage and impaired liver function. Folic acid is an exogenous antioxidant that can boost the antioxidant defense mechanism (Glutathione Reductase), lowering free radicals and improving liver function. Determine the correlation between adjuvant folic acid and liver function in chronic schizophrenic patients. This was a placebo-controlled, double-blinded randomized control trial. The study sample included 36 patients in the control group and 36 patients in the treatment group. Subjects were patients who had suffered from schizophrenia for at least 2 years and received antipsychotics. Research subjects in the treatment group received folic acid supplementation. The intervention was conducted for 21 days during hospitalization. The level of AST (U/L) and ALT (U/L) was measured before and after supplementation. Following folic acid supplementation, AST levels were significantly improved (26.950 U/L compared to prior to treatment 33.09 U/L, p= <0.001). ALT levels after treatment were increased but there was no significant difference observed (p= 0.835). Folic acid supplementation improves AST levels significantly.
Pengaruh Pemberian Aromaterapi Lemon terhadap Skor Kecemasan Mahasiswi Fakultas Kedokteran Universitas Diponegoro Fitrikasari, Alifiati; Fajriyanti, Nur Isnaeni; Wardani, Natalia Dewi; Jusup, Innawati
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.522 KB) | DOI: 10.36408/mhjcm.v7i2.408

Abstract

Background: Based by Riskesdas in 2013, 6% of Indonesia’s population the age of 15 years old and more had emotional disorders which shown by symptoms of anxiety and depression. In university students, the study found that 25% of them had light anxiety, 60% had moderate anxiety, and 15% had severe anxiety. The mean of medical student who had anxiety symptoms around the world are 12-69%. Relaxation therapy able to decrease anxiety level, which by giving aromatherapy, it able to stimulates the brain to relax. Lemon is one of the aromatherapies that found effectively able to decrease anxiety symptoms by its refreshingly sharp smell and lifting the mood, which strengthening its user’s psyche. To measure the anxiety score, the author used the Zung Self-rating Anxiety Scale (ZSAS). The objective of this study aimed to investigate the effect of inhaling lemon aromatherapy on anxiety in female students of Medical Faculty of Diponegoro University Methods: This study used experimental pre and post-test without control design. Zung Self-rating Anxiety Scale was used to investigate the anxiety level of the samples. 32 persons volunteered as participants by 1 of them dropped out. The group inhaled lemon aromatherapy for 2 weeks. At the end of week 2, the participants’ anxiety was measured, and the results were statistically analysed. Saphiro-Wilk Test was used as the normality test while the results of the measured anxiety were tested by Wilcoxon Test. Results: There was a significant decreased anxiety score of the participants after inhaling lemon aromatherapy for two weeks. Based by pre and post-test result, the mean of anxiety score decreased from 37.32 to 31.84 (p=0.000). Conclusions: Lemon aromatherapy essential oil is able to significantly decrease the anxiety score of female students of Faculty of Medicine Diponegoro University. Keywords: Lemon aromatherapy, anxiety, medical student
Correlation of Duration of Antipsychotic Therapy with Hemoglobin Levels in People with Schizophrenia Siregar, Jessica Anggun Cristine; Jusup, Innawati; Jaeri, Santoso; Wardani, Natalia Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.908

Abstract

Background: Schizophrenia is a serious mental disorder with various unknown causes accompanied by a collection of positive symptoms, negative symptoms, disorganization in thinking, speaking or movement and cognitive dysfunction. The therapeutic modality used to treat these symptoms is antipsychotic therapy. Over a certain period of time, the use of antipsychotics can cause hematological syndrome which affects the process of red blood cell formation and hemoglobin levels. Low hemoglobin levels can worsen neuronal function in the brain, thereby aggravating symptoms in schizophrenia. Aim: Analyzing the relationship between duration of antipsychotic therapy <2 years and ≥2 years with hemoglobin levels in schizophrenia patients. Method: This research is an analytical observational study with a cross-sectional approach in which research subjects were obtained using a consecutive sampling method from medical records of patients with schizophrenia (ODS) at RSJD Dr. Amino Gondohutomo Semarang (n=68) divided into 2 groups consisting of patients with a duration of therapy <2 years and a duration of therapy ≥2 years. The relationship between duration of antipsychotic therapy and hemoglobin levels was analyzed using unpaired t-test. Result:  The mean hemoglobin value for people with schizophrenia in the group with a duration of therapy <2 years is 14.09, while that in the group with a duration of therapy ≥2 years is 14.06 with a p value = 0.928. Conclusion: There was no relationship between hemoglobin levels in people with schizophrenia and duration of therapy both <2 years and ≥2 years.
Relationship between Stress Level and Risk of Eating Disorder in Undergraduate Students during the COVID-19 Pandemic Clara, Jessica; Hadiati, Titis; Jusup, Innawati; Sarjana A.S., Widodo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.953

Abstract

BACKGROUND: The prevalence of undergraduate students' stress before COVID-19 pandemic in Indonesia was 36.7-71.6%, where undergraduate students' age was classified as the age group for the onset of eating disorders. During the COVID-19 pandemic, students must continue their studies. However, modifications of daily routines in pandemic have a negative effect on mental health, increase negative stress (distress), and it could increase the incidence of eating disorders symptoms. AIMS:  The purpose of this study was to find out the relationship between stress level in undergraduate student and the risk of eating disorder they might have during the COVID-19 Pandemic. METHOD: This study used cross sectional study design and conducted on June 2021. The subjects were 110 active students who studied in Faculty of Medicine Diponegoro University who was chosen using consecutive sampling technique. The Perceived Stress Scale-10 questionnaire was used to measure the students’ stress level for the past month and the Eating Attitude Test-26 questionnaire was used to determine the students' risk of having an eating disoder. Both questionnaires were selected because it has been proven as reliable questionnaires with high sensitivity and specificity (Cronbach's alpha >0.7). RESULT:  The result showed that out of 110 students who have been subjects of this study, 25,5% of respondents experienced low stress, 68,2% of respondents experienced moderate stress, and 6,4% of respondents experienced high stress. It also showed that 4,5% of respondents have the risk of having an eating disorder. CONCLUSION: There is a significant correlation (p=0,005) between the stress level and risk of eating disorder with very weak positive relationship direction (r=0,097).
Prevalensi gangguan cemas dengan perilaku non-suicidal self-injury pada pasien poli rawat jalan Innawati Jusup; Widodo Sarjana; Tanjung Ayu Sumekar; Fanti Saktini
Link Journal of Mental Health Vol 2 No 1 (2025): October : Journal of Mental Health
Publisher : CV LINK Education Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63425/ljmh.v2i1.90

Abstract

Pendahuluan: Gangguan kecemasan ditandai dengan kekhawatiran yang berlebihan dan tidak terkendali. Prevalensi gangguan ini sepanjang hidup mencapai 4,3% pada populasi umum. Manifestasi klinisnya beragam dan dapat berdampak negatif terhadap kesejahteraan psikososial, fungsi peran, produktivitas kerja atau akademik, serta kualitas hidup pasien. Tujuan: Mengetahui prevalensi gangguan kecemasan yang disertai dengan perilaku Non-Suicidal Self-Injury (NSSI) pada pasien yang berkunjung ke poliklinik psikiatri rawat jalan. Metode: Penelitian ini menggunakan pendekatan analisis deskriptif dan observasional analitik. Data dikumpulkan dari rekam medis selama periode Januari-Desember 2023. Lokasi penelitian berada di Rumah Sakit Nasional Diponegoro, Semarang. Penilaian psikometri dilakukan menggunakan instrumen Hamilton Anxiety Rating Scale (HAM-A). Analisis deskriptif untuk menggambarkan karakteristik responden dan perilaku NSSI, serta menggunakan uji Mann-Whitney untuk membandingkan tingkat kecemasan (skor HAM-A) antara kelompok yang melakukan dan tidak melakukan self-harm. Hasil: Sebanyak 96 responden berpartisipasi dalam penelitian ini, dengan mayoritas merupakan mahasiswa (63,8%), mencerminkan lokasi rumah sakit yang berdekatan dengan kawasan kampus. Dari 19 pasien yang menunjukkan perilaku NSSI, sebanyak 94,7% adalah perempuan. Selain itu, 68,4% dari mereka mengalami lebih dari satu jenis stresor, dengan stresor utama berasal dari lingkungan keluarga dan pendidikan. Tidak ditemukan perbedaan signifikan dalam skor HAM-A antara pasien dengan perilaku NSSI dan yang tidak. Kesimpulan: Prevalensi gangguan kecemasan yang disertai perilaku NSSI sebesar 27,54%, dengan prevalensi lebih tinggi pada mahasiswa perempuan yang mengalami lebih dari satu jenis stresor, terutama yang berkaitan dengan keluarga dan pendidikan.
Co-Authors Alifiati Fitrikasari Amallia Nugettsiana Setyawati Andreas Johan Hardjosoesanto Andreas Tigor Partomuan Andrew Johan Asady, Julianata Asikin, Hang Gunawan Astika Widy Utomo Banundari Rachmawati Clara, Jessica Dwi Ngestiningsih Fajriyanti, Nur Isnaeni Fanti Saktini Haidati, Titis Jaeri, Santoso Liko Maryudhiyanto Linda Kartika Sari Margaretha, Christine Miranti Anggun Sari Muchlis Achsan Udji Sofro Natalia Dewi Wardani Naufal Fauzan Ihsan Nihayatul Istianah Prawara, Ananta Siddhi Putri Theresia LA Bancin Raharja, Tommy Sandjaja, Alicia Santoso Jaeri Sarjana A.S., Widodo Siregar, Jessica Anggun Cristine Stefani Pramudita Jaya Suharto Suharto Tanjung Ayu Sumekar Titis Hadiati, Titis Widodo Sarjana AS, Widodo Yethie Hillda Pranata